m6A-centered Disease Response Information
General Information of the Disease (ID: M6ADIS0026)
Name |
Unspecific body region injury
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ICD |
ICD-11: ND56
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Full List of Target Gene(s) of This m6A-centered Disease Response
hsa-miR-422a
In total 1 item(s) under this target gene | ||||
Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene | [1] | |||
Response Summary | Oxygen glucose deprivation/re-oxygenation (OGD/R) induces neuronal injury via mechanisms that are believed to mimic the pathways associated with brain ischemia. METTL3 shRNA reversed OGD/R-induced Lnc-D63785 m6A methylation to decrease hsa-miR-422a accumulation. | |||
Responsed Disease | Unspecific body region injury [ICD-11: ND56] | |||
Target Regulator | Methyltransferase-like 3 (METTL3) | WRITER | ||
Target Regulation | Up regulation | |||
Cell Process | Neuronal cell apoptosis | |||
In-vitro Model | SH-SY5Y | Neuroblastoma | Homo sapiens | CVCL_0019 |
mmu-miR-7212-5p
In total 1 item(s) under this target gene | ||||
Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene | [2] | |||
Response Summary | Down-regulation of METTL3 promotes osteogenic processes both in vitro and in vivo, and this effect is recapitulated by the suppression of mmu-miR-7212-5p maturation. miR-7212-5p inhibits osteoblast differentiation in MC3T3-E1 cells by targeting FGFR3. | |||
Responsed Disease | Unspecific body region injury [ICD-11: ND56] | |||
Target Regulator | Methyltransferase-like 3 (METTL3) | WRITER | ||
Target Regulation | Up regulation | |||
Cell Process | Cell differentiation | |||
In-vitro Model | MC3T3-E1 | Normal | Mus musculus | CVCL_0409 |
In-vivo Model | A longitudinal incision was made on the skin and the muscles were separated to expose the femur. A transverse osteotomy was performed in the mid-diaphysis of the femur, and the bones were stabilized by inserting a 23-gauge intramedullary needle. Equal amounts (100 uL) of phosphate-buffered saline (PBS), plasmid METTL3 and agomiR-7212-5p (10 mg/kg body weight) were locally injected into the femoral fracture site. | |||
Lnc_D63785
In total 1 item(s) under this target gene | ||||
Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene | [1] | |||
Response Summary | Oxygen glucose deprivation/re-oxygenation (OGD/R) induces neuronal injury via mechanisms that are believed to mimic the pathways associated with brain ischemia. METTL3 shRNA reversed OGD/R-induced Lnc_D63785 m6A methylation to decrease miR-422a accumulation. | |||
Responsed Disease | Unspecific body region injury [ICD-11: ND56] | |||
Target Regulator | Methyltransferase-like 3 (METTL3) | WRITER | ||
Target Regulation | Down regulation | |||
Cell Process | Neuronal cell apoptosis | |||
In-vitro Model | SH-SY5Y | Neuroblastoma | Homo sapiens | CVCL_0019 |
References