m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00131)
Target Name microRNA 211 (MIR211)
Synonyms
MIR211; MIRN211; hsa-mir-211
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Gene Name MIR211
Chromosomal Location 15q13.3
Family MicroRNA MIR204/211 family
Gene ID 406993
HGNC ID
HGNC:31588
miRBase ID
MI0000287
Ensembl Gene ID
ENSG00000207702
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
MIR211 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1) [READER]
 Regulator Info 
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary Systematically analyzed 21 m6A regulators in adrenocortical carcinoma samples from The Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO) database. Taking the intersection of these mRNAs and 21 m6A-related genes as potential functional molecules, these data indicated that 12 lncRNAs can dysregulate the behavior of microRNA 211 (MIR211) so that it promotes the expression of key m6A gene HNRNPA2B1.
Responsed Disease Adrenocortical carcinoma ICD-11: 2D11
 Disease Info 
Methyltransferase-like 14 (METTL14) [WRITER]
 Regulator Info 
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [2]
Response Summary microRNA 211 (MIR211) is a novel tumor suppressor in T-cell lymphoblastic lymphoma,it regulated by METTL14. Targeting of miR-211/TCF12 axis is a potential treatment for T-cell lymphoblastic lymphoma patients.
Target Regulation Up regulation
Responsed Disease Lymphoma ICD-11: 2A70
 Disease Info 
In-vitro Model CCRF-CEM T acute lymphoblastic leukemia Homo sapiens CVCL_0207
H9 Sezary syndrome Homo sapiens CVCL_1240
Jurkat T acute lymphoblastic leukemia Homo sapiens CVCL_0065
SUP-T1 Childhood T lymphoblastic lymphoma Homo sapiens CVCL_1714
In-vivo Model Subcutaneously injected with 5 × 106 Jurkat cells and fed under Specific Pathogen Free (SPF) conditions. One week later, tumor mass was injected once a week with Agomir NC, Agomir-211, Antagomir NC and Antagomir 211, respectively, for three weeks.
Lymphoma [ICD-11: 2A70]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [2]
Response Summary microRNA 211 (MIR211) is a novel tumor suppressor in T-cell lymphoblastic lymphoma,it regulated by METTL14. Targeting of miR-211/TCF12 axis is a potential treatment for T-cell lymphoblastic lymphoma patients.
Responsed Disease Lymphoma [ICD-11: 2A70]
Target Regulator Methyltransferase-like 14 (METTL14) WRITER
 Regulator Info 
Target Regulation Up regulation
In-vitro Model CCRF-CEM T acute lymphoblastic leukemia Homo sapiens CVCL_0207
H9 Sezary syndrome Homo sapiens CVCL_1240
Jurkat T acute lymphoblastic leukemia Homo sapiens CVCL_0065
SUP-T1 Childhood T lymphoblastic lymphoma Homo sapiens CVCL_1714
In-vivo Model Subcutaneously injected with 5 × 106 Jurkat cells and fed under Specific Pathogen Free (SPF) conditions. One week later, tumor mass was injected once a week with Agomir NC, Agomir-211, Antagomir NC and Antagomir 211, respectively, for three weeks.
Adrenocortical carcinoma [ICD-11: 2D11]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary Systematically analyzed 21 m6A regulators in adrenocortical carcinoma samples from The Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO) database. Taking the intersection of these mRNAs and 21 m6A-related genes as potential functional molecules, these data indicated that 12 lncRNAs can dysregulate the behavior of microRNA 211 (MIR211) so that it promotes the expression of key m6A gene HNRNPA2B1.
Responsed Disease Adrenocortical carcinoma [ICD-11: 2D11]
Target Regulator Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1) READER
 Regulator Info 
References
Ref 1 Analysis of m6A-Related Signatures in the Tumor Immune Microenvironment and Identification of Clinical Prognostic Regulators in Adrenocortical Carcinoma. Front Immunol. 2021 Mar 3;12:637933. doi: 10.3389/fimmu.2021.637933. eCollection 2021.
Ref 2 MicroRNA-211 attenuates cell proliferation in T-cell lymphoblastic lymphoma through targeting TCF12. Leuk Res. 2021 Nov;110:106653. doi: 10.1016/j.leukres.2021.106653. Epub 2021 Jun 29.