m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00639)

Target Name	Tyrosine-protein phosphatase non-receptor type 6 (PTPN6)
Synonyms	Hematopoietic cell protein-tyrosine phosphatase; Protein-tyrosine phosphatase 1C; PTP-1C; Protein-tyrosine phosphatase SHP-1; SH-PTP1 Click to Show/Hide
Gene Name	PTPN6
Chromosomal Location	12p13.31
Family	Protein-tyrosine phosphatase family, Non-receptor class 2 subfamily
Function	Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis. Click to Show/Hide
Gene ID	5777
Uniprot ID	PTN6_HUMAN
HGNC ID	HGNC:9658
KEGG ID	hsa:5777

Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)

PTPN6 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).

Browse Regulator

Browse Disease

Methyltransferase-like 14 (METTL14) [WRITER]

Regulator Info

*Representative RNA-seq result indicating the expression of this target gene regulated by METTL14*
Cell Line	IL7H6 cell line	Mus musculus
Treatment: METTL14 knockout IL7H6 cells Control: Wild type IL7H6 cells		GSE151071
Regulation		logFC: -1.44E+00 p-value: 2.37E-10
More Results	Click to View More RNA-seq Results

In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene			[1]
Response Summary	Imbalanced osteogenic/adipogenic differentiation of bone marrow mesenchymal stem cells BMSCs is considered the core pathological characteristic of SONFH. METTL14 regulated Tyrosine-protein phosphatase non-receptor type 6 (PTPN6) expression by increasing PTPN6 mRNA stability in an m6A-dependent manner. Moreover, PTPN6 knockdown abrogated the beneficial effects of METTL14 overexpression on BMSCs.
Target Regulation	Up regulation
Responsed Disease	Osteonecrosis, unspecified	ICD-11: FB81.Z	Disease Info
Pathway Response	Wnt signaling pathway		hsa04310
In-vitro Model	BMSCs (BMSCs were obtained from the femurs and tibias of 2-3-week-old Sprague-Dawley male rats (Animal Center of Sun Yat-sen University))

Osteonecrosis [ICD-11: FB81]

Disease Info

In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response			[1]
Response Summary	Imbalanced osteogenic/adipogenic differentiation of bone marrow mesenchymal stem cells BMSCs is considered the core pathological characteristic of SONFH. METTL14 regulated Tyrosine-protein phosphatase non-receptor type 6 (PTPN6) expression by increasing PTPN6 mRNA stability in an m6A-dependent manner. Moreover, PTPN6 knockdown abrogated the beneficial effects of METTL14 overexpression on BMSCs.
Responsed Disease	Osteonecrosis, unspecified [ICD-11: FB81.Z]
Target Regulator	Methyltransferase-like 14 (METTL14)	WRITER	Regulator Info
Target Regulation	Up regulation
Pathway Response	Wnt signaling pathway		hsa04310
In-vitro Model	BMSCs (BMSCs were obtained from the femurs and tibias of 2-3-week-old Sprague-Dawley male rats (Animal Center of Sun Yat-sen University))

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR00639)

Tyrosine-protein phosphatase non-receptor type 6 (PTPN6)

Adenosine-to-Inosine editing (A-to-I)

In total 4 m6A sequence/site(s) in this target gene
mod ID: A2ISITE005354		Click to Show/Hide the Full List
mod site	chr12:6947518-6947519:+		[2]
Sequence	GTCTCTACAAAAAATAAGAAATTAGCTGGGTGTGGTGGCAC
Transcript ID List	ENST00000399448.5; ENST00000543120.5; ENST00000538318.5; ENST00000534900.5; ENST00000543115.5; rmsk_3715140; ENST00000542848.5
External Link	RMBase: RNA-editing_site_26605
mod ID: A2ISITE005355		Click to Show/Hide the Full List
mod site	chr12:6947521-6947522:+		[2]
Sequence	TCTACAAAAAATAAGAAATTAGCTGGGTGTGGTGGCACACG
Transcript ID List	ENST00000399448.5; ENST00000538318.5; ENST00000542848.5; ENST00000543120.5; ENST00000543115.5; rmsk_3715140; ENST00000534900.5
External Link	RMBase: RNA-editing_site_26606
mod ID: A2ISITE005356		Click to Show/Hide the Full List
mod site	chr12:6947569-6947570:+		[2]
Sequence	GTTCCAGCTATGGAGAGGCTAAGGTGAGAGGCTTGCTTGAG
Transcript ID List	ENST00000542848.5; ENST00000538318.5; ENST00000543120.5; rmsk_3715140; ENST00000534900.5; ENST00000399448.5; ENST00000543115.5
External Link	RMBase: RNA-editing_site_26607
mod ID: A2ISITE005357		Click to Show/Hide the Full List
mod site	chr12:6951167-6951168:+		[3]
Sequence	TACTGCATGTGTTGTCACATATGTGCAATGCCATGCTCCTG
Transcript ID List	ENST00000543120.5; ENST00000399448.5; ENST00000542848.5; ENST00000538318.5; ENST00000534900.5; ENST00000543115.5
External Link	RMBase: RNA-editing_site_26608

N6-methyladenosine (m6A)

In total 44 m6A sequence/site(s) in this target gene
mod ID: M6ASITE010514		Click to Show/Hide the Full List
mod site	chr12:6951375-6951376:+		[4]
Sequence	AGTGGAGTGGCAGCCCCAGAACTGGGACCACCGGGGGTGGT
Motif Score	3.373380952
Cell/Tissue List	MM6; Jurkat; CD4T; peripheral-blood
Seq Type List	m6A-seq
Transcript ID List	ENST00000538318.5; ENST00000543744.1; ENST00000543115.5; ENST00000540740.5; ENST00000542462.1; ENST00000545153.5; ENST00000541698.5; ENST00000456013.5; ENST00000535462.5; ENST00000543120.5; ENST00000399448.5; ENST00000416215.6; ENST00000534900.5; ENST00000538715.5; ENST00000542848.5; ENST00000318974.14; ENST00000536521.5
External Link	RMBase: m6A_site_175374
mod ID: M6ASITE010515		Click to Show/Hide the Full List
mod site	chr12:6951381-6951382:+		[5]
Sequence	GTGGCAGCCCCAGAACTGGGACCACCGGGGGTGGTGAGGCG
Motif Score	3.622404762
Cell/Tissue List	LCLs; MM6; Jurkat; CD4T; peripheral-blood; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000534900.5; ENST00000399448.5; ENST00000542462.1; ENST00000545153.5; ENST00000543115.5; ENST00000541698.5; ENST00000542848.5; ENST00000538318.5; ENST00000543120.5; ENST00000540740.5; ENST00000318974.14; ENST00000535462.5; ENST00000543744.1; ENST00000538715.5; ENST00000536521.5; ENST00000416215.6; ENST00000456013.5
External Link	RMBase: m6A_site_175375
mod ID: M6ASITE010516		Click to Show/Hide the Full List
mod site	chr12:6951458-6951459:+		[5]
Sequence	TGAGCTCTCTGCCTGCCCAGACTAGCTGCACCTCCTCATTC
Motif Score	3.319380952
Cell/Tissue List	LCLs; MM6; Jurkat; CD4T; peripheral-blood; endometrial; NB4
Seq Type List	m6A-seq
Transcript ID List	ENST00000399448.5; ENST00000538715.5; ENST00000318974.14; ENST00000540740.5; ENST00000539365.1; ENST00000416215.6; ENST00000542462.1; ENST00000541698.5; ENST00000543120.5; ENST00000534900.5; ENST00000542277.5; ENST00000545153.5; ENST00000543115.5; ENST00000542848.5; ENST00000456013.5; ENST00000538318.5; ENST00000536013.5; ENST00000535462.5; ENST00000543744.1; ENST00000536521.5
External Link	RMBase: m6A_site_175376
mod ID: M6ASITE010517		Click to Show/Hide the Full List
mod site	chr12:6951544-6951545:+		[4]
Sequence	GGGCCTGCCACCCACGGTAGACAGGAGGCAAGGGTGCCTGG
Motif Score	2.897386905
Cell/Tissue List	MM6; Jurkat; CD4T; peripheral-blood; endometrial; NB4
Seq Type List	m6A-seq
Transcript ID List	ENST00000540740.5; ENST00000416215.6; ENST00000538318.5; ENST00000534900.5; ENST00000538715.5; ENST00000535462.5; ENST00000543744.1; ENST00000542462.1; ENST00000543115.5; ENST00000536013.5; ENST00000542848.5; ENST00000399448.5; ENST00000545153.5; ENST00000539365.1; ENST00000541698.5; ENST00000318974.14; ENST00000543120.5; ENST00000536521.5; ENST00000456013.5; ENST00000542277.5
External Link	RMBase: m6A_site_175377
mod ID: M6ASITE010518		Click to Show/Hide the Full List
mod site	chr12:6951575-6951576:+		[4]
Sequence	GGGTGCCTGGTGCCCACGGGACCCCTCCTCACTGCCCTGCC
Motif Score	3.622404762
Cell/Tissue List	MM6; CD4T; peripheral-blood; endometrial; NB4
Seq Type List	m6A-seq
Transcript ID List	ENST00000540740.5; ENST00000456013.5; ENST00000534900.5; ENST00000538318.5; ENST00000541698.5; ENST00000543115.5; ENST00000536521.5; ENST00000416215.6; ENST00000399448.5; ENST00000542848.5; ENST00000535462.5; ENST00000538715.5; ENST00000545153.5; ENST00000542462.1; ENST00000543744.1; ENST00000542277.5; ENST00000318974.14; ENST00000539365.1; ENST00000543120.5; ENST00000536013.5
External Link	RMBase: m6A_site_175378
mod ID: M6ASITE010519		Click to Show/Hide the Full List
mod site	chr12:6951622-6951623:+		[6]
Sequence	GCCCAGGTGGTTTCACCGAGACCTCAGTGGGCTGGATGCAG
Motif Score	2.876744048
Cell/Tissue List	peripheral-blood; endometrial; MM6
Seq Type List	m6A-seq
Transcript ID List	ENST00000541698.5; ENST00000540740.5; ENST00000543744.1; ENST00000318974.14; ENST00000539365.1; ENST00000542277.5; ENST00000535462.5; ENST00000545153.5; ENST00000536013.5; ENST00000542848.5; ENST00000543115.5; ENST00000534900.5; ENST00000536521.5; ENST00000542462.1; ENST00000538715.5; ENST00000399448.5; ENST00000543120.5; ENST00000416215.6; ENST00000538318.5; ENST00000456013.5
External Link	RMBase: m6A_site_175379
mod ID: M6ASITE010520		Click to Show/Hide the Full List
mod site	chr12:6951645-6951646:+		[6]
Sequence	TCAGTGGGCTGGATGCAGAGACCCTGCTCAAGGGCCGAGGT
Motif Score	2.876744048
Cell/Tissue List	peripheral-blood; endometrial; MM6
Seq Type List	m6A-seq
Transcript ID List	ENST00000543120.5; ENST00000538715.5; ENST00000543115.5; ENST00000540740.5; ENST00000416215.6; ENST00000536521.5; ENST00000545153.5; ENST00000542462.1; ENST00000536013.5; ENST00000543744.1; ENST00000538318.5; ENST00000534900.5; ENST00000318974.14; ENST00000542848.5; ENST00000456013.5; ENST00000542277.5; ENST00000541698.5; ENST00000399448.5; ENST00000539365.1; ENST00000535462.5
External Link	RMBase: m6A_site_175380
mod ID: M6ASITE010521		Click to Show/Hide the Full List
mod site	chr12:6951703-6951704:+		[6]
Sequence	GGCTCGGCCCAGTCGCAAGAACCAGGGTGACTTCTCGCTCT
Motif Score	2.930744048
Cell/Tissue List	peripheral-blood; endometrial; MM6
Seq Type List	m6A-seq
Transcript ID List	ENST00000535462.5; ENST00000536521.5; ENST00000456013.5; ENST00000534900.5; ENST00000540740.5; ENST00000543120.5; ENST00000542277.5; ENST00000545153.5; ENST00000541698.5; ENST00000539365.1; ENST00000542462.1; ENST00000543744.1; ENST00000416215.6; ENST00000538715.5; ENST00000542848.5; ENST00000318974.14; ENST00000536013.5; ENST00000538318.5; ENST00000543115.5; ENST00000399448.5
External Link	RMBase: m6A_site_175381
mod ID: M6ASITE010522		Click to Show/Hide the Full List
mod site	chr12:6951793-6951794:+		[6]
Sequence	TTGTGCCATCCAGGCCCTGAACCACTCATTCCTGGTTCCCC
Motif Score	2.930744048
Cell/Tissue List	peripheral-blood; MM6
Seq Type List	m6A-seq
Transcript ID List	ENST00000542462.1; ENST00000538318.5; ENST00000539365.1; ENST00000538715.5; ENST00000399448.5; ENST00000543120.5; ENST00000542848.5; ENST00000416215.6; ENST00000456013.5; ENST00000318974.14; ENST00000543744.1; ENST00000542277.5; ENST00000536013.5; ENST00000536521.5; ENST00000540740.5; ENST00000541698.5; ENST00000545153.5; ENST00000543115.5; ENST00000534900.5; ENST00000535462.5
External Link	RMBase: m6A_site_175382
mod ID: M6ASITE010523		Click to Show/Hide the Full List
mod site	chr12:6952017-6952018:+		[6]
Sequence	GACCCATATTCGGATCCAGAACTCAGGGGATTTCTATGACC
Motif Score	3.373380952
Cell/Tissue List	peripheral-blood
Seq Type List	m6A-seq
Transcript ID List	ENST00000399448.5; ENST00000536013.5; ENST00000543120.5; ENST00000545153.5; ENST00000538715.5; ENST00000540740.5; ENST00000541698.5; ENST00000535462.5; ENST00000543115.5; ENST00000542848.5; ENST00000318974.14; ENST00000542462.1; ENST00000534900.5; ENST00000543744.1; ENST00000542277.5; ENST00000416215.6; ENST00000539365.1; ENST00000456013.5; ENST00000536521.5; ENST00000538318.5
External Link	RMBase: m6A_site_175383
mod ID: M6ASITE010524		Click to Show/Hide the Full List
mod site	chr12:6952113-6952114:+		[6]
Sequence	GCAGCAGGGTGTCCTGCAGGACCGCGACGGCACCATCATCC
Motif Score	3.622404762
Cell/Tissue List	peripheral-blood; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000543120.5; ENST00000538715.5; ENST00000399448.5; ENST00000543744.1; ENST00000536521.5; ENST00000416215.6; ENST00000542277.5; ENST00000534900.5; ENST00000536013.5; ENST00000542462.1; ENST00000456013.5; ENST00000539365.1; ENST00000543115.5; ENST00000538318.5; ENST00000540740.5; ENST00000318974.14; ENST00000535462.5; ENST00000541698.5; ENST00000545153.5; ENST00000542848.5
External Link	RMBase: m6A_site_175384
mod ID: M6ASITE010525		Click to Show/Hide the Full List
mod site	chr12:6952152-6952153:+		[6]
Sequence	CCACCTCAAGTACCCGCTGAACTGCTCCGATCCCACTAGTG
Motif Score	3.373380952
Cell/Tissue List	peripheral-blood; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000456013.5; ENST00000536521.5; ENST00000543115.5; ENST00000542277.5; ENST00000542462.1; ENST00000538318.5; ENST00000543120.5; ENST00000535462.5; ENST00000538715.5; ENST00000545153.5; ENST00000318974.14; ENST00000541698.5; ENST00000543744.1; ENST00000399448.5; ENST00000536013.5; ENST00000540740.5; ENST00000416215.6; ENST00000534900.5; ENST00000542848.5; ENST00000539365.1
External Link	RMBase: m6A_site_175385
mod ID: M6ASITE010526		Click to Show/Hide the Full List
mod site	chr12:6952234-6952235:+		[6]
Sequence	TGAGCCGGCTCCCACCCTGAACAGCCAGGGAGGCAGGGAGA
Motif Score	2.951386905
Cell/Tissue List	peripheral-blood
Seq Type List	m6A-seq
Transcript ID List	ENST00000538715.5; ENST00000542277.5; ENST00000543744.1; ENST00000318974.14; ENST00000534900.5; ENST00000538318.5; ENST00000456013.5; ENST00000545153.5; ENST00000540740.5; ENST00000399448.5; ENST00000543120.5; ENST00000416215.6; ENST00000541698.5; ENST00000539365.1; ENST00000536013.5; ENST00000542462.1; ENST00000542848.5; ENST00000535462.5
External Link	RMBase: m6A_site_175386
mod ID: M6ASITE010527		Click to Show/Hide the Full List
mod site	chr12:6952254-6952255:+		[6]
Sequence	ACAGCCAGGGAGGCAGGGAGACTGGCAGCCGGCGCTGCCTA
Motif Score	3.319380952
Cell/Tissue List	peripheral-blood
Seq Type List	m6A-seq
Transcript ID List	ENST00000541698.5; ENST00000540740.5; ENST00000536013.5; ENST00000399448.5; ENST00000538715.5; ENST00000456013.5; ENST00000545153.5; ENST00000539365.1; ENST00000543120.5; ENST00000318974.14; ENST00000542848.5; ENST00000535462.5; ENST00000538318.5; ENST00000416215.6; ENST00000542462.1; ENST00000543744.1; ENST00000542277.5; ENST00000534900.5
External Link	RMBase: m6A_site_175387
mod ID: M6ASITE010528		Click to Show/Hide the Full List
mod site	chr12:6952582-6952583:+		[7]
Sequence	TCACCCCAGCACATGTTAGGACAGTGAGGAGCTGACACTGG
Motif Score	3.643047619
Cell/Tissue List	CD34
Seq Type List	m6A-seq
Transcript ID List	ENST00000535462.5; ENST00000534900.5; ENST00000541698.5; ENST00000318974.14; ENST00000416215.6; ENST00000542848.5; ENST00000543744.1; ENST00000542277.5; ENST00000538715.5; ENST00000545153.5; ENST00000456013.5; ENST00000538318.5; ENST00000543120.5; ENST00000539365.1; ENST00000542462.1; ENST00000536013.5; ENST00000399448.5; ENST00000540740.5
External Link	RMBase: m6A_site_175388
mod ID: M6ASITE010529		Click to Show/Hide the Full List
mod site	chr12:6952632-6952633:+		[7]
Sequence	GGGGATGAATGCTTGCCAAGACACTTGATGCCTTGTCCCAG
Motif Score	2.897386905
Cell/Tissue List	CD34
Seq Type List	m6A-seq
Transcript ID List	ENST00000542277.5; ENST00000541698.5; ENST00000318974.14; ENST00000399448.5; ENST00000538715.5; ENST00000539365.1; ENST00000456013.5; ENST00000540740.5; ENST00000534900.5; ENST00000416215.6; ENST00000543120.5; ENST00000535462.5; ENST00000542848.5; ENST00000543744.1; ENST00000536013.5; ENST00000542462.1; ENST00000538318.5; ENST00000545153.5
External Link	RMBase: m6A_site_175389
mod ID: M6ASITE010530		Click to Show/Hide the Full List
mod site	chr12:6953300-6953301:+		[7]
Sequence	AGGGGGCTTTTGGCACCGAGACCCTCTAAAGCTCATGTCCT
Motif Score	2.876744048
Cell/Tissue List	CD34
Seq Type List	m6A-seq
Transcript ID List	ENST00000539365.1; ENST00000542848.5; ENST00000543120.5; ENST00000538318.5; ENST00000540740.5; ENST00000542462.1; ENST00000545153.5; ENST00000542277.5; ENST00000456013.5; ENST00000543744.1; ENST00000416215.6; ENST00000541698.5; ENST00000536013.5; ENST00000318974.14; ENST00000538715.5; ENST00000535462.5; ENST00000534900.5; ENST00000399448.5
External Link	RMBase: m6A_site_175390
mod ID: M6ASITE010531		Click to Show/Hide the Full List
mod site	chr12:6954908-6954909:+		[8]
Sequence	GAGCCTCAGCCAGCCTGGAGACTTCGTGCTTTCTGTGCTCA
Motif Score	3.319380952
Cell/Tissue List	HepG2; peripheral-blood; endometrial; NB4; MM6
Seq Type List	m6A-seq
Transcript ID List	ENST00000541698.5; ENST00000542848.5; ENST00000543120.5; ENST00000318974.14; ENST00000456013.5; ENST00000545153.5; ENST00000399448.5; ENST00000538715.5; ENST00000535462.5; ENST00000538318.5; ENST00000534900.5; ENST00000539365.1; ENST00000536013.5; ENST00000416215.6; ENST00000542462.1
External Link	RMBase: m6A_site_175391
mod ID: M6ASITE010532		Click to Show/Hide the Full List
mod site	chr12:6955180-6955181:+		[8]
Sequence	ACACAGTGGGTGGTTTGGAGACCTTCGACAGCCTCACGGAC
Motif Score	2.876744048
Cell/Tissue List	HepG2; peripheral-blood; endometrial; NB4; MM6
Seq Type List	m6A-seq
Transcript ID List	ENST00000318974.14; ENST00000541698.5; ENST00000542848.5; ENST00000542462.1; ENST00000538318.5; ENST00000456013.5; ENST00000539365.1; ENST00000399448.5; ENST00000545153.5; ENST00000416215.6; ENST00000536013.5
External Link	RMBase: m6A_site_175392
mod ID: M6ASITE010533		Click to Show/Hide the Full List
mod site	chr12:6955199-6955200:+		[8]
Sequence	GACCTTCGACAGCCTCACGGACCTGGTGGAGCATTTCAAGA
Motif Score	3.622404762
Cell/Tissue List	HepG2; peripheral-blood; endometrial; NB4; MM6
Seq Type List	m6A-seq
Transcript ID List	ENST00000542848.5; ENST00000545153.5; ENST00000536013.5; ENST00000456013.5; ENST00000318974.14; ENST00000538318.5; ENST00000539365.1; ENST00000416215.6; ENST00000399448.5
External Link	RMBase: m6A_site_175393
mod ID: M6ASITE010534		Click to Show/Hide the Full List
mod site	chr12:6955411-6955412:+		[4]
Sequence	GAATGCGGCTGACATTGAGAACCGAGTGTTGGAACTGAACA
Motif Score	2.930744048
Cell/Tissue List	MM6; Huh7; peripheral-blood; endometrial; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000318974.14; ENST00000399448.5; ENST00000539365.1; ENST00000416215.6; ENST00000545153.5; ENST00000456013.5
External Link	RMBase: m6A_site_175394
mod ID: M6ASITE010535		Click to Show/Hide the Full List
mod site	chr12:6955424-6955425:+		[9]
Sequence	ATTGAGAACCGAGTGTTGGAACTGAACAAGAAGCAGGAGTC
Motif Score	3.373380952
Cell/Tissue List	HeLa; MM6; Huh7; peripheral-blood; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000545153.5; ENST00000399448.5; ENST00000456013.5; ENST00000539365.1; ENST00000318974.14; ENST00000416215.6
External Link	RMBase: m6A_site_175395
mod ID: M6ASITE010536		Click to Show/Hide the Full List
mod site	chr12:6955429-6955430:+		[9]
Sequence	GAACCGAGTGTTGGAACTGAACAAGAAGCAGGAGTCCGAGG
Motif Score	2.951386905
Cell/Tissue List	HeLa; MM6; Huh7; peripheral-blood; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000456013.5; ENST00000318974.14; ENST00000545153.5; ENST00000539365.1; ENST00000416215.6; ENST00000399448.5
External Link	RMBase: m6A_site_175396
mod ID: M6ASITE010537		Click to Show/Hide the Full List
mod site	chr12:6955684-6955685:+		[9]
Sequence	GCAGAAGCAGGAGGTGAAGAACTTGCACCAGCGTCTGGAAG
Motif Score	3.373380952
Cell/Tissue List	HeLa; MM6; Huh7; CD4T; peripheral-blood; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000318974.14; ENST00000399448.5; ENST00000416215.6; ENST00000456013.5
External Link	RMBase: m6A_site_175397
mod ID: M6ASITE010538		Click to Show/Hide the Full List
mod site	chr12:6955720-6955721:+		[9]
Sequence	GGAAGGGCAGCGGCCAGAGAACAAGGGCAAGAACCGCTACA
Motif Score	2.951386905
Cell/Tissue List	HeLa; A549; MM6; Huh7; Jurkat; CD4T; peripheral-blood; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000416215.6; ENST00000456013.5; ENST00000318974.14; ENST00000399448.5
External Link	RMBase: m6A_site_175398
mod ID: M6ASITE010539		Click to Show/Hide the Full List
mod site	chr12:6955732-6955733:+		[9]
Sequence	GCCAGAGAACAAGGGCAAGAACCGCTACAAGAACATTCTCC
Motif Score	2.930744048
Cell/Tissue List	HeLa; A549; MM6; Huh7; Jurkat; CD4T; peripheral-blood; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000399448.5; ENST00000318974.14; ENST00000456013.5; ENST00000416215.6
External Link	RMBase: m6A_site_175399
mod ID: M6ASITE010540		Click to Show/Hide the Full List
mod site	chr12:6955744-6955745:+		[10]
Sequence	GGGCAAGAACCGCTACAAGAACATTCTCCCCTGTGAGCACC
Motif Score	2.951386905
Cell/Tissue List	A549; MM6; Huh7; Jurkat; CD4T; peripheral-blood; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000456013.5; ENST00000416215.6; ENST00000399448.5; ENST00000318974.14
External Link	RMBase: m6A_site_175400
mod ID: M6ASITE010541		Click to Show/Hide the Full List
mod site	chr12:6956174-6956175:+		[10]
Sequence	AGTGATCCTGCAGGGACGGGACAGTAACATCCCCGGGTCCG
Motif Score	3.643047619
Cell/Tissue List	A549; MM6; Huh7; Jurkat; CD4T; peripheral-blood; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000456013.5; ENST00000318974.14; ENST00000399448.5; ENST00000416215.6
External Link	RMBase: m6A_site_175401
mod ID: M6ASITE010542		Click to Show/Hide the Full List
mod site	chr12:6956451-6956452:+		[10]
Sequence	GCCCTGATGAGAACGCTAAGACCTACATCGCCAGCCAGGGT
Motif Score	2.876744048
Cell/Tissue List	A549; Huh7; peripheral-blood; HEC-1-A; NB4; MM6
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000318974.14; ENST00000456013.5; ENST00000399448.5; ENST00000416215.6
External Link	RMBase: m6A_site_175402
mod ID: M6ASITE010543		Click to Show/Hide the Full List
mod site	chr12:6956521-6956522:+		[6]
Sequence	GCAGATGGCGTGGCAGGAGAACAGCCGTGTCATCGTCATGA
Motif Score	2.951386905
Cell/Tissue List	peripheral-blood
Seq Type List	m6A-seq
Transcript ID List	ENST00000456013.5; ENST00000416215.6; ENST00000399448.5; ENST00000318974.14
External Link	RMBase: m6A_site_175403
mod ID: M6ASITE010544		Click to Show/Hide the Full List
mod site	chr12:6959766-6959767:+		[6]
Sequence	GTCCATGCAGAGCTGGGCAAACCTCCATCATCACTTGCCCG
Motif Score	2.185083333
Cell/Tissue List	peripheral-blood
Seq Type List	m6A-seq
Transcript ID List	ENST00000318974.14; ENST00000456013.5; ENST00000539029.5; ENST00000399448.5; ENST00000542761.5; ENST00000416215.6; ENST00000537533.1
External Link	RMBase: m6A_site_175404
mod ID: M6ASITE010545		Click to Show/Hide the Full List
mod site	chr12:6959979-6959980:+		[7]
Sequence	CATCGACATGCTCATGGAGAACATCTCCACCAAGGGTGAGG
Motif Score	2.951386905
Cell/Tissue List	CD34; MM6; peripheral-blood; TREX; endometrial; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000537533.1; ENST00000456013.5; ENST00000399448.5; ENST00000318974.14; ENST00000539029.5; ENST00000542761.5; ENST00000416215.6
External Link	RMBase: m6A_site_175405
mod ID: M6ASITE010546		Click to Show/Hide the Full List
mod site	chr12:6960093-6960094:+		[7]
Sequence	TGCCCCCCACCCAGGCCTGGACTGTGACATTGACATCCAGA
Motif Score	4.065041667
Cell/Tissue List	CD34; MM6; peripheral-blood; TREX; endometrial; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000539029.5; ENST00000399448.5; ENST00000318974.14; ENST00000537533.1; ENST00000542761.5; ENST00000456013.5; ENST00000416215.6
External Link	RMBase: m6A_site_175406
mod ID: M6ASITE010547		Click to Show/Hide the Full List
mod site	chr12:6960116-6960117:+		[7]
Sequence	GTGACATTGACATCCAGAAGACCATCCAGATGGTGCGGGCG
Motif Score	2.876744048
Cell/Tissue List	CD34; MM6; peripheral-blood; TREX; endometrial; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000539029.5; ENST00000399448.5; ENST00000537533.1; ENST00000456013.5; ENST00000542761.5; ENST00000318974.14; ENST00000416215.6
External Link	RMBase: m6A_site_175407
mod ID: M6ASITE010548		Click to Show/Hide the Full List
mod site	chr12:6960209-6960210:+		[9]
Sequence	CCATCGCCCAGTTCATTGAAACCACTAAGAAGAAGCTGGAG
Motif Score	2.185083333
Cell/Tissue List	HeLa; CD34; MM6; Huh7; peripheral-blood; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000318974.14; ENST00000456013.5; ENST00000416215.6; ENST00000537533.1; ENST00000542761.5; ENST00000399448.5; ENST00000539029.5
External Link	RMBase: m6A_site_175408
mod ID: M6ASITE010549		Click to Show/Hide the Full List
mod site	chr12:6960374-6960375:+		[9]
Sequence	CCAGGAGTCGGAGTACGGGAACATCACCTATCCCCCAGCCA
Motif Score	2.951386905
Cell/Tissue List	HeLa; CD34; MM6; Huh7; peripheral-blood; HEK293A-TOA; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000542761.5; ENST00000416215.6; ENST00000539029.5; ENST00000318974.14; ENST00000537533.1; ENST00000456013.5; ENST00000399448.5
External Link	RMBase: m6A_site_175409
mod ID: M6ASITE010550		Click to Show/Hide the Full List
mod site	chr12:6960684-6960685:+		[9]
Sequence	GCTTGGAGTCTAGTGCAGGGACCGTGGCTGCGTCACCTGTG
Motif Score	3.622404762
Cell/Tissue List	HeLa; CD34; MM6; Huh7; HEK293A-TOA; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000416215.6; ENST00000456013.5; ENST00000318974.14; ENST00000537533.1; ENST00000539029.5; ENST00000399448.5
External Link	RMBase: m6A_site_175410
mod ID: M6ASITE010551		Click to Show/Hide the Full List
mod site	chr12:6960725-6960726:+		[7]
Sequence	AGACGGGGTGGCCAGAGGGGACTGCCAGTGCCGGGTCCCCC
Motif Score	4.065041667
Cell/Tissue List	CD34; MM6; CD4T
Seq Type List	m6A-seq
Transcript ID List	ENST00000456013.5; ENST00000539029.5; ENST00000399448.5; ENST00000416215.6; ENST00000537533.1; ENST00000318974.14
External Link	RMBase: m6A_site_175411
mod ID: M6ASITE010552		Click to Show/Hide the Full List
mod site	chr12:6960805-6960806:+		[7]
Sequence	CCCCCTGCACCCGGCTGCAGACACAAGGAGGATGTGTATGA
Motif Score	2.897386905
Cell/Tissue List	CD34; MM6; CD4T; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000416215.6; ENST00000318974.14; ENST00000539029.5; ENST00000456013.5; ENST00000399448.5; ENST00000537533.1
External Link	RMBase: m6A_site_175412
mod ID: M6ASITE010553		Click to Show/Hide the Full List
mod site	chr12:6960828-6960829:+		[9]
Sequence	CAAGGAGGATGTGTATGAGAACCTGCACACTAAGAACAAGA
Motif Score	2.930744048
Cell/Tissue List	HeLa; CD34; MM6; CD4T; endometrial; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000456013.5; ENST00000537533.1; ENST00000318974.14; ENST00000416215.6; ENST00000539029.5; ENST00000399448.5
External Link	RMBase: m6A_site_175413
mod ID: M6ASITE010554		Click to Show/Hide the Full List
mod site	chr12:6960843-6960844:+		[9]
Sequence	TGAGAACCTGCACACTAAGAACAAGAGGGAGGAGAAAGTGA
Motif Score	2.951386905
Cell/Tissue List	HeLa; CD34; MM6; CD4T; peripheral-blood; endometrial; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000456013.5; ENST00000399448.5; ENST00000416215.6; ENST00000539029.5; ENST00000537533.1; ENST00000318974.14
External Link	RMBase: m6A_site_175414
mod ID: M6ASITE010555		Click to Show/Hide the Full List
mod site	chr12:6960882-6960883:+		[9]
Sequence	GAAGAAGCAGCGGTCAGCAGACAAGGAGAAGAGCAAGGGTT
Motif Score	2.897386905
Cell/Tissue List	HeLa; CD34; MM6; CD4T; peripheral-blood; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq
Transcript ID List	ENST00000416215.6; ENST00000318974.14; ENST00000456013.5; ENST00000537533.1; ENST00000539029.5; ENST00000399448.5
External Link	RMBase: m6A_site_175415
mod ID: M6ASITE010556		Click to Show/Hide the Full List
mod site	chr12:6961161-6961162:+		[9]
Sequence	GTGGAAGCATTTCGCGATGGACAGACTCACAACCTGAACCT
Motif Score	3.643047619
Cell/Tissue List	HeLa; CD34; HepG2; MM6; Huh7; CD4T; peripheral-blood; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000318974.14; ENST00000399448.5; ENST00000537533.1; ENST00000539029.5; ENST00000456013.5; ENST00000416215.6
External Link	RMBase: m6A_site_175416
mod ID: M6ASITE010557		Click to Show/Hide the Full List
mod site	chr12:6961178-6961179:+		[9]
Sequence	TGGACAGACTCACAACCTGAACCTAGGAGTGCCCCATTCTT
Motif Score	2.930744048
Cell/Tissue List	HeLa; CD34; MM6; Huh7; CD4T; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000318974.14; ENST00000537533.1; ENST00000416215.6; ENST00000456013.5; ENST00000399448.5; ENST00000539029.5
External Link	RMBase: m6A_site_175417

Ref 1	METTL14 benefits the mesenchymal stem cells in patients with steroid-associated osteonecrosis of the femoral head by regulating the m6A level of PTPN6. Aging (Albany NY). 2021 Dec 15;13(24):25903-25919. doi: 10.18632/aging.203778. Epub 2021 Dec 15.
Ref 2	Comprehensive analysis of RNA-Seq data reveals extensive RNA editing in a human transcriptome. Nat Biotechnol. 2012 Feb 12;30(3):253-60. doi: 10.1038/nbt.2122.
Ref 3	RADAR: a rigorously annotated database of A-to-I RNA editing. Nucleic Acids Res. 2014 Jan;42(Database issue):D109-13. doi: 10.1093/nar/gkt996. Epub 2013 Oct 25.
Ref 4	FTO Plays an Oncogenic Role in Acute Myeloid Leukemia as a N(6)-Methyladenosine RNA Demethylase. Cancer Cell. 2017 Jan 9;31(1):127-141. doi: 10.1016/j.ccell.2016.11.017. Epub 2016 Dec 22.
Ref 5	N6-Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection. Cell Host Microbe. 2016 Nov 9;20(5):654-665. doi: 10.1016/j.chom.2016.09.015. Epub 2016 Oct 20.
Ref 6	R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m(6)A/MYC/CEBPA Signaling. Cell. 2018 Jan 11;172(1-2):90-105.e23. doi: 10.1016/j.cell.2017.11.031. Epub 2017 Dec 14.
Ref 7	Suppression of m(6)A reader Ythdf2 promotes hematopoietic stem cell expansion. Cell Res. 2018 Sep;28(9):904-917. doi: 10.1038/s41422-018-0072-0. Epub 2018 Jul 31.
Ref 8	Efficacy of MEK inhibition in patients with histiocytic neoplasms. Nature. 2019 Mar;567(7749):521-524. doi: 10.1038/s41586-019-1012-y. Epub 2019 Mar 13.
Ref 9	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 10	The m(6)A Methyltransferase METTL3 Promotes Translation in Human Cancer Cells. Mol Cell. 2016 May 5;62(3):335-345. doi: 10.1016/j.molcel.2016.03.021. Epub 2016 Apr 21.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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