m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00664)
Target Name Polycomb complex protein BMI-1 (BMI1)
Synonyms
Polycomb group RING finger protein 4; RING finger protein 51
    Click to Show/Hide
Gene Name BMI1
Chromosomal Location 10p12.2
Function
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A. In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2.
    Click to Show/Hide
Gene ID 648
Uniprot ID
BMI1_HUMAN
HGNC ID
HGNC:1066
Ensembl Gene ID
ENSG00000168283
KEGG ID
hsa:100532731
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
BMI1 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) [READER]
 Regulator Info 
Representative RNA-seq result indicating the expression of this target gene regulated by IGF2BP1
Cell Line PANC-1 cell line Homo sapiens
Treatment: siIGF2BP1 PANC-1 cells
Control: siControl PANC-1 cells
 GSE161087
Regulation
logFC: -6.85E-01
p-value: 1.16E-03
More Results Click to View More RNA-seq Results
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary METTL3 promotes Polycomb complex protein BMI-1 (BMI1) translation in OSCC under the cooperation with m6A reader IGF2BP1. And the study revealed that METTL3 promotes OSCC proliferation and metastasis through BMI1 m6A methylation.
Target Regulation Up regulation
Responsed Disease Oral squamous cell carcinoma ICD-11: 2B6E.0
 Disease Info 
In-vitro Model UM1 Tongue squamous cell carcinoma Homo sapiens CVCL_VH00
SCC-9 Tongue squamous cell carcinoma Homo sapiens CVCL_1685
SCC-25 Tongue squamous cell carcinoma Homo sapiens CVCL_1682
SCC-15 Tongue squamous cell carcinoma Homo sapiens CVCL_1681
HSC-3 Tongue squamous cell carcinoma Homo sapiens CVCL_1288
HOK Normal Hexagrammos otakii CVCL_YE19
In-vivo Model To construct the subcutaneous tumorigenesis model, the cells were suspended in 100 uL of PBS and Matrigel matrix (BD Biosciences, USA) (1:1) and injected into the right flanks of 6-week-old female BALB/c nude mice.To construct the lymph node metastasis model, we injected 1 × 105/50 uL stably infected SCC9 cells into the left hind footpads of BALB/c mice.
Methyltransferase-like 3 (METTL3) [WRITER]
 Regulator Info 
Representative RNA-seq result indicating the expression of this target gene regulated by METTL3
Cell Line Pancreatic islets Mus musculus
Treatment: Mettl3 knockout mice
Control: Mettl3 flox/flox mice
 GSE155612
Regulation
logFC: 5.95E-01
p-value: 1.91E-03
More Results Click to View More RNA-seq Results
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary METTL3 promotes Polycomb complex protein BMI-1 (BMI1) translation in OSCC under the cooperation with m6A reader IGF2BP1. And the study revealed that METTL3 promotes OSCC proliferation and metastasis through BMI1 m6A methylation.
Target Regulation Up regulation
Responsed Disease Oral squamous cell carcinoma ICD-11: 2B6E.0
 Disease Info 
In-vitro Model UM1 Tongue squamous cell carcinoma Homo sapiens CVCL_VH00
SCC-9 Tongue squamous cell carcinoma Homo sapiens CVCL_1685
SCC-25 Tongue squamous cell carcinoma Homo sapiens CVCL_1682
SCC-15 Tongue squamous cell carcinoma Homo sapiens CVCL_1681
HSC-3 Tongue squamous cell carcinoma Homo sapiens CVCL_1288
HOK Normal Hexagrammos otakii CVCL_YE19
In-vivo Model To construct the subcutaneous tumorigenesis model, the cells were suspended in 100 uL of PBS and Matrigel matrix (BD Biosciences, USA) (1:1) and injected into the right flanks of 6-week-old female BALB/c nude mice.To construct the lymph node metastasis model, we injected 1 × 105/50 uL stably infected SCC9 cells into the left hind footpads of BALB/c mice.
Head and neck squamous carcinoma [ICD-11: 2B6E]
 Disease Info 
In total 2 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary METTL3 promotes Polycomb complex protein BMI-1 (BMI1) translation in OSCC under the cooperation with m6A reader IGF2BP1. And the study revealed that METTL3 promotes OSCC proliferation and metastasis through BMI1 m6A methylation.
Responsed Disease Oral squamous cell carcinoma [ICD-11: 2B6E.0]
Target Regulator Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) READER
 Regulator Info 
Target Regulation Up regulation
In-vitro Model UM1 Tongue squamous cell carcinoma Homo sapiens CVCL_VH00
SCC-9 Tongue squamous cell carcinoma Homo sapiens CVCL_1685
SCC-25 Tongue squamous cell carcinoma Homo sapiens CVCL_1682
SCC-15 Tongue squamous cell carcinoma Homo sapiens CVCL_1681
HSC-3 Tongue squamous cell carcinoma Homo sapiens CVCL_1288
HOK Normal Hexagrammos otakii CVCL_YE19
In-vivo Model To construct the subcutaneous tumorigenesis model, the cells were suspended in 100 uL of PBS and Matrigel matrix (BD Biosciences, USA) (1:1) and injected into the right flanks of 6-week-old female BALB/c nude mice.To construct the lymph node metastasis model, we injected 1 × 105/50 uL stably infected SCC9 cells into the left hind footpads of BALB/c mice.
Experiment 2 Reporting the m6A-centered Disease Response [1]
Response Summary METTL3 promotes Polycomb complex protein BMI-1 (BMI1) translation in OSCC under the cooperation with m6A reader IGF2BP1. And the study revealed that METTL3 promotes OSCC proliferation and metastasis through BMI1 m6A methylation.
Responsed Disease Oral squamous cell carcinoma [ICD-11: 2B6E.0]
Target Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
Target Regulation Up regulation
In-vitro Model UM1 Tongue squamous cell carcinoma Homo sapiens CVCL_VH00
SCC-9 Tongue squamous cell carcinoma Homo sapiens CVCL_1685
SCC-25 Tongue squamous cell carcinoma Homo sapiens CVCL_1682
SCC-15 Tongue squamous cell carcinoma Homo sapiens CVCL_1681
HSC-3 Tongue squamous cell carcinoma Homo sapiens CVCL_1288
HOK Normal Hexagrammos otakii CVCL_YE19
In-vivo Model To construct the subcutaneous tumorigenesis model, the cells were suspended in 100 uL of PBS and Matrigel matrix (BD Biosciences, USA) (1:1) and injected into the right flanks of 6-week-old female BALB/c nude mice.To construct the lymph node metastasis model, we injected 1 × 105/50 uL stably infected SCC9 cells into the left hind footpads of BALB/c mice.
References
Ref 1 METTL3 Promotes Tumorigenesis and Metastasis through BMI1 m(6)A Methylation in Oral Squamous Cell Carcinoma. Mol Ther. 2020 Oct 7;28(10):2177-2190. doi: 10.1016/j.ymthe.2020.06.024. Epub 2020 Jun 24.