m6A-centered Crosstalk Information
Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
| Crosstalk ID |
M6ACROT03227
|
[1] | |||
m6A modification
KDM4B
KDM4B
WTAP
Methylation
 : m6A sites
Direct
Enhancement
Histone modification
Regulated Target
KDM4B
Downstream Gene
|
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| m6A Modification: | |||||
|---|---|---|---|---|---|
| m6A Regulator | Wilms tumor 1-associating protein (WTAP) | WRITER | |||
| m6A Target | Lysine-specific demethylase 4B (KDM4B) | ||||
| Epigenetic Regulation that have Cross-talk with This m6A Modification: | |||||
| Epigenetic Regulation Type | Histone modification (HistMod) | ||||
| Epigenetic Regulator | Lysine-specific demethylase 4B (KDM4B) | ERASER | View Details | ||
| Crosstalk Relationship | m6A → Histone modification | Enhancement | |||
| Crosstalk Mechanism | m6A modification impacts directly histone modification through modulating the expression level of histone-associated enzymes | ||||
| Crosstalk Summary | In t(8; 21) AML cell lines, WTAP could regulate the expression of Lysine-specific demethylase 4B (KDM4B) by regulating the m6A modification of the 3'UTR of KDM4B mRNA, and silencing the expression of KDM4B could inhibit the cellular proliferation in vitro. | ||||
| Responsed Disease | T(8; 21) acute myeloid leukemia | ICD-11: XH3CX5 | |||
| Cell Process | Cell proliferation | ||||