m6A-centered Disease Response Information

General Information of the Disease (ID: M6ADIS0148)
Name
Gestational diabetes mellitus
ICD
ICD-11: JA63
Full List of Target Gene(s) of This m6A-centered Disease Response
Insulin receptor (INSR)
 Target Info 
In total 1 item(s) under this target gene
Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene [1]
Response Summary Down-regulation of m6A both in the 3'-UTR and CDS near stop codons of placental mRNAs is involved in gestational diabetes mellitus(GDM) development in Han Chinese women. MazF-qPCR verified that the m6A levels of the BAMBI 3'-UTR and CDS were significantly decreased in GDM. m6A levels of GDM related genes (Insulin receptor (INSR) and IRS1) were significantly reduced in GDM.
Responsed Disease Gestational diabetes mellitus [ICD-11: JA63]
Insulin receptor substrate 1 (IRS1)
 Target Info 
In total 1 item(s) under this target gene
Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene [1]
Response Summary Down-regulation of m6A both in the 3'-UTR and CDS near stop codons of placental mRNAs is involved in gestational diabetes mellitus(GDM) development in Han Chinese women. MazF-qPCR verified that the m6A levels of the BAMBI 3'-UTR and CDS were significantly decreased in GDM. m6A levels of GDM related genes (INSR and Insulin receptor substrate 1 (IRS1)) were significantly reduced in GDM.
Responsed Disease Gestational diabetes mellitus [ICD-11: JA63]
Non-metastatic gene A protein (BAMBI)
 Target Info 
In total 1 item(s) under this target gene
Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene [1]
Response Summary Down-regulation of m6A both in the 3'-UTR and CDS near stop codons of placental mRNAs is involved in gestational diabetes mellitus(GDM) development in Han Chinese women. MazF-qPCR verified that the m6A levels of the Non-metastatic gene A protein (BAMBI) 3'-UTR and CDS were significantly decreased in GDM. m6A levels of GDM related genes (INSR and IRS1) were significantly reduced in GDM.
Responsed Disease Gestational diabetes mellitus [ICD-11: JA63]
Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Disease
In total 1 item(s) under this disease
Crosstalk ID: M6ACROT05820
 Crosstalk Info 
m6A Regulator Methyltransferase-like 3 (METTL3)
 Regulator Info 
m6A Target hsa_circ_0072380 (Circ_ZNF131)
 Target Gene 
Epigenetic Regulator hsa_circ_0072380 (Circ_ZNF131)
Crosstalk relationship m6A → ncRNA
References
Ref 1 m6A mRNA methylation regulates the development of gestational diabetes mellitus in Han Chinese women. Genomics. 2021 May;113(3):1048-1056. doi: 10.1016/j.ygeno.2021.02.016. Epub 2021 Mar 2.
Ref 2 Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007.
Ref 3 LY294002-geldanamycin heterodimers as selective inhibitors of the PI3K and PI3K-related family. Bioorg Med Chem Lett. 2001 Apr 9;11(7):909-13. doi: 10.1016/s0960-894x(01)00099-3.
Ref 4 The novel Nrf2 inducer TFM-735 ameliorates experimental autoimmune encephalomyelitis in mice. Eur J Pharmacol. 2017 May 5;802:76-84. doi: 10.1016/j.ejphar.2017.02.044. Epub 2017 Feb 27.