m6A-centered Disease Response Information
General Information of the Disease (ID: M6ADIS0106)
| Name |
Pulpitis
|
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|---|---|---|---|---|---|
| ICD |
ICD-11: DA09
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Full List of Target Gene(s) of This m6A-centered Disease Response
Myeloid differentiation primary response protein MyD88 (MYD88)
| In total 1 item(s) under this target gene | ||||
| Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene | [1] | |||
| Response Summary | Knocked down METTL3 and demonstrated that METTL3 depletion decreased the expression of inflammatory cytokines and the phosphorylation of IKK-alpha/beta, p65 and IKappa-B-alpha in the NF-Kappa-B signalling pathway as well as p38, ERK and JNK in the MAPK signalling pathway in LPS-induced HDPCs. METTL3 inhibits the LPS-induced inflammatory response of HDPCs by regulating alternative splicing of Myeloid differentiation primary response protein MyD88 (MYD88). | |||
| Responsed Disease | Pulpitis [ICD-11: DA09] | |||
| Target Regulator | Methyltransferase-like 3 (METTL3) | WRITER | ||
| Target Regulation | Down regulation | |||
| Pathway Response | MAPK signaling pathway | hsa04010 | ||
| Cell Process | Alternative splicing | |||
Serine/threonine-protein kinase PLK1 (PLK1)
| In total 1 item(s) under this target gene | ||||
| Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene | [2] | |||
| Response Summary | Impaired METTL3 expression in dental pulp stem cells led to increasing cell senescence and apoptosis by interfering with the mitotic cell cycle in a m6A-dependent manner. The protein interaction network of differentially expressed genes identified Serine/threonine-protein kinase PLK1 (PLK1), a critical cycle modulator, as the target of METTL3-mediated m6A methylation in DPSCs. | |||
| Responsed Disease | Pulpitis [ICD-11: DA09] | |||
| Target Regulator | Methyltransferase-like 3 (METTL3) | WRITER | ||
| Target Regulation | Down regulation | |||
| Cell Process | Cell senescence | |||
| In-vitro Model | DPSC | Normal | Homo sapiens | CVCL_AV90 |
References