m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00610)
Target Name Suppressor of cytokine signaling 3 (SOCS3)
Synonyms
SOCS-3; Cytokine-inducible SH2 protein 3; CIS-3; STAT-induced STAT inhibitor 3; SSI-3
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Gene Name SOCS3
Chromosomal Location 17q25.3
Function
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including IL6ST/gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity and regulates IL6 signaling. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells (By similarity). Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
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Gene ID 9021
Uniprot ID
SOCS3_HUMAN
HGNC ID
HGNC:19391
Ensembl Gene ID
ENSG00000184557
KEGG ID
hsa:9021
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
SOCS3 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
YTH domain-containing family protein 2 (YTHDF2) [READER]
 Regulator Info 
Representative RNA-seq result indicating the expression of this target gene regulated by YTHDF2
Cell Line mouse embryonic stem cells Mus musculus
Treatment: shYthdf2 embryonic stem cells
Control: shLuc embryonic stem cells
 GSE156437
Regulation
logFC: -1.05E+00
p-value: 3.86E-03
More Results Click to View More RNA-seq Results
Representative RIP-seq result supporting the interaction between SOCS3 and the regulator
Cell Line Hela Homo sapiens
Regulation logFC: 1.46E+00 GSE49339
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary ALKBH5 inactivated STAT3 pathway by increasing Suppressor of cytokine signaling 3 (SOCS3) expression via an m6A-YTHDF2-dependent manner.Reducing m6A mRNA levels in human osteosarcoma cells through ALKBH5 up-regulation lead to cell proliferation inhibition, cell apoptosis and cycle arrest.
Target Regulation Down regulation
Responsed Disease Osteosarcoma ICD-11: 2B51
 Disease Info 
Pathway Response JAK-STAT signaling pathway hsa04630
In-vitro Model U2OS Osteosarcoma Homo sapiens CVCL_0042
OS3 [Human osteosarcoma] Osteosarcoma Homo sapiens CVCL_F866
OS2 [Human osteosarcoma] Osteosarcoma Homo sapiens CVCL_F865
OS1 [Human osteosarcoma] Osteosarcoma Homo sapiens CVCL_F864
KHOS/NP Osteosarcoma Homo sapiens CVCL_2546
RNA demethylase ALKBH5 (ALKBH5) [ERASER]
 Regulator Info 
Representative RNA-seq result indicating the expression of this target gene regulated by ALKBH5
Cell Line RPMI-8226 cell line Homo sapiens
Treatment: shALKBH5 RPMI8226 cells
Control: shNC RPMI8226 cells
 GSE180214
Regulation
logFC: -7.50E-01
p-value: 1.38E-03
More Results Click to View More RNA-seq Results
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary ALKBH5 inactivated STAT3 pathway by increasing Suppressor of cytokine signaling 3 (SOCS3) expression via an m6A-YTHDF2-dependent manner. Reducing m6A mRNA levels in human osteosarcoma cells through ALKBH5 up-regulation lead to cell proliferation inhibition, cell apoptosis and cycle arrest.
Target Regulation Down regulation
Responsed Disease Osteosarcoma ICD-11: 2B51
 Disease Info 
Pathway Response JAK-STAT signaling pathway hsa04630
In-vitro Model U2OS Osteosarcoma Homo sapiens CVCL_0042
OS3 [Human osteosarcoma] Osteosarcoma Homo sapiens CVCL_F866
OS2 [Human osteosarcoma] Osteosarcoma Homo sapiens CVCL_F865
OS1 [Human osteosarcoma] Osteosarcoma Homo sapiens CVCL_F864
KHOS/NP Osteosarcoma Homo sapiens CVCL_2546
Osteosarcoma [ICD-11: 2B51]
 Disease Info 
In total 2 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary ALKBH5 inactivated STAT3 pathway by increasing Suppressor of cytokine signaling 3 (SOCS3) expression via an m6A-YTHDF2-dependent manner. Reducing m6A mRNA levels in human osteosarcoma cells through ALKBH5 up-regulation lead to cell proliferation inhibition, cell apoptosis and cycle arrest.
Responsed Disease Osteosarcoma [ICD-11: 2B51]
Target Regulator RNA demethylase ALKBH5 (ALKBH5) ERASER
 Regulator Info 
Target Regulation Down regulation
Pathway Response JAK-STAT signaling pathway hsa04630
In-vitro Model U2OS Osteosarcoma Homo sapiens CVCL_0042
OS3 [Human osteosarcoma] Osteosarcoma Homo sapiens CVCL_F866
OS2 [Human osteosarcoma] Osteosarcoma Homo sapiens CVCL_F865
OS1 [Human osteosarcoma] Osteosarcoma Homo sapiens CVCL_F864
KHOS/NP Osteosarcoma Homo sapiens CVCL_2546
Experiment 2 Reporting the m6A-centered Disease Response [1]
Response Summary ALKBH5 inactivated STAT3 pathway by increasing Suppressor of cytokine signaling 3 (SOCS3) expression via an m6A-YTHDF2-dependent manner.Reducing m6A mRNA levels in human osteosarcoma cells through ALKBH5 up-regulation lead to cell proliferation inhibition, cell apoptosis and cycle arrest.
Responsed Disease Osteosarcoma [ICD-11: 2B51]
Target Regulator YTH domain-containing family protein 2 (YTHDF2) READER
 Regulator Info 
Target Regulation Down regulation
Pathway Response JAK-STAT signaling pathway hsa04630
In-vitro Model U2OS Osteosarcoma Homo sapiens CVCL_0042
OS3 [Human osteosarcoma] Osteosarcoma Homo sapiens CVCL_F866
OS2 [Human osteosarcoma] Osteosarcoma Homo sapiens CVCL_F865
OS1 [Human osteosarcoma] Osteosarcoma Homo sapiens CVCL_F864
KHOS/NP Osteosarcoma Homo sapiens CVCL_2546
References
Ref 1 ALKBH5 regulates STAT3 activity to affect the proliferation and tumorigenicity of osteosarcoma via an m6A-YTHDF2-dependent manner. EBioMedicine. 2022 Jun;80:104019. doi: 10.1016/j.ebiom.2022.104019. Epub 2022 Apr 28.