m6A Target Gene Information
General Information of the m6A Target Gene (ID: M6ATAR00001)
| Target Name | Lnc_D63785 | ||||
|---|---|---|---|---|---|
| Gene Name | Lnc_D63785 | ||||
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
Lnc_D63785
can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
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Methyltransferase-like 3 (METTL3) [WRITER]
| In total 1 item(s) under this regulator | ||||
| Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene | [1] | |||
| Response Summary | Oxygen glucose deprivation/re-oxygenation (OGD/R) induces neuronal injury via mechanisms that are believed to mimic the pathways associated with brain ischemia. METTL3 shRNA reversed OGD/R-induced Lnc_D63785 m6A methylation to decrease miR-422a accumulation. | |||
| Target Regulation | Down regulation | |||
| Responsed Disease | Unspecific body region injury | ICD-11: ND56 | ||
| Cell Process | Neuronal cell apoptosis | |||
| In-vitro Model | SH-SY5Y | Neuroblastoma | Homo sapiens | CVCL_0019 |
Unspecific body region injury [ICD-11: ND56]
| In total 1 item(s) under this disease | ||||
| Experiment 1 Reporting the m6A-centered Disease Response | [1] | |||
| Response Summary | Oxygen glucose deprivation/re-oxygenation (OGD/R) induces neuronal injury via mechanisms that are believed to mimic the pathways associated with brain ischemia. METTL3 shRNA reversed OGD/R-induced Lnc_D63785 m6A methylation to decrease miR-422a accumulation. | |||
| Responsed Disease | Unspecific body region injury [ICD-11: ND56] | |||
| Target Regulator | Methyltransferase-like 3 (METTL3) | WRITER | ||
| Target Regulation | Down regulation | |||
| Cell Process | Neuronal cell apoptosis | |||
| In-vitro Model | SH-SY5Y | Neuroblastoma | Homo sapiens | CVCL_0019 |
Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator
Non-coding RNA
m6A Regulator: Methyltransferase-like 3 (METTL3)
| In total 3 item(s) under this m6A regulator | ||
| Crosstalk ID: M6ACROT05446 | ||
| Epigenetic Regulator | Lnc_D63785 | |
| Regulated Target | hsa-miR-422a | |
| Crosstalk relationship | m6A → ncRNA | |
| Disease | Unspecific body region injury | |
| Crosstalk ID: M6ACROT05447 | ||
| Epigenetic Regulator | hsa-miR-422a | |
| Regulated Target | Mitogen-activated protein kinase kinase 6 (MAP2K6) | |
| Crosstalk relationship | m6A → ncRNA | |
| Disease | Unspecific body region injury | |
| Crosstalk ID: M6ACROT05940 | ||
| Epigenetic Regulator | hsa-miR-422a | |
| Regulated Target | Myocyte enhancer factor 2D (MEF2D) | |
| Crosstalk relationship | m6A → ncRNA | |
| Disease | Unspecific body region injury | |