m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR01525)
Target Name Methyltransferase-like protein 1 (METTL1)
Gene Name METTL1
Chromosomal Location 12q14.1
Family Class I-like SAM-binding methyltransferase superfamily, TrmB family
Function
Catalytic component of METTL1-WDR4 methyltransferase complex that mediates the formation of N(7)-methylguanine in a subset of RNA species, such as tRNAs, mRNAs and microRNAs (miRNAs) (PubMed:12403464, PubMed:31031083, PubMed:31031084, PubMed:36599982, PubMed:36599985, PubMed:37379838, PubMed:37369656). Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in a large subset of tRNAs that contain the 5'-RAGGU-3' motif within the variable loop (PubMed:12403464, PubMed:34352207, PubMed:34352206, PubMed:36599982, PubMed:36599985, PubMed:37369656). M7G46 interacts with C13-G22 in the D-loop to stabilize tRNA tertiary structure and protect tRNAs from decay (PubMed:36599982, PubMed:36599985). Also acts as a methyltransferase for a subset of internal N(7)-methylguanine in mRNAs (PubMed:31031084, PubMed:37379838). Internal N(7)-methylguanine methylation of mRNAs in response to stress promotes their relocalization to stress granules, thereby suppressing their translation (PubMed:31031084, PubMed:37379838). Also methylates a specific subset of miRNAs, such as let-7 (PubMed:31031083). N(7)-methylguanine methylation of let-7 miRNA promotes let-7 miRNA processing by disrupting an inhibitory secondary structure within the primary miRNA transcript (pri-miRNA) (PubMed:31031083). Acts as a regulator of embryonic stem cell self-renewal and differentiation (By similarity).
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Gene ID 4234
Uniprot ID
TRMB_HUMAN
HGNC ID
HGNC:7030
KEGG ID
hsa:4234
Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator
RNA modification
m6A Regulator: Methyltransferase-like 3 (METTL3)
 Regulator Info 
In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT00011
 Crosstalk Info 
Epigenetic Regulator Methyltransferase-like protein 1 (METTL1)
Regulated Target Cyclin-dependent kinase 4 (CDK4)
Crosstalk relationship m6A → m7G
Disease Neck squamous cell carcinoma
 Disease Info 
Drug Palbociclib
 Drug Info 
RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR01525)
Methyltransferase-like protein 1 (METTL1)
5-methylcytidine (m5C)
In total 1 m6A sequence/site(s) in this target gene
mod ID: M5CSITE000070 Click to Show/Hide the Full List
mod site chr12:57769651-57769652:- [2]
Sequence AAGATGTTCTTCCTCTTCCCCGACCCACATTTCAAGCGGAC
Seq Type List Bisulfite-seq
Transcript ID List ENST00000553125.5; ENST00000548504.1; ENST00000257848.7; ENST00000547653.1; ENST00000324871.12; ENST00000551117.1
External Link RMBase: m5C_site_10554
N6-methyladenosine (m6A)
In total 33 m6A sequence/site(s) in this target gene
mod ID: M6ASITE013684 Click to Show/Hide the Full List
mod site chr12:57768498-57768499:- [3]
Sequence CTGTCCTCTCCCTGCGTAAGACTTGACCTGGGGAATCTGTG
Motif Score 3.319380952
Cell/Tissue List Huh7
Seq Type List MeRIP-seq
Transcript ID List ENST00000546609.1; ENST00000324871.12
External Link RMBase: m6A_site_195842
mod ID: M6ASITE013685 Click to Show/Hide the Full List
mod site chr12:57768652-57768653:- [4]
Sequence GAGGAATGTAGTCCATCTAAACTGCTTGCTAGGCTCAATTA
Motif Score 2.627720238
Cell/Tissue List HeLa; HepG2; HEK293T; A549; U2OS; H1A; H1B; GM12878; MM6; Huh7; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; NB4
Seq Type List m6A-seq; MeRIP-seq; DART-seq
Transcript ID List ENST00000324871.12; ENST00000547653.1; ENST00000257848.7; ENST00000546609.1
External Link RMBase: m6A_site_195843
mod ID: M6ASITE013686 Click to Show/Hide the Full List
mod site chr12:57768757-57768758:- [4]
Sequence AGATGGTCAAAGGACTTTGGACCATAGGGGATCTTTGGAAG
Motif Score 3.622404762
Cell/Tissue List HeLa; HepG2; HEK293T; A549; U2OS; H1A; H1B; hESCs; fibroblasts; GM12878; LCLs; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000324871.12; ENST00000257848.7; ENST00000547653.1; ENST00000546609.1
External Link RMBase: m6A_site_195844
mod ID: M6ASITE013687 Click to Show/Hide the Full List
mod site chr12:57768764-57768765:- [4]
Sequence CTGACTGAGATGGTCAAAGGACTTTGGACCATAGGGGATCT
Motif Score 4.065041667
Cell/Tissue List HeLa; HepG2; HEK293T; A549; U2OS; H1A; H1B; hESCs; fibroblasts; GM12878; LCLs; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4; AML
Seq Type List m6A-seq; MeRIP-seq; miCLIP
Transcript ID List ENST00000324871.12; ENST00000546609.1; ENST00000547653.1; ENST00000257848.7
External Link RMBase: m6A_site_195845
mod ID: M6ASITE013688 Click to Show/Hide the Full List
mod site chr12:57768793-57768794:- [4]
Sequence CCCTCCACTGCCAACAGAAAACAAAGCAGCTGACTGAGATG
Motif Score 2.20572619
Cell/Tissue List HeLa; HepG2; HEK293T; A549; hESC-HEK293T; U2OS; H1A; H1B; hESCs; fibroblasts; GM12878; LCLs; CD8T; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List m6A-seq; MeRIP-seq; MAZTER-seq; m6A-CLIP/IP
Transcript ID List ENST00000257848.7; ENST00000546609.1; ENST00000324871.12; ENST00000547653.1
External Link RMBase: m6A_site_195846
mod ID: M6ASITE013689 Click to Show/Hide the Full List
mod site chr12:57768839-57768840:- [5]
Sequence AGAACCCACTGGTGTTCATGACTACCCCTGGCTCCTCTCAC
Motif Score 3.28175
Cell/Tissue List HEK293T
Seq Type List DART-seq
Transcript ID List ENST00000546609.1; ENST00000257848.7; ENST00000324871.12; ENST00000547653.1
External Link RMBase: m6A_site_195847
mod ID: M6ASITE013690 Click to Show/Hide the Full List
mod site chr12:57768856-57768857:- [4]
Sequence GGGGAGCTGCCCAGGGCAGAACCCACTGGTGTTCATGACTA
Motif Score 2.930744048
Cell/Tissue List HeLa; HepG2; HEK293T; A549; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; LCLs; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; NB4
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000324871.12; ENST00000257848.7; ENST00000546609.1; ENST00000547653.1
External Link RMBase: m6A_site_195848
mod ID: M6ASITE013691 Click to Show/Hide the Full List
mod site chr12:57768900-57768901:- [4]
Sequence TTGAGACTGCTGGAGCTGAGACACAGTACTCTCTTAAAGAA
Motif Score 2.897386905
Cell/Tissue List HeLa; HepG2; HEK293T; A549; hESC-HEK293T; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; H1299; MM6; Huh7; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; NB4
Seq Type List m6A-seq; MeRIP-seq; MAZTER-seq
Transcript ID List ENST00000324871.12; ENST00000257848.7; ENST00000547653.1; ENST00000546609.1
External Link RMBase: m6A_site_195849
mod ID: M6ASITE013692 Click to Show/Hide the Full List
mod site chr12:57768915-57768916:- [4]
Sequence CCTGGGTCTTCCCAGTTGAGACTGCTGGAGCTGAGACACAG
Motif Score 3.319380952
Cell/Tissue List HeLa; HepG2; HEK293T; A549; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; H1299; MM6; Huh7; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; NB4
Seq Type List m6A-seq; MeRIP-seq; m6A-CLIP/IP
Transcript ID List ENST00000324871.12; ENST00000257848.7; ENST00000546609.1; ENST00000547653.1
External Link RMBase: m6A_site_195850
mod ID: M6ASITE013693 Click to Show/Hide the Full List
mod site chr12:57768972-57768973:- [4]
Sequence GCTTACTCTACCTTAGCTGGACCTCGTCTCCCAGGGATTAG
Motif Score 3.622404762
Cell/Tissue List HeLa; HepG2; HEK293T; A549; U2OS; H1A; H1B; hESCs; fibroblasts; GM12878; MM6; Huh7; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; NB4
Seq Type List m6A-seq; MeRIP-seq; m6A-CLIP/IP
Transcript ID List ENST00000547653.1; ENST00000546609.1; ENST00000257848.7; ENST00000324871.12
External Link RMBase: m6A_site_195851
mod ID: M6ASITE013694 Click to Show/Hide the Full List
mod site chr12:57769015-57769016:- [4]
Sequence TCCAGGCAGTGACCTCCCAAACCAGCCTGCCTGGTCACTGA
Motif Score 2.185083333
Cell/Tissue List HeLa; HEK293T; A549; HepG2; U2OS; H1A; H1B; hESCs; fibroblasts; GM12878; MM6; Huh7; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; endometrial; NB4
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000324871.12; ENST00000257848.7; ENST00000547653.1
External Link RMBase: m6A_site_195852
mod ID: M6ASITE013695 Click to Show/Hide the Full List
mod site chr12:57769049-57769050:- [5]
Sequence CCAGCCATCTTCCGAAGAATACAAGATCCCGTCCTCCAGGC
Motif Score 2.110482143
Cell/Tissue List HEK293T; hESC-HEK293T
Seq Type List DART-seq; MAZTER-seq
Transcript ID List ENST00000257848.7; ENST00000547653.1; ENST00000548504.1; ENST00000324871.12
External Link RMBase: m6A_site_195853
mod ID: M6ASITE013696 Click to Show/Hide the Full List
mod site chr12:57769130-57769131:- [6]
Sequence AGTGAAGACCCCGTTGTGGGACATCTAGGCACCTCAACTGA
Motif Score 3.643047619
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000257848.7; ENST00000548504.1; ENST00000547653.1; ENST00000324871.12
External Link RMBase: m6A_site_195854
mod ID: M6ASITE013697 Click to Show/Hide the Full List
mod site chr12:57769368-57769369:- [6]
Sequence ATAACCGATGTGCTGGAGCTACACGACTGGATGTGCACTCA
Motif Score 2.078666667
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000547653.1; ENST00000324871.12; ENST00000548504.1; ENST00000257848.7; ENST00000551117.1
External Link RMBase: m6A_site_195855
mod ID: M6ASITE013698 Click to Show/Hide the Full List
mod site chr12:57769625-57769626:- [6]
Sequence ACATTTCAAGCGGACAAAGCACAAGTGGCGAATCATCAGTC
Motif Score 2.830589286
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000257848.7; ENST00000547653.1; ENST00000553125.5; ENST00000551117.1; ENST00000548504.1; ENST00000324871.12
External Link RMBase: m6A_site_195856
mod ID: M6ASITE013699 Click to Show/Hide the Full List
mod site chr12:57769632-57769633:- [7]
Sequence CCGACCCACATTTCAAGCGGACAAAGCACAAGTGGCGAATC
Motif Score 3.643047619
Cell/Tissue List MT4; Huh7
Seq Type List MeRIP-seq
Transcript ID List ENST00000257848.7; ENST00000553125.5; ENST00000551117.1; ENST00000324871.12; ENST00000547653.1; ENST00000548504.1
External Link RMBase: m6A_site_195857
mod ID: M6ASITE013700 Click to Show/Hide the Full List
mod site chr12:57769781-57769782:- [6]
Sequence GCACCTTCCTAACTTCTTCTACAAGGGCCAGGTGGGGAGGG
Motif Score 2.078666667
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000548504.1; ENST00000257848.7; ENST00000551117.1; ENST00000324871.12; ENST00000553125.5
External Link RMBase: m6A_site_195858
mod ID: M6ASITE013701 Click to Show/Hide the Full List
mod site chr12:57769832-57769833:- [6]
Sequence TCCTGCAGGTGGCTTCCAGAACATCGCCTGTCTCCGTAGCA
Motif Score 2.951386905
Cell/Tissue List hESC-HEK293T; Huh7
Seq Type List MAZTER-seq; MeRIP-seq
Transcript ID List ENST00000551117.1; ENST00000257848.7; ENST00000324871.12; ENST00000548504.1; ENST00000553125.5
External Link RMBase: m6A_site_195859
mod ID: M6ASITE013702 Click to Show/Hide the Full List
mod site chr12:57769877-57769878:- [3]
Sequence GGTCTCAGACTATGTACAAGACCGGATTCGGGCCCTACGCG
Motif Score 2.876744048
Cell/Tissue List Huh7
Seq Type List MeRIP-seq
Transcript ID List ENST00000553125.5; ENST00000551117.1; ENST00000324871.12; ENST00000257848.7
External Link RMBase: m6A_site_195860
mod ID: M6ASITE013703 Click to Show/Hide the Full List
mod site chr12:57769882-57769883:- [6]
Sequence GTGAAGGTCTCAGACTATGTACAAGACCGGATTCGGGCCCT
Motif Score 2.856142857
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000551117.1; ENST00000553125.5; ENST00000324871.12; ENST00000257848.7
External Link RMBase: m6A_site_195861
mod ID: M6ASITE013704 Click to Show/Hide the Full List
mod site chr12:57769889-57769890:- [3]
Sequence GATCCGGGTGAAGGTCTCAGACTATGTACAAGACCGGATTC
Motif Score 3.319380952
Cell/Tissue List Huh7
Seq Type List MeRIP-seq
Transcript ID List ENST00000257848.7; ENST00000551117.1; ENST00000553125.5; ENST00000324871.12
External Link RMBase: m6A_site_195862
mod ID: M6ASITE013705 Click to Show/Hide the Full List
mod site chr12:57769931-57769932:- [6]
Sequence ACTGTCACCGCTGTTCCCAGACACACTTATTCTGGGTCTGG
Motif Score 2.897386905
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000324871.12; ENST00000553125.5; ENST00000257848.7; ENST00000551117.1
External Link RMBase: m6A_site_195863
mod ID: M6ASITE013706 Click to Show/Hide the Full List
mod site chr12:57769951-57769952:- [8]
Sequence CTATTTCTGTGTGCAGTGGAACTGTCACCGCTGTTCCCAGA
Motif Score 3.373380952
Cell/Tissue List peripheral-blood
Seq Type List m6A-seq
Transcript ID List ENST00000257848.7; ENST00000324871.12; ENST00000553125.5; ENST00000551117.1
External Link RMBase: m6A_site_195864
mod ID: M6ASITE013707 Click to Show/Hide the Full List
mod site chr12:57770767-57770768:- [3]
Sequence GTTGTGGCCAGTGATCCTGAACTGTCTTTTCTCAGAGATTC
Motif Score 3.373380952
Cell/Tissue List Huh7
Seq Type List MeRIP-seq
Transcript ID List ENST00000548681.1; ENST00000257848.7; ENST00000324871.12; ENST00000553125.5; ENST00000551117.1; ENST00000549773.1
External Link RMBase: m6A_site_195865
mod ID: M6ASITE013708 Click to Show/Hide the Full List
mod site chr12:57771122-57771123:- [4]
Sequence GGCCCAAGTGGAGTTTGCAGACATAGGCTGTGGCTATGGTG
Motif Score 2.897386905
Cell/Tissue List HeLa; HepG2; A549; hESC-HEK293T
Seq Type List m6A-seq; MeRIP-seq; MAZTER-seq
Transcript ID List ENST00000553125.5; ENST00000548681.1; ENST00000549773.1; ENST00000324871.12; ENST00000257848.7; ENST00000551117.1
External Link RMBase: m6A_site_195866
mod ID: M6ASITE013709 Click to Show/Hide the Full List
mod site chr12:57771233-57771234:- [4]
Sequence TGTGAAGCCAGAGGAGATGGACTGGTCTGAGCTATACCCAG
Motif Score 4.065041667
Cell/Tissue List HeLa; HepG2; HEK293T; A549; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; endometrial; GSCs
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000549773.1; ENST00000548681.1; ENST00000257848.7; ENST00000324871.12; ENST00000553125.5; ENST00000551117.1
External Link RMBase: m6A_site_195867
mod ID: M6ASITE013710 Click to Show/Hide the Full List
mod site chr12:57771546-57771547:- [4]
Sequence CCAGTCTCGGGAGAAGGGGAACTTGTGCCCCAGAAAGGGCA
Motif Score 3.373380952
Cell/Tissue List HeLa; HepG2; HEK293T; A549; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; endometrial; GSCs
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000549773.1; ENST00000551117.1; ENST00000553125.5; ENST00000257848.7; ENST00000548681.1; ENST00000324871.12
External Link RMBase: m6A_site_195868
mod ID: M6ASITE013711 Click to Show/Hide the Full List
mod site chr12:57771597-57771598:- [4]
Sequence TCCCTCCCCGCAGAGCACAAACACAAAGTAGGATCCCAGTG
Motif Score 2.20572619
Cell/Tissue List HeLa; HepG2; HEK293T; A549; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; endometrial; HEC-1-A
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000551117.1; ENST00000548681.1; ENST00000549773.1; ENST00000553125.5; ENST00000324871.12; ENST00000257848.7
External Link RMBase: m6A_site_195869
mod ID: M6ASITE013712 Click to Show/Hide the Full List
mod site chr12:57771985-57771986:- [6]
Sequence CTCCAACCCCATGGCGGACCACACGCTGCGCTAGTGAGGAG
Motif Score 2.053113095
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000553125.5; ENST00000549773.1; ENST00000324871.12; ENST00000257848.7; ENST00000548681.1; ENST00000551117.1
External Link RMBase: m6A_site_195870
mod ID: M6ASITE013713 Click to Show/Hide the Full List
mod site chr12:57771988-57771989:- [4]
Sequence TCACTCCAACCCCATGGCGGACCACACGCTGCGCTAGTGAG
Motif Score 3.622404762
Cell/Tissue List HeLa; HepG2; A549; CD4T; peripheral-blood; GSC-11; HEK293T; HEK293A-TOA; iSLK; MSC; TIME; endometrial; HEC-1-A
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000324871.12; ENST00000548681.1; ENST00000257848.7; ENST00000549773.1; ENST00000553125.5; ENST00000551117.1
External Link RMBase: m6A_site_195871
mod ID: M6ASITE013714 Click to Show/Hide the Full List
mod site chr12:57772070-57772071:- [4]
Sequence CTGGGATCATGGCAGCCGAGACTCGGAACGTGGCCGGAGCA
Motif Score 3.319380952
Cell/Tissue List HeLa; HepG2; A549; H1A; fibroblasts; CD4T; peripheral-blood; GSC-11; HEK293T; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; AML
Seq Type List m6A-seq; MeRIP-seq; miCLIP
Transcript ID List ENST00000551117.1; ENST00000324871.12; ENST00000549773.1; ENST00000548681.1; ENST00000257848.7; ENST00000553125.5
External Link RMBase: m6A_site_195872
mod ID: M6ASITE013715 Click to Show/Hide the Full List
mod site chr12:57772091-57772092:- [4]
Sequence ATTTGGTAGAGAAACCCCGGACTGGGATCATGGCAGCCGAG
Motif Score 4.065041667
Cell/Tissue List HeLa; HepG2; fibroblasts; A549; GSC-11; HEK293T; HEK293A-TOA; iSLK; MSC; TIME; endometrial
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000324871.12; ENST00000549773.1; ENST00000553125.5; ENST00000257848.7; ENST00000548681.1
External Link RMBase: m6A_site_195873
mod ID: M6ASITE013716 Click to Show/Hide the Full List
mod site chr12:57772098-57772099:- [4]
Sequence CACGTGGATTTGGTAGAGAAACCCCGGACTGGGATCATGGC
Motif Score 2.185083333
Cell/Tissue List HeLa; HepG2; fibroblasts; A549; GSC-11; HEK293T; HEK293A-TOA; iSLK; MSC; TIME; endometrial
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000324871.12; ENST00000548681.1; ENST00000553125.5; ENST00000257848.7; ENST00000549773.1
External Link RMBase: m6A_site_195874