m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00559)
Target Name Insulin receptor substrate 1 (IRS1)
Synonyms
IRS-1
    Click to Show/Hide
Gene Name IRS1
Chromosomal Location 2q36.3
Function
May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity).
    Click to Show/Hide
Gene ID 3667
Uniprot ID
IRS1_HUMAN
HGNC ID
HGNC:6125
Ensembl Gene ID
ENSG00000169047
KEGG ID
hsa:3667
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
IRS1 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
YTH domain-containing family protein 2 (YTHDF2) [READER]
 Regulator Info 
Representative RIP-seq result supporting the interaction between IRS1 and the regulator
Cell Line Hela Homo sapiens
Regulation logFC: 1.86E+00 GSE49339
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary YTHDF2 inhibited the proliferation and invasion of endometrial cancer(EC) via inhibiting Insulin receptor substrate 1 (IRS1) expression in m6A epigenetic way, which suggests a potential therapeutic target for EC.
Target Regulation Down regulation
Responsed Disease Endometrial cancer ICD-11: 2C76
 Disease Info 
Pathway Response PI3K-Akt signaling pathway hsa04151
In-vitro Model T HESCs Normal Homo sapiens CVCL_C464
RL95-2 Endometrial adenosquamous carcinoma Homo sapiens CVCL_0505
HEC-1-A Endometrial adenocarcinoma Homo sapiens CVCL_0293
Endometrial cancer [ICD-11: 2C76]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary YTHDF2 inhibited the proliferation and invasion of endometrial cancer(EC) via inhibiting Insulin receptor substrate 1 (IRS1) expression in m6A epigenetic way, which suggests a potential therapeutic target for EC.
Responsed Disease Endometrial cancer [ICD-11: 2C76]
Target Regulator YTH domain-containing family protein 2 (YTHDF2) READER
 Regulator Info 
Target Regulation Down regulation
Pathway Response PI3K-Akt signaling pathway hsa04151
In-vitro Model T HESCs Normal Homo sapiens CVCL_C464
RL95-2 Endometrial adenosquamous carcinoma Homo sapiens CVCL_0505
HEC-1-A Endometrial adenocarcinoma Homo sapiens CVCL_0293
Gestational diabetes mellitus [ICD-11: JA63]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response []
Response Summary Down-regulation of m6A both in the 3'-UTR and CDS near stop codons of placental mRNAs is involved in gestational diabetes mellitus(GDM) development in Han Chinese women. MazF-qPCR verified that the m6A levels of the BAMBI 3'-UTR and CDS were significantly decreased in GDM. m6A levels of GDM related genes (INSR and Insulin receptor substrate 1 (IRS1)) were significantly reduced in GDM.
Responsed Disease Gestational diabetes mellitus [ICD-11: JA63]
References
Ref 1 YTHDF2 inhibit the tumorigenicity of endometrial cancer via downregulating the expression of IRS1 methylated with m(6)A. J Cancer. 2021 May 5;12(13):3809-3818. doi: 10.7150/jca.54527. eCollection 2021.