m6A Target Gene Information
General Information of the m6A Target Gene (ID: M6ATAR00067)
Target Name | hsa_circ_0008399 | ||||
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Synonyms |
hsa-circ-0008399
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Gene Name | hsa_circ_0008399 |
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
hsa_circ_0008399
can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
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Methyltransferase-like 14 (METTL14) [WRITER]
In total 1 item(s) under this regulator | ||||
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene | [1] | |||
Response Summary | Circ0008399 bound WTAP to promote formation of the WTAP/METTL3/METTL14 m6A methyltransferase complex, reduce cisplatin sensitivity in bladder cancer, implicating the potential therapeutic value of targeting this axis. | |||
Target Regulation | Up regulation | |||
Responsed Disease | Bladder cancer | ICD-11: 2C94 | ||
Responsed Drug | Cisplatin | Approved | ||
Pathway Response | Protein export | hsa03060 | ||
Cell Process | Eukaryotic translation | |||
Cell apoptosis | ||||
In-vitro Model | 5637 | Bladder carcinoma | Homo sapiens | CVCL_0126 |
RT-4 | Bladder carcinoma | Homo sapiens | CVCL_0036 | |
UM-UC-3 | Bladder carcinoma | Homo sapiens | CVCL_1783 | |
In-vivo Model | Chose 4-week-old female BALB/c nude mice for tumor xenograft experiments, which randomly were divided into four groups (n = 5 per group). Bladder cancer cells (3 × 106) were subcutaneously injected into the right axilla of the nude mice. | |||
Methyltransferase-like 3 (METTL3) [WRITER]
In total 1 item(s) under this regulator | ||||
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene | [1] | |||
Response Summary | Circ0008399 bound WTAP to promote formation of the WTAP/METTL3/METTL14 m6A methyltransferase complex, reduce cisplatin sensitivity in bladder cancer, implicating the potential therapeutic value of targeting this axis. | |||
Target Regulation | Up regulation | |||
Responsed Disease | Bladder cancer | ICD-11: 2C94 | ||
Responsed Drug | Cisplatin | Approved | ||
Pathway Response | Protein export | hsa03060 | ||
Cell Process | Eukaryotic translation | |||
Cell apoptosis | ||||
In-vitro Model | 5637 | Bladder carcinoma | Homo sapiens | CVCL_0126 |
RT-4 | Bladder carcinoma | Homo sapiens | CVCL_0036 | |
UM-UC-3 | Bladder carcinoma | Homo sapiens | CVCL_1783 | |
In-vivo Model | Chose 4-week-old female BALB/c nude mice for tumor xenograft experiments, which randomly were divided into four groups (n = 5 per group). Bladder cancer cells (3 × 106) were subcutaneously injected into the right axilla of the nude mice. | |||
Wilms tumor 1-associating protein (WTAP) [WRITER]
In total 1 item(s) under this regulator | ||||
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene | [1] | |||
Response Summary | Circ0008399 bound WTAP to promote formation of the WTAP/METTL3/METTL14 m6A methyltransferase complex, reduce cisplatin sensitivity in bladder cancer, implicating the potential therapeutic value of targeting this axis. | |||
Target Regulation | Up regulation | |||
Responsed Disease | Bladder cancer | ICD-11: 2C94 | ||
Responsed Drug | Cisplatin | Approved | ||
Pathway Response | Protein export | hsa03060 | ||
Cell Process | Eukaryotic translation | |||
Cell apoptosis | ||||
In-vitro Model | 5637 | Bladder carcinoma | Homo sapiens | CVCL_0126 |
RT-4 | Bladder carcinoma | Homo sapiens | CVCL_0036 | |
UM-UC-3 | Bladder carcinoma | Homo sapiens | CVCL_1783 | |
In-vivo Model | Chose 4-week-old female BALB/c nude mice for tumor xenograft experiments, which randomly were divided into four groups (n = 5 per group). Bladder cancer cells (3 × 106) were subcutaneously injected into the right axilla of the nude mice. | |||
Bladder cancer [ICD-11: 2C94]
In total 3 item(s) under this disease | ||||
Experiment 1 Reporting the m6A-centered Disease Response | [1] | |||
Response Summary | Circ0008399 bound WTAP to promote formation of the WTAP/METTL3/METTL14 m6A methyltransferase complex, reduce cisplatin sensitivity in bladder cancer, implicating the potential therapeutic value of targeting this axis. | |||
Responsed Disease | Bladder cancer [ICD-11: 2C94] | |||
Target Regulator | Methyltransferase-like 14 (METTL14) | WRITER | ||
Target Regulation | Up regulation | |||
Responsed Drug | Cisplatin | Approved | ||
Pathway Response | Protein export | hsa03060 | ||
Cell Process | Eukaryotic translation | |||
Cell apoptosis | ||||
In-vitro Model | 5637 | Bladder carcinoma | Homo sapiens | CVCL_0126 |
RT-4 | Bladder carcinoma | Homo sapiens | CVCL_0036 | |
UM-UC-3 | Bladder carcinoma | Homo sapiens | CVCL_1783 | |
In-vivo Model | Chose 4-week-old female BALB/c nude mice for tumor xenograft experiments, which randomly were divided into four groups (n = 5 per group). Bladder cancer cells (3 × 106) were subcutaneously injected into the right axilla of the nude mice. | |||
Experiment 2 Reporting the m6A-centered Disease Response | [1] | |||
Response Summary | Circ0008399 bound WTAP to promote formation of the WTAP/METTL3/METTL14 m6A methyltransferase complex, reduce cisplatin sensitivity in bladder cancer, implicating the potential therapeutic value of targeting this axis. | |||
Responsed Disease | Bladder cancer [ICD-11: 2C94] | |||
Target Regulator | Methyltransferase-like 3 (METTL3) | WRITER | ||
Target Regulation | Up regulation | |||
Responsed Drug | Cisplatin | Approved | ||
Pathway Response | Protein export | hsa03060 | ||
Cell Process | Eukaryotic translation | |||
Cell apoptosis | ||||
In-vitro Model | 5637 | Bladder carcinoma | Homo sapiens | CVCL_0126 |
RT-4 | Bladder carcinoma | Homo sapiens | CVCL_0036 | |
UM-UC-3 | Bladder carcinoma | Homo sapiens | CVCL_1783 | |
In-vivo Model | Chose 4-week-old female BALB/c nude mice for tumor xenograft experiments, which randomly were divided into four groups (n = 5 per group). Bladder cancer cells (3 × 106) were subcutaneously injected into the right axilla of the nude mice. | |||
Experiment 3 Reporting the m6A-centered Disease Response | [1] | |||
Response Summary | Circ0008399 bound WTAP to promote formation of the WTAP/METTL3/METTL14 m6A methyltransferase complex, reduce cisplatin sensitivity in bladder cancer, implicating the potential therapeutic value of targeting this axis. | |||
Responsed Disease | Bladder cancer [ICD-11: 2C94] | |||
Target Regulator | Wilms tumor 1-associating protein (WTAP) | WRITER | ||
Target Regulation | Up regulation | |||
Responsed Drug | Cisplatin | Approved | ||
Pathway Response | Protein export | hsa03060 | ||
Cell Process | Eukaryotic translation | |||
Cell apoptosis | ||||
In-vitro Model | 5637 | Bladder carcinoma | Homo sapiens | CVCL_0126 |
RT-4 | Bladder carcinoma | Homo sapiens | CVCL_0036 | |
UM-UC-3 | Bladder carcinoma | Homo sapiens | CVCL_1783 | |
In-vivo Model | Chose 4-week-old female BALB/c nude mice for tumor xenograft experiments, which randomly were divided into four groups (n = 5 per group). Bladder cancer cells (3 × 106) were subcutaneously injected into the right axilla of the nude mice. | |||
Cisplatin
[Approved]
In total 3 item(s) under this drug | ||||
Experiment 1 Reporting the m6A-centered Drug Response | [1] | |||
Response Summary | Circ0008399 bound WTAP to promote formation of the WTAP/METTL3/METTL14 m6A methyltransferase complex, reduce cisplatin sensitivity in bladder cancer, implicating the potential therapeutic value of targeting this axis. | |||
Target Regulator | Methyltransferase-like 14 (METTL14) | WRITER | ||
Target Regulation | Up regulation | |||
Responsed Disease | Bladder cancer | ICD-11: 2C94 | ||
Pathway Response | Protein export | hsa03060 | ||
Cell Process | Eukaryotic translation | |||
Cell apoptosis | ||||
In-vitro Model | 5637 | Bladder carcinoma | Homo sapiens | CVCL_0126 |
RT-4 | Bladder carcinoma | Homo sapiens | CVCL_0036 | |
UM-UC-3 | Bladder carcinoma | Homo sapiens | CVCL_1783 | |
In-vivo Model | Chose 4-week-old female BALB/c nude mice for tumor xenograft experiments, which randomly were divided into four groups (n = 5 per group). Bladder cancer cells (3 × 106) were subcutaneously injected into the right axilla of the nude mice. | |||
Experiment 2 Reporting the m6A-centered Drug Response | [1] | |||
Response Summary | Circ0008399 bound WTAP to promote formation of the WTAP/METTL3/METTL14 m6A methyltransferase complex, reduce cisplatin sensitivity in bladder cancer, implicating the potential therapeutic value of targeting this axis. | |||
Target Regulator | Methyltransferase-like 3 (METTL3) | WRITER | ||
Target Regulation | Up regulation | |||
Responsed Disease | Bladder cancer | ICD-11: 2C94 | ||
Pathway Response | Protein export | hsa03060 | ||
Cell Process | Eukaryotic translation | |||
Cell apoptosis | ||||
In-vitro Model | 5637 | Bladder carcinoma | Homo sapiens | CVCL_0126 |
RT-4 | Bladder carcinoma | Homo sapiens | CVCL_0036 | |
UM-UC-3 | Bladder carcinoma | Homo sapiens | CVCL_1783 | |
In-vivo Model | Chose 4-week-old female BALB/c nude mice for tumor xenograft experiments, which randomly were divided into four groups (n = 5 per group). Bladder cancer cells (3 × 106) were subcutaneously injected into the right axilla of the nude mice. | |||
Experiment 3 Reporting the m6A-centered Drug Response | [1] | |||
Response Summary | Circ0008399 bound WTAP to promote formation of the WTAP/METTL3/METTL14 m6A methyltransferase complex, reduce cisplatin sensitivity in bladder cancer, implicating the potential therapeutic value of targeting this axis. | |||
Target Regulator | Wilms tumor 1-associating protein (WTAP) | WRITER | ||
Target Regulation | Up regulation | |||
Responsed Disease | Bladder cancer | ICD-11: 2C94 | ||
Pathway Response | Protein export | hsa03060 | ||
Cell Process | Eukaryotic translation | |||
Cell apoptosis | ||||
In-vitro Model | 5637 | Bladder carcinoma | Homo sapiens | CVCL_0126 |
RT-4 | Bladder carcinoma | Homo sapiens | CVCL_0036 | |
UM-UC-3 | Bladder carcinoma | Homo sapiens | CVCL_1783 | |
In-vivo Model | Chose 4-week-old female BALB/c nude mice for tumor xenograft experiments, which randomly were divided into four groups (n = 5 per group). Bladder cancer cells (3 × 106) were subcutaneously injected into the right axilla of the nude mice. | |||