m6A-centered Disease Response Information
General Information of the Disease (ID: M6ADIS0137)
| Name |
Atopic eczema
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|---|---|---|---|---|---|
| ICD |
ICD-11: EA80
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Full List of Target Gene(s) of This m6A-centered Disease Response
Metastasis associated lung adenocarcinoma transcript 1 (MALAT1)
| In total 1 item(s) under this target gene | ||||
| Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene | [1] | |||
| Response Summary | CircRNA hsa_circ_0004287 was upregulated in peripheral blood mononuclear cells of both AD and psoriasis patients. hsa_circ_0004287 reduced the stability of its host gene Metastasis associated lung adenocarcinoma transcript 1 (MALAT1) by competitively binding to IGF2BP3 with MALAT1 in an N6-methyladenosine (m6A)-dependent manner. | |||
| Responsed Disease | Atopic eczema [ICD-11: EA80] | |||
| Target Regulator | Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) | READER | ||
| Target Regulation | Up regulation | |||
| Pathway Response | MAPK signaling pathway | hsa04010 | ||
| Ubiquitin mediated proteolysis | hsa04120 | |||
| Cell Process | Inflammation | |||
| Proteasome pathway degradation | ||||
| In-vitro Model | RAW 264.7 | Mouse leukemia | Mus musculus | CVCL_0493 |
| In-vivo Model | IMQ-induced psoriatic model was constructed by applying 10 mg per ear 5% IMQ for 8 consecutive days, and 6 ug macrophage-specific control or hsa_circ_0004287 plasmid was topically applied every 2 days (5 mice per group per experiment). | |||
hsa_circ_0004287
| In total 1 item(s) under this target gene | ||||
| Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene | [1] | |||
| Response Summary | hsa_circ_0004287 was upregulated in peripheral blood mononuclear cells of both AD and psoriasis patients. hsa_circ_0004287 reduced the stability of its host gene metastasis associated lung adenocarcinoma transcript 1 (MALAT1) by competitively binding to IGF2BP3 with MALAT1 in an N6-methyladenosine (m6A)-dependent manner. | |||
| Responsed Disease | Atopic eczema [ICD-11: EA80] | |||
| Target Regulator | Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) | READER | ||
| Target Regulation | Up regulation | |||
| Pathway Response | MAPK signaling pathway | hsa04010 | ||
| Ubiquitin mediated proteolysis | hsa04120 | |||
| Cell Process | Inflammation | |||
| Proteasome pathway degradation | ||||
| In-vitro Model | RAW 264.7 | Mouse leukemia | Mus musculus | CVCL_0493 |
| In-vivo Model | IMQ-induced psoriatic model was constructed by applying 10 mg per ear 5% IMQ for 8 consecutive days, and 6 ug macrophage-specific control or hsa_circ_0004287 plasmid was topically applied every 2 days (5 mice per group per experiment). | |||
Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Disease
| In total 4 item(s) under this disease | ||
| Crosstalk ID: M6ACROT05275 | ||
| m6A Regulator | Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) | |
| m6A Target | Metastasis associated lung adenocarcinoma transcript 1 (MALAT1) | |
| Epigenetic Regulator | hsa_circ_0004287 (Circ_MALAT1) | |
| Regulated Target | Insulin like growth factor 2 mRNA binding protein 3 (IGF2BP3) | |
| Crosstalk relationship | ncRNA → m6A | |
| Crosstalk ID: M6ACROT05637 | ||
| m6A Regulator | Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) | |
| m6A Target | hsa_circ_0004287 | |
| Epigenetic Regulator | hsa_circ_0004287 (Circ_MALAT1) | |
| Regulated Target | Metastasis associated lung adenocarcinoma transcript 1 (MALAT1) | |
| Crosstalk relationship | m6A → ncRNA | |
| Crosstalk ID: M6ACROT05638 | ||
| m6A Regulator | Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) | |
| m6A Target | Metastasis associated lung adenocarcinoma transcript 1 (MALAT1) | |
| Epigenetic Regulator | Metastasis associated lung adenocarcinoma transcript 1 (MALAT1) | |
| Regulated Target | Protein S100-A8 (S100A8) | |
| Crosstalk relationship | m6A → ncRNA | |
| Crosstalk ID: M6ACROT06028 | ||
| m6A Regulator | Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) | |
| m6A Target | Metastasis associated lung adenocarcinoma transcript 1 (MALAT1) | |
| Epigenetic Regulator | Metastasis associated lung adenocarcinoma transcript 1 (MALAT1) | |
| Regulated Target | Protein S100-A9 (S100A9) | |
| Crosstalk relationship | m6A → ncRNA | |
References