m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
Crosstalk ID
M6ACROT00636
 [1], [2], [3], [4]
m6A modification MIR222 MIR222 METTL3 Methylation : m6A sites Indirect Enhancement RNA modification CDKN1B CDKN1B ALKBH3 Demethylation : modification sites
m6A Modification:
m6A Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
m6A Target microRNA 222 (MIR222)
 Targert Gene 
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type RNA modification (RNAMod)  >> N1-methyladenosine (m1A)
Epigenetic Regulator Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 (ALKBH3) ERASER View Details
Regulated Target Cyclin-dependent kinase inhibitor 1B (CDKN1B/p27) View Details
Crosstalk Relationship m6A  →  m1A Enhancement
Crosstalk Mechanism m6A modification indirectly impacts RNA modification through downstream signaling pathways
Crosstalk Summary METTL3 interacts with microRNA 222 (MIR222), decreasing its m6A level and promoting its physical interaction with Cyclin-dependent kinase inhibitor 1B (CDKN1B/p27), which was regulated by ALKBH3-mediated m1A modification.
In-vitro Model
 A-549 Lung adenocarcinoma Homo sapiens CVCL_0023
MDA-MB-231 Breast adenocarcinoma Homo sapiens CVCL_0062
T24 Bladder carcinoma Homo sapiens CVCL_0554
Ej138 Bladder carcinoma Homo sapiens CVCL_2443
References
Ref 1 ALKBH3, a human AlkB homologue, contributes to cell survival in human non-small-cell lung cancer. Br J Cancer. 2011 Feb 15;104(4):700-6. doi: 10.1038/sj.bjc.6606012. Epub 2011 Feb 1.
Ref 2 N6-methyladenosine marks primary microRNAs for processing. Nature. 2015 Mar 26;519(7544):482-5. doi: 10.1038/nature14281. Epub 2015 Mar 18.
Ref 3 METTL3 promote tumor proliferation of bladder cancer by accelerating pri-miR221/222 maturation in m6A-dependent manner. Mol Cancer. 2019 Jun 22;18(1):110. doi: 10.1186/s12943-019-1036-9.
Ref 4 MiR-222 promotes the progression of polycystic ovary syndrome by targeting p27 Kip1. Pathol Res Pract. 2019 May;215(5):918-923. doi: 10.1016/j.prp.2019.01.038. Epub 2019 Jan 28.