m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
Crosstalk ID
M6ACROT05396
 [1]
m6A modification FAM225A FAM225A METTL3 Methylation : m6A sites Direct Enhancement Non-coding RNA FAM225A ITGB3  lncRNA       miRNA   circRNA
m6A Modification:
m6A Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
m6A Target Family with sequence similarity 225 member A (FAM225A)
 Targert Gene 
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type Non-coding RNA (ncRNA)
Epigenetic Regulator Family with sequence similarity 225 member A (FAM225A) LncRNA View Details
Regulated Target Integrin subunit beta 3 (ITGB3) View Details
Crosstalk Relationship m6A  →  ncRNA Enhancement
Crosstalk Mechanism m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA
Crosstalk Summary Family with sequence similarity 225 member A (FAM225A) functioned as a competing endogenous RNA (ceRNA) for sponging miR-590-3p and miR-1275, leading to the upregulation of their target Integrin subunit beta 3 (ITGB3), and the activation of FAK/PI3K/Akt signaling to promote Nasopharyngeal carcinoma cell proliferation and invasion. FAM225A showed lower RNA stability after silencing of METTL3.
Responsed Disease Nasopharyngeal carcinoma ICD-11: 2B6B
 Disease Info 
Pathway Response PI3K-Akt signaling pathway hsa04151
Cell Process Cell proliferation and metastasis
In-vitro Model
 CNE-1 Normal Homo sapiens CVCL_6888
CNE-2 Nasopharyngeal carcinoma Homo sapiens CVCL_6889
HONE-1 Nasopharyngeal carcinoma Homo sapiens CVCL_8706
SUNE1 Nasopharyngeal carcinoma Homo sapiens CVCL_6946
HNE-1 Nasopharyngeal carcinoma Homo sapiens CVCL_0308
5-8F Nasopharyngeal carcinoma Homo sapiens CVCL_C528
6-10B Nasopharyngeal carcinoma Homo sapiens CVCL_C529
C666-1 Nasopharyngeal carcinoma Homo sapiens CVCL_7949
HK-1 Lung large cell carcinoma Homo sapiens CVCL_7047
S18 Nasopharyngeal carcinoma Homo sapiens CVCL_B0U9
S26 Nasopharyngeal carcinoma Homo sapiens CVCL_B0UB
NP69SV40T
 N.A. Homo sapiens CVCL_F755
N2Tert (The human immortalized nasopharyngeal epithelial cell lines)
In-vivo Model For the tumor growth model, 1 × 106 HNE1-Scrambled or HNE1-shFAM2225A 2# cells were injected into the axilla of the mice, and the tumor size was measured every 3 days.
Full List of Potential Compound(s) Related to This m6A-centered Crosstalk
Integrin subunit beta 3 (ITGB3) 77 Compound(s) Regulating the Target Click to Show/Hide the Full List
 Compound Name XEMILOFIBAN Discontinued in Phase 3 [2]
Synonyms
Xemilofiban [INN]; 149820-74-6; UNII-P614JI3IYK; SC-54684A; SC 54684A; P614JI3IYK; SC-54684; CHEMBL76098; Ethyl-3S-((4-((4-(aminoiminomethyl)phenyl)amino)-1,4-dioxobutyl)amino)-4-pentynoate; C18H22N4O4; 4-Pentynoic acid, 3-((4-((4-(aminoiminomethyl)phenyl)amino)-1,4-dioxobutyl)amino)-, ethyl ester, (S)-; CS-551; AC1Q5MFX; AC1L1U8F; SCHEMBL50663; DTXSID60164410; ZINC1535967; BDBM50083460; KB-81502; LS-102305; ethyl(3s)-3-[3-[(p-amidinophenyl)carbamoyl]propionamido]-4-pentynoate
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MOA Inhibitor
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CID: 60957
TTD: D07EXV
 Compound Name DMP-802 Discontinued in Phase 1 [3]
Synonyms
CHEMBL117989; CHEMBL275611; SCHEMBL7748060; BDBM50075566; (S)-3-{2-[(R)-3-(4-Carbamimidoyl-phenyl)-4,5-dihydro-isoxazol-5-yl]-acetylamino}-2-(3,5-dimethyl-isoxazole-4-sulfonylamino)-propionic acid
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MOA Inhibitor
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CID: 9812185
TTD: D0K0NP
 Compound Name L-709780 Terminated [4]
Synonyms
CHEMBL32960; BDBM50078448; l709780; N-[2-[2-(4-Piperidinyl)ethyl]-3-oxoisoindoline-5-ylcarbonyl]-beta-alanine; 3-{[3-Oxo-2-(2-piperidin-4-yl-ethyl)-2,3-dihydro-1H-isoindole-5-carbonyl]-amino}-propionic acid(L-709780); 3-{[3-Oxo-2-(2-piperidin-4-yl-ethyl)-2,3-dihydro-1H-isoindole-5-carbonyl]-amino}-propionic acid
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MOA Inhibitor
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CID: 9885190
TTD: D03GCN
 Compound Name Ro-43-8857 Terminated [3]
Synonyms
CHEMBL290497; SCHEMBL8381416; BDBM50003852; alpha,alpha'-[[4-[[Methyl(4-amidinobenzoyl)amino]acetyl]-o-phenylene]bis(oxy)]diacetic acid; (4-{2-[(4-Carbamimidoyl-benzoyl)-methyl-amino]-acetyl}-2-carboxymethoxy-phenoxy)-acetic acid; (5-{2-[(4-Carbamimidoyl-benzoyl)-methyl-amino]-acetyl}-2-carboxymethoxy-phenoxy)-acetic acid
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MOA Inhibitor
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CID: 9933077
TTD: D03QHI
 Compound Name SKF-107260 Terminated [5]
Synonyms
F 107260; CHEMBL18734; [(7s,13s)-13-{3-[(diaminomethylidene)amino]propyl}-14-methyl-6,9,12,15-tetraoxo-6,7,8,9,10,11,12,13,14,15-decahydro-5h-dibenzo[c,p][1,2,5,8,11,14]dithiatetraazacycloheptadecin-7-yl]acetic acid; 136620-00-3; Skf 107260; F-107260; AC1L4UPG; AC1Q6GV5; Cyclo-S,S-(mba-(N(alpha)-Me)arg-gly-asp-man); CTK4C0386; DTXSID70159857; BDBM50036088; BDBM50230131; Cyclo-S,S-(2-mercaptobenzoyl-N(alpha)-methylarginyl-glycyl-aspartyl-2-mercaptophenylamide)
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MOA Inhibitor
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CID: 164393
TTD: D08CQL
 Compound Name L-738167 Terminated [3]
Synonyms
CHEMBL298655; L 738167; 163212-43-9; AC1L4BHI; SCHEMBL609722; DTXSID30167534; YLFFZEQHDMFOEC-NRFANRHFSA-N; BDBM50058239; L-Alanine, N-((4-methylphenyl)sulfonyl)-3-(((5,6,7,8-tetrahydro-4-oxo-5-(2-(4-piperidinyl)ethyl)-4H-pyrazolo(1,5-a)(1,4)diazepin-2-yl)carbonyl)amino)-; 3-{[4-Oxo-5-(2-piperidin-4-yl-ethyl)-5,6,7,8-tetrahydro-4H-1,5,8a-triaza-azulene-2-carbonyl]-amino}-2-(toluene-4-sulfonylamino)-propionic acid (L-738167)
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MOA Inhibitor
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CID: 153986
TTD: D08LIG
 Compound Name DMP-757 Terminated [6]
Synonyms
CHEMBL65617; BDBM50285199; [(5S,11S,14S)-11-(3-Guanidino-propyl)-14-isopropyl-12-methyl-4,7,10,13,16-pentaoxo-3,6,9,12,15-pentaaza-bicyclo[15.3.1]henicosa-1(20),17(21),18-trien-5-yl]-acetic acid
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MOA Inhibitor
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CID: 10031011
TTD: D0U4ZY
 Compound Name Ro-43-5054 Terminated [3]
Synonyms
CHEMBL117775; SCHEMBL7306316; BDBM50092124; 2-{2-[3-(4-Carbamimidoyl-benzoylamino)-propionylamino]-3-carboxy-propionylamino}-3-methyl-butyric acid (Ro 43-5054)
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MOA Inhibitor
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CID: 44343754
TTD: D0Z0XQ
 Compound Name SC-47643 Terminated [7]
Synonyms
CHEMBL129921; BDBM50035970; 3-(8-Guanidino-octanoylamino)-N-[2-(4-methoxy-phenyl)-ethyl]-succinamic acid
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MOA Inhibitor
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CID: 124392
TTD: D0G9BX
 Compound Name SB-223245 Terminated [8]
Synonyms
CHEMBL50106; SCHEMBL245523; BDBM50059133; {7-[(1H-Benzoimidazol-2-ylmethyl)-methyl-carbamoyl]-4-methyl-3-oxo-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-2-yl}-acetic acid; {(S)-7-[(1H-Benzoimidazol-2-ylmethyl)-methyl-carbamoyl]-4-methyl-3-oxo-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-2-yl}-acetic acid
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MOA Inhibitor
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CID: 9823503
TTD: D0LT1S
 Compound Name L-739758 Investigative [3]
Synonyms
CHEMBL78760; BDBM50078437; 3-{[5-(2-Piperidin-4-yl-ethyl)-thieno[2,3-b]thiophene-2-carbonyl]-amino}-2-(pyridine-3-sulfonylamino)-propionic acid(L-739758); (S)-3-{[5-(2-Piperidin-4-yl-ethyl)-thieno[2,3-b]thiophene-2-carbonyl]-amino}-2-(pyridine-3-sulfonylamino)-propionic acid; (2S)-2-[(3-Pyridinyl)sulfonylamino]-3-[[5-[2-(4-piperidinyl)ethyl]thieno[2,3-b]thiophen-2-yl]carbonylamino]propanoic acid
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CID: 9958398
TTD: D01XUU
 Compound Name ISIS 25237 Investigative [9]
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TTD: D02MYZ
 Compound Name ROXIFIBAN Investigative [3]
Synonyms
UNII-Q476FMZ72G; DMP754; 170902-47-3; CHEMBL18301; Q476FMZ72G; DMP-754; Roxifiban [INN]; AC1L42MF; SCHEMBL344302; DTXSID70168969; BDBM50075579; methyl (2S)-2-(butoxycarbonylamino)-3-[[2-[(5R)-3-(4-carbamimidoylphenyl)-4,5-dihydro-1,2-oxazol-5-yl]acetyl]amino]propanoate; L-Alanine, 3-(((3-(4-(aminoiminomethyl)phenyl)-4,5-dihydro-5-isoxazolyl)acetyl)amino)-N-(butoxycarbonyl)-, methyl ester, (R)-; L-Alanine, 3-((((5R)-3-(4-(aminoiminomethyl)phenyl)-4,5-dihydro-5-isoxazolyl)acetyl)amino)-N-(butoxycarbonyl)-, methy
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MOA Inhibitor
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CID: 177230
TTD: D04BHL
 Compound Name RWJ-53419 Investigative [10]
Synonyms
CHEMBL421547; BDBM50104598; 2-Benzyloxycarbonylamino-3-{[(R)-1-(3-piperidin-4-yl-propionyl)-piperidine-3-carbonyl]-amino}-propionic acid
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MOA Inhibitor
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CID: 44322318
TTD: D04XTP
 Compound Name L-750034 Investigative [11]
Synonyms
CHEMBL326492; BDBM50076058; 2-((S)-Benzenesulfonylamino)-3-(4-piperazin-1-yl-benzoylamino)-propionic acid; 2-Benzenesulfonylamino-3-(4-piperazin-1-yl-benzoylamino)-propionic acid(L-750034); (S)-2-Benzenesulfonylamino-3-(4-piperazin-1-yl-benzoylamino)-propionic acid
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MOA Inhibitor
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CID: 11743533
TTD: D05AGK
 Compound Name L-756568 Investigative [3]
Synonyms
CHEMBL96097; BDBM50092097; (S)-2-Benzenesulfonylamino-3-{[5-(piperidin-4-ylmethoxy)-1H-indole-2-carbonyl]-amino}-propionic acid; 2-Benzenesulfonylamino-3-{[5-(piperidin-4-ylmethoxy)-1H-indole-2-carbonyl]-amino}-propionic acid(L-756568)
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CID: 9805998
TTD: D06LHH
 Compound Name SC-54701A Investigative [12]
Synonyms
UNII-TN585Y92BI; SC-54701; CHEMBL311572; TN585Y92BI; Xemilofiban acid; Xemilofiban acid [MI]; SCHEMBL7080314; BDBM50031565; 4-Pentynoic acid, 3-((4-((4-(aminoiminomethyl)phenyl)amino)-1,4-dioxobutyl)amino)-, (3S)-; 149193-61-3; (S)-3-[3-(4-Carbamimidoyl-phenylcarbamoyl)-propionylamino]-pent-4-ynoic acid; 3-[3-(4-Carbamimidoyl-phenylcarbamoyl)-propionylamino]-pent-4-ynoic acid ethyl ester; 3-[3-(4-Carbamimidoyl-phenylcarbamoyl)-propionylamino]-pent-4-ynoic acid (SC-54701A)
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CID: 9862322
TTD: D08RLR
 Compound Name L-734115 Investigative [3]
Synonyms
CHEMBL40502; BDBM50058236; N-(Butylsulfonyl)-3-[[4,5,6,7-tetrahydro-4-oxo-5-[2-(4-piperidinyl)ethyl]pyrazolo[1,5-a]pyrazin]-2-ylcarbonylamino]-L-alanine; (S)-2-(Butane-1-sulfonylamino)-3-{[4-oxo-5-(2-piperidin-4-yl-ethyl)-4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyrazine-2-carbonyl]-amino}-propionic acid; 2-(Butane-1-sulfonylamino)-3-{[4-oxo-5-(2-piperidin-4-yl-ethyl)-4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyrazine-2-carbonyl]-amino}-propionic acid(L-734115)
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CID: 9913833
TTD: D0C8LA
 Compound Name SB-207043 Investigative [5]
Synonyms
CHEMBL606910
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CID: 52942958
TTD: D0M7KS
 Compound Name ISIS 196103 Investigative [9]
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TTD: D0Q2ZS
 Compound Name L-746233 Investigative [3]
Synonyms
CHEMBL79294; BDBM50078442; 3-{[3-Oxo-2-(2-piperidin-4-yl-ethyl)-2,3-dihydro-1H-isoindole-5-carbonyl]-amino}-2-(pyridine-3-sulfonylamino)-propionic acid(L-746233); (2S)-2-[(3-Pyridinyl)sulfonylamino]-3-[[2-[2-(4-piperidinyl)ethyl]-3-oxoisoindolin-5-yl]carbonylamino]propanoic acid; (S)-3-{[3-Oxo-2-(2-piperidin-4-yl-ethyl)-2,3-dihydro-1H-isoindole-5-carbonyl]-amino}-2-(pyridine-3-sulfonylamino)-propionic acid
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CID: 10324223
TTD: D0S8DT
 Compound Name L-767679 Investigative [3]
Synonyms
CHEMBL57886; L 767679; AC1L42P7; BDBM50054538; 182198-53-4; 3-[2-(1-Oxo-7-piperazin-1-yl-3,4-dihydro-1H-isoquinolin-2-yl)-acetylamino]-pent-4-ynoic acid(L-767679); (S)-3-[2-(1-Oxo-7-piperazin-1-yl-3,4-dihydro-1H-isoquinolin-2-yl)-acetylamino]-pent-4-ynoic acid; (3S)-3-[[2-(1-oxo-7-piperazin-1-yl-3,4-dihydroisoquinolin-2-yl)acetyl]amino]pent-4-ynoic acid; 4-Pentynoic acid, 3-(((3,4-dihydro-1-oxo-7-(1-piperazinyl)-2(1H)-isoquinolinyl)acetyl)amino)-, (3S)-
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CID: 177364
TTD: D0W5ZK
 Compound Name C(RGDfF) Investigative [13]
Synonyms
CHEMBL380434
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CID: 10699123
TTD: D00YBU
 Compound Name Ac-Asp-Arg-Leu-Asp-Ser-OH Investigative [14]
Synonyms
CHEMBL238484; Acetyl-Asp-Arg-Leu-Asp-Ser-OH; ZINC28869420
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MOA Inhibitor
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CID: 11764797
TTD: D01AXA
 Compound Name C[-Arg-Gly-Asp-Acpca21-] Investigative [15]
Synonyms
CHEMBL534711
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CID: 11613122
TTD: D01BZH
 Compound Name C-[-Arg-Gly-Asp-Acpca32-] Investigative [15]
Synonyms
CHEMBL556402
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CID: 11583738
TTD: D01MGI
 Compound Name 3-(3-(carbamoyl)benzamido)propanoic acid Investigative [16]
Synonyms
CHEMBL219603
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CID: 44418280
TTD: D01ZJF
 Compound Name Cyclo-[-Arg-Gly-Asp-Amp22-] Investigative [17]
Synonyms
CHEMBL406912
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CID: 24822283
TTD: D03KLT
 Compound Name Cyclo-[-Arg-Gly-Asp-Amp21-] Investigative [17]
Synonyms
CHEMBL411863; BDBM50372589
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CID: 24822953
TTD: D03YLY
 Compound Name Cypate-[(RGD)2-NH2]2 Investigative [18]
MOA Inhibitor
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CID: 91936295
TTD: D04MCL
 Compound Name C[-Arg-Gly-Asp-Acpca35-] Investigative [15]
Synonyms
CHEMBL534713
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CID: 11540460
TTD: D04WVG
 Compound Name C[RGDf-(S)-alpha-TfmV] Investigative [13]
Synonyms
CHEMBL203693
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MOA Inhibitor
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CID: 10416726
TTD: D05EWB
 Compound Name Cyclo-[-Arg-Gly-Asp-Amp26-] Investigative [17]
Synonyms
CHEMBL406680
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CID: 24822444
TTD: D05GXK
 Compound Name E[c(RGDyK)]2 Investigative [19]
Synonyms
CHEMBL414385
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CID: 44388431
TTD: D05MJG
 Compound Name C-[-Arg-Gly-Asp-Acpca30-] Investigative [15]
Synonyms
CHEMBL540622
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MOA Inhibitor
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CID: 11712622
TTD: D05VEC
 Compound Name C[-Arg-Gly-Asp-Acpca36-] Investigative [15]
Synonyms
CHEMBL557157
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MOA Inhibitor
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CID: 11518823
TTD: D06JLN
 Compound Name Gly-Arg-Gly-Asp-Ser Investigative [20]
Synonyms
96426-21-0; GRGDS; glycyl-arginyl-glycyl-aspartyl-serine; H-Gly-Arg-Gly-Asp-Ser-OH; CHEMBL417553; L-Serine, N-(N-(N-(N2-glycyl-L-arginyl)glycyl)-L-alpha-aspartyl)-; GRGDS Peptide; C17H30N8O9; AC1L3XCA; NH2-Gly-Arg-Gly-Asp-Ser; SCHEMBL17440322; RGNVSYKVCGAEHK-GUBZILKMSA-N; HY-P0295; ZINC13455558; MFCD00076459; BDBM50414896; BDBM50006330; AKOS030622941; NCGC00167212-01; Gly-Arg-Gly-Asp-Ser, > LS-178299; FT-0772116; L-Serine,glycyl-L-arginylglycyl-L-a-aspartyl-
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CID: 123811
TTD: D06LKH
 Compound Name Cyclo-[-Arg-Gly-Asp-Amp25-] Investigative [17]
Synonyms
CHEMBL270690
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CID: 24822784
TTD: D07QJD
 Compound Name C(RGDfMeF) Investigative [13]
Synonyms
CHEMBL383747
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CID: 44408450
TTD: D07UOF
 Compound Name C[RGDf-(R)-alpha-TfmV] Investigative [13]
Synonyms
CHEMBL203077
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MOA Inhibitor
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CID: 11505585
TTD: D08CFM
 Compound Name C(Arg-Gly-Asp-D-Phe-Val) Investigative [21]
Synonyms
CHEMBL383412
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CID: 44411994
TTD: D08DSG
 Compound Name C-[-Arg-Gly-Asp-Acpca31-] Investigative [15]
Synonyms
CHEMBL534934
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CID: 11533023
TTD: D09PLA
 Compound Name RGDechi Investigative [21]
MOA Inhibitor
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CID: 91936353
TTD: D0D4QZ
 Compound Name 3-(3-(benzamido)-5-nitrobenzamido)propanoic acid Investigative [16]
Synonyms
CHEMBL218226
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CID: 44418282
TTD: D0G7QJ
 Compound Name Cyclo(RGDfV) (control) Investigative [18]
Synonyms
CHEMBL206344
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CID: 44409460
TTD: D0G8JI
 Compound Name C[RGDf-(R)-N-Me-alpha-TfmF] Investigative [13]
Synonyms
CHEMBL381590
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CID: 11643340
TTD: D0H4EK
 Compound Name ISONIPECOTAMIDE Investigative [22]
Synonyms
Piperidine-4-carboxamide; 39546-32-2; 4-Piperidinecarboxamide; Hexahydroisonicotinamide; 4-carbamoylpiperidine; UNII-CZE2810T4X; CZE2810T4X; DPBWFNDFMCCGGJ-UHFFFAOYSA-N; Piperidine-4-carboxylic acid amide; MFCD00038012; 4-Piperdinecarboxamide; Isonipecotamide, 98%; piperidin-4-carboxamid; iso nipecotamide; iso-nipecotamide; Isonipecotinamide; Piperidine-4-carboxylicacidamide; NSC82318; EINECS 254-501-6; NSC 82318; ISONIPECTOAMIDE; ACMC-20aipw; PubChem9754; Isonipecotic acid amide; 4-piperidine-carboxamide
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CID: 3772
TTD: D0H4MB
 Compound Name C[RGDf-(S)-alpha-TfmF] Investigative [13]
Synonyms
CHEMBL204309
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CID: 9831456
TTD: D0I5BY
 Compound Name CYCLORGDFV Investigative [23]
Synonyms
cyclo(Arg-Gly-Asp-D-Phe-Val); CHEMBL411941; cyclo[Arg-Gly-Asp-D-Phe-Val]; Cyclo(-Arg-Gly-Asp-D-Phe-Val); 137813-35-5; c-[-Arg-Gly-Asp-fV-]; c[Arg-Gly-Asp-(R)-Phe-Val]; cyclo-(Arg-Gly-Asp-D-Phe-Val); Cyclo(Arg-Gly-Asp-D-Phe-Val-); cyclo(-Arg-Gly-Asp-D-Phe-Val-); BDBM50237601; ZINC17655303; NCGC00167283-01; [(2S,5R,8S,11S)-5-Benzyl-11-(3-guanidino-propyl)-8-isopropyl-3,6,9,12,15-pentaoxo-1,4,7,10,13pentaaza-cyclopentadec-2-yl]-acetic acid
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CID: 9851104
TTD: D0ID6U
 Compound Name Cyclo-[-Arg-Gly-Asp-Amp28-] Investigative [17]
Synonyms
CHEMBL270683
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CID: 24824620
TTD: D0J6SP
 Compound Name E[c(RGDyK)]2-PTX conjugate Investigative [19]
MOA Inhibitor
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CID: 91933274
TTD: D0K5DM
 Compound Name Cypate-[(RGD)3-NH2]1 Investigative [18]
MOA Inhibitor
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CID: 91936298
TTD: D0L2PQ
 Compound Name C[-Arg-Gly-Asp-Acpca19-] Investigative [15]
Synonyms
CHEMBL539338
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MOA Inhibitor
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CID: 11569720
TTD: D0LF7W
 Compound Name Gly-Arg-Gly-Asp-Ser-Pro-Lys Investigative [24]
Synonyms
Grgdspk; 111119-28-9; Glycyl-arginyl-glycyl-aspartyl-seryl-prolyl-lysine; CHEMBL58763; AC1L2XSM; SCHEMBL891576; DTXSID20149506; HY-P0322; BDBM50079446; ZINC38989354; MFCD00076462; AKOS027382824; N2-(1-(N-(N-(N-(N2-Glycyl-L-arginyl)glycyl)-L-alpha-aspartyl)-L-seryl)-L-prolyl)-L-lysine; NCGC00167196-01; FT-0773649; Gly-Arg-Gly-Asp-Ser-Pro-Lys, > glycyl- arginyl-glycyl-aspartyl-seryl-prolyl-lysine; L-Lysine,glycyl-L-arginylglycyl-L-a-aspartyl-L-seryl-L-prolyl-
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MOA Inhibitor
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CID: 130667
TTD: D0LV6B
 Compound Name C[RGDf-(R)-alpha-TfmF] Investigative [13]
Synonyms
CHEMBL381589
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MOA Inhibitor
External Link
CID: 11636164
TTD: D0M0BN
 Compound Name C[RGDf-(S)-N-Me-alpha-TfmF] Investigative [13]
Synonyms
CHEMBL413574
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MOA Inhibitor
External Link
CID: 10372586
TTD: D0M6NQ
 Compound Name Cypate-[(RGD)4-NH2]2 Investigative [18]
MOA Inhibitor
External Link
CID: 91936297
TTD: D0N9NA
 Compound Name C[-Arg-Gly-Asp-Acpca34-] Investigative [15]
Synonyms
CHEMBL534933
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MOA Inhibitor
External Link
CID: 11584047
TTD: D0O6DN
 Compound Name Cyclo-[-Arg-Gly-Asp-Amp24-] Investigative [17]
Synonyms
CHEMBL437072
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MOA Inhibitor
External Link
CID: 24823110
TTD: D0O9FL
 Compound Name Cypate-[(RGD)2-NH2]1 Investigative [18]
Synonyms
CHEMBL438186
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MOA Inhibitor
External Link
CID: 44409497
TTD: D0P4RB
 Compound Name N-(3,5-dichlorophenyl)imidodicarbonimidic diamide Investigative [25]
Synonyms
CHEMBL40929; 1672-93-1; Imidodicarbonimidic diamide, N-(3,5-dichlorophenyl)-; 1-(diaminomethylidene)-2-(3,5-dichlorophenyl)guanidine; AC1LBJDA; Maybridge1_007061; SCHEMBL891475; CTK7D2196; CTK0E5441; DTXSID50339817; 1-(3,5-dichlorophenyl)biguanide; BUXACHZAYWAZJL-UHFFFAOYSA-N; MolPort-003-943-662; ZINC4370978; ZX-AN037609; ALBB-022022; CCG-43794; STL482580; RJF 00091; BDBM50100971; AKOS003623024; MCULE-3366928787; CCG-245923; Biguanidine, 1-(3,5-dichlorophenyl)-; NCGC00331378-01
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MOA Inhibitor
External Link
CID: 558969
TTD: D0R9AD
 Compound Name C[-Arg-Gly-Asp-Acpca22-] Investigative [15]
Synonyms
CHEMBL539850
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MOA Inhibitor
External Link
CID: 11540715
TTD: D0R9GW
 Compound Name ST-1646 Investigative [17]
Synonyms
CHEMBL392303
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MOA Inhibitor
External Link
CID: 44439175
TTD: D0R9SJ
 Compound Name Cyclo[RGDfK(cypate)] Investigative [18]
Synonyms
CHEMBL407126
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MOA Inhibitor
External Link
CID: 44409643
TTD: D0T1II
 Compound Name 3-(3-(carbamoyl)benzamido)-3-phenylpropanoic acid Investigative [16]
Synonyms
CHEMBL220128; BDBM50323318; 3-phenyl-3-(3-(1,2,3,4-tetrahydroisoquinolin-7-ylcarbamoyl)benzamido)propanoic acid
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MOA Inhibitor
External Link
CID: 44418281
TTD: D0TP8S
 Compound Name Cyclo-[-Arg-Gly-Asp-Amp27-] Investigative [17]
Synonyms
CHEMBL272436
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MOA Inhibitor
External Link
CID: 44456982
TTD: D0U0VF
 Compound Name C[RGD-(R)-alpha-TfmfV] Investigative [13]
Synonyms
CHEMBL377066
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MOA Inhibitor
External Link
CID: 44408397
TTD: D0U2NV
 Compound Name C-[-Arg-Gly-Asp-Acpca33-] Investigative [15]
Synonyms
CHEMBL534712
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MOA Inhibitor
External Link
CID: 11670104
TTD: D0UE7H
 Compound Name Cypate-[(RGD)3-NH2]2 Investigative [18]
MOA Inhibitor
External Link
CID: 91936296
TTD: D0UO0Y
 Compound Name C[RGD-(S)-alpha-TfmfV] Investigative [13]
Synonyms
CHEMBL379056
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MOA Inhibitor
External Link
CID: 9986643
TTD: D0V0JC
 Compound Name C[-Arg-Gly-Asp-Acpca20-] Investigative [15]
Synonyms
CHEMBL540618
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MOA Inhibitor
External Link
CID: 11656381
TTD: D0W6CJ
 Compound Name C[RGDf-(S,R)-alpha-Dfm-F] Investigative [13]
Synonyms
CHEMBL379911
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MOA Inhibitor
External Link
CID: 11614485
TTD: D0WK2F
 Compound Name AcDRGDS Investigative [26]
Synonyms
CHEMBL241297; Acetyl-Asp-Arg-Gly-Asp-Ser-OH
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MOA Inhibitor
External Link
CID: 10415998
TTD: D0X4EE
 Compound Name Cypate-[(RGD)4-NH2]1 Investigative [18]
MOA Inhibitor
External Link
CID: 91936299
TTD: D0Y8UD
 Compound Name Cyclo-[-Arg-Gly-Asp-Amp23-] Investigative [17]
Synonyms
CHEMBL410050
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MOA Inhibitor
External Link
CID: 24822282
TTD: D0Z6WZ
 Compound Name SB-265123 Investigative [27]
Synonyms
CHEMBL288493; SCHEMBL244383; HODBWQCCKYDYPY-NRFANRHFSA-N; {3-[3-(Pyridin-2-ylamino)-propoxy]-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-10-yl}-acetic acid; BDBM50078714; {(S)-3-[3-(Pyridin-2-ylamino)-propoxy]-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-10-yl}-acetic acid; (S)-10,11-Dihydro-3-[3-(pyridin-2-ylamino)-1-propyloxy]-5H-dibenzo[a,d]cycloheptene-10-acetic acid
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MOA Inhibitor
External Link
CID: 9952958
TTD: D0R3CY
 Compound Name C(-GRGDfL-) Investigative [28]
Synonyms
CHEMBL235999
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MOA Inhibitor
External Link
CID: 15409414
TTD: D0B4JU
2B6B: Nasopharyngeal carcinoma 20 Compound(s) Regulating the Disease Click to Show/Hide the Full List
 Compound Name Lotilaner Approved [29]
External Link
TTD: DV87CQ
 Compound Name Toripalimab Approved in China [30]
External Link
TTD: D92OCI
 Compound Name Tabelecleucel Phase 2 [31]
Synonyms
Tab-cel
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External Link
TTD: DY4Q6M
 Compound Name A167 Phase 3 [32]
Synonyms
KL-A167
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External Link
TTD: DI89WD
 Compound Name MLN4924 Phase 1 [33]
Synonyms
Pevonedistat; 905579-51-3; MLN-4924; MLN 4924; UNII-S3AZD8D215; S3AZD8D215; Sulfamic acid [(1S,2S,4R)-4-[4-[[(1S)-2,3-dihydro-1H-inden-1-yl]amino]-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-2-hydroxycyclopentyl]methyl ester; ((1S,2S,4R)-4-(4-(((S)-2,3-dihydro-1H-inden-1-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2-hydroxycyclopentyl)methyl sulfamate; C21H25N5O4S; [(1s,2s,4r)-4-{4-[(1s)-2,3-Dihydro-1h-Inden-1-Ylamino]-7h-Pyrrolo[2,3-D]pyrimidin-7-Yl}-2-Hydroxycyclopentyl]methyl Sulfamate; Pevonedistat [USAN:INN]; 3gzn
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External Link
CID: 16720766
TTD: D0ZD2M
DrugBank: DB11759
 Compound Name TT10 Phase 3 [34]
Synonyms
EBVST; GVYPHJQPOHDZEI-UHFFFAOYSA-N; TT-10; 2230640-94-3
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External Link
CID: 134827875
TTD: D0NS3O
 Compound Name DE-766 Phase 3 [35]
External Link
TTD: D0FJ1W
 Compound Name Avastin+/-Tarceva Phase 3 [36]
Synonyms
Juglone; 481-39-0; 5-Hydroxy-1,4-naphthoquinone; 5-Hydroxy-1,4-naphthalenedione; Regianin; Juglon; Nucin; 5-Hydroxynaphthalene-1,4-dione; Walnut extract; 5-Hydroxynaphthoquinone; Akhnot; Yuglon; 8-Hydroxy-1,4-naphthoquinone; CI Natural Brown 7; 1,4-NAPHTHALENEDIONE, 5-HYDROXY-; 5-Hydroxy-p-naphthoquinone; 1,4-Naphthoquinone, 5-hydroxy-; CI 75500; Juglane; Jugnlon; Iuglon; Caswell No 515AA; 1,4-Naphthoquinone, 8-hydroxy-; 5-Hydroxy-1,4-naphthosemiquinone; 5-Hydroxy-1,4-naftochinon; UNII-W6Q80SK9L6; NSC 622948; NSC 153189; CCRIS
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External Link
CID: 3806
TTD: D0C0NH
 Compound Name MK-2206 Phase 2 [37]
Synonyms
1032349-93-1; UNII-51HZG6MP1K; MK 2206; 51HZG6MP1K; CHEMBL1079175; CHEBI:67271; NCGC00186465-01; 8-[4-(1-aminocyclobutyl)phenyl]-9-phenyl-2H-[1,2,4]triazolo[3,4-f][1,6]naphthyridin-3-one; DSSTox_RID_83143; DSSTox_CID_28874; 8-[4-(1-aminocyclobutyl)phenyl]-9-phenyl-1,2,4-Triazolo[3,4-f][1,6]naphthyridin-3(2H)-one; DSSTox_GSID_48948; 8-[4-(1-aminocyclobutyl)phenyl]-9-phenyl[1,2,4]triazolo[3,4-f][1,6]naphthyridin-3(2H)-one; 1,2,4-Triazolo[3,4-f][1,6]naphthyridin-3(2H)-one, 8-[4-(1-aminocyclobutyl)phenyl]-9-phenyl-;
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External Link
CID: 24964624
TTD: D0W3RW
 Compound Name R-roscovitine Phase 2 [38]
Synonyms
Seliciclib; roscovitine; 186692-46-6; (R)-roscovitine; CYC202; CYC-202; CYC 202; 2-(R)-(1-Ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine; UNII-0ES1C2KQ94; Roscovitine (Seliciclib,CYC202); NSC 701554; AL-39256; CHEMBL14762; 0ES1C2KQ94; CHEBI:45307; NSC701554; NSC-701554; (2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]amino]butan-1-ol; (R)-2-((6-(Benzylamino)-9-isopropyl-9H-purin-2-yl)amino)butan-1-ol; (2R)-2-[[6-(benzylamino)-9-propan-2-ylpurin-2-yl]amino]butan-1-ol; RRC; Rosco; M02443; BMK1-E12; CYC202, Seliciclib, R-roscovitine, Roscovitine; (2r)-2-{[6-(benzylamino)-9-isopropyl-9h-purin-2-yl]amino}-1-butanol; 2-(R)-[[9-(1-Methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol; 2-[[9-(1-Methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-(R)-1-butanol; 6-(Benzylamino)-2(R)-[[1-(hydroxymethyl)propyl]amino]-9-isopropylpurine
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External Link
CID: 160355
TTD: D05ADP
DrugBank: DB06195
 Compound Name Epstein-barr virus-specific immunotherapy Phase 2 [39]
Synonyms
Epstein-barr virus-specific immunotherapy (nasopharyngeal carcinoma)
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External Link
TTD: D03XEY
 Compound Name LMP1-CAR-T cells Phase 1/2 [40]
External Link
TTD: D0RJ2V
 Compound Name APG-1387 Phase 1 [41]
Synonyms
AKLBERUGKZNEJY-RTEPGWBGSA-N; SCHEMBL15490706
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External Link
CID: 73336238
TTD: D0NP8P
 Compound Name GSK618334 Phase 1 [42]
Synonyms
Fingolimod hydrochloride; 162359-56-0; FTY720; Fingolimod HCl; Gilenya; Gilenia; Fty-720; Fty 720; Fingolimod (FTY720) HCl; Fingolimod (hydrochloride); 2-Amino-2-(4-octylphenethyl)propane-1,3-diol hydrochloride; 2-Amino-2-(2-(4-octylphenyl)ethyl)-1,3-propanediol hydrochloride; UNII-G926EC510T; Fingolimod hydrochloride [USAN]; CHEBI:63112; G926EC510T; 2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol hydrochloride; AK-33554; 2-AMINO-2-[2-(4-OCTYL-PHENYL)-ETHYL]-PROPANE-1,3-DIOL HCL; Fingolimod-d4 Hydrochloride
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External Link
CID: 107969
TTD: D0HI1K
 Compound Name PD173074 Investigative [43]
External Link
CID: 1401
TTD: D0VF6E
 Compound Name Ad5f35-LMPd1-2-transduced autologous dendritic cells Investigative [44]
Synonyms
AddLMP1-I-LMP2; LMP1/LMP2 cytotoxic T-lymphocytes vaccine (nasopharyngeal cancer), Baylor College of Medicine; Ad5f35-LMPd1-2-transduced autologous dendritic cells (EBV-associated cancer); Ad5f35-LMPd1-2-transduced autologous dendritic cells (EBV-associated cancer),NCI
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External Link
TTD: D0Q8PF
 Compound Name THZ1 Investigative [45]
Synonyms
HY-80013
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External Link
CID: 73602827
TTD: D0LO5B
 Compound Name SAIT301 Investigative [35]
External Link
TTD: D07QNH
 Compound Name HITOPK-032 Investigative [46]
Synonyms
HI-TOPK-32; HI-TOPK-032; C20H11N5OS; N-(12-cyanoindolizino[2,3-b]quinoxalin-2-yl)thiophene-2-carboxamide; 799819-78-6; N-(12-cyano-2-indolizino[2,3-b]quinoxalinyl)-2-thiophenecarboxamide; AC1LYXW6; HI-TOPC-032; SCHEMBL15270774; DTXSID00365681; AOB1064; SYN5181; MolPort-002-572-638; ACN-S001950; ZINC2320807; STK548195; AKOS005476059; CS-6900; MCULE-6063579279; ACN-001741; AS-16541; HY-101550; B5640; J3.626.778J
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External Link
CID: 1936439
TTD: D06DPJ
 Compound Name Ro5203280 Investigative [47]
Synonyms
Ro3280; Ro 3280; PharmaGSID_48511; 4-((9-Cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-yl)amino)-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide; DJNZZLZKAXGMMC-UHFFFAOYSA-N; 79C; DSSTox_RID_82762; DSSTox_CID_28485; DSSTox_GSID_48511; SCHEMBL1559146; GTPL9403; DTXSID4048511; AOB5394
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External Link
CID: 25015677
TTD: D05WDM
References
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Ref 9 US patent application no. 7,425,545, Modulation of C-reactive protein expression.
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Ref 13 Incorporation of the unusual C(alpha)-fluoroalkylamino acids into cyclopeptides: synthesis of arginine-glycine-aspartate (RGD) analogues and study of their conformational and biological behavior. J Med Chem. 2006 Mar 9;49(5):1808-17. doi: 10.1021/jm0511334.
Ref 14 Synthesis and biological evaluation of non-peptide alpha(v)beta(3)/alpha(5)beta(1) integrin dual antagonists containing 5,6-dihydropyridin-2-one scaffolds. Bioorg Med Chem. 2007 Dec 1;15(23):7380-90. doi: 10.1016/j.bmc.2007.07.049. Epub 2007 Aug 22.
Ref 15 Grafting aminocyclopentane carboxylic acids onto the RGD tripeptide sequence generates low nanomolar alphaVbeta3/alphaVbeta5 integrin dual binders. J Med Chem. 2005 Dec 1;48(24):7675-87. doi: 10.1021/jm050698x.
Ref 16 Derivatives of 7-amino-1,2,3,4-tetrahydroisoquinoline and isophthalic acids as novel fibrinogen receptor antagonists. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5294-7. doi: 10.1016/j.bmcl.2006.07.090. Epub 2006 Aug 21.
Ref 17 Discovery of subnanomolar arginine-glycine-aspartate-based alphaVbeta3/alphaVbeta5 integrin binders embedding 4-aminoproline residues. J Med Chem. 2008 Mar 27;51(6):1771-82. doi: 10.1021/jm701214z. Epub 2008 Feb 28.
Ref 18 Design, synthesis, and evaluation of near infrared fluorescent multimeric RGD peptides for targeting tumors. J Med Chem. 2006 Apr 6;49(7):2268-75. doi: 10.1021/jm050947h.
Ref 19 Synthesis and biological evaluation of dimeric RGD peptide-paclitaxel conjugate as a model for integrin-targeted drug delivery. J Med Chem. 2005 Feb 24;48(4):1098-106. doi: 10.1021/jm049165z.
Ref 20 alphavbeta3 Integrin-targeting Arg-Gly-Asp (RGD) peptidomimetics containing oligoethylene glycol (OEG) spacers. J Med Chem. 2009 Nov 26;52(22):7029-43. doi: 10.1021/jm901133z.
Ref 21 Novel and selective alpha(v)beta3 receptor peptide antagonist: design, synthesis, and biological behavior. J Med Chem. 2006 Jun 1;49(11):3416-20. doi: 10.1021/jm060233m.
Ref 22 Piperidine-containing beta-arylpropionic acids as potent antagonists of alphavbeta3/alphavbeta5 integrins. Bioorg Med Chem Lett. 2004 Oct 18;14(20):5227-32. doi: 10.1016/j.bmcl.2004.06.061.
Ref 23 Antiangiogenic effect of dual/selective alpha(5)beta(1)/alpha(v)beta(3) integrin antagonists designed on partially modified retro-inverso cyclotetrapeptide mimetics. J Med Chem. 2010 Jan 14;53(1):106-18. doi: 10.1021/jm9013532.
Ref 24 N-Methylated cyclic RGD peptides as highly active and selective alpha(V)beta(3) integrin antagonists. J Med Chem. 1999 Aug 12;42(16):3033-40. doi: 10.1021/jm970832g.
Ref 25 Emerging targets in osteoporosis disease modification. J Med Chem. 2010 Jun 10;53(11):4332-53. doi: 10.1021/jm9018756.
Ref 26 Inhibition of cancer cell adhesion by heterochiral Pro-containing RGD mimetics. Bioorg Med Chem Lett. 2007 Apr 15;17(8):2329-33. doi: 10.1016/j.bmcl.2007.01.073. Epub 2007 Jan 27.
Ref 27 1,2,3,4-Tetrahydroquinoline-containing alphaVbeta3 integrin antagonists with enhanced oral bioavailability. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5937-41. doi: 10.1016/j.bmcl.2004.08.067.
Ref 28 Multiple N-methylation by a designed approach enhances receptor selectivity. J Med Chem. 2007 Nov 29;50(24):5878-81. doi: 10.1021/jm701044r. Epub 2007 Nov 1.
Ref 29 FDA Approved Drug Products from FDA Official Website. 2023. Application Number: 217603
Ref 30 Toripalimab: the First Domestic Anti-Tumor PD-1 Antibody in China. Front Immunol. 2022 Jan 12;12:730666.
Ref 31 ClinicalTrials.gov (NCT00953420) Carboplatin and Docetaxel Followed by Epstein-Barr Virus Cytotoxic T Lymphocytes (CADEN). U.S. National Institutes of Health.
Ref 32 ClinicalTrials.gov (NCT05294172) KL-A167 Injection Combined With Cisplatin and Gemcitabine vs Placebo Combined With Cisplatin and Gemcitabine in the Treatment of Recurrent or Metastatic Nasopharyngeal Carcinoma: A Randomized, Double-blind, Placebo-controlled, Multicenter Phase III Clinical Trial. U.S.National Institutes of Health.
Ref 33 Promoting tumorigenesis in nasopharyngeal carcinoma, NEDD8 serves as a potential theranostic target.Cell Death Dis. 2017 Jun 1;8(6):e2834.
Ref 34 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
Ref 35 Nasopharyngeal carcinoma: Current treatment options and future directions. J Nasopharyng Carcinoma, 2014, 1(16): e16.
Ref 36 Overexpression of PIN1 Enhances Cancer Growth and Aggressiveness with Cyclin D1 Induction in EBV-Associated Nasopharyngeal Carcinoma.PLoS One. 2016 Jun 3;11(6):e0156833.
Ref 37 UBE2T promotes nasopharyngeal carcinoma cell proliferation, invasion, and metastasis by activating the AKT/GSK3/-catenin pathway.Oncotarget. 2016 Mar 22;7(12):15161-72.
Ref 38 Therapeutic efficacy of seliciclib in combination with ionizing radiation for human nasopharyngeal carcinoma.Clin Cancer Res. 2009 Jun 1;15(11):3716-24.
Ref 39 ClinicalTrials.gov (NCT00834093) A Phase II Study of Epstein-Barr Virus-Specific Immunotherapy for Nasopharyngeal Carcinoma. U.S. National Institutes of Health.
Ref 40 ClinicalTrials.gov (NCT02980315) A New EBV Related Technologies of T Cells in Treating Malignant Tumors and Clinical Application
Ref 41 XIAP Limits Autophagic Degradation of Sox2 and Is A Therapeutic Target in Nasopharyngeal Carcinoma Stem Cells.Theranostics. 2018 Feb 5;8(6):1494-1510.
Ref 42 Sphingosine kinase 1 is a potential therapeutic target for nasopharyngeal carcinoma. Oncotarget. 2016 Dec 6;7(49):80586-80598. doi: 10.18632/oncotarget.13014.
Ref 43 Recurrent FGFR3-TACC3 fusion gene in nasopharyngeal carcinoma.Cancer Biol Ther. 2014;15(12):1613-21.
Ref 44 CA patent application no. 876139, Nanotherapeutics for drug targeting.
Ref 45 Super-Enhancers Promote Transcriptional Dysregulation in Nasopharyngeal Carcinoma.Cancer Res. 2017 Dec 1;77(23):6614-6626.
Ref 46 PDZ binding kinase (PBK) is a theranostic target for nasopharyngeal carcinoma: driving tumor growth via ROS signaling and correlating with patient survival.Oncotarget. 2016 May 3;7(18):26604-16.
Ref 47 Polo-like kinase inhibitor Ro5203280 has potent antitumor activity in nasopharyngeal carcinoma.Mol Cancer Ther. 2013 Aug;12(8):1393-401.