Epigenetic Target Information

General Information of the Epigenetic Target (ID: EPITAR00349)
Target Name Dickkopf-related protein 2 (DKK2)
Synonyms
Dickkopf-2; Dkk-2; hDkk-2
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Gene Name DKK2
Sequence
MAALMRSKDSSCCLLLLAAVLMVESSQIGSSRAKLNSIKSSLGGETPGQAANRSAGMYQGLAFGGSKKGKNLGQAYPCSSDKECEVGRYCHSPHQGSSACMVCRRKKKRCHRDGMCCPSTRCNNGICIPVTESILTPHIPALDGTRHRDRNHGHYSNHDLGWQNLGRPHTKMSHIKGHEGDPCLRSSDCIEGFCCARHFWTKICKPVLHQGEVCTKQRKKGSHGLEIFQRCDCAKGLSCKVWKDATYSSKARLHVCQKI
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Family Dickkopf family
Function
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).
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Gene ID 27123
HGNC ID HGNC:2892
Ensembl Gene ID ENSG00000155011
KEGG ID hsa:27123
Chromosomal Location 4q25
RNA Modification Sequencing Data Associated with the Target (ID: EPITAR00349)
Dickkopf-related protein 2 (DKK2)
2'-O-Methylation (2'-O-Me)
In total 3 m6A sequence/site(s) in this target gene
mod ID: 2OMSITE000343 Click to Show/Hide the Full List
mod site chr4:107003639-107003640:- [1]
Sequence CTGGTGTATATGCTTGGCTGAGGAGCCAATGGGGCACAACT
Cell/Tissue List HeLa
Seq Type List 2OMe-seq
Transcript ID List ENST00000513208.5; rmsk_1401695; ENST00000285311.8; ENST00000510534.1; ENST00000510463.1
External Link RMBase: Nm_site_5253
mod ID: 2OMSITE000341 Click to Show/Hide the Full List
mod site chr4:107003635-107003636:- [2]
Sequence TGTATATGCTTGGCTGAGGAGCCAATGGGGCACAACTACCA
Cell/Tissue List PA1
Seq Type List RibOxi-seq
Transcript ID List ENST00000510534.1; ENST00000285311.8; rmsk_1401695; ENST00000513208.5; ENST00000510463.1
External Link RMBase: Nm_site_5251
mod ID: 2OMSITE000342 Click to Show/Hide the Full List
mod site chr4:107003637-107003638:- [1]
Sequence GGTGTATATGCTTGGCTGAGGAGCCAATGGGGCACAACTAC
Cell/Tissue List HeLa
Seq Type List 2OMe-seq
Transcript ID List ENST00000510534.1; ENST00000510463.1; rmsk_1401695; ENST00000513208.5; ENST00000285311.8
External Link RMBase: Nm_site_5252
N6-methyladenosine (m6A)
In total 6 m6A sequence/site(s) in this target gene
mod ID: M6ASITE067014 Click to Show/Hide the Full List
mod site chr4:106923796-106923797:- [3]
Sequence AAGGGAGAAAGAAAACATGAACTGAATAGATTAGAATGGGT
Motif Score 3.373380952
Cell/Tissue List fibroblasts
Seq Type List m6A-seq
Transcript ID List ENST00000285311.8; ENST00000513208.5
External Link RMBase: m6A_site_646833
mod ID: M6ASITE067015 Click to Show/Hide the Full List
mod site chr4:106923802-106923803:- [3]
Sequence CACAAAAAGGGAGAAAGAAAACATGAACTGAATAGATTAGA
Motif Score 2.20572619
Cell/Tissue List fibroblasts
Seq Type List m6A-seq
Transcript ID List ENST00000285311.8; ENST00000513208.5
External Link RMBase: m6A_site_646834
mod ID: M6ASITE067016 Click to Show/Hide the Full List
mod site chr4:106923923-106923924:- [3]
Sequence AGGAACATCATCAATTGCAGACTGTGAAGTTGTGTATTTAA
Motif Score 3.319380952
Cell/Tissue List fibroblasts
Seq Type List m6A-seq
Transcript ID List ENST00000513208.5; ENST00000285311.8; ENST00000510534.1
External Link RMBase: m6A_site_646835
mod ID: M6ASITE067017 Click to Show/Hide the Full List
mod site chr4:106923939-106923940:- [3]
Sequence AATTTGATCACCATTGAGGAACATCATCAATTGCAGACTGT
Motif Score 2.951386905
Cell/Tissue List fibroblasts
Seq Type List m6A-seq
Transcript ID List ENST00000513208.5; ENST00000285311.8; ENST00000510534.1
External Link RMBase: m6A_site_646836
mod ID: M6ASITE067018 Click to Show/Hide the Full List
mod site chr4:106923977-106923978:- [3]
Sequence ACCTACTCCTCCAAAGCCAGACTCCATGTGTGTCAGAAAAT
Motif Score 3.319380952
Cell/Tissue List fibroblasts
Seq Type List m6A-seq
Transcript ID List ENST00000285311.8; ENST00000513208.5; ENST00000510534.1; ENST00000510463.1
External Link RMBase: m6A_site_646837
mod ID: M6ASITE067019 Click to Show/Hide the Full List
mod site chr4:107003374-107003375:- [4]
Sequence TAGGGCCTAAAAGATGGTGAACTATGCCTGAGCAGAGGAAA
Motif Score 3.373380952
Cell/Tissue List AML
Seq Type List miCLIP
Transcript ID List ENST00000285311.8; ENST00000510463.1; ENST00000513208.5; ENST00000510534.1; rmsk_1401694
External Link RMBase: m6A_site_646838