m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00639)
Target Name Tyrosine-protein phosphatase non-receptor type 6 (PTPN6)
Synonyms
Hematopoietic cell protein-tyrosine phosphatase; Protein-tyrosine phosphatase 1C; PTP-1C; Protein-tyrosine phosphatase SHP-1; SH-PTP1
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Gene Name PTPN6
Chromosomal Location 12p13.31
Family Protein-tyrosine phosphatase family, Non-receptor class 2 subfamily
Function
Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis.
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Gene ID 5777
Uniprot ID
PTN6_HUMAN
HGNC ID
HGNC:9658
Ensembl Gene ID
ENSG00000111679
KEGG ID
hsa:5777
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
PTPN6 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Methyltransferase-like 14 (METTL14) [WRITER]
 Regulator Info 
Representative RNA-seq result indicating the expression of this target gene regulated by METTL14
Cell Line IL7H6 cell line Mus musculus
Treatment: METTL14 knockout IL7H6 cells
Control: Wild type IL7H6 cells
 GSE151071
Regulation
logFC: -1.44E+00
p-value: 2.37E-10
More Results Click to View More RNA-seq Results
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary Imbalanced osteogenic/adipogenic differentiation of bone marrow mesenchymal stem cells BMSCs is considered the core pathological characteristic of SONFH. METTL14 regulated Tyrosine-protein phosphatase non-receptor type 6 (PTPN6) expression by increasing PTPN6 mRNA stability in an m6A-dependent manner. Moreover, PTPN6 knockdown abrogated the beneficial effects of METTL14 overexpression on BMSCs.
Target Regulation up regulation
Responsed Disease Osteonecrosis, unspecified ICD-11: FB81.Z
 Disease Info 
Pathway Response Wnt signaling pathway hsa04310
In-vitro Model ()
Osteonecrosis [ICD-11: FB81]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary Imbalanced osteogenic/adipogenic differentiation of bone marrow mesenchymal stem cells BMSCs is considered the core pathological characteristic of SONFH. METTL14 regulated Tyrosine-protein phosphatase non-receptor type 6 (PTPN6) expression by increasing PTPN6 mRNA stability in an m6A-dependent manner. Moreover, PTPN6 knockdown abrogated the beneficial effects of METTL14 overexpression on BMSCs.
Responsed Disease Osteonecrosis, unspecified [ICD-11: FB81.Z]
Target Regulator Methyltransferase-like 14 (METTL14) WRITER
 Regulator Info 
Target Regulation up regulation
Pathway Response Wnt signaling pathway hsa04310
In-vitro Model ()
References
Ref 1 METTL14 benefits the mesenchymal stem cells in patients with steroid-associated osteonecrosis of the femoral head by regulating the m6A level of PTPN6. Aging (Albany NY). 2021 Dec 15;13(24):25903-25919. doi: 10.18632/aging.203778. Epub 2021 Dec 15.