m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00565)

Target Name	MAP kinase signal-integrating kinase 2 (MNK2)
Synonyms	MAP kinase signal-integrating kinase 2; MAPK signal-integrating kinase 2; Mnk2 Click to Show/Hide
Gene Name	MNK2
Chromosomal Location	19p13.3
Family	Protein kinase superfamily, CAMK Ser/Thr protein kinase family
Function	Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Required for mediating PP2A-inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from cytoplasm to nucleus. Isoform 1 displays a high basal kinase activity, but isoform 2 exhibits a very low kinase activity. Acts as a mediator of the suppressive effects of IFNgamma on hematopoiesis. Negative regulator for signals that control generation of arsenic trioxide As(2)O(3)-dependent apoptosis and anti-leukemic responses. Involved in anti-apoptotic signaling in response to serum withdrawal. Click to Show/Hide
Gene ID	2872
Uniprot ID	MKNK2_HUMAN
HGNC ID	HGNC:7111
KEGG ID	hsa:2872

Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)

MNK2 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).

Browse Regulator

Browse Disease

Methyltransferase-like 3 (METTL3) [WRITER]

Regulator Info

*Representative RNA-seq result indicating the expression of this target gene regulated by METTL3*
Cell Line	LX2 cell line	Homo sapiens
Treatment: shMETTL3 LX2 cells Control: shLuc LX2 cells		GSE207909
Regulation		logFC: 1.09E+00 p-value: 4.06E-29
More Results	Click to View More RNA-seq Results
*Representative RIP-seq result supporting the interaction between MNK2 and the regulator*
Cell Line	MDA-MB-231	Homo sapiens
Regulation	logFC: 1.25E+00	GSE60213

In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene				[1]
Response Summary	m6A writers METTL3/METTL14 and the m6A reader YTHDF1 orchestrate MAP kinase signal-integrating kinase 2 (MNK2) expression posttranscriptionally and thus control ERK signaling, which is required for the maintenance of muscle myogenesis and contributes to regeneration.
Target Regulation	Up regulation
Responsed Disease	Muscular dystrophies		ICD-11: 8C70	Disease Info
Pathway Response	MAPK signaling pathway			hsa04010
In-vitro Model	HEK293T	Normal	Homo sapiens	CVCL_0063
In-vitro Model	C2C12	Normal	Mus musculus	CVCL_0188
In-vivo Model	For mouse muscle injury and regeneration experiment, tibialis anterior (TA) muscles of 6-week-old male mice were injected with 25 uL of 10 uM cardiotoxin (CTX, Merck Millipore, 217503), 0.9% normal saline (Saline) were used as control. The regenerated muscles were collected at day 1, 3, 5, and 10 post-injection. TA muscles were isolated for Hematoxylin and eosin staining or frozen in liquid nitrogen for RNA and protein extraction.

Methyltransferase-like 14 (METTL14) [WRITER]

Regulator Info

In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene				[1]
Response Summary	m6A writers METTL3/METTL14 and the m6A reader YTHDF1 orchestrate MAP kinase signal-integrating kinase 2 (MNK2) expression posttranscriptionally and thus control ERK signaling, which is required for the maintenance of muscle myogenesis and contributes to regeneration.
Target Regulation	Up regulation
Responsed Disease	Muscular dystrophies		ICD-11: 8C70	Disease Info
Pathway Response	MAPK signaling pathway			hsa04010
In-vitro Model	HEK293T	Normal	Homo sapiens	CVCL_0063
In-vitro Model	C2C12	Normal	Mus musculus	CVCL_0188
In-vivo Model	For mouse muscle injury and regeneration experiment, tibialis anterior (TA) muscles of 6-week-old male mice were injected with 25 uL of 10 uM cardiotoxin (CTX, Merck Millipore, 217503), 0.9% normal saline (Saline) were used as control. The regenerated muscles were collected at day 1, 3, 5, and 10 post-injection. TA muscles were isolated for Hematoxylin and eosin staining or frozen in liquid nitrogen for RNA and protein extraction.

YTH domain-containing family protein 1 (YTHDF1) [READER]

Regulator Info

In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene				[1]
Response Summary	m6A writers METTL3/METTL14 and the m6A reader YTHDF1 orchestrate MAP kinase signal-integrating kinase 2 (MNK2) expression posttranscriptionally and thus control ERK signaling, which is required for the maintenance of muscle myogenesis contributes to regeneration.
Target Regulation	Up regulation
Responsed Disease	Muscular dystrophies		ICD-11: 8C70	Disease Info
Pathway Response	MAPK signaling pathway			hsa04010
In-vitro Model	HEK293T	Normal	Homo sapiens	CVCL_0063
In-vitro Model	C2C12	Normal	Mus musculus	CVCL_0188
In-vivo Model	For mouse muscle injury and regeneration experiment, tibialis anterior (TA) muscles of 6-week-old male mice were injected with 25 uL of 10 uM cardiotoxin (CTX, Merck Millipore, 217503), 0.9% normal saline (Saline) were used as control. The regenerated muscles were collected at day 1, 3, 5, and 10 post-injection. TA muscles were isolated for Hematoxylin and eosin staining or frozen in liquid nitrogen for RNA and protein extraction.

Muscular dystrophies [ICD-11: 8C70]

Disease Info

In total 3 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response				[1]
Response Summary	m6A writers METTL3/METTL14 and the m6A reader YTHDF1 orchestrate MAP kinase signal-integrating kinase 2 (MNK2) expression posttranscriptionally and thus control ERK signaling, which is required for the maintenance of muscle myogenesis and contributes to regeneration.
Responsed Disease	Muscular dystrophies [ICD-11: 8C70]
Target Regulator	Methyltransferase-like 14 (METTL14)		WRITER	Regulator Info
Target Regulation	Up regulation
Pathway Response	MAPK signaling pathway			hsa04010
In-vitro Model	HEK293T	Normal	Homo sapiens	CVCL_0063
In-vitro Model	C2C12	Normal	Mus musculus	CVCL_0188
In-vivo Model	For mouse muscle injury and regeneration experiment, tibialis anterior (TA) muscles of 6-week-old male mice were injected with 25 uL of 10 uM cardiotoxin (CTX, Merck Millipore, 217503), 0.9% normal saline (Saline) were used as control. The regenerated muscles were collected at day 1, 3, 5, and 10 post-injection. TA muscles were isolated for Hematoxylin and eosin staining or frozen in liquid nitrogen for RNA and protein extraction.
Experiment 2 Reporting the m6A-centered Disease Response				[1]
Response Summary	m6A writers METTL3/METTL14 and the m6A reader YTHDF1 orchestrate MAP kinase signal-integrating kinase 2 (MNK2) expression posttranscriptionally and thus control ERK signaling, which is required for the maintenance of muscle myogenesis and contributes to regeneration.
Responsed Disease	Muscular dystrophies [ICD-11: 8C70]
Target Regulator	Methyltransferase-like 3 (METTL3)		WRITER	Regulator Info
Target Regulation	Up regulation
Pathway Response	MAPK signaling pathway			hsa04010
In-vitro Model	HEK293T	Normal	Homo sapiens	CVCL_0063
In-vitro Model	C2C12	Normal	Mus musculus	CVCL_0188
In-vivo Model	For mouse muscle injury and regeneration experiment, tibialis anterior (TA) muscles of 6-week-old male mice were injected with 25 uL of 10 uM cardiotoxin (CTX, Merck Millipore, 217503), 0.9% normal saline (Saline) were used as control. The regenerated muscles were collected at day 1, 3, 5, and 10 post-injection. TA muscles were isolated for Hematoxylin and eosin staining or frozen in liquid nitrogen for RNA and protein extraction.
Experiment 3 Reporting the m6A-centered Disease Response				[1]
Response Summary	m6A writers METTL3/METTL14 and the m6A reader YTHDF1 orchestrate MAP kinase signal-integrating kinase 2 (MNK2) expression posttranscriptionally and thus control ERK signaling, which is required for the maintenance of muscle myogenesis contributes to regeneration.
Responsed Disease	Muscular dystrophies [ICD-11: 8C70]
Target Regulator	YTH domain-containing family protein 1 (YTHDF1)		READER	Regulator Info
Target Regulation	Up regulation
Pathway Response	MAPK signaling pathway			hsa04010
In-vitro Model	HEK293T	Normal	Homo sapiens	CVCL_0063
In-vitro Model	C2C12	Normal	Mus musculus	CVCL_0188
In-vivo Model	For mouse muscle injury and regeneration experiment, tibialis anterior (TA) muscles of 6-week-old male mice were injected with 25 uL of 10 uM cardiotoxin (CTX, Merck Millipore, 217503), 0.9% normal saline (Saline) were used as control. The regenerated muscles were collected at day 1, 3, 5, and 10 post-injection. TA muscles were isolated for Hematoxylin and eosin staining or frozen in liquid nitrogen for RNA and protein extraction.

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR00565)

MAP kinase signal-integrating kinase 2 (MNK2)

N4-acetylcytidine (ac4C)

In total 1 m6A sequence/site(s) in this target gene
mod ID: AC4SITE000245		Click to Show/Hide the Full List
mod site	chr19:2046380-2046381:-		[2]
Sequence	CCGGGCCACCGACAGCTTCTCGGGCAGGTTTGAAGGTGAGC
Cell/Tissue List	H1
Seq Type List	ac4C-seq
Transcript ID List	ENST00000591601.5; ENST00000586828.5; ENST00000250896.7; ENST00000309340.11
External Link	RMBase: ac4C_site_911

Adenosine-to-Inosine editing (A-to-I)

In total 2 m6A sequence/site(s) in this target gene
mod ID: A2ISITE008721		Click to Show/Hide the Full List
mod site	chr19:2047110-2047111:-		[3]
Sequence	TCTTGCCTTGCTGAGGTGCTAGGAGGCCTCACGCCTTCCAC
Transcript ID List	ENST00000309340.11; ENST00000250896.7; ENST00000589534.2; ENST00000586828.5; ENST00000591601.5; ENST00000589509.5
External Link	RMBase: RNA-editing_site_64250
mod ID: A2ISITE008722		Click to Show/Hide the Full List
mod site	chr19:2047602-2047603:-		[3]
Sequence	ACCAGGCTGGCAGCCCGCCTAGTGACTCACCTCCTTCCCAC
Transcript ID List	ENST00000589534.2; ENST00000591601.5; ENST00000250896.7; ENST00000589509.5; ENST00000586828.5; ENST00000309340.11
External Link	RMBase: RNA-editing_site_64251

5-methylcytidine (m5C)

In total 15 m6A sequence/site(s) in this target gene
mod ID: M5CSITE001586		Click to Show/Hide the Full List
mod site	chr19:2038349-2038350:-
Sequence	TCACCGCCCGCCCTTCCCGGCGCAGCCCCCGAGCTCCACAG
Cell/Tissue List	muscle
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000309340.11; ENST00000588014.5; ENST00000591142.5; ENST00000250896.7; ENST00000589441.5; ENST00000591601.5; ENST00000587416.5
External Link	RMBase: m5C_site_21751
mod ID: M5CSITE001587		Click to Show/Hide the Full List
mod site	chr19:2039318-2039319:-		[4]
Sequence	CCCCTCCCCGGTCCCCCGCCCTGCTCACCTCTACTATGAAG
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000591142.5; ENST00000587416.5; ENST00000591601.5; ENST00000309340.11; ENST00000588014.5; ENST00000250896.7; ENST00000589441.5
External Link	RMBase: m5C_site_21752
mod ID: M5CSITE001588		Click to Show/Hide the Full List
mod site	chr19:2040318-2040319:-
Sequence	CGGGGTGGGCGCTTGGCTCCCGGGGCACCCAGGTGCACTCC
Cell/Tissue List	lung
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000591588.1; ENST00000585667.1; ENST00000586620.2; ENST00000250896.7; ENST00000591601.5; ENST00000589441.5; ENST00000586828.5; ENST00000588014.5; ENST00000587416.5; ENST00000309340.11; ENST00000591142.5
External Link	RMBase: m5C_site_21753
mod ID: M5CSITE001589		Click to Show/Hide the Full List
mod site	chr19:2040706-2040707:-
Sequence	GCCTAGCCTGCCGTCAGTCTCAAGCCCAGGCTGTGCCTCCA
Cell/Tissue List	heart; muscle; spleen
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000250896.7; ENST00000586828.5; ENST00000309340.11; ENST00000591142.5; ENST00000588014.5; ENST00000589441.5; ENST00000591588.1; ENST00000586620.2; ENST00000585667.1; ENST00000591601.5; ENST00000587416.5
External Link	RMBase: m5C_site_21754
mod ID: M5CSITE001590		Click to Show/Hide the Full List
mod site	chr19:2042042-2042043:-
Sequence	CGGCTGACGCGCCCCTCCCCCGCCCGCAGTGCGGCTCGGCG
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000587416.5; ENST00000591142.5; ENST00000586828.5; ENST00000588014.5; ENST00000309340.11; ENST00000586620.2; ENST00000250896.7; ENST00000591588.1; ENST00000585667.1; ENST00000591601.5
External Link	RMBase: m5C_site_21755
mod ID: M5CSITE001591		Click to Show/Hide the Full List
mod site	chr19:2042043-2042044:-
Sequence	CCGGCTGACGCGCCCCTCCCCCGCCCGCAGTGCGGCTCGGC
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000591142.5; ENST00000587416.5; ENST00000309340.11; ENST00000585667.1; ENST00000591588.1; ENST00000586828.5; ENST00000586620.2; ENST00000250896.7; ENST00000591601.5; ENST00000588014.5
External Link	RMBase: m5C_site_21756
mod ID: M5CSITE001592		Click to Show/Hide the Full List
mod site	chr19:2042044-2042045:-
Sequence	CCCGGCTGACGCGCCCCTCCCCCGCCCGCAGTGCGGCTCGG
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000586828.5; ENST00000591601.5; ENST00000250896.7; ENST00000585667.1; ENST00000591142.5; ENST00000587416.5; ENST00000588014.5; ENST00000591588.1; ENST00000586620.2; ENST00000309340.11
External Link	RMBase: m5C_site_21757
mod ID: M5CSITE001593		Click to Show/Hide the Full List
mod site	chr19:2042045-2042046:-
Sequence	CCCCGGCTGACGCGCCCCTCCCCCGCCCGCAGTGCGGCTCG
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000591142.5; ENST00000591601.5; ENST00000309340.11; ENST00000586620.2; ENST00000587416.5; ENST00000588014.5; ENST00000591588.1; ENST00000585667.1; ENST00000586828.5; ENST00000250896.7
External Link	RMBase: m5C_site_21758
mod ID: M5CSITE001594		Click to Show/Hide the Full List
mod site	chr19:2042046-2042047:-
Sequence	ACCCCGGCTGACGCGCCCCTCCCCCGCCCGCAGTGCGGCTC
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000587416.5; ENST00000585667.1; ENST00000309340.11; ENST00000591588.1; ENST00000591601.5; ENST00000588014.5; ENST00000250896.7; ENST00000586620.2; ENST00000591142.5; ENST00000586828.5
External Link	RMBase: m5C_site_21759
mod ID: M5CSITE001595		Click to Show/Hide the Full List
mod site	chr19:2042048-2042049:-
Sequence	AAACCCCGGCTGACGCGCCCCTCCCCCGCCCGCAGTGCGGC
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000591601.5; ENST00000586620.2; ENST00000250896.7; ENST00000587416.5; ENST00000591588.1; ENST00000309340.11; ENST00000585667.1; ENST00000586828.5; ENST00000591142.5; ENST00000588014.5
External Link	RMBase: m5C_site_21760
mod ID: M5CSITE001596		Click to Show/Hide the Full List
mod site	chr19:2042049-2042050:-
Sequence	GAAACCCCGGCTGACGCGCCCCTCCCCCGCCCGCAGTGCGG
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000585667.1; ENST00000591142.5; ENST00000586620.2; ENST00000250896.7; ENST00000586828.5; ENST00000591588.1; ENST00000587416.5; ENST00000591601.5; ENST00000309340.11; ENST00000588014.5
External Link	RMBase: m5C_site_21761
mod ID: M5CSITE001597		Click to Show/Hide the Full List
mod site	chr19:2042050-2042051:-
Sequence	GGAAACCCCGGCTGACGCGCCCCTCCCCCGCCCGCAGTGCG
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000591588.1; ENST00000250896.7; ENST00000588014.5; ENST00000591142.5; ENST00000586620.2; ENST00000587416.5; ENST00000309340.11; ENST00000591601.5; ENST00000585667.1; ENST00000586828.5
External Link	RMBase: m5C_site_21762
mod ID: M5CSITE001598		Click to Show/Hide the Full List
mod site	chr19:2042051-2042052:-
Sequence	GGGAAACCCCGGCTGACGCGCCCCTCCCCCGCCCGCAGTGC
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000586620.2; ENST00000586828.5; ENST00000591588.1; ENST00000250896.7; ENST00000585667.1; ENST00000587416.5; ENST00000591142.5; ENST00000591601.5; ENST00000588014.5; ENST00000309340.11
External Link	RMBase: m5C_site_21763
mod ID: M5CSITE001599		Click to Show/Hide the Full List
mod site	chr19:2042097-2042098:-
Sequence	GCGCAGGTGACCCGCAGTTACCCGGGCTCGGTTCCCACGTA
Cell/Tissue List	liver
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000585667.1; ENST00000588014.5; ENST00000250896.7; ENST00000587416.5; ENST00000586828.5; ENST00000309340.11; ENST00000591142.5; ENST00000591601.5
External Link	RMBase: m5C_site_21764
mod ID: M5CSITE001600		Click to Show/Hide the Full List
mod site	chr19:2050803-2050804:-
Sequence	CAGGGTTTCCACCGTTCGTTCAAGGTGAGGCCCGGGGTCGG
Cell/Tissue List	muscle; testis
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000589509.5; ENST00000586828.5; ENST00000591601.5; ENST00000309340.11; ENST00000589534.2; ENST00000250896.7
External Link	RMBase: m5C_site_21765

N6-methyladenosine (m6A)

In total 72 m6A sequence/site(s) in this target gene
mod ID: M6ASITE037986		Click to Show/Hide the Full List
mod site	chr19:2037475-2037476:-		[5]
Sequence	GATTTAATAAAAGTCAAAAAACTTGCTGTGTGCCTGAGTTT
Motif Score	2.627720238
Cell/Tissue List	HeLa; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000591142.5; ENST00000587416.5; ENST00000591601.5; ENST00000589441.5; ENST00000309340.11
External Link	RMBase: m6A_site_408847
mod ID: M6ASITE037987		Click to Show/Hide the Full List
mod site	chr19:2037538-2037539:-		[6]
Sequence	GAGCTCAGAAGTTTTCCTTTACACCAACTGTCAATGCCGGA
Motif Score	2.07285119
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000591601.5; ENST00000250896.7; ENST00000587416.5; ENST00000309340.11; ENST00000591142.5; ENST00000589441.5
External Link	RMBase: m6A_site_408848
mod ID: M6ASITE037988		Click to Show/Hide the Full List
mod site	chr19:2037565-2037566:-		[5]
Sequence	AATTCCAATGTACCAGGTGAACTGACGGAGCTCAGAAGTTT
Motif Score	3.373380952
Cell/Tissue List	HeLa; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000591142.5; ENST00000309340.11; ENST00000587416.5; ENST00000591601.5; ENST00000250896.7; ENST00000589441.5
External Link	RMBase: m6A_site_408849
mod ID: M6ASITE037989		Click to Show/Hide the Full List
mod site	chr19:2037600-2037601:-		[6]
Sequence	TTTTTTAAAGTGGGGGAAAAACATCCAAGCACTTTAATTCC
Motif Score	2.20572619
Cell/Tissue List	HEK293T; hESC-HEK293T; Huh7
Seq Type List	MeRIP-seq; MAZTER-seq
Transcript ID List	ENST00000591142.5; ENST00000587416.5; ENST00000589441.5; ENST00000250896.7; ENST00000309340.11; ENST00000591601.5
External Link	RMBase: m6A_site_408850
mod ID: M6ASITE037990		Click to Show/Hide the Full List
mod site	chr19:2037631-2037632:-		[7]
Sequence	AAGACAAAAAAAAAAAAAAAACCTCAAAAGTTTTTTTAAAG
Motif Score	2.185083333
Cell/Tissue List	HEK293T; A549; MM6; Huh7
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000587416.5; ENST00000309340.11; ENST00000591601.5; ENST00000591142.5; ENST00000250896.7; ENST00000589441.5
External Link	RMBase: m6A_site_408851
mod ID: M6ASITE037991		Click to Show/Hide the Full List
mod site	chr19:2037648-2037649:-		[5]
Sequence	TGTTACGATGTTTTTAAAAGACAAAAAAAAAAAAAAAACCT
Motif Score	2.897386905
Cell/Tissue List	HeLa; HEK293T; hESC-HEK293T; A549; MM6; Huh7; TREX
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq
Transcript ID List	ENST00000591601.5; ENST00000591142.5; ENST00000587416.5; ENST00000309340.11; ENST00000589441.5; ENST00000250896.7
External Link	RMBase: m6A_site_408852
mod ID: M6ASITE037992		Click to Show/Hide the Full List
mod site	chr19:2037725-2037726:-		[5]
Sequence	ATGAGTGAAGATCCTGGAGGACCCTGGGCCCCAGGCCAGCT
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; MM6; Huh7; TREX; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000309340.11; ENST00000589441.5; ENST00000591601.5; ENST00000591142.5; ENST00000587416.5; ENST00000250896.7
External Link	RMBase: m6A_site_408853
mod ID: M6ASITE037993		Click to Show/Hide the Full List
mod site	chr19:2037758-2037759:-		[5]
Sequence	GACCTGGAGGACTGGTCAGAACCGTTACTGTGAATGAGTGA
Motif Score	2.930744048
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; MM6; Huh7; TREX; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000589441.5; ENST00000591601.5; ENST00000587416.5; ENST00000591142.5; ENST00000309340.11; ENST00000250896.7
External Link	RMBase: m6A_site_408854
mod ID: M6ASITE037994		Click to Show/Hide the Full List
mod site	chr19:2037768-2037769:-		[5]
Sequence	ATCCACGTGCGACCTGGAGGACTGGTCAGAACCGTTACTGT
Motif Score	4.065041667
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; MM6; Huh7; TREX; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000591601.5; ENST00000587416.5; ENST00000250896.7; ENST00000589441.5; ENST00000591142.5; ENST00000309340.11
External Link	RMBase: m6A_site_408855
mod ID: M6ASITE037995		Click to Show/Hide the Full List
mod site	chr19:2037823-2037824:-		[5]
Sequence	TTTTTTTTTCTGAAGGTGGGACAGTCACTTCCTCCTCCCTC
Motif Score	3.643047619
Cell/Tissue List	HeLa; hESC-HEK293T; HepG2; A549; HEC-1-A; AML
Seq Type List	m6A-seq; MAZTER-seq; miCLIP
Transcript ID List	ENST00000589441.5; ENST00000591142.5; ENST00000309340.11; ENST00000250896.7; ENST00000591601.5; ENST00000587416.5
External Link	RMBase: m6A_site_408856
mod ID: M6ASITE037996		Click to Show/Hide the Full List
mod site	chr19:2037922-2037923:-		[8]
Sequence	ATCAAAGAACAAGCAAATGGACCCCCGCCCGCTGCAGGCGC
Motif Score	3.622404762
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000587416.5; ENST00000591142.5; ENST00000309340.11; ENST00000589441.5; ENST00000591601.5; ENST00000250896.7
External Link	RMBase: m6A_site_408857
mod ID: M6ASITE037997		Click to Show/Hide the Full List
mod site	chr19:2037934-2037935:-		[6]
Sequence	CTGCCTTTTTGTATCAAAGAACAAGCAAATGGACCCCCGCC
Motif Score	2.951386905
Cell/Tissue List	hESC-HEK293T; HeLa
Seq Type List	MAZTER-seq; m6A-seq
Transcript ID List	ENST00000250896.7; ENST00000309340.11; ENST00000589441.5; ENST00000587416.5; ENST00000591601.5; ENST00000591142.5
External Link	RMBase: m6A_site_408858
mod ID: M6ASITE037998		Click to Show/Hide the Full List
mod site	chr19:2038044-2038045:-		[5]
Sequence	GTGGACTGCCCCTTCCAAAGACCCCTGGGGGGGGTGGGGCA
Motif Score	2.876744048
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000309340.11; ENST00000591142.5; ENST00000589441.5; ENST00000250896.7; ENST00000587416.5; ENST00000591601.5
External Link	RMBase: m6A_site_408859
mod ID: M6ASITE037999		Click to Show/Hide the Full List
mod site	chr19:2038060-2038061:-		[5]
Sequence	CCCACTGCCCATATCTGTGGACTGCCCCTTCCAAAGACCCC
Motif Score	4.065041667
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000587416.5; ENST00000591601.5; ENST00000591142.5; ENST00000250896.7; ENST00000309340.11; ENST00000589441.5
External Link	RMBase: m6A_site_408860
mod ID: M6ASITE038000		Click to Show/Hide the Full List
mod site	chr19:2038167-2038168:-		[5]
Sequence	TGGGGGTGGGGGCCTCGGAGACCGTCTGCCTGGCCCTGCTG
Motif Score	2.876744048
Cell/Tissue List	HeLa; MM6
Seq Type List	m6A-seq
Transcript ID List	ENST00000591601.5; ENST00000589441.5; ENST00000591142.5; ENST00000309340.11; ENST00000250896.7; ENST00000587416.5
External Link	RMBase: m6A_site_408861
mod ID: M6ASITE038001		Click to Show/Hide the Full List
mod site	chr19:2038232-2038233:-		[5]
Sequence	AAAAAACAACACATCGATGGACTTTGCTTCCCTGTTCTTGA
Motif Score	4.065041667
Cell/Tissue List	HeLa; A549; AML
Seq Type List	m6A-seq; m6A-CLIP/IP; miCLIP
Transcript ID List	ENST00000591601.5; ENST00000309340.11; ENST00000591142.5; ENST00000250896.7; ENST00000589441.5; ENST00000587416.5
External Link	RMBase: m6A_site_408862
mod ID: M6ASITE038002		Click to Show/Hide the Full List
mod site	chr19:2038247-2038248:-		[5]
Sequence	TAGTTTTTCCTTAAAAAAAAACAACACATCGATGGACTTTG
Motif Score	2.20572619
Cell/Tissue List	HeLa; hESC-HEK293T
Seq Type List	m6A-seq; MAZTER-seq
Transcript ID List	ENST00000587416.5; ENST00000309340.11; ENST00000589441.5; ENST00000591601.5; ENST00000250896.7; ENST00000588014.5; ENST00000591142.5
External Link	RMBase: m6A_site_408863
mod ID: M6ASITE038003		Click to Show/Hide the Full List
mod site	chr19:2038605-2038606:-		[5]
Sequence	GTCCTTAGAGCTGAGCCCAGACCCCGGGGTCTGGCCGAATC
Motif Score	2.876744048
Cell/Tissue List	HeLa; CD34
Seq Type List	m6A-seq
Transcript ID List	ENST00000591601.5; ENST00000589441.5; ENST00000588014.5; ENST00000250896.7; ENST00000591142.5; ENST00000587416.5; ENST00000309340.11
External Link	RMBase: m6A_site_408864
mod ID: M6ASITE038004		Click to Show/Hide the Full List
mod site	chr19:2038739-2038740:-		[5]
Sequence	CAATGTGGGGGGTCCTGAAGACACCCCCTTGGGGCACCCGA
Motif Score	2.897386905
Cell/Tissue List	HeLa; CD34; A549; MM6; peripheral-blood; TREX; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000591601.5; ENST00000589441.5; ENST00000587416.5; ENST00000591142.5; ENST00000588014.5; ENST00000309340.11; ENST00000250896.7
External Link	RMBase: m6A_site_408865
mod ID: M6ASITE038005		Click to Show/Hide the Full List
mod site	chr19:2038774-2038775:-		[5]
Sequence	GCAGCAGGCAGAGGGGCTGGACAGGCACTGTCAGCCAATGT
Motif Score	3.643047619
Cell/Tissue List	HeLa; CD34; A549; MM6; peripheral-blood; TREX; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000588014.5; ENST00000309340.11; ENST00000250896.7; ENST00000587416.5; ENST00000591601.5; ENST00000589441.5; ENST00000591142.5
External Link	RMBase: m6A_site_408866
mod ID: M6ASITE038006		Click to Show/Hide the Full List
mod site	chr19:2038832-2038833:-		[9]
Sequence	CCTCCACACCAAGGCCTGAGACAGCAGGAGCCCCGCCTGGC
Motif Score	2.897386905
Cell/Tissue List	CD34; HepG2; HeLa; A549; MM6; peripheral-blood; TREX
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000309340.11; ENST00000587416.5; ENST00000591601.5; ENST00000591142.5; ENST00000250896.7; ENST00000589441.5; ENST00000588014.5
External Link	RMBase: m6A_site_408867
mod ID: M6ASITE038007		Click to Show/Hide the Full List
mod site	chr19:2038847-2038848:-		[6]
Sequence	CGCCGCTGCCCCTCCCCTCCACACCAAGGCCTGAGACAGCA
Motif Score	2.053113095
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000588014.5; ENST00000591142.5; ENST00000250896.7; ENST00000589441.5; ENST00000309340.11; ENST00000587416.5; ENST00000591601.5
External Link	RMBase: m6A_site_408868
mod ID: M6ASITE038008		Click to Show/Hide the Full List
mod site	chr19:2038889-2038890:-		[10]
Sequence	GCCTCCGACCTTGACCTTAAACTGCAGCTGACCCCAGGGGC
Motif Score	2.627720238
Cell/Tissue List	HepG2; HeLa; A549; MM6; Huh7; peripheral-blood; TREX
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000309340.11; ENST00000589441.5; ENST00000250896.7; ENST00000587416.5; ENST00000591142.5; ENST00000591601.5; ENST00000588014.5
External Link	RMBase: m6A_site_408869
mod ID: M6ASITE038009		Click to Show/Hide the Full List
mod site	chr19:2038929-2038930:-		[8]
Sequence	GGCCCGTCTGTCTGTCCAGGACTCCTGGTGGCCAGATTCGG
Motif Score	4.065041667
Cell/Tissue List	HeLa; A549; Huh7; peripheral-blood; AML
Seq Type List	m6A-seq; MeRIP-seq; miCLIP
Transcript ID List	ENST00000250896.7; ENST00000587416.5; ENST00000591601.5; ENST00000591142.5; ENST00000588014.5; ENST00000309340.11; ENST00000589441.5
External Link	RMBase: m6A_site_408870
mod ID: M6ASITE038010		Click to Show/Hide the Full List
mod site	chr19:2038969-2038970:-		[6]
Sequence	CCTTGTCCCCATGATAGTTGACAATCGGGGCTTCCTGCAAG
Motif Score	2.859755952
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000588014.5; ENST00000589441.5; ENST00000250896.7; ENST00000309340.11; ENST00000591142.5; ENST00000591601.5; ENST00000587416.5
External Link	RMBase: m6A_site_408871
mod ID: M6ASITE038011		Click to Show/Hide the Full List
mod site	chr19:2039145-2039146:-		[5]
Sequence	CAGCCCGCAGTATTTCAGGGACAGGCTCTTCCCCTCTATCC
Motif Score	3.643047619
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000589441.5; ENST00000250896.7; ENST00000591142.5; ENST00000587416.5; ENST00000591601.5; ENST00000588014.5; ENST00000309340.11
External Link	RMBase: m6A_site_408872
mod ID: M6ASITE038012		Click to Show/Hide the Full List
mod site	chr19:2039187-2039188:-		[5]
Sequence	GAGCTGGGGAGGGGCACAGGACCCTGCCCTCGTGTTCCCTC
Motif Score	3.622404762
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000591142.5; ENST00000309340.11; ENST00000591601.5; ENST00000588014.5; ENST00000587416.5; ENST00000250896.7; ENST00000589441.5
External Link	RMBase: m6A_site_408873
mod ID: M6ASITE038013		Click to Show/Hide the Full List
mod site	chr19:2039622-2039623:-		[11]
Sequence	CCCAGTGGTCCTGGTGGGAGACCACGCCTGACCCTCCCATC
Motif Score	2.876744048
Cell/Tissue List	HepG2; HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000591601.5; ENST00000250896.7; ENST00000588014.5; ENST00000586828.5; ENST00000587416.5; ENST00000309340.11; ENST00000591142.5; ENST00000589441.5
External Link	RMBase: m6A_site_408874
mod ID: M6ASITE038014		Click to Show/Hide the Full List
mod site	chr19:2039775-2039776:-		[5]
Sequence	GCTGGCCCAGCACGACGAGGACCTGGCTGAGGAGGAGGCCG
Motif Score	3.622404762
Cell/Tissue List	HeLa; CD34; HepG2; peripheral-blood; HEK293T; endometrial; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000587416.5; ENST00000309340.11; ENST00000591142.5; ENST00000250896.7; ENST00000591601.5; ENST00000586828.5; ENST00000589441.5; ENST00000588014.5
External Link	RMBase: m6A_site_408875
mod ID: M6ASITE038015		Click to Show/Hide the Full List
mod site	chr19:2039802-2039803:-		[5]
Sequence	GGCTGAGGCCATTGCCATGAACCGGCAGCTGGCCCAGCACG
Motif Score	2.930744048
Cell/Tissue List	HeLa; CD34; HepG2; peripheral-blood; HEK293T; endometrial; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000591142.5; ENST00000250896.7; ENST00000309340.11; ENST00000588014.5; ENST00000591601.5; ENST00000587416.5; ENST00000586828.5; ENST00000589441.5
External Link	RMBase: m6A_site_408876
mod ID: M6ASITE038016		Click to Show/Hide the Full List
mod site	chr19:2039838-2039839:-		[5]
Sequence	CAGGAACAGCTGTGCCAAAGACCTCACGTCCTTCGCGGCTG
Motif Score	2.876744048
Cell/Tissue List	HeLa; HepG2; peripheral-blood; HEK293T; endometrial; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000586828.5; ENST00000591601.5; ENST00000589441.5; ENST00000250896.7; ENST00000591142.5; ENST00000588014.5; ENST00000587416.5; ENST00000309340.11
External Link	RMBase: m6A_site_408877
mod ID: M6ASITE038017		Click to Show/Hide the Full List
mod site	chr19:2039853-2039854:-		[5]
Sequence	CCCCACCCCGTTTCCCAGGAACAGCTGTGCCAAAGACCTCA
Motif Score	2.951386905
Cell/Tissue List	HeLa; HepG2; HEK293T; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000250896.7; ENST00000591601.5; ENST00000587416.5; ENST00000591142.5; ENST00000309340.11; ENST00000589441.5; ENST00000588014.5; ENST00000586828.5
External Link	RMBase: m6A_site_408878
mod ID: M6ASITE038018		Click to Show/Hide the Full List
mod site	chr19:2039916-2039917:-		[5]
Sequence	TTCCCCCAGGGCCTTCACAGACCCCAGGGGTCCCCTGAGGG
Motif Score	2.876744048
Cell/Tissue List	HeLa; HEK293T; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000586828.5; ENST00000587416.5; ENST00000591142.5; ENST00000591601.5; ENST00000589441.5; ENST00000588014.5; ENST00000250896.7; ENST00000309340.11
External Link	RMBase: m6A_site_408879
mod ID: M6ASITE038019		Click to Show/Hide the Full List
mod site	chr19:2040050-2040051:-		[5]
Sequence	ATTTGTGAAAGACCCGGAGAACTGCTTTGGGGTCGGGGAGG
Motif Score	3.373380952
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000588014.5; ENST00000586828.5; ENST00000309340.11; ENST00000587416.5; ENST00000589441.5; ENST00000591588.1; ENST00000250896.7; ENST00000591601.5; ENST00000591142.5
External Link	RMBase: m6A_site_408880
mod ID: M6ASITE038020		Click to Show/Hide the Full List
mod site	chr19:2040059-2040060:-		[5]
Sequence	GGTTAAGACATTTGTGAAAGACCCGGAGAACTGCTTTGGGG
Motif Score	2.876744048
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000309340.11; ENST00000588014.5; ENST00000589441.5; ENST00000591142.5; ENST00000591588.1; ENST00000591601.5; ENST00000250896.7; ENST00000586828.5; ENST00000587416.5
External Link	RMBase: m6A_site_408881
mod ID: M6ASITE038021		Click to Show/Hide the Full List
mod site	chr19:2040072-2040073:-		[5]
Sequence	GGCGGGGTTTCCAGGTTAAGACATTTGTGAAAGACCCGGAG
Motif Score	2.897386905
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000250896.7; ENST00000586828.5; ENST00000587416.5; ENST00000591142.5; ENST00000591601.5; ENST00000309340.11; ENST00000588014.5; ENST00000589441.5; ENST00000591588.1
External Link	RMBase: m6A_site_408882
mod ID: M6ASITE038022		Click to Show/Hide the Full List
mod site	chr19:2040108-2040109:-		[12]
Sequence	GGCCCGCAGGGGTGCTCGGGACCCCTGAGTCCAGGGGGCGG
Motif Score	3.622404762
Cell/Tissue List	HEK293T; endometrial; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000588014.5; ENST00000591588.1; ENST00000250896.7; ENST00000591601.5; ENST00000309340.11; ENST00000591142.5; ENST00000587416.5; ENST00000589441.5; ENST00000586828.5
External Link	RMBase: m6A_site_408883
mod ID: M6ASITE038023		Click to Show/Hide the Full List
mod site	chr19:2040163-2040164:-		[5]
Sequence	GTTGCAGTGCGCCCCGGAGAACACCTTGCCCACTCCCATGG
Motif Score	2.951386905
Cell/Tissue List	HeLa; HEK293T; endometrial; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000589441.5; ENST00000587416.5; ENST00000591601.5; ENST00000250896.7; ENST00000588014.5; ENST00000586828.5; ENST00000591588.1; ENST00000585667.1; ENST00000591142.5; ENST00000309340.11
External Link	RMBase: m6A_site_408884
mod ID: M6ASITE038024		Click to Show/Hide the Full List
mod site	chr19:2040245-2040246:-		[5]
Sequence	GCATGGCATCCCTTGGCCAGACACCCCACCCAGCGCCCCAG
Motif Score	2.897386905
Cell/Tissue List	HeLa; HEK293T; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000591588.1; ENST00000589441.5; ENST00000250896.7; ENST00000586828.5; ENST00000585667.1; ENST00000587416.5; ENST00000591142.5; ENST00000309340.11; ENST00000588014.5; ENST00000591601.5
External Link	RMBase: m6A_site_408885
mod ID: M6ASITE038025		Click to Show/Hide the Full List
mod site	chr19:2040732-2040733:-		[13]
Sequence	AGCGAGCCCAGCTCACATAGACCCCAGCCTAGCCTGCCGTC
Motif Score	2.876744048
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000588014.5; ENST00000586828.5; ENST00000585667.1; ENST00000591588.1; ENST00000591142.5; ENST00000309340.11; ENST00000250896.7; ENST00000587416.5; ENST00000586620.2; ENST00000591601.5; ENST00000589441.5
External Link	RMBase: m6A_site_408886
mod ID: M6ASITE038026		Click to Show/Hide the Full List
mod site	chr19:2040787-2040788:-		[13]
Sequence	CTTCCTGGAGGGTGGTGGGGACCCACAGCCTGCAGCAGGCT
Motif Score	3.622404762
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000586828.5; ENST00000591601.5; ENST00000250896.7; ENST00000309340.11; ENST00000591588.1; ENST00000586620.2; ENST00000585667.1; ENST00000587416.5; ENST00000591142.5; ENST00000589441.5; ENST00000588014.5
External Link	RMBase: m6A_site_408887
mod ID: M6ASITE038027		Click to Show/Hide the Full List
mod site	chr19:2040809-2040810:-		[13]
Sequence	CAGGAGCAGCTACTCAGAGAACCTTCCTGGAGGGTGGTGGG
Motif Score	2.930744048
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000589441.5; ENST00000591601.5; ENST00000591588.1; ENST00000585667.1; ENST00000250896.7; ENST00000588014.5; ENST00000591142.5; ENST00000587416.5; ENST00000586828.5; ENST00000586620.2; ENST00000309340.11
External Link	RMBase: m6A_site_408888
mod ID: M6ASITE038028		Click to Show/Hide the Full List
mod site	chr19:2040945-2040946:-		[5]
Sequence	GCCCTGAGGGTGTAGCCTGGACACCCTGAGATGCACTGAGG
Motif Score	3.643047619
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000309340.11; ENST00000585667.1; ENST00000586620.2; ENST00000589441.5; ENST00000591601.5; ENST00000591588.1; ENST00000591142.5; ENST00000588014.5; ENST00000587416.5; ENST00000250896.7; ENST00000586828.5
External Link	RMBase: m6A_site_408889
mod ID: M6ASITE038029		Click to Show/Hide the Full List
mod site	chr19:2041121-2041122:-		[5]
Sequence	CATCTCCTGCGCTGCCAAAGACCTCATCTCCAAGCTGCTGG
Motif Score	2.876744048
Cell/Tissue List	HeLa; HEK293T
Seq Type List	m6A-seq
Transcript ID List	ENST00000587416.5; ENST00000591142.5; ENST00000586828.5; ENST00000589441.5; ENST00000588014.5; ENST00000591601.5; ENST00000591588.1; ENST00000250896.7; ENST00000309340.11; ENST00000585667.1; ENST00000586620.2
External Link	RMBase: m6A_site_408890
mod ID: M6ASITE038030		Click to Show/Hide the Full List
mod site	chr19:2041151-2041152:-		[5]
Sequence	GTACGAGTTCCCCGACAAGGACTGGGCCCACATCTCCTGCG
Motif Score	4.065041667
Cell/Tissue List	HeLa; peripheral-blood; HEK293T
Seq Type List	m6A-seq
Transcript ID List	ENST00000586828.5; ENST00000591601.5; ENST00000585667.1; ENST00000589441.5; ENST00000591142.5; ENST00000586620.2; ENST00000250896.7; ENST00000588014.5; ENST00000591588.1; ENST00000309340.11; ENST00000587416.5
External Link	RMBase: m6A_site_408891
mod ID: M6ASITE038031		Click to Show/Hide the Full List
mod site	chr19:2041867-2041868:-		[5]
Sequence	TGGCAGCGACTGCGGCTGGGACCGCGGCGAGGCCTGCCCTG
Motif Score	3.622404762
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000585667.1; ENST00000250896.7; ENST00000591588.1; ENST00000591142.5; ENST00000591601.5; ENST00000587416.5; ENST00000586828.5; ENST00000586620.2; ENST00000309340.11; ENST00000588014.5
External Link	RMBase: m6A_site_408892
mod ID: M6ASITE038032		Click to Show/Hide the Full List
mod site	chr19:2041966-2041967:-		[6]
Sequence	CGAGGAGGCTAGCATCTACGACAAGCGCTGCGACCTGTGGA
Motif Score	2.865571429
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000585667.1; ENST00000250896.7; ENST00000586828.5; ENST00000591142.5; ENST00000588014.5; ENST00000309340.11; ENST00000587416.5; ENST00000591588.1; ENST00000591601.5; ENST00000586620.2
External Link	RMBase: m6A_site_408893
mod ID: M6ASITE038033		Click to Show/Hide the Full List
mod site	chr19:2042017-2042018:-		[14]
Sequence	GCAGTGCGGCTCGGCGGAGTACATGGCCCCGGAGGTAGTGG
Motif Score	2.856142857
Cell/Tissue List	brain; hESC-HEK293T
Seq Type List	m6A-REF-seq; MAZTER-seq
Transcript ID List	ENST00000586828.5; ENST00000585667.1; ENST00000587416.5; ENST00000591588.1; ENST00000591142.5; ENST00000591601.5; ENST00000586620.2; ENST00000309340.11; ENST00000250896.7; ENST00000588014.5
External Link	RMBase: m6A_site_408894
mod ID: M6ASITE038034		Click to Show/Hide the Full List
mod site	chr19:2042066-2042067:-		[5]
Sequence	TTCCCACGTAATGCTGGGAAACCCCGGCTGACGCGCCCCTC
Motif Score	2.185083333
Cell/Tissue List	HeLa; peripheral-blood
Seq Type List	m6A-seq
Transcript ID List	ENST00000309340.11; ENST00000591588.1; ENST00000588014.5; ENST00000586828.5; ENST00000250896.7; ENST00000587416.5; ENST00000591601.5; ENST00000585667.1; ENST00000591142.5; ENST00000586620.2
External Link	RMBase: m6A_site_408895
mod ID: M6ASITE038035		Click to Show/Hide the Full List
mod site	chr19:2042463-2042464:-		[15]
Sequence	CGGCATCAAACTCAACGGGGACTGCTCCCCTATCTCCACCC
Motif Score	4.065041667
Cell/Tissue List	peripheral-blood; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000586828.5; ENST00000309340.11; ENST00000588014.5; ENST00000587416.5; ENST00000585667.1; ENST00000591601.5; ENST00000250896.7
External Link	RMBase: m6A_site_408896
mod ID: M6ASITE038036		Click to Show/Hide the Full List
mod site	chr19:2042474-2042475:-		[15]
Sequence	GACCTGGGCAGCGGCATCAAACTCAACGGGGACTGCTCCCC
Motif Score	2.627720238
Cell/Tissue List	peripheral-blood; endometrial; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000309340.11; ENST00000588014.5; ENST00000585667.1; ENST00000591601.5; ENST00000587416.5; ENST00000586828.5; ENST00000250896.7
External Link	RMBase: m6A_site_408897
mod ID: M6ASITE038037		Click to Show/Hide the Full List
mod site	chr19:2042631-2042632:-		[16]
Sequence	CAGGGACCTAAAGCCGGAAAACATCCTCTGTGAGCACCCCA
Motif Score	2.20572619
Cell/Tissue List	HepG2; hESC-HEK293T; peripheral-blood; endometrial; HEC-1-A
Seq Type List	m6A-seq; MAZTER-seq
Transcript ID List	ENST00000588014.5; ENST00000591601.5; ENST00000587416.5; ENST00000309340.11; ENST00000586828.5; ENST00000250896.7; ENST00000585667.1
External Link	RMBase: m6A_site_408898
mod ID: M6ASITE038038		Click to Show/Hide the Full List
mod site	chr19:2042646-2042647:-		[11]
Sequence	CCCAGGCATCGCCCACAGGGACCTAAAGCCGGAAAACATCC
Motif Score	3.622404762
Cell/Tissue List	HepG2; peripheral-blood; endometrial; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000585667.1; ENST00000250896.7; ENST00000587416.5; ENST00000591601.5; ENST00000586828.5; ENST00000309340.11
External Link	RMBase: m6A_site_408899
mod ID: M6ASITE038040		Click to Show/Hide the Full List
mod site	chr19:2042699-2042700:-		[11]
Sequence	GACTCCTGGAAGACCTCCAGACCCTCACCCCGTCGTGGTTC
Motif Score	2.876744048
Cell/Tissue List	HepG2; peripheral-blood; endometrial; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000250896.7; ENST00000585667.1; ENST00000586828.5; ENST00000309340.11; ENST00000591601.5
External Link	RMBase: m6A_site_408900
mod ID: M6ASITE038041		Click to Show/Hide the Full List
mod site	chr19:2042707-2042708:-		[11]
Sequence	CTGCCAAGGACTCCTGGAAGACCTCCAGACCCTCACCCCGT
Motif Score	2.876744048
Cell/Tissue List	HepG2; peripheral-blood; endometrial; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000250896.7; ENST00000309340.11; ENST00000586828.5; ENST00000591601.5; ENST00000585667.1
External Link	RMBase: m6A_site_408901
mod ID: M6ASITE038042		Click to Show/Hide the Full List
mod site	chr19:2042718-2042719:-		[11]
Sequence	CCTAGGGCCGCCTGCCAAGGACTCCTGGAAGACCTCCAGAC
Motif Score	4.065041667
Cell/Tissue List	HepG2; peripheral-blood; endometrial; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000250896.7; ENST00000585667.1; ENST00000591601.5; ENST00000309340.11; ENST00000586828.5
External Link	RMBase: m6A_site_408902
mod ID: M6ASITE038043		Click to Show/Hide the Full List
mod site	chr19:2042770-2042771:-		[6]
Sequence	CGCCTTGGACTTTCTGCATAACAAAGGTAGGTGGTGACCCC
Motif Score	2.168095238
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000309340.11; ENST00000250896.7; ENST00000591601.5; ENST00000585667.1; ENST00000586828.5
External Link	RMBase: m6A_site_408903
mod ID: M6ASITE038044		Click to Show/Hide the Full List
mod site	chr19:2042782-2042783:-		[11]
Sequence	GGACGTGGCCAGCGCCTTGGACTTTCTGCATAACAAAGGTA
Motif Score	4.065041667
Cell/Tissue List	HepG2; MT4; peripheral-blood; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000586828.5; ENST00000250896.7; ENST00000585667.1; ENST00000309340.11; ENST00000591601.5
External Link	RMBase: m6A_site_408904
mod ID: M6ASITE038045		Click to Show/Hide the Full List
mod site	chr19:2042848-2042849:-		[6]
Sequence	CTCCATCCTGAGCCACATCCACAAGCGCCGGCACTTCAACG
Motif Score	2.053113095
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000309340.11; ENST00000586828.5; ENST00000591601.5; ENST00000250896.7; ENST00000585667.1
External Link	RMBase: m6A_site_408905
mod ID: M6ASITE038046		Click to Show/Hide the Full List
mod site	chr19:2042854-2042855:-		[6]
Sequence	CCCAGGCTCCATCCTGAGCCACATCCACAAGCGCCGGCACT
Motif Score	2.053113095
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000591601.5; ENST00000309340.11; ENST00000586828.5; ENST00000585667.1; ENST00000250896.7
External Link	RMBase: m6A_site_408906
mod ID: M6ASITE038047		Click to Show/Hide the Full List
mod site	chr19:2043158-2043159:-		[5]
Sequence	TGAGTTCTTCGAGGAGGAGGACCGCTTCTACCTGGTGTTTG
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; U2OS; MT4; Huh7; peripheral-blood; HEK293T; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000309340.11; ENST00000250896.7; ENST00000585667.1; ENST00000586828.5; ENST00000591601.5
External Link	RMBase: m6A_site_408907
mod ID: M6ASITE038048		Click to Show/Hide the Full List
mod site	chr19:2043507-2043508:-		[5]
Sequence	ATGCTGTACCAGTGCCAGGGACACAGGTAGGTGAGCCACCC
Motif Score	3.643047619
Cell/Tissue List	HeLa; HepG2; hESC-HEK293T; U2OS; MT4; Huh7; peripheral-blood; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MAZTER-seq; MeRIP-seq
Transcript ID List	ENST00000250896.7; ENST00000309340.11; ENST00000586828.5; ENST00000591601.5; ENST00000585667.1
External Link	RMBase: m6A_site_408908
mod ID: M6ASITE038049		Click to Show/Hide the Full List
mod site	chr19:2043559-2043560:-		[14]
Sequence	CATTGAGAAGCAGCCAGGCCACATTCGGAGCAGGGTTTTCA
Motif Score	2.053113095
Cell/Tissue List	liver; hESC-HEK293T
Seq Type List	m6A-REF-seq; MAZTER-seq
Transcript ID List	ENST00000309340.11; ENST00000250896.7; ENST00000591601.5; ENST00000586828.5
External Link	RMBase: m6A_site_408909
mod ID: M6ASITE038050		Click to Show/Hide the Full List
mod site	chr19:2046226-2046227:-		[5]
Sequence	GCGCTCATGCCCGAGTGCAGACCTGCATCAACCTGATCACC
Motif Score	2.876744048
Cell/Tissue List	HeLa; CD34; HepG2; U2OS; MT4; MM6; Huh7; peripheral-blood; HEK293T; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000250896.7; ENST00000591601.5; ENST00000586828.5; ENST00000309340.11
External Link	RMBase: m6A_site_408910
mod ID: M6ASITE038051		Click to Show/Hide the Full List
mod site	chr19:2046443-2046444:-		[6]
Sequence	GCCCGCCAGCCAGCCCATTGACATCCCGGACGCCAAGAAGA
Motif Score	2.859755952
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000250896.7; ENST00000591601.5; ENST00000586828.5; ENST00000309340.11
External Link	RMBase: m6A_site_408911
mod ID: M6ASITE038052		Click to Show/Hide the Full List
mod site	chr19:2046467-2046468:-		[6]
Sequence	GGGCGTGCCTCCTGGAACAGACATGCCCGCCAGCCAGCCCA
Motif Score	2.897386905
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000309340.11; ENST00000250896.7; ENST00000589509.5; ENST00000591601.5; ENST00000586828.5
External Link	RMBase: m6A_site_408912
mod ID: M6ASITE038053		Click to Show/Hide the Full List
mod site	chr19:2046638-2046639:-		[5]
Sequence	AGACCAGCCCGACCACGGAGACTCTGACTTTGGCCTGCAGT
Motif Score	3.319380952
Cell/Tissue List	HeLa; CD34; HEK293T; endometrial; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000589509.5; ENST00000586828.5; ENST00000309340.11; ENST00000250896.7; ENST00000589534.2; ENST00000591601.5
External Link	RMBase: m6A_site_408913
mod ID: M6ASITE038054		Click to Show/Hide the Full List
mod site	chr19:2046656-2046657:-		[5]
Sequence	CGAGCTGGCCTTCTCCCTAGACCAGCCCGACCACGGAGACT
Motif Score	2.876744048
Cell/Tissue List	HeLa; CD34; HEK293T; endometrial; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000309340.11; ENST00000586828.5; ENST00000591601.5; ENST00000589509.5; ENST00000589534.2; ENST00000250896.7
External Link	RMBase: m6A_site_408914
mod ID: M6ASITE038055		Click to Show/Hide the Full List
mod site	chr19:2046683-2046684:-		[5]
Sequence	CTCTCCCCTGCAGGGGCAGAACCCCTTCGAGCTGGCCTTCT
Motif Score	2.930744048
Cell/Tissue List	HeLa; CD34; HEK293T; endometrial; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000589534.2; ENST00000589509.5; ENST00000250896.7; ENST00000309340.11; ENST00000586828.5; ENST00000591601.5
External Link	RMBase: m6A_site_408915
mod ID: M6ASITE038056		Click to Show/Hide the Full List
mod site	chr19:2050827-2050828:-		[5]
Sequence	GTGCAGAAGAAACCAGCCGAACTTCAGGGTTTCCACCGTTC
Motif Score	3.373380952
Cell/Tissue List	HeLa; HEK293T
Seq Type List	m6A-seq
Transcript ID List	ENST00000586828.5; ENST00000250896.7; ENST00000591601.5; ENST00000589509.5; ENST00000309340.11; ENST00000589534.2
External Link	RMBase: m6A_site_408916
mod ID: M6ASITE038057		Click to Show/Hide the Full List
mod site	chr19:2050836-2050837:-		[5]
Sequence	CAGAAGATGGTGCAGAAGAAACCAGCCGAACTTCAGGGTTT
Motif Score	2.185083333
Cell/Tissue List	HeLa; HEK293T
Seq Type List	m6A-seq
Transcript ID List	ENST00000589509.5; ENST00000589534.2; ENST00000586828.5; ENST00000309340.11; ENST00000591601.5; ENST00000250896.7
External Link	RMBase: m6A_site_408917
mod ID: M6ASITE038058		Click to Show/Hide the Full List
mod site	chr19:2050857-2050858:-		[5]
Sequence	CCCCCGCTGGCGGGGCCCGGACAGAAGATGGTGCAGAAGAA
Motif Score	3.643047619
Cell/Tissue List	HeLa; HEK293T
Seq Type List	m6A-seq
Transcript ID List	ENST00000250896.7; ENST00000589534.2; ENST00000309340.11; ENST00000589509.5; ENST00000591601.5
External Link	RMBase: m6A_site_408918

2'-O-Methylation (2'-O-Me)

In total 1 m6A sequence/site(s) in this target gene
mod ID: 2OMSITE000185		Click to Show/Hide the Full List
mod site	chr19:2037754-2037755:-		[17]
Sequence	TGGAGGACTGGTCAGAACCGTTACTGTGAATGAGTGAAGAT
Cell/Tissue List	HeLa
Seq Type List	Nm-seq
Transcript ID List	ENST00000250896.7; ENST00000591601.5; ENST00000587416.5; ENST00000309340.11; ENST00000589441.5; ENST00000591142.5
External Link	RMBase: Nm_site_2732

Pseudouridine (Pseudo)

In total 1 m6A sequence/site(s) in this target gene
mod ID: PSESITE000117		Click to Show/Hide the Full List
mod site	chr19:2037587-2037588:-		[18]
Sequence	GGGAAAAACATCCAAGCACTTTAATTCCAATGTACCAGGTG
Transcript ID List	ENST00000589441.5; ENST00000250896.7; ENST00000587416.5; ENST00000309340.11; ENST00000591142.5; ENST00000591601.5
External Link	RMBase: Pseudo_site_2404

Ref 1	Dynamic m(6)A mRNA Methylation Reveals the Role of METTL3/14-m(6)A-MNK2-ERK Signaling Axis in Skeletal Muscle Differentiation and Regeneration. Front Cell Dev Biol. 2021 Oct 1;9:744171. doi: 10.3389/fcell.2021.744171. eCollection 2021.
Ref 2	NAT10-mediated N4-acetylcytidine mRNA modification regulates self-renewal in human embryonic stem cells. Nucleic Acids Res. 2023 Sep 8;51(16):8514-8531. doi: 10.1093/nar/gkad628.
Ref 3	RADAR: a rigorously annotated database of A-to-I RNA editing. Nucleic Acids Res. 2014 Jan;42(Database issue):D109-13. doi: 10.1093/nar/gkt996. Epub 2013 Oct 25.
Ref 4	5-methylcytosine promotes mRNA export - NSUN2 as the methyltransferase and ALYREF as an m(5)C reader. Cell Res. 2017 May;27(5):606-625. doi: 10.1038/cr.2017.55. Epub 2017 Apr 18.
Ref 5	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 6	Deciphering the "m(6)A Code" via Antibody-Independent Quantitative Profiling. Cell. 2019 Jul 25;178(3):731-747.e16. doi: 10.1016/j.cell.2019.06.013. Epub 2019 Jun 27.
Ref 7	Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5' sites. Cell Rep. 2014 Jul 10;8(1):284-96. doi: 10.1016/j.celrep.2014.05.048. Epub 2014 Jun 26.
Ref 8	N6-methyladenosine-dependent regulation of messenger RNA stability. Nature. 2014 Jan 2;505(7481):117-20. doi: 10.1038/nature12730. Epub 2013 Nov 27.
Ref 9	Suppression of m(6)A reader Ythdf2 promotes hematopoietic stem cell expansion. Cell Res. 2018 Sep;28(9):904-917. doi: 10.1038/s41422-018-0072-0. Epub 2018 Jul 31.
Ref 10	Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq. Nature. 2012 Apr 29;485(7397):201-6. doi: 10.1038/nature11112.
Ref 11	Efficacy of MEK inhibition in patients with histiocytic neoplasms. Nature. 2019 Mar;567(7749):521-524. doi: 10.1038/s41586-019-1012-y. Epub 2019 Mar 13.
Ref 12	Dynamics of Human and Viral RNA Methylation during Zika Virus Infection. Cell Host Microbe. 2016 Nov 9;20(5):666-673. doi: 10.1016/j.chom.2016.10.002. Epub 2016 Oct 20.
Ref 13	m(6)A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer. Nat Cell Biol. 2018 Sep;20(9):1074-1083. doi: 10.1038/s41556-018-0174-4. Epub 2018 Aug 27.
Ref 14	Single-base mapping of m(6)A by an antibody-independent method. Sci Adv. 2019 Jul 3;5(7):eaax0250. doi: 10.1126/sciadv.aax0250. eCollection 2019 Jul.
Ref 15	R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m(6)A/MYC/CEBPA Signaling. Cell. 2018 Jan 11;172(1-2):90-105.e23. doi: 10.1016/j.cell.2017.11.031. Epub 2017 Dec 14.
Ref 16	Histone H3 trimethylation at lysine 36 guides m(6)A RNA modification co-transcriptionally. Nature. 2019 Mar;567(7748):414-419. doi: 10.1038/s41586-019-1016-7. Epub 2019 Mar 13.
Ref 17	Nm-seq maps 2'-O-methylation sites in human mRNA with base precision. Nat Methods. 2017 Jul;14(7):695-698. doi: 10.1038/nmeth.4294. Epub 2017 May 15.
Ref 18	Chemical pulldown reveals dynamic pseudouridylation of the mammalian transcriptome. Nat Chem Biol. 2015 Aug;11(8):592-7. doi: 10.1038/nchembio.1836. Epub 2015 Jun 15.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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