m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
Crosstalk ID
M6ACROT05562
 [1]
m6A modification MIR222 MIR222 METTL3 Methylation : m6A sites Direct Enhancement Non-coding RNA pri-miR-222 DKK2  lncRNA       miRNA   circRNA
m6A Modification:
m6A Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
m6A Target microRNA 222 (MIR222)
 Targert Gene 
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type Non-coding RNA (ncRNA)
Epigenetic Regulator MicroRNA 222 (MIR222) microRNA View Details
Regulated Target Dickkopf-related protein 2 (DKK2) View Details
Crosstalk Relationship m6A  →  ncRNA Enhancement
Crosstalk Mechanism m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA
Crosstalk Summary METTL3 positively modulates the pri-miR221/pri-miR-222 maturation process in an m6A-dependent manner and subsequently activates Wnt/Beta-catenin signaling by inhibiting Dickkopf-related protein 2 (DKK2), thus promoting Ang-II-induced cardiac hypertrophy.
Responsed Disease Cardiomegaly ICD-11: BC45
 Disease Info 
Pathway Response Wnt signaling pathway hsa04310
In-vitro Model
 NRCMs (Primary neonatal rat cardiomyocytes (NRCMs)NRCMs were prepared from the hearts of 2- to 3-day-old SD rats according to the following protocol)
In-vivo Model The pump was prefilled with Ang-II or saline and then incubated in sterile saline at 37 ℃ for 48 h. After the mice were anesthetized with 3.0% isoflurane mixed with oxygen, an incision was made on the back skin of the mice, and the pump was implanted into the subcutaneous area, followed by suturing the incision. After the operation, the mice were given buprenorphine (0.1 mg/kg) to reach analgesia. Finally, the regaining consciousness mice were returned to cages and fed until the end of the experiment.
Full List of Potential Compound(s) Related to This m6A-centered Crosstalk
BC45: Cardiomegaly 1 Compound(s) Regulating the Disease Click to Show/Hide the Full List
 Compound Name UK-356202 Clinical trial [2]
Synonyms
compound 13j [PMID: 15149680]; UK-356,202
    Click to Show/Hide
External Link
CID: 9885167
TTD: D0G0YZ
References
Ref 1 METTL3 mediates Ang-II-induced cardiac hypertrophy through accelerating pri-miR-221/222 maturation in an m6A-dependent manner. Cell Mol Biol Lett. 2022 Jul 14;27(1):55. doi: 10.1186/s11658-022-00349-1.
Ref 2 Selective urokinase-type plasminogen activator (uPA) inhibitors. Part 3: 1-isoquinolinylguanidines. Bioorg Med Chem Lett. 2004 Jun 21;14(12):3227-30. doi: 10.1016/j.bmcl.2004.03.094.