m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00156)
Target Name H19 imprinted maternally expressed transcript (H19)
Synonyms
H19; H19, imprinted maternally expressed untranslated mRNA; H19, imprinted maternally expressed transcript (non-protein coding); D11S813E; ASM; ASM1; NCRNA00008; LINC00008; MIR675HG; non-protein coding RNA 8; long intergenic non-protein coding RNA 8; MIR675 host gene; adult skeletal muscle
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Gene Name H19
Chromosomal Location 11p15.5
Family MicroRNA non-coding host genes; Long non-coding RNAs with non-systematic symbols
Gene ID 283120
HGNC ID
HGNC:4713
Ensembl Gene ID
ENSG00000130600
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
H19 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
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Methyltransferase-like 3 (METTL3) [WRITER]
 Regulator Info 
Representative RNA-seq result indicating the expression of this target gene regulated by METTL3
Cell Line DKO-1 cell line Homo sapiens
Treatment: METTL3 knockdown DKO-1 cell
Control: DKO-1 cell
 GSE182382
Regulation
logFC: -2.53E+00
p-value: 9.95E-11
More Results Click to View More RNA-seq Results
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary Either knockdown of METTL3 or METTL14 notably reversed the hypoxic preconditioning-induced enhancement of cell viability, anti-apoptosis ability, and H19 imprinted maternally expressed transcript (H19) expression.
Target Regulation Up regulation
Responsed Disease Abnormalities of breathing ICD-11: MD11
 Disease Info 
Cell Process Cell viability
Cell apoptosis
In-vitro Model H9c2(2-1) Normal Rattus norvegicus CVCL_0286
In-vivo Model In vivo myocardial I/R injury was performed by 60 min of ligation of LAD followed by 5 h of reperfusion.
Methyltransferase-like 14 (METTL14) [WRITER]
 Regulator Info 
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary Either knockdown of METTL3 or METTL14 notably reversed the hypoxic preconditioning-induced enhancement of cell viability, anti-apoptosis ability, and H19 imprinted maternally expressed transcript (H19) expression.
Target Regulation Up regulation
Responsed Disease Abnormalities of breathing ICD-11: MD11
 Disease Info 
Cell Process Cell viability
Cell apoptosis
In-vitro Model H9c2(2-1) Normal Rattus norvegicus CVCL_0286
In-vivo Model In vivo myocardial I/R injury was performed by 60 min of ligation of LAD followed by 5 h of reperfusion.
Abnormalities of breathing [ICD-11: MD11]
 Disease Info 
In total 2 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary Either knockdown of METTL3 or METTL14 notably reversed the hypoxic preconditioning-induced enhancement of cell viability, anti-apoptosis ability, and H19 imprinted maternally expressed transcript (H19) expression.
Responsed Disease Abnormalities of breathing [ICD-11: MD11]
Target Regulator Methyltransferase-like 14 (METTL14) WRITER
 Regulator Info 
Target Regulation Up regulation
Cell Process Cell viability
Cell apoptosis
In-vitro Model H9c2(2-1) Normal Rattus norvegicus CVCL_0286
In-vivo Model In vivo myocardial I/R injury was performed by 60 min of ligation of LAD followed by 5 h of reperfusion.
Experiment 2 Reporting the m6A-centered Disease Response [1]
Response Summary Either knockdown of METTL3 or METTL14 notably reversed the hypoxic preconditioning-induced enhancement of cell viability, anti-apoptosis ability, and H19 imprinted maternally expressed transcript (H19) expression.
Responsed Disease Abnormalities of breathing [ICD-11: MD11]
Target Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
Target Regulation Up regulation
Cell Process Cell viability
Cell apoptosis
In-vitro Model H9c2(2-1) Normal Rattus norvegicus CVCL_0286
In-vivo Model In vivo myocardial I/R injury was performed by 60 min of ligation of LAD followed by 5 h of reperfusion.
References
Ref 1 N6-methyladenosine methyltransferase plays a role in hypoxic preconditioning partially through the interaction with lncRNA H19. Acta Biochim Biophys Sin (Shanghai). 2020 Dec 29;52(12):1306-1315. doi: 10.1093/abbs/gmaa130.