m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00147)
Target Name HLA complex group 11 (HCG11)
Synonyms
HCG11; HLA complex group 11; HLA complex group 11 (non-protein coding); bK14H9.3; FLJ14049; FLJ30357
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Gene Name HCG11
Chromosomal Location 6p22.2
Family Long non-coding RNAs with non-systematic symbols
Gene ID 493812
HGNC ID
HGNC:17707
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
HCG11 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Methyltransferase-like 14 (METTL14) [WRITER]
 Regulator Info 
Representative RNA-seq result indicating the expression of this target gene regulated by METTL14
Cell Line MDA-MB-231 Homo sapiens
Treatment: siMETTL14 MDA-MB-231 cells
Control: MDA-MB-231 cells
 GSE81164
Regulation
logFC: -6.19E-01
p-value: 1.66E-04
More Results Click to View More RNA-seq Results
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary HLA complex group 11 (HCG11) mediated by METTL14 inhibited the growth of lung adenocarcinoma via IGF2BP2/LATS1. The m6A modification of HCG11 promoted its nuclear exportation and binding by Insulin Like Growth Factor 2 MRNA Binding Protein 2 (IGF2BP2), resulting in increased stability.
Target Regulation Down regulation
Responsed Disease Lung adenocarcinoma ICD-11: 2C25.0
 Disease Info 
Pathway Response Nucleotide excision repair hsa03420
Cell Process RNA stabilization
In-vitro Model A-549 Lung adenocarcinoma Homo sapiens CVCL_0023
HBE (Human bronchial epithelial cell line)
NCI-H1975 Lung adenocarcinoma Homo sapiens CVCL_1511
NCI-H522 Lung adenocarcinoma Homo sapiens CVCL_1567
PC-9 Lung adenocarcinoma Homo sapiens CVCL_B260
In-vivo Model LUAD cells stably HCG11 and/or LATS1 overexpressed or silenced were subcutaneously injected into the flank of the BALB/c nude mice (male, 4 weeks old).
Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) [READER]
 Regulator Info 
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary HLA complex group 11 (HCG11) mediated by METTL14 inhibited the growth of lung adenocarcinoma via IGF2BP2/LATS1. The m6A modification of HCG11 promoted its nuclear exportation and binding by Insulin Like Growth Factor 2 MRNA Binding Protein 2 (IGF2BP2), resulting in increased stability.
Target Regulation Up regulation
Responsed Disease Lung adenocarcinoma ICD-11: 2C25.0
 Disease Info 
Pathway Response Nucleotide excision repair hsa03420
Cell Process RNA stabilization
In-vitro Model A-549 Lung adenocarcinoma Homo sapiens CVCL_0023
HBE (Human bronchial epithelial cell line)
NCI-H1975 Lung adenocarcinoma Homo sapiens CVCL_1511
NCI-H522 Lung adenocarcinoma Homo sapiens CVCL_1567
PC-9 Lung adenocarcinoma Homo sapiens CVCL_B260
In-vivo Model LUAD cells stably HCG11 and/or LATS1 overexpressed or silenced were subcutaneously injected into the flank of the BALB/c nude mice (male, 4 weeks old).
Lung cancer [ICD-11: 2C25]
 Disease Info 
In total 2 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary HLA complex group 11 (HCG11) mediated by METTL14 inhibited the growth of lung adenocarcinoma via IGF2BP2/LATS1. The m6A modification of HCG11 promoted its nuclear exportation and binding by Insulin Like Growth Factor 2 MRNA Binding Protein 2 (IGF2BP2), resulting in increased stability.
Responsed Disease Lung adenocarcinoma [ICD-11: 2C25.0]
Target Regulator Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) READER
 Regulator Info 
Target Regulation Up regulation
Pathway Response Nucleotide excision repair hsa03420
Cell Process RNA stabilization
In-vitro Model A-549 Lung adenocarcinoma Homo sapiens CVCL_0023
HBE (Human bronchial epithelial cell line)
NCI-H1975 Lung adenocarcinoma Homo sapiens CVCL_1511
NCI-H522 Lung adenocarcinoma Homo sapiens CVCL_1567
PC-9 Lung adenocarcinoma Homo sapiens CVCL_B260
In-vivo Model LUAD cells stably HCG11 and/or LATS1 overexpressed or silenced were subcutaneously injected into the flank of the BALB/c nude mice (male, 4 weeks old).
Experiment 2 Reporting the m6A-centered Disease Response [1]
Response Summary HLA complex group 11 (HCG11) mediated by METTL14 inhibited the growth of lung adenocarcinoma via IGF2BP2/LATS1. The m6A modification of HCG11 promoted its nuclear exportation and binding by Insulin Like Growth Factor 2 MRNA Binding Protein 2 (IGF2BP2), resulting in increased stability.
Responsed Disease Lung adenocarcinoma [ICD-11: 2C25.0]
Target Regulator Methyltransferase-like 14 (METTL14) WRITER
 Regulator Info 
Target Regulation Down regulation
Pathway Response Nucleotide excision repair hsa03420
Cell Process RNA stabilization
In-vitro Model A-549 Lung adenocarcinoma Homo sapiens CVCL_0023
HBE (Human bronchial epithelial cell line)
NCI-H1975 Lung adenocarcinoma Homo sapiens CVCL_1511
NCI-H522 Lung adenocarcinoma Homo sapiens CVCL_1567
PC-9 Lung adenocarcinoma Homo sapiens CVCL_B260
In-vivo Model LUAD cells stably HCG11 and/or LATS1 overexpressed or silenced were subcutaneously injected into the flank of the BALB/c nude mice (male, 4 weeks old).
Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator
Histone modification
m6A Regulator: Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2)
 Regulator Info 
In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT03466
 Crosstalk Info 
Epigenetic Regulator Histone-lysine N-methyltransferase SETD1A (SETD1A)
Regulated Target Histone H3 lysine 4 trimethylation (H3K4me3)
Crosstalk relationship Histone modification → m6A
Disease Lung cancer
 Disease Info 
Non-coding RNA
m6A Regulator: Methyltransferase-like 14 (METTL14)
 Regulator Info 
In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT05523
 Crosstalk Info 
Epigenetic Regulator HLA complex group 11 (HCG11)
Regulated Target Serine/threonine-protein kinase LATS1 (LATS1)
Crosstalk relationship m6A → ncRNA
Disease Lung cancer
 Disease Info 
m6A Regulator: Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2)
 Regulator Info 
In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT05524
 Crosstalk Info 
Epigenetic Regulator HLA complex group 11 (HCG11)
Regulated Target Serine/threonine-protein kinase LATS1 (LATS1)
Crosstalk relationship m6A → ncRNA
Disease Lung cancer
 Disease Info 
RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR00147)
HLA complex group 11 (HCG11)
N6-methyladenosine (m6A)
In total 26 m6A sequence/site(s) in this target gene
mod ID: M6ASITE074152 Click to Show/Hide the Full List
mod site chr6:26521824-26521825:+ [2]
Sequence GAGCTAGGGGGCGCCCCGGGACAGGCCGCGCCCTCTGCCCT
Motif Score 3.643047619
Cell/Tissue List HeLa; HEK293T; HepG2; MSC
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000411553.3
External Link RMBase: m6A_site_709883
mod ID: M6ASITE074153 Click to Show/Hide the Full List
mod site chr6:26521969-26521970:+ [2]
Sequence GGCGGCCTCTCCCAGTCCGGACCCTGCCGGCCGTCGGGTCT
Motif Score 3.622404762
Cell/Tissue List HeLa; HEK293T; A549; HepG2; H1B; H1A; MM6; CD4T; HEK293A-TOA; iSLK; MSC; endometrial; NB4
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000411553.3
External Link RMBase: m6A_site_709884
mod ID: M6ASITE074154 Click to Show/Hide the Full List
mod site chr6:26522020-26522021:+ [2]
Sequence GCCTGCCGGGCCTGGACGAAACCCCCGCCGAGCAGCCTGGA
Motif Score 2.185083333
Cell/Tissue List HeLa; HEK293T; A549; HepG2; H1A; H1B; MM6; CD4T; HEK293A-TOA; iSLK; MSC; endometrial; NB4
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000411553.3
External Link RMBase: m6A_site_709885
mod ID: M6ASITE074155 Click to Show/Hide the Full List
mod site chr6:26522238-26522239:+ [2]
Sequence CTCTGTCGCCATTGGGCGAGACCTACCTAGTCCTAACGACA
Motif Score 2.876744048
Cell/Tissue List HeLa; CD34; HEK293T; A549; HepG2; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; MM6; CD4T; HEK293A-TOA; iSLK; MSC; endometrial; NB4
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000411553.3
External Link RMBase: m6A_site_709886
mod ID: M6ASITE074156 Click to Show/Hide the Full List
mod site chr6:26522263-26522264:+ [2]
Sequence CCTAGTCCTAACGACAACGGACAAAGGCCTTAACGGGCCTG
Motif Score 3.643047619
Cell/Tissue List HeLa; CD34; HEK293T; A549; HepG2; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; MM6; CD4T; HEK293A-TOA; iSLK; MSC; endometrial; NB4
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000411553.3
External Link RMBase: m6A_site_709887
mod ID: M6ASITE074157 Click to Show/Hide the Full List
mod site chr6:26522360-26522361:+ [2]
Sequence GTTGGTCTCCGTACTACCAGACCTTGCTGTCGGAAGAGACA
Motif Score 2.876744048
Cell/Tissue List HeLa; HEK293T; A549; HepG2; H1A; H1B; hESCs; GM12878; MM6; CD4T; HEK293A-TOA; iSLK; MSC; endometrial; NB4
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000411553.3
External Link RMBase: m6A_site_709888
mod ID: M6ASITE074158 Click to Show/Hide the Full List
mod site chr6:26522378-26522379:+ [2]
Sequence AGACCTTGCTGTCGGAAGAGACAAATGGTAGAATGACAGGC
Motif Score 2.897386905
Cell/Tissue List HeLa; HEK293T; A549; HepG2; H1A; H1B; hESCs; GM12878; MM6; HEK293A-TOA; iSLK; MSC; endometrial; NB4
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000411553.3
External Link RMBase: m6A_site_709889
mod ID: M6ASITE074159 Click to Show/Hide the Full List
mod site chr6:26522521-26522522:+ [2]
Sequence CCCCAACCTTTTAATAGAAAACATTTGTCACATCTAGCCCT
Motif Score 2.20572619
Cell/Tissue List HeLa; HEK293T; HepG2; hNPCs; fibroblasts; A549; GM12878; MM6; Huh7; iSLK
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000411553.3
External Link RMBase: m6A_site_709890
mod ID: M6ASITE074160 Click to Show/Hide the Full List
mod site chr6:26522661-26522662:+ [2]
Sequence TCCGGAGTTGACTTTTGGAAACTGAGTTGTTAGACGGCCTC
Motif Score 2.627720238
Cell/Tissue List HeLa; HEK293T; HepG2; H1A; H1B; hNPCs; hESCs; fibroblasts; A549; GM12878; MM6; Huh7; HEK293A-TOA; iSLK; MSC; AML
Seq Type List m6A-seq; MeRIP-seq; miCLIP
Transcript ID List ENST00000411553.3
External Link RMBase: m6A_site_709891
mod ID: M6ASITE074161 Click to Show/Hide the Full List
mod site chr6:26522736-26522737:+ [2]
Sequence AGATGACATGGAGCTCGAAGACCTGAGAAGGAAAAAAAGAA
Motif Score 2.876744048
Cell/Tissue List HeLa; HEK293T; A549; HepG2; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; MM6; Huh7; HEK293A-TOA; iSLK; MSC
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000411553.3
External Link RMBase: m6A_site_709892
mod ID: M6ASITE074162 Click to Show/Hide the Full List
mod site chr6:26522770-26522771:+ [2]
Sequence AAAAGAAGGTTCTATGCTAGACTGGTCATATTTAGAAGACA
Motif Score 3.319380952
Cell/Tissue List HeLa; HEK293T; A549; HepG2; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; MM6; Huh7; HEK293A-TOA; iSLK; MSC
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000411553.3
External Link RMBase: m6A_site_709893
mod ID: M6ASITE074163 Click to Show/Hide the Full List
mod site chr6:26522788-26522789:+ [2]
Sequence AGACTGGTCATATTTAGAAGACATTTTCATATTCTATCCAT
Motif Score 2.897386905
Cell/Tissue List HeLa; HEK293T; brain; kidney; A549; HepG2; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; MM6; Huh7; HEK293A-TOA; iSLK; MSC
Seq Type List m6A-seq; MeRIP-seq; m6A-REF-seq
Transcript ID List ENST00000411553.3
External Link RMBase: m6A_site_709894
mod ID: M6ASITE074164 Click to Show/Hide the Full List
mod site chr6:26522934-26522935:+ [3]
Sequence TTAAAATTAGAGGTAGTAAAACCACATTTTGTAAATATCTT
Motif Score 2.185083333
Cell/Tissue List HEK293T; Huh7
Seq Type List MeRIP-seq
Transcript ID List ENST00000411553.3
External Link RMBase: m6A_site_709895
mod ID: M6ASITE074165 Click to Show/Hide the Full List
mod site chr6:26524437-26524438:+ [4]
Sequence ATGACAAAAGTAGTTAGTAAACTAACGCATTTTGTACACTT
Motif Score 2.627720238
Cell/Tissue List HEK293T
Seq Type List MeRIP-seq
Transcript ID List ENST00000411553.3
External Link RMBase: m6A_site_709896
mod ID: M6ASITE074166 Click to Show/Hide the Full List
mod site chr6:26524494-26524495:+ [2]
Sequence GAGGCTGTCTTCTGAAAAGGACTTTTTGGAAGTGAAATGAT
Motif Score 4.065041667
Cell/Tissue List HeLa; HEK293T; MSC
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000411553.3
External Link RMBase: m6A_site_709897
mod ID: M6ASITE074167 Click to Show/Hide the Full List
mod site chr6:26524985-26524986:+ [2]
Sequence TGTGCTGTGTATATAAGCAGACATAGGAGTCCTAATTTATA
Motif Score 2.897386905
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000411553.3
External Link RMBase: m6A_site_709898
mod ID: M6ASITE074168 Click to Show/Hide the Full List
mod site chr6:26525058-26525059:+ [2]
Sequence GGCAAAAGTAGAGTTAGTAAACTAATACATTGAGTACACTT
Motif Score 2.627720238
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000411553.3
External Link RMBase: m6A_site_709899
mod ID: M6ASITE074169 Click to Show/Hide the Full List
mod site chr6:26525099-26525100:+ [2]
Sequence TGTGTTAAAATTCATAAGGAACACTTCTTAAAAACAGAAGT
Motif Score 2.951386905
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000411553.3
External Link RMBase: m6A_site_709900
mod ID: M6ASITE074170 Click to Show/Hide the Full List
mod site chr6:26525112-26525113:+ [2]
Sequence ATAAGGAACACTTCTTAAAAACAGAAGTAAAATTGTTAAAC
Motif Score 2.20572619
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000411553.3
External Link RMBase: m6A_site_709901
mod ID: M6ASITE074171 Click to Show/Hide the Full List
mod site chr6:26525234-26525235:+ [2]
Sequence AGAATGTTCCTATTTAGAAGACACTCAAATTATAGTCTATG
Motif Score 2.897386905
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000411553.3
External Link RMBase: m6A_site_709902
mod ID: M6ASITE074172 Click to Show/Hide the Full List
mod site chr6:26525303-26525304:+ [2]
Sequence TACTGTGTATATAATGGAAAACTTAAGTGCAGTTTGAAACA
Motif Score 2.627720238
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000411553.3
External Link RMBase: m6A_site_709903
mod ID: M6ASITE074173 Click to Show/Hide the Full List
mod site chr6:26525567-26525568:+ [2]
Sequence GAATCGCTTGAGCCCGGGAGACAGAGGTTGCAGTAAGCCGA
Motif Score 2.897386905
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List rmsk_1898288; ENST00000411553.3
External Link RMBase: m6A_site_709904
mod ID: M6ASITE074174 Click to Show/Hide the Full List
mod site chr6:26525589-26525590:+ [2]
Sequence AGAGGTTGCAGTAAGCCGAGACCACACCACTGCACTCCAGC
Motif Score 2.876744048
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000411553.3; rmsk_1898288
External Link RMBase: m6A_site_709905
mod ID: M6ASITE074175 Click to Show/Hide the Full List
mod site chr6:26525626-26525627:+ [2]
Sequence CAGCATGGCGACAGAGCAAGACTCCATCTCAAAAAAAAAAA
Motif Score 3.319380952
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000411553.3; rmsk_1898288
External Link RMBase: m6A_site_709906
mod ID: M6ASITE074176 Click to Show/Hide the Full List
mod site chr6:26525761-26525762:+ [2]
Sequence TTGGGAATGGAATTGTTAAAACTTGATGCTTAGGAGCGTAT
Motif Score 2.627720238
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000411553.3
External Link RMBase: m6A_site_709907
mod ID: M6ASITE074177 Click to Show/Hide the Full List
mod site chr6:26526286-26526287:+ [2]
Sequence GGTGACAATGTGTGATAAAAACTAGAGCTAGTGGGCCAGGC
Motif Score 2.627720238
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000411553.3
External Link RMBase: m6A_site_709908
Pseudouridine (Pseudo)
In total 1 m6A sequence/site(s) in this target gene
mod ID: PSESITE000224 Click to Show/Hide the Full List
mod site chr6:26526714-26526715:+ [5]
Sequence TCAGGACTTGTTCATTAGGTTGGCAGCAGAGGGGCAGAAGG
Transcript ID List ENST00000411553.3
External Link RMBase: Pseudo_site_4086