m6A-centered Crosstalk Information
Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
| Crosstalk ID |
M6ACROT00637
|
[1], [2], [3], [4] | |||
.png)
.png)
 : m6A sites
Indirect
Enhancement
RNA modification
CDKN1B
CDKN1B
NSUN2
Methylation
 : modification sites
|
|||||
| m6A Modification: | |||||
|---|---|---|---|---|---|
| m6A Regulator | Methyltransferase-like 3 (METTL3) | WRITER | |||
| m6A Target | microRNA 222 (MIR222) | ||||
| Epigenetic Regulation that have Cross-talk with This m6A Modification: | |||||
| Epigenetic Regulation Type | RNA modification (RNAMod) >> 5-methylcytidine (m5C) | ||||
| Epigenetic Regulator | RNA cytosine C(5)-methyltransferase NSUN2 (NSUN2) | WRITER | View Details | ||
| Regulated Target | Cyclin-dependent kinase inhibitor 1B (CDKN1B/p27) | View Details | |||
| Crosstalk Relationship | m6A → m5C | Enhancement | |||
| Crosstalk Mechanism | m6A modification indirectly impacts RNA modification through downstream signaling pathways | ||||
| Crosstalk Summary | METTL3 interacts with microRNA 222 (MIR222), increasing its m6A level and promoting its physical interaction with Cyclin-dependent kinase inhibitor 1B (CDKN1B/p27), which was regulated by NSUN2-mediated m5C modification. | ||||
In-vitro Model |
HeLa | Endocervical adenocarcinoma | Homo sapiens | CVCL_0030 | |
| MDA-MB-231 | Breast adenocarcinoma | Homo sapiens | CVCL_0062 | ||
| T24 | Bladder carcinoma | Homo sapiens | CVCL_0554 | ||
| Ej138 | Bladder carcinoma | Homo sapiens | CVCL_2443 | ||
References