m6A Target Gene Information
General Information of the m6A Target Gene (ID: M6ATAR00370)
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
PLK1
can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
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Methyltransferase-like 3 (METTL3) [WRITER]
Representative RNA-seq result indicating the expression of this target gene regulated by METTL3 | ||
Cell Line | LX2 cell line | Homo sapiens |
Treatment: shMETTL3 LX2 cells
Control: shLuc LX2 cells
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GSE207909 | |
Regulation |
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logFC: -8.98E-01 p-value: 1.15E-18 |
More Results | Click to View More RNA-seq Results |
In total 1 item(s) under this regulator | ||||
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene | [1] | |||
Response Summary | Impaired METTL3 expression in dental pulp stem cells led to increasing cell senescence and apoptosis by interfering with the mitotic cell cycle in a m6A-dependent manner. The protein interaction network of differentially expressed genes identified Serine/threonine-protein kinase PLK1 (PLK1), a critical cycle modulator, as the target of METTL3-mediated m6A methylation in DPSCs. | |||
Target Regulation | Down regulation | |||
Responsed Disease | Pulpitis | ICD-11: DA09 | ||
Cell Process | Cell senescence | |||
In-vitro Model | DPSC | Normal | Homo sapiens | CVCL_AV90 |
Pulpitis [ICD-11: DA09]
In total 1 item(s) under this disease | ||||
Experiment 1 Reporting the m6A-centered Disease Response | [1] | |||
Response Summary | Impaired METTL3 expression in dental pulp stem cells led to increasing cell senescence and apoptosis by interfering with the mitotic cell cycle in a m6A-dependent manner. The protein interaction network of differentially expressed genes identified Serine/threonine-protein kinase PLK1 (PLK1), a critical cycle modulator, as the target of METTL3-mediated m6A methylation in DPSCs. | |||
Responsed Disease | Pulpitis [ICD-11: DA09] | |||
Target Regulator | Methyltransferase-like 3 (METTL3) | WRITER | ||
Target Regulation | Down regulation | |||
Cell Process | Cell senescence | |||
In-vitro Model | DPSC | Normal | Homo sapiens | CVCL_AV90 |