m6A-centered Disease Response Information

General Information of the Disease (ID: M6ADIS0148)
Name
Gestational diabetes mellitus
ICD
ICD-11: JA63
Full List of Target Gene(s) of This m6A-centered Disease Response
Insulin receptor (INSR)
 Target Info 
In total 1 item(s) under this target gene
Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene [1]
Response Summary Down-regulation of m6A both in the 3'-UTR and CDS near stop codons of placental mRNAs is involved in gestational diabetes mellitus(GDM) development in Han Chinese women. MazF-qPCR verified that the m6A levels of the BAMBI 3'-UTR and CDS were significantly decreased in GDM. m6A levels of GDM related genes (Insulin receptor (INSR) and IRS1) were significantly reduced in GDM.
Responsed Disease Gestational diabetes mellitus [ICD-11: JA63]
Insulin receptor substrate 1 (IRS1)
 Target Info 
In total 1 item(s) under this target gene
Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene [1]
Response Summary Down-regulation of m6A both in the 3'-UTR and CDS near stop codons of placental mRNAs is involved in gestational diabetes mellitus(GDM) development in Han Chinese women. MazF-qPCR verified that the m6A levels of the BAMBI 3'-UTR and CDS were significantly decreased in GDM. m6A levels of GDM related genes (INSR and Insulin receptor substrate 1 (IRS1)) were significantly reduced in GDM.
Responsed Disease Gestational diabetes mellitus [ICD-11: JA63]
Non-metastatic gene A protein (BAMBI)
 Target Info 
In total 1 item(s) under this target gene
Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene [1]
Response Summary Down-regulation of m6A both in the 3'-UTR and CDS near stop codons of placental mRNAs is involved in gestational diabetes mellitus(GDM) development in Han Chinese women. MazF-qPCR verified that the m6A levels of the Non-metastatic gene A protein (BAMBI) 3'-UTR and CDS were significantly decreased in GDM. m6A levels of GDM related genes (INSR and IRS1) were significantly reduced in GDM.
Responsed Disease Gestational diabetes mellitus [ICD-11: JA63]
References
Ref 1 m6A mRNA methylation regulates the development of gestational diabetes mellitus in Han Chinese women. Genomics. 2021 May;113(3):1048-1056. doi: 10.1016/j.ygeno.2021.02.016. Epub 2021 Mar 2.