Epigenetic Target Information

General Information of the Epigenetic Target (ID: EPITAR00165)

Target Name	Cyclin-dependent kinase inhibitor 1B (CDKN1B/p27)
Synonyms	Cyclin-dependent kinase inhibitor p27; p27Kip1; KIP1 Click to Show/Hide
Gene Name	CDKN1B
Sequence	MSNVRVSNGSPSLERMDARQAEHPKPSACRNLFGPVDHEELTRDLEKHCRDMEEASQRKWNFDFQNHKPLEGKYEWQEVEKGSLPEFYYRPPRPPKGACKVPAQESQDVSGSRPAAPLIGAPANSEDTHLVDPKTDPSDSQTGLAEQCAGIRKRPATDDSSTQNKRANRTEENVSDGSPNAGSVEQTPKKPGLRRRQT Click to Show/Hide
Family	CDI family
Function	Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry. Click to Show/Hide
Gene ID	1027
HGNC ID	HGNC:1785
Ensembl Gene ID	ENSG00000111276
KEGG ID	hsa:1027
Chromosomal Location	12p13.1

RNA Modification Sequencing Data Associated with the Target (ID: EPITAR00165)

Cyclin-dependent kinase inhibitor 1B (CDKN1B/p27)

Adenosine-to-Inosine editing (A-to-I)

In total 1 m6A sequence/site(s) in this target gene
mod ID: A2ISITE005422		Click to Show/Hide the Full List
mod site	chr12:12715355-12715356:+		[1]
Sequence	GAAAAACTAAAGAGGATGAGACCTCTTGCTTGATCCTAGGT
Transcript ID List	ENST00000477087.1
External Link	RMBase: RNA-editing_site_26991

N6-methyladenosine (m6A)

In total 49 m6A sequence/site(s) in this target gene
mod ID: M6ASITE010820		Click to Show/Hide the Full List
mod site	chr12:12717523-12717524:+		[2]
Sequence	AGAGCGGCTGGGTTCGCGGGACCCGCGGGCTTGCACCCGCC
Motif Score	3.622404762
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; GM12878; MM6; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; TIME; TREX; MSC; endometrial; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000228872.9; ENST00000477087.1
External Link	RMBase: m6A_site_177624
mod ID: M6ASITE010821		Click to Show/Hide the Full List
mod site	chr12:12717547-12717548:+		[2]
Sequence	GCGGGCTTGCACCCGCCCAGACTCGGACGGGCTTTGCCACC
Motif Score	3.319380952
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; GM12878; MM6; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; TIME; TREX; MSC; endometrial; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000228872.9; ENST00000477087.1
External Link	RMBase: m6A_site_177625
mod ID: M6ASITE010822		Click to Show/Hide the Full List
mod site	chr12:12717634-12717635:+		[2]
Sequence	AGTCCATTTGATCAGCGGAGACTCGGCGGCCGGGCCGGGGC
Motif Score	3.319380952
Cell/Tissue List	HeLa; CD34; HepG2; GM12878; MM6; peripheral-blood; GSC-11; HEK293T; iSLK; TREX; MSC; endometrial; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000228872.9; ENST00000477087.1
External Link	RMBase: m6A_site_177626
mod ID: M6ASITE010823		Click to Show/Hide the Full List
mod site	chr12:12717826-12717827:+		[2]
Sequence	CGAGAGAGGCGGTCGTGCAGACCCGGGAGAAAGATGTCAAA
Motif Score	2.876744048
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; U2OS; A549; MM6; Huh7; Jurkat; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000228872.9; ENST00000396340.1; ENST00000477087.1
External Link	RMBase: m6A_site_177627
mod ID: M6ASITE010824		Click to Show/Hide the Full List
mod site	chr12:12717930-12717931:+		[2]
Sequence	CAAGCCCTCGGCCTGCAGGAACCTCTTCGGCCCGGTGGACC
Motif Score	2.930744048
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; LCLs; MT4; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000396340.1; ENST00000477087.1; ENST00000228872.9; ENST00000442489.1
External Link	RMBase: m6A_site_177628
mod ID: M6ASITE010825		Click to Show/Hide the Full List
mod site	chr12:12717948-12717949:+		[2]
Sequence	GAACCTCTTCGGCCCGGTGGACCACGAAGAGTTAACCCGGG
Motif Score	3.622404762
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; LCLs; MT4; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000396340.1; ENST00000228872.9; ENST00000442489.1; ENST00000477087.1
External Link	RMBase: m6A_site_177629
mod ID: M6ASITE010826		Click to Show/Hide the Full List
mod site	chr12:12717969-12717970:+		[2]
Sequence	CCACGAAGAGTTAACCCGGGACTTGGAGAAGCACTGCAGAG
Motif Score	4.065041667
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; LCLs; CD8T; MT4; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq; m6A-CLIP/IP
Transcript ID List	ENST00000396340.1; ENST00000477087.1; ENST00000442489.1; ENST00000228872.9
External Link	RMBase: m6A_site_177630
mod ID: M6ASITE010827		Click to Show/Hide the Full List
mod site	chr12:12717990-12717991:+		[2]
Sequence	CTTGGAGAAGCACTGCAGAGACATGGAAGAGGCGAGCCAGC
Motif Score	2.897386905
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; hESC-HEK293T; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; LCLs; MT4; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4; AML
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq; miCLIP
Transcript ID List	ENST00000442489.1; ENST00000228872.9; ENST00000477087.1; ENST00000396340.1
External Link	RMBase: m6A_site_177631
mod ID: M6ASITE010828		Click to Show/Hide the Full List
mod site	chr12:12718038-12718039:+		[3]
Sequence	GAATTTCGATTTTCAGAATCACAAACCCCTAGAGGGCAAGT
Motif Score	2.047297619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000228872.9; ENST00000396340.1; ENST00000442489.1; ENST00000477087.1
External Link	RMBase: m6A_site_177632
mod ID: M6ASITE010829		Click to Show/Hide the Full List
mod site	chr12:12718042-12718043:+		[2]
Sequence	TTCGATTTTCAGAATCACAAACCCCTAGAGGGCAAGTACGA
Motif Score	2.185083333
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; LCLs; MT4; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000442489.1; ENST00000396340.1; ENST00000228872.9; ENST00000477087.1
External Link	RMBase: m6A_site_177633
mod ID: M6ASITE010830		Click to Show/Hide the Full List
mod site	chr12:12718108-12718109:+		[2]
Sequence	TTGCCCGAGTTCTACTACAGACCCCCGCGGCCCCCCAAAGG
Motif Score	2.876744048
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; U2OS; H1A; H1B; hNPCs; GM12878; LCLs; MT4; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000228872.9; ENST00000477087.1; ENST00000442489.1; ENST00000396340.1
External Link	RMBase: m6A_site_177634
mod ID: M6ASITE010831		Click to Show/Hide the Full List
mod site	chr12:12718218-12718219:+		[2]
Sequence	GGCTCCGGCTAACTCTGAGGACACGCATTTGGTGGACCCAA
Motif Score	3.643047619
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; hESC-HEK293T; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; LCLs; CD8T; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq; m6A-CLIP/IP
Transcript ID List	ENST00000477087.1; ENST00000442489.1; ENST00000228872.9; ENST00000396340.1
External Link	RMBase: m6A_site_177635
mod ID: M6ASITE010832		Click to Show/Hide the Full List
mod site	chr12:12718233-12718234:+		[2]
Sequence	TGAGGACACGCATTTGGTGGACCCAAAGACTGATCCGTCGG
Motif Score	3.622404762
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; LCLs; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000228872.9; ENST00000396340.1; ENST00000442489.1; ENST00000477087.1
External Link	RMBase: m6A_site_177636
mod ID: M6ASITE010833		Click to Show/Hide the Full List
mod site	chr12:12718241-12718242:+		[2]
Sequence	CGCATTTGGTGGACCCAAAGACTGATCCGTCGGACAGCCAG
Motif Score	3.319380952
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; LCLs; CD8T; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq; m6A-CLIP/IP
Transcript ID List	ENST00000396340.1; ENST00000228872.9; ENST00000442489.1; ENST00000477087.1
External Link	RMBase: m6A_site_177637
mod ID: M6ASITE010834		Click to Show/Hide the Full List
mod site	chr12:12718254-12718255:+		[2]
Sequence	CCCAAAGACTGATCCGTCGGACAGCCAGACGGGGTTAGCGG
Motif Score	3.643047619
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; LCLs; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000228872.9; ENST00000477087.1; ENST00000442489.1; ENST00000396340.1
External Link	RMBase: m6A_site_177638
mod ID: M6ASITE010835		Click to Show/Hide the Full List
mod site	chr12:12718839-12718840:+		[2]
Sequence	CTTAGATTCTTCTACTCAAAACAAAAGAGCCAACAGAACAG
Motif Score	2.20572619
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; hESC-HEK293T; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; LCLs; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq
Transcript ID List	ENST00000477087.1; ENST00000228872.9; ENST00000442489.1; ENST00000396340.1
External Link	RMBase: m6A_site_177639
mod ID: M6ASITE010836		Click to Show/Hide the Full List
mod site	chr12:12718856-12718857:+		[2]
Sequence	AAAACAAAAGAGCCAACAGAACAGAAGAAAATGTTTCAGAC
Motif Score	2.951386905
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; U2OS; H1B; H1A; hNPCs; fibroblasts; GM12878; LCLs; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000228872.9; ENST00000442489.1; ENST00000477087.1; ENST00000396340.1
External Link	RMBase: m6A_site_177640
mod ID: M6ASITE010837		Click to Show/Hide the Full List
mod site	chr12:12718946-12718947:+		[4]
Sequence	TCAGAAGACGTCAAACGTAAACAGCTCGGTGGGTTGATCAC
Motif Score	2.20572619
Cell/Tissue List	CD34; HEK293T; HeLa; A549; Huh7; Jurkat; peripheral-blood; HEK293A-TOA; iSLK; TREX; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000442489.1; ENST00000477087.1; ENST00000396340.1; ENST00000228872.9
External Link	RMBase: m6A_site_177641
mod ID: M6ASITE010838		Click to Show/Hide the Full List
mod site	chr12:12721127-12721128:+		[5]
Sequence	TTTAAAAATACATATCGCTGACTTCATGGAATGGACATCCT
Motif Score	3.28175
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000442489.1; ENST00000396340.1; ENST00000228872.9; ENST00000477087.1
External Link	RMBase: m6A_site_177642
mod ID: M6ASITE010839		Click to Show/Hide the Full List
mod site	chr12:12721141-12721142:+		[2]
Sequence	TCGCTGACTTCATGGAATGGACATCCTGTATAAGCACTGAA
Motif Score	3.643047619
Cell/Tissue List	HeLa; HEK293T; brain; hESC-HEK293T; hNPCs; fibroblasts; A549; Huh7; HEK293A-TOA; iSLK; AML
Seq Type List	m6A-seq; MeRIP-seq; m6A-REF-seq; MAZTER-seq; m6A-CLIP/IP; miCLIP
Transcript ID List	ENST00000396340.1; ENST00000442489.1; ENST00000228872.9; ENST00000477087.1
External Link	RMBase: m6A_site_177643
mod ID: M6ASITE010840		Click to Show/Hide the Full List
mod site	chr12:12721164-12721165:+		[2]
Sequence	TCCTGTATAAGCACTGAAAAACAACAACACAATAACACTAA
Motif Score	2.20572619
Cell/Tissue List	HeLa; HEK293T; hESC-HEK293T; hNPCs; hESCs; fibroblasts; A549; Huh7; HEK293A-TOA; iSLK
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq
Transcript ID List	ENST00000442489.1; ENST00000228872.9; ENST00000396340.1; ENST00000477087.1
External Link	RMBase: m6A_site_177644
mod ID: M6ASITE010841		Click to Show/Hide the Full List
mod site	chr12:12721178-12721179:+		[3]
Sequence	TGAAAAACAACAACACAATAACACTAAAATTTTAGGCACTC
Motif Score	2.168095238
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000396340.1; ENST00000477087.1; ENST00000442489.1; ENST00000228872.9
External Link	RMBase: m6A_site_177645
mod ID: M6ASITE010842		Click to Show/Hide the Full List
mod site	chr12:12721180-12721181:+		[5]
Sequence	AAAAACAACAACACAATAACACTAAAATTTTAGGCACTCTT
Motif Score	2.506922619
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000477087.1; ENST00000228872.9; ENST00000442489.1; ENST00000396340.1
External Link	RMBase: m6A_site_177646
mod ID: M6ASITE010843		Click to Show/Hide the Full List
mod site	chr12:12721271-12721272:+		[5]
Sequence	TTCCTTATTTGCTTCATTGTACTACCTGTGTATATAGTTTT
Motif Score	3.278136905
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000228872.9; ENST00000442489.1; ENST00000396340.1
External Link	RMBase: m6A_site_177647
mod ID: M6ASITE010844		Click to Show/Hide the Full List
mod site	chr12:12721274-12721275:+		[5]
Sequence	CTTATTTGCTTCATTGTACTACCTGTGTATATAGTTTTTAC
Motif Score	2.05802381
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000442489.1; ENST00000228872.9; ENST00000396340.1
External Link	RMBase: m6A_site_177648
mod ID: M6ASITE010845		Click to Show/Hide the Full List
mod site	chr12:12721307-12721308:+		[3]
Sequence	GTTTTTACCTTTTATGTAGCACATAAACTTTGGGGAAGGGA
Motif Score	2.830589286
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000396340.1; ENST00000228872.9
External Link	RMBase: m6A_site_177649
mod ID: M6ASITE010846		Click to Show/Hide the Full List
mod site	chr12:12721313-12721314:+		[2]
Sequence	ACCTTTTATGTAGCACATAAACTTTGGGGAAGGGAGGGCAG
Motif Score	2.627720238
Cell/Tissue List	HeLa; HEK293T; BGC823; hNPCs; hESCs; A549; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000228872.9; ENST00000396340.1
External Link	RMBase: m6A_site_177650
mod ID: M6ASITE010847		Click to Show/Hide the Full List
mod site	chr12:12721348-12721349:+		[2]
Sequence	GGGCAGGGTGGGGCTGAGGAACTGACGTGGAGCGGGGTATG
Motif Score	3.373380952
Cell/Tissue List	HeLa; HEK293T; BGC823; hESCs; A549; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000228872.9; ENST00000396340.1
External Link	RMBase: m6A_site_177651
mod ID: M6ASITE010848		Click to Show/Hide the Full List
mod site	chr12:12721483-12721484:+		[2]
Sequence	ATGTAATGTCCCTTTCAGAGACAGCTGATACTTCATTTAAA
Motif Score	2.897386905
Cell/Tissue List	HeLa; liver
Seq Type List	m6A-seq; m6A-REF-seq
Transcript ID List	ENST00000228872.9
External Link	RMBase: m6A_site_177652
mod ID: M6ASITE010849		Click to Show/Hide the Full List
mod site	chr12:12721522-12721523:+		[2]
Sequence	AAAAAATCACAAAAATTTGAACACTGGCTAAAGATAATTGC
Motif Score	2.951386905
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000228872.9
External Link	RMBase: m6A_site_177653
mod ID: M6ASITE010850		Click to Show/Hide the Full List
mod site	chr12:12721554-12721555:+		[3]
Sequence	GATAATTGCTATTTATTTTTACAAGAAGTTTATTCTCATTT
Motif Score	2.07285119
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000228872.9
External Link	RMBase: m6A_site_177654
mod ID: M6ASITE010851		Click to Show/Hide the Full List
mod site	chr12:12721652-12721653:+		[2]
Sequence	TTTTTAAAAAAGCAACAGAAACCTATCCTCACTGCCCTCCC
Motif Score	2.185083333
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000228872.9
External Link	RMBase: m6A_site_177655
mod ID: M6ASITE010852		Click to Show/Hide the Full List
mod site	chr12:12721662-12721663:+		[5]
Sequence	AGCAACAGAAACCTATCCTCACTGCCCTCCCCAGTCTCTCT
Motif Score	2.469291667
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000228872.9
External Link	RMBase: m6A_site_177656
mod ID: M6ASITE010853		Click to Show/Hide the Full List
mod site	chr12:12721813-12721814:+		[3]
Sequence	TGCTTTTATTAAATTTGTTGACAAAATTTTCTCATTTTCTT
Motif Score	2.859755952
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000228872.9
External Link	RMBase: m6A_site_177657
mod ID: M6ASITE010854		Click to Show/Hide the Full List
mod site	chr12:12721837-12721838:+		[5]
Sequence	AATTTTCTCATTTTCTTTTCACTTCGGGCTGTGTAAACACA
Motif Score	2.469291667
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000228872.9
External Link	RMBase: m6A_site_177658
mod ID: M6ASITE010855		Click to Show/Hide the Full List
mod site	chr12:12721853-12721854:+		[3]
Sequence	TTTCACTTCGGGCTGTGTAAACACAGTCAAAATAATTCTAA
Motif Score	2.20572619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000228872.9
External Link	RMBase: m6A_site_177659
mod ID: M6ASITE010856		Click to Show/Hide the Full List
mod site	chr12:12721910-12721911:+		[3]
Sequence	AAAGATCTGTAAGTAACTTCACATTAAAAAATGAAATATTT
Motif Score	2.047297619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000228872.9
External Link	RMBase: m6A_site_177660
mod ID: M6ASITE010857		Click to Show/Hide the Full List
mod site	chr12:12721946-12721947:+		[5]
Sequence	TATTTTTTAATTTAAAGCTTACTCTGTCCATTTATCCACAG
Motif Score	2.494845238
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000228872.9
External Link	RMBase: m6A_site_177661
mod ID: M6ASITE010858		Click to Show/Hide the Full List
mod site	chr12:12722008-12722009:+		[3]
Sequence	AGGTTCATGTAGAGAAAAGCACACTTGTAGGATAAGTGAAA
Motif Score	2.830589286
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000228872.9
External Link	RMBase: m6A_site_177662
mod ID: M6ASITE010859		Click to Show/Hide the Full List
mod site	chr12:12722047-12722048:+		[2]
Sequence	AATGGATACTACATCTTTAAACAGTATTTCATTGCCTGTGT
Motif Score	2.20572619
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000228872.9
External Link	RMBase: m6A_site_177663
mod ID: M6ASITE010860		Click to Show/Hide the Full List
mod site	chr12:12722076-12722077:+		[2]
Sequence	CATTGCCTGTGTATGGAAAAACCATTTGAAGTGTACCTGTG
Motif Score	2.185083333
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000228872.9
External Link	RMBase: m6A_site_177664
mod ID: M6ASITE010861		Click to Show/Hide the Full List
mod site	chr12:12722098-12722099:+		[3]
Sequence	CATTTGAAGTGTACCTGTGTACATAACTCTGTAAAAACACT
Motif Score	2.856142857
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000228872.9
External Link	RMBase: m6A_site_177665
mod ID: M6ASITE010862		Click to Show/Hide the Full List
mod site	chr12:12722114-12722115:+		[2]
Sequence	GTGTACATAACTCTGTAAAAACACTGAAAAATTATACTAAC
Motif Score	2.20572619
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000228872.9
External Link	RMBase: m6A_site_177666
mod ID: M6ASITE010863		Click to Show/Hide the Full List
mod site	chr12:12722116-12722117:+		[5]
Sequence	GTACATAACTCTGTAAAAACACTGAAAAATTATACTAACTT
Motif Score	2.506922619
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000228872.9
External Link	RMBase: m6A_site_177667
mod ID: M6ASITE010864		Click to Show/Hide the Full List
mod site	chr12:12722167-12722168:+		[2]
Sequence	AAAGATTTTTTTTAATCTAGACAATATACAAGCCAAAGTGG
Motif Score	2.897386905
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000228872.9
External Link	RMBase: m6A_site_177668
mod ID: M6ASITE010865		Click to Show/Hide the Full List
mod site	chr12:12722174-12722175:+		[3]
Sequence	TTTTTTAATCTAGACAATATACAAGCCAAAGTGGCATGTTT
Motif Score	2.110482143
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000228872.9
External Link	RMBase: m6A_site_177669
mod ID: M6ASITE010866		Click to Show/Hide the Full List
mod site	chr12:12722278-12722279:+		[5]
Sequence	CTATGCTTAAAAGGTTGCATACTGAGCCAAGTATAATTTTT
Motif Score	2.53247619
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000228872.9
External Link	RMBase: m6A_site_177670
mod ID: M6ASITE010867		Click to Show/Hide the Full List
mod site	chr12:12722331-12722332:+		[3]
Sequence	AAAAGATGCCAATTATTGTTACACATTAAGTAATCAATAAA
Motif Score	2.07285119
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000228872.9
External Link	RMBase: m6A_site_177671
mod ID: M6ASITE010868		Click to Show/Hide the Full List
mod site	chr12:12722356-12722357:+		[2]
Sequence	TTAAGTAATCAATAAAGAAAACTTCCATAGCTATTCATTGA
Motif Score	2.627720238
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000228872.9
External Link	RMBase: m6A_site_177672

N7-methylguanosine (m7G)

In total 1 m6A sequence/site(s) in this target gene
mod ID: m7GSITE000012		Click to Show/Hide the Full List
mod site	chr12:12721335-12721336:+		[6]
Sequence	TTTGGGGAAGGGAGGGCAGGGTGGGGCTGAGGAACTGACGT
Cell/Tissue List	A549; HeLa; HepG2
Seq Type List	BoRed-seq&m7G-RIP-seq; m7G-seq
Transcript ID List	ENST00000396340.1; ENST00000228872.9
External Link	RMBase: m7G_site_196

Ref 1	RADAR: a rigorously annotated database of A-to-I RNA editing. Nucleic Acids Res. 2014 Jan;42(Database issue):D109-13. doi: 10.1093/nar/gkt996. Epub 2013 Oct 25.
Ref 2	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 3	Deciphering the "m(6)A Code" via Antibody-Independent Quantitative Profiling. Cell. 2019 Jul 25;178(3):731-747.e16. doi: 10.1016/j.cell.2019.06.013. Epub 2019 Jun 27.
Ref 4	Suppression of m(6)A reader Ythdf2 promotes hematopoietic stem cell expansion. Cell Res. 2018 Sep;28(9):904-917. doi: 10.1038/s41422-018-0072-0. Epub 2018 Jul 31.
Ref 5	DART-seq: an antibody-free method for global m(6)A detection. Nat Methods. 2019 Dec;16(12):1275-1280. doi: 10.1038/s41592-019-0570-0. Epub 2019 Sep 23.
Ref 6	METTL1 Promotes let-7 MicroRNA Processing via m7G Methylation. Mol Cell. 2019 Jun 20;74(6):1278-1290.e9. doi: 10.1016/j.molcel.2019.03.040. Epub 2019 Apr 25.

Epigenetic Target Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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