m6A Target Gene Information
General Information of the m6A Target Gene (ID: M6ATAR00445)
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
VANGL1
can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
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Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) [READER]
In total 1 item(s) under this regulator | ||||
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene | [1] | |||
Response Summary | Up-regulation of Vang-like protein 1 (VANGL1) by IGF2BPs and miR-29b-3p attenuates the detrimental effect of irradiation on lung adenocarcinoma. Increased m6A level of VANGL1 and reduced miR-29b-3p took the responsibility of VANGL1 overexpression upon irradiation. | |||
Target Regulation | Up regulation | |||
Responsed Disease | Lung adenocarcinoma | ICD-11: 2C25.0 | ||
Pathway Response | Nucleotide excision repair | hsa03420 | ||
Cell Process | DNA repair | |||
In-vitro Model | A-549 | Lung adenocarcinoma | Homo sapiens | CVCL_0023 |
NCI-H1299 | Lung large cell carcinoma | Homo sapiens | CVCL_0060 | |
In-vivo Model | Two hundred milliliters of A549 cells (1 × 106) were injected into the left flank of the back of each mouse. | |||
Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) [READER]
In total 1 item(s) under this regulator | ||||
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene | [1] | |||
Response Summary | Up-regulation of Vang-like protein 1 (VANGL1) by IGF2BPs and miR-29b-3p attenuates the detrimental effect of irradiation on lung adenocarcinoma. Increased m6A level of VANGL1 and reduced miR-29b-3p took the responsibility of VANGL1 overexpression upon irradiation. | |||
Target Regulation | Up regulation | |||
Responsed Disease | Lung adenocarcinoma | ICD-11: 2C25.0 | ||
Pathway Response | Nucleotide excision repair | hsa03420 | ||
Cell Process | DNA repair | |||
In-vitro Model | A-549 | Lung adenocarcinoma | Homo sapiens | CVCL_0023 |
NCI-H1299 | Lung large cell carcinoma | Homo sapiens | CVCL_0060 | |
In-vivo Model | Two hundred milliliters of A549 cells (1 × 106) were injected into the left flank of the back of each mouse. | |||
Lung cancer [ICD-11: 2C25]
In total 1 item(s) under this disease | ||||
Experiment 1 Reporting the m6A-centered Disease Response | [1] | |||
Response Summary | Up-regulation of Vang-like protein 1 (VANGL1) by IGF2BPs and miR-29b-3p attenuates the detrimental effect of irradiation on lung adenocarcinoma. Increased m6A level of VANGL1 and reduced miR-29b-3p took the responsibility of VANGL1 overexpression upon irradiation. | |||
Responsed Disease | Lung adenocarcinoma [ICD-11: 2C25.0] | |||
Target Regulator | Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) | READER | ||
Target Regulation | Up regulation | |||
Pathway Response | Nucleotide excision repair | hsa03420 | ||
Cell Process | DNA repair | |||
In-vitro Model | A-549 | Lung adenocarcinoma | Homo sapiens | CVCL_0023 |
NCI-H1299 | Lung large cell carcinoma | Homo sapiens | CVCL_0060 | |
In-vivo Model | Two hundred milliliters of A549 cells (1 × 106) were injected into the left flank of the back of each mouse. | |||