m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00134)
Target Name microRNA 186 (MIR186)
Synonyms
MIR186; MIRN186; hsa-mir-186
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Gene Name MIR186
Chromosomal Location 1p31.1
Family MicroRNAs
Gene ID 406962
HGNC ID
HGNC:31557
miRBase ID
MI0000483
Ensembl Gene ID
ENSG00000207721
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
MIR186 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Methyltransferase-like 3 (METTL3) [WRITER]
 Regulator Info 
Representative RNA-seq result indicating the expression of this target gene regulated by METTL3
Cell Line mouse embryonic stem cells Mus musculus
Treatment: METTL3-/- ESCs
Control: Wild type ESCs
 GSE145309
Regulation
logFC: 8.42E-01
p-value: 2.96E-03
More Results Click to View More RNA-seq Results
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary microRNA 186 (MIR186)/METTL3 axis contributed to the progression of Hepatoblastoma via the Wnt/beta-catenin signalling pathway.
Target Regulation Down regulation
Responsed Disease Hepatoblastoma ICD-11: 2C12.01
 Disease Info 
Pathway Response Wnt signaling pathway hsa04310
Cell Process Cell aggressive
In-vitro Model HCCLM9 Adult hepatocellular carcinoma Homo sapiens CVCL_A5CU
HEK293 Normal Homo sapiens CVCL_0045
Hepa 1-6 Hepatocellular carcinoma of the mouse Mus musculus CVCL_0327
Hep-G2 Hepatoblastoma Homo sapiens CVCL_0027
HuH-6 Hepatoblastoma Homo sapiens CVCL_4381
In-vivo Model Cells transfected with miR-186 overexpression lentivirus (Lenti-miR-186), miR-186 inhibitor (Lenti-anti-miR-186), Lenti-miR-186 & METTL3 overexpression plasmid (Lenti-METTL3), Lenti-anti-miR-186 & METTL3 shRNA (sh-METTL3) or empty lentivirus control (Lenti-NC) were subcutaneously injected into the lower flank of nude mice.
Heterogeneous nuclear ribonucleoproteins C1/C2 (HNRNPC) [READER]
 Regulator Info 
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [2]
Response Summary HNRNPC, YTHDF, ZC3H13, YTHDC2, and METTL14 were dysregulated in esophageal cancer tissues. miR-186 interacted with HNRNPC and suppressed the expression of HNRNPC. Four miRNAs (microRNA 186 (MIR186), miR-320c, miR-320d, and miR-320b) were used to construct a prognostic signature, which could serve as a prognostic predictor independent from routine clinicopathological features.
Responsed Disease Esophageal cancer ICD-11: 2B70
 Disease Info 
In-vitro Model HEEC cell line (Normal esophageal epithelial cell line)
KYSE-30 Esophageal squamous cell carcinoma Homo sapiens CVCL_1351
TE-1 Esophageal squamous cell carcinoma Homo sapiens CVCL_1759
Esophageal cancer [ICD-11: 2B70]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [2]
Response Summary HNRNPC, YTHDF, ZC3H13, YTHDC2, and METTL14 were dysregulated in esophageal cancer tissues. miR-186 interacted with HNRNPC and suppressed the expression of HNRNPC. Four miRNAs (microRNA 186 (MIR186), miR-320c, miR-320d, and miR-320b) were used to construct a prognostic signature, which could serve as a prognostic predictor independent from routine clinicopathological features.
Responsed Disease Esophageal cancer [ICD-11: 2B70]
Target Regulator Heterogeneous nuclear ribonucleoproteins C1/C2 (HNRNPC) READER
 Regulator Info 
In-vitro Model HEEC cell line (Normal esophageal epithelial cell line)
KYSE-30 Esophageal squamous cell carcinoma Homo sapiens CVCL_1351
TE-1 Esophageal squamous cell carcinoma Homo sapiens CVCL_1759
Liver cancer [ICD-11: 2C12]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary microRNA 186 (MIR186)/METTL3 axis contributed to the progression of Hepatoblastoma via the Wnt/beta-catenin signalling pathway.
Responsed Disease Hepatoblastoma [ICD-11: 2C12.01]
Target Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
Target Regulation Down regulation
Pathway Response Wnt signaling pathway hsa04310
Cell Process Cell aggressive
In-vitro Model HCCLM9 Adult hepatocellular carcinoma Homo sapiens CVCL_A5CU
HEK293 Normal Homo sapiens CVCL_0045
Hepa 1-6 Hepatocellular carcinoma of the mouse Mus musculus CVCL_0327
Hep-G2 Hepatoblastoma Homo sapiens CVCL_0027
HuH-6 Hepatoblastoma Homo sapiens CVCL_4381
In-vivo Model Cells transfected with miR-186 overexpression lentivirus (Lenti-miR-186), miR-186 inhibitor (Lenti-anti-miR-186), Lenti-miR-186 & METTL3 overexpression plasmid (Lenti-METTL3), Lenti-anti-miR-186 & METTL3 shRNA (sh-METTL3) or empty lentivirus control (Lenti-NC) were subcutaneously injected into the lower flank of nude mice.
References
Ref 1 Cross talk between RNA N6-methyladenosine methyltransferase-like 3 and miR-186 regulates hepatoblastoma progression through Wnt/Beta-catenin signalling pathway. Cell Prolif. 2020 Mar;53(3):e12768. doi: 10.1111/cpr.12768. Epub 2020 Jan 22.
Ref 2 Network analysis of miRNA targeting m6A-related genes in patients with esophageal cancer. PeerJ. 2021 Jul 29;9:e11893. doi: 10.7717/peerj.11893. eCollection 2021.