m6A-centered Disease Response Information

General Information of the Disease (ID: M6ADIS0123)

Name	Abnormalities of breathing
ICD	ICD-11: MD11

Full List of Target Gene(s) of This m6A-centered Disease Response

H19 imprinted maternally expressed transcript (H19)

Target Info

In total 2 item(s) under this target gene
Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene				[1]
Response Summary	Either knockdown of METTL3 or METTL14 notably reversed the hypoxic preconditioning-induced enhancement of cell viability, anti-apoptosis ability, and H19 imprinted maternally expressed transcript (H19) expression.
Responsed Disease	Abnormalities of breathing [ICD-11: MD11]
Target Regulator	Methyltransferase-like 3 (METTL3)		WRITER	Regulator Info
Target Regulation	Up regulation
Cell Process	Cell viability
	Cell apoptosis
In-vitro Model	H9c2(2-1)	Normal	Rattus norvegicus	CVCL_0286
In-vivo Model	In vivo myocardial I/R injury was performed by 60 min of ligation of LAD followed by 5 h of reperfusion.
Experiment 2 Reporting the m6A-centered Disease Response by This Target Gene				[1]
Response Summary	Either knockdown of METTL3 or METTL14 notably reversed the hypoxic preconditioning-induced enhancement of cell viability, anti-apoptosis ability, and H19 imprinted maternally expressed transcript (H19) expression.
Responsed Disease	Abnormalities of breathing [ICD-11: MD11]
Target Regulator	Methyltransferase-like 14 (METTL14)		WRITER	Regulator Info
Target Regulation	Up regulation
Cell Process	Cell viability
	Cell apoptosis
In-vitro Model	H9c2(2-1)	Normal	Rattus norvegicus	CVCL_0286
In-vivo Model	In vivo myocardial I/R injury was performed by 60 min of ligation of LAD followed by 5 h of reperfusion.

References

Ref 1	N6-methyladenosine methyltransferase plays a role in hypoxic preconditioning partially through the interaction with lncRNA H19. Acta Biochim Biophys Sin (Shanghai). 2020 Dec 29;52(12):1306-1315. doi: 10.1093/abbs/gmaa130.