m6A-centered Disease Response Information
General Information of the Disease (ID: M6ADIS0181)
| Name |
Osteonecrosis
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|---|---|---|---|---|---|
| ICD |
ICD-11: FB81
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Full List of Target Gene(s) of This m6A-centered Disease Response
Tyrosine-protein phosphatase non-receptor type 6 (PTPN6)
| In total 1 item(s) under this target gene | ||||
| Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene | [1] | |||
| Response Summary | Imbalanced osteogenic/adipogenic differentiation of bone marrow mesenchymal stem cells BMSCs is considered the core pathological characteristic of SONFH. METTL14 regulated Tyrosine-protein phosphatase non-receptor type 6 (PTPN6) expression by increasing PTPN6 mRNA stability in an m6A-dependent manner. Moreover, PTPN6 knockdown abrogated the beneficial effects of METTL14 overexpression on BMSCs. | |||
| Responsed Disease | Osteonecrosis, unspecified [ICD-11: FB81.Z] | |||
| Target Regulator | Methyltransferase-like 14 (METTL14) | WRITER | ||
| Target Regulation | up regulation | |||
| Pathway Response | Wnt signaling pathway | hsa04310 | ||
| In-vitro Model | () | |||