m6A-centered Crosstalk Information
Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
| Crosstalk ID |
M6ACROT05820
|
[1] | |||
m6A modification
Circ_ZNF131
Circ_ZNF131
METTL3
Methylation
 : m6A sites
Direct
Inhibition
Non-coding RNA
hsa_circ_0072380
Regulated Target
lncRNA miRNA circRNA
|
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| m6A Modification: | |||||
|---|---|---|---|---|---|
| m6A Regulator | Methyltransferase-like 3 (METTL3) | WRITER | |||
| m6A Target | hsa_circ_0072380 (Circ_ZNF131) | ||||
| Epigenetic Regulation that have Cross-talk with This m6A Modification: | |||||
| Epigenetic Regulation Type | Non-coding RNA (ncRNA) | ||||
| Epigenetic Regulator | hsa_circ_0072380 (Circ_ZNF131) | circRNA | View Details | ||
| Crosstalk Relationship | m6A → ncRNA | Inhibition | |||
| Crosstalk Mechanism | m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA | ||||
| Crosstalk Summary | knocking down METTL3 significantly reduced m6A modification of hsa_circ_0072380 (Circ_ZNF131), indicating that METTL3 regulated changes in m6A modification of hsa_circ_0072380. Our study revealed the important regulatory role of METTL3 and m6A modification of hsa_circ_0072380 in GDM. | ||||
| Responsed Disease | Gestational diabetes mellitus | ICD-11: JA63 | |||
| Cell Process | Cell proliferation | ||||
| Cell migration | |||||
| Cell invasion | |||||
In-vitro Model |
JEG-3 | Gestational choriocarcinoma | Homo sapiens | CVCL_0363 | |