m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00080)
Target Name LncRNA activating regulator of DKK1 (LNCAROD)
Synonyms
LNCAROD; LINC01468; long intergenic non-protein coding RNA 1468; lnc-MBL2-4; A-ROD; Activating Regulator of DKK1
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Gene Name LNCAROD
Chromosomal Location 10q21.1
Family Long non-coding RNAs with non-systematic symbols
Gene ID 101928687
HGNC ID
HGNC:50913
Ensembl Gene ID
ENSG00000231131
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
LNCAROD can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Methyltransferase-like 3 (METTL3) [WRITER]
 Regulator Info 
Representative RNA-seq result indicating the expression of this target gene regulated by METTL3
Cell Line Caco-2 cell line Homo sapiens
Treatment: shMETTL3 Caco-2 cells
Control: shNTC Caco-2 cells
 GSE167075
Regulation
logFC: 9.04E-01
p-value: 2.47E-45
More Results Click to View More RNA-seq Results
Representative RIP-seq result supporting the interaction between LNCAROD and the regulator
Cell Line MDA-MB-231 Homo sapiens
Regulation logFC: 5.11E+00 GSE60213
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary The N6-methyladenosine (m6A) modification mediated by METTL3 and METTL14 enhanced the stability of LncRNA activating regulator of DKK1 (LNCAROD) in head and neck squamous cell carcinoma cells. LNCAROD is stabilized by m6A methylation and promotes cancer progression via forming a ternary complex with HSPA1A and YBX1 in head and neck squamous cell carcinoma.
Target Regulation Up regulation
Responsed Disease Head and neck squamous carcinoma ICD-11: 2B6E
 Disease Info 
Pathway Response Proteasome hsa03050
Cell Process Proteasomal degradation
In-vitro Model C666-1 Nasopharyngeal carcinoma Homo sapiens CVCL_7949
CAL-27 Tongue squamous cell carcinoma Homo sapiens CVCL_1107
FaDu Hypopharyngeal squamous cell carcinoma Homo sapiens CVCL_1218
HK1 Nasopharyngeal carcinoma Acipenser baerii CVCL_YE27
NP69 (A human immortalized nasopharyngeal epithelial)
Tca8113 Endocervical adenocarcinoma Homo sapiens CVCL_6851
Methyltransferase-like 14 (METTL14) [WRITER]
 Regulator Info 
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary The N6-methyladenosine (m6A) modification mediated by METTL3 and METTL14 enhanced the stability of LncRNA activating regulator of DKK1 (LNCAROD) in head and neck squamous cell carcinoma cells. LNCAROD is stabilized by m6A methylation and promotes cancer progression via forming a ternary complex with HSPA1A and YBX1 in head and neck squamous cell carcinoma.
Target Regulation Up regulation
Responsed Disease Head and neck squamous carcinoma ICD-11: 2B6E
 Disease Info 
Pathway Response Proteasome hsa03050
Cell Process Proteasomal degradation
In-vitro Model C666-1 Nasopharyngeal carcinoma Homo sapiens CVCL_7949
CAL-27 Tongue squamous cell carcinoma Homo sapiens CVCL_1107
FaDu Hypopharyngeal squamous cell carcinoma Homo sapiens CVCL_1218
HK1 Nasopharyngeal carcinoma Acipenser baerii CVCL_YE27
NP69 (A human immortalized nasopharyngeal epithelial)
Tca8113 Endocervical adenocarcinoma Homo sapiens CVCL_6851
Head and neck squamous carcinoma [ICD-11: 2B6E]
 Disease Info 
In total 2 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary The N6-methyladenosine (m6A) modification mediated by METTL3 and METTL14 enhanced the stability of LncRNA activating regulator of DKK1 (LNCAROD) in head and neck squamous cell carcinoma cells. LNCAROD is stabilized by m6A methylation and promotes cancer progression via forming a ternary complex with HSPA1A and YBX1 in head and neck squamous cell carcinoma.
Responsed Disease Head and neck squamous carcinoma [ICD-11: 2B6E]
Target Regulator Methyltransferase-like 14 (METTL14) WRITER
 Regulator Info 
Target Regulation Up regulation
Pathway Response Proteasome hsa03050
Cell Process Proteasomal degradation
In-vitro Model C666-1 Nasopharyngeal carcinoma Homo sapiens CVCL_7949
CAL-27 Tongue squamous cell carcinoma Homo sapiens CVCL_1107
FaDu Hypopharyngeal squamous cell carcinoma Homo sapiens CVCL_1218
HK1 Nasopharyngeal carcinoma Acipenser baerii CVCL_YE27
NP69 (A human immortalized nasopharyngeal epithelial)
Tca8113 Endocervical adenocarcinoma Homo sapiens CVCL_6851
Experiment 2 Reporting the m6A-centered Disease Response [1]
Response Summary The N6-methyladenosine (m6A) modification mediated by METTL3 and METTL14 enhanced the stability of LncRNA activating regulator of DKK1 (LNCAROD) in head and neck squamous cell carcinoma cells. LNCAROD is stabilized by m6A methylation and promotes cancer progression via forming a ternary complex with HSPA1A and YBX1 in head and neck squamous cell carcinoma.
Responsed Disease Head and neck squamous carcinoma [ICD-11: 2B6E]
Target Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
Target Regulation Up regulation
Pathway Response Proteasome hsa03050
Cell Process Proteasomal degradation
In-vitro Model C666-1 Nasopharyngeal carcinoma Homo sapiens CVCL_7949
CAL-27 Tongue squamous cell carcinoma Homo sapiens CVCL_1107
FaDu Hypopharyngeal squamous cell carcinoma Homo sapiens CVCL_1218
HK1 Nasopharyngeal carcinoma Acipenser baerii CVCL_YE27
NP69 (A human immortalized nasopharyngeal epithelial)
Tca8113 Endocervical adenocarcinoma Homo sapiens CVCL_6851
Liver cancer [ICD-11: 2C12]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response []
Response Summary LncRNA activating regulator of DKK1 (LNCAROD) induces PKM2 upregulation via simultaneously enhancing SRSF3-mediated PKM switching to PKM2 and sponging miR-145-5p to increase PKM2 level, eventually increasing hepatocellular carcinoma cell aerobic glycolysis to participate in tumor malignancy and chemoresistance, especially under hypoxic microenvironment.
Responsed Disease Hepatocellular carcinoma [ICD-11: 2C12.02]
Pathway Response Glycolysis / Gluconeogenesis hsa00010
Cell Process Aerobic glycolysis
In-vitro Model ()
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In-vivo Model HCC-LM3 cells with silenced LNCAROD or the negative control were subcutaneously injected into the flank region of the mice at 2 × 106 cells.
References
Ref 1 LNCAROD is stabilized by m6A methylation and promotes cancer progression via forming a ternary complex with HSPA1A and YBX1 in head and neck squamous cell carcinoma. Mol Oncol. 2020 Jun;14(6):1282-1296. doi: 10.1002/1878-0261.12676. Epub 2020 Apr 13.