m6A-centered Disease Response Information
General Information of the Disease (ID: M6ADIS0035)
| Name |
Cutaneous squamous cell carcinoma
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|---|---|---|---|---|---|
| ICD |
ICD-11: 2C31
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Full List of Target Gene(s) of This m6A-centered Disease Response
Tumor protein 63 (TP63)
| In total 1 item(s) under this target gene | ||||
| Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene | [1] | |||
| Response Summary | METTL3 knock down and methylation inhibitor cycloleucine could decrease the m6A levels and the expression of DeltaNp63 in Cutaneous squamous cell carcinoma. | |||
| Responsed Disease | Cutaneous squamous cell carcinoma [ICD-11: 2C31.Z] | |||
| Target Regulator | Methyltransferase-like 3 (METTL3) | WRITER | ||
| Target Regulation | Up regulation | |||
| Pathway Response | Signaling pathways regulating pluripotency of stem cells | hsa04550 | ||
| Cell Process | Cell proliferation | |||
| In-vitro Model | A-431 | Skin squamous cell carcinoma | Homo sapiens | CVCL_0037 |
| HSC-1 | Skin squamous cell carcinoma | Homo sapiens | CVCL_2807 | |
| In-vivo Model | 2 × 106 cells were suspended in 150 uL DMEM. The A431 cells (scrambled group and shRNA1 group) were injected subcutaneously into the flanks of nude mice. | |||
Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Disease
| In total 1 item(s) under this disease | ||
| Crosstalk ID: M6ACROT00011 | ||
| m6A Regulator | Methyltransferase-like 3 (METTL3) | |
| m6A Target | Methyltransferase-like protein 1 (METTL1) | |
| Epigenetic Regulator | Methyltransferase-like protein 1 (METTL1) | |
| Regulated Target | Cyclin-dependent kinase 4 (CDK4) | |
| Crosstalk relationship | m6A → m7G | |
| Drug | Palbociclib | |
References