m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00147)
Target Name HLA complex group 11 (HCG11)
Synonyms
HCG11; HLA complex group 11; HLA complex group 11 (non-protein coding); bK14H9.3; FLJ14049; FLJ30357
    Click to Show/Hide
Gene Name HCG11
Chromosomal Location 6p22.2
Family Long non-coding RNAs with non-systematic symbols
Gene ID 493812
HGNC ID
HGNC:17707
Ensembl Gene ID
ENSG00000228223
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
HCG11 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Methyltransferase-like 14 (METTL14) [WRITER]
 Regulator Info 
Representative RNA-seq result indicating the expression of this target gene regulated by METTL14
Cell Line MDA-MB-231 Homo sapiens
Treatment: siMETTL14 MDA-MB-231 cells
Control: MDA-MB-231 cells
 GSE81164
Regulation
logFC: -6.19E-01
p-value: 1.66E-04
More Results Click to View More RNA-seq Results
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary HLA complex group 11 (HCG11) mediated by METTL14 inhibited the growth of lung adenocarcinoma via IGF2BP2/LATS1. The m6A modification of HCG11 promoted its nuclear exportation and binding by Insulin Like Growth Factor 2 MRNA Binding Protein 2 (IGF2BP2), resulting in increased stability.
Target Regulation Down regulation
Responsed Disease Lung adenocarcinoma ICD-11: 2C25.0
 Disease Info 
Pathway Response Nucleotide excision repair hsa03420
Cell Process RNA stabilization
In-vitro Model A-549 Lung adenocarcinoma Homo sapiens CVCL_0023
HBE (Human bronchial epithelial cell line)
NCI-H1975 Lung adenocarcinoma Homo sapiens CVCL_1511
NCI-H522 Lung adenocarcinoma Homo sapiens CVCL_1567
PC-9 Lung adenocarcinoma Homo sapiens CVCL_B260
In-vivo Model LUAD cells stably HCG11 and/or LATS1 overexpressed or silenced were subcutaneously injected into the flank of the BALB/c nude mice (male, 4 weeks old).
Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) [READER]
 Regulator Info 
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary HLA complex group 11 (HCG11) mediated by METTL14 inhibited the growth of lung adenocarcinoma via IGF2BP2/LATS1. The m6A modification of HCG11 promoted its nuclear exportation and binding by Insulin Like Growth Factor 2 MRNA Binding Protein 2 (IGF2BP2), resulting in increased stability.
Target Regulation Up regulation
Responsed Disease Lung adenocarcinoma ICD-11: 2C25.0
 Disease Info 
Pathway Response Nucleotide excision repair hsa03420
Cell Process RNA stabilization
In-vitro Model A-549 Lung adenocarcinoma Homo sapiens CVCL_0023
HBE (Human bronchial epithelial cell line)
NCI-H1975 Lung adenocarcinoma Homo sapiens CVCL_1511
NCI-H522 Lung adenocarcinoma Homo sapiens CVCL_1567
PC-9 Lung adenocarcinoma Homo sapiens CVCL_B260
In-vivo Model LUAD cells stably HCG11 and/or LATS1 overexpressed or silenced were subcutaneously injected into the flank of the BALB/c nude mice (male, 4 weeks old).
Lung cancer [ICD-11: 2C25]
 Disease Info 
In total 2 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary HLA complex group 11 (HCG11) mediated by METTL14 inhibited the growth of lung adenocarcinoma via IGF2BP2/LATS1. The m6A modification of HCG11 promoted its nuclear exportation and binding by Insulin Like Growth Factor 2 MRNA Binding Protein 2 (IGF2BP2), resulting in increased stability.
Responsed Disease Lung adenocarcinoma [ICD-11: 2C25.0]
Target Regulator Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) READER
 Regulator Info 
Target Regulation Up regulation
Pathway Response Nucleotide excision repair hsa03420
Cell Process RNA stabilization
In-vitro Model A-549 Lung adenocarcinoma Homo sapiens CVCL_0023
HBE (Human bronchial epithelial cell line)
NCI-H1975 Lung adenocarcinoma Homo sapiens CVCL_1511
NCI-H522 Lung adenocarcinoma Homo sapiens CVCL_1567
PC-9 Lung adenocarcinoma Homo sapiens CVCL_B260
In-vivo Model LUAD cells stably HCG11 and/or LATS1 overexpressed or silenced were subcutaneously injected into the flank of the BALB/c nude mice (male, 4 weeks old).
Experiment 2 Reporting the m6A-centered Disease Response [1]
Response Summary HLA complex group 11 (HCG11) mediated by METTL14 inhibited the growth of lung adenocarcinoma via IGF2BP2/LATS1. The m6A modification of HCG11 promoted its nuclear exportation and binding by Insulin Like Growth Factor 2 MRNA Binding Protein 2 (IGF2BP2), resulting in increased stability.
Responsed Disease Lung adenocarcinoma [ICD-11: 2C25.0]
Target Regulator Methyltransferase-like 14 (METTL14) WRITER
 Regulator Info 
Target Regulation Down regulation
Pathway Response Nucleotide excision repair hsa03420
Cell Process RNA stabilization
In-vitro Model A-549 Lung adenocarcinoma Homo sapiens CVCL_0023
HBE (Human bronchial epithelial cell line)
NCI-H1975 Lung adenocarcinoma Homo sapiens CVCL_1511
NCI-H522 Lung adenocarcinoma Homo sapiens CVCL_1567
PC-9 Lung adenocarcinoma Homo sapiens CVCL_B260
In-vivo Model LUAD cells stably HCG11 and/or LATS1 overexpressed or silenced were subcutaneously injected into the flank of the BALB/c nude mice (male, 4 weeks old).
References
Ref 1 LncRNA HCG11 mediated by METTL14 inhibits the growth of lung adenocarcinoma via IGF2BP2/LATS1. Biochem Biophys Res Commun. 2021 Nov 26;580:74-80. doi: 10.1016/j.bbrc.2021.09.083. Epub 2021 Oct 2.