General Information of the Disease (ID: M6ADIS0164)
Name
Asthma
ICD
ICD-11: CA23
Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Disease
In total 3 item(s) under this disease
Crosstalk ID: M6ACROT05095
m6A Regulator Methyltransferase-like 3 (METTL3)
m6A Target Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (COX4I1)
Epigenetic Regulator PM2.5-associated exosomal transcript PAET
Regulated Target Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship ncRNA → m6A
Crosstalk ID: M6ACROT05096
m6A Regulator YTH domain-containing family protein 3 (YTHDF3)
m6A Target Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (COX4I1)
Epigenetic Regulator PM2.5-associated exosomal transcript PAET
Regulated Target Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship ncRNA → m6A
Crosstalk ID: M6ACROT05760
m6A Regulator Methyltransferase-like 3 (METTL3)
m6A Target hsa-miR-143-3p
Epigenetic Regulator hsa-miR-143-3p
Regulated Target Mothers against decapentaplegic homolog 3 (SMAD3)
Crosstalk relationship m6A → ncRNA
References
Ref 1 Effect of the carbocyclic nucleoside analogue MDL 201,112 on inhibition of interferon-gamma-induced priming of Lewis (LEW/N) rat macrophages for enhanced respiratory burst and MHC class II Ia+ antigen expression. J Leukoc Biol. 1994 Aug;56(2):133-44. doi: 10.1002/jlb.56.2.133.
Ref 2 Clinical pipeline report, company report or official report of Roche (2009).
Ref 3 TAS6417, A Novel EGFR Inhibitor Targeting Exon 20 Insertion Mutations. Mol Cancer Ther. 2018 Aug;17(8):1648-1658. doi: 10.1158/1535-7163.MCT-17-1206. Epub 2018 May 10.
Ref 4 Further Characterization of the Metabolism of Desloratadine and Its Cytochrome P450 and UDP-glucuronosyltransferase Inhibition Potential: Identification of Desloratadine as a Relatively Selective UGT2B10 Inhibitor. Drug Metab Dispos. 2015 Sep;43(9):1294-302. doi: 10.1124/dmd.115.065011. Epub 2015 Jul 1.
Ref 5 US patent application no. 7,427,470, Antisense modulation of helicase-moi expression.