m6A-centered Disease Response Information
General Information of the Disease (ID: M6ADIS0178)
Name |
Acute viral hepatitis
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ICD |
ICD-11: 1E50
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Full List of Target Gene(s) of This m6A-centered Disease Response
RIG-I-like receptor 1 (RIG-I)
In total 4 item(s) under this target gene | ||||
Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene | [1] | |||
Response Summary | METTL3 and METTL14 leads to an increase in viral RNA recognition by RIG-I-like receptor 1 (RIG-I), thereby stimulating type I interferon production. The obvious advantage is that m6A deficiency in HBV and HCV induces a higher IFN synthesis and in turn enhance adaptive immunity. | |||
Responsed Disease | Acute hepatitis B [ICD-11: 1E50.1] | |||
Target Regulator | Methyltransferase-like 3 (METTL3) | WRITER | ||
Target Regulation | Down regulation | |||
Pathway Response | RIG-I-like receptor signaling pathway | hsa04622 | ||
In-vitro Model | Huh-7 | Adult hepatocellular carcinoma | Homo sapiens | CVCL_0336 |
Hep-G2 | Hepatoblastoma | Homo sapiens | CVCL_0027 | |
Experiment 2 Reporting the m6A-centered Disease Response by This Target Gene | [1] | |||
Response Summary | METTL3 and METTL14 leads to an increase in viral RNA recognition by RIG-I-like receptor 1 (RIG-I), thereby stimulating type I interferon production. The obvious advantage is that m6A deficiency in HBV and HCV induces a higher IFN synthesis and in turn enhance adaptive immunity. | |||
Responsed Disease | Acute hepatitis B [ICD-11: 1E50.1] | |||
Target Regulator | Methyltransferase-like 14 (METTL14) | WRITER | ||
Target Regulation | Down regulation | |||
Pathway Response | RIG-I-like receptor signaling pathway | hsa04622 | ||
In-vitro Model | Huh-7 | Adult hepatocellular carcinoma | Homo sapiens | CVCL_0336 |
Hep-G2 | Hepatoblastoma | Homo sapiens | CVCL_0027 | |
Experiment 3 Reporting the m6A-centered Disease Response by This Target Gene | [1] | |||
Response Summary | METTL3 and METTL14 leads to an increase in viral RNA recognition by RIG-I-like receptor 1 (RIG-I), thereby stimulating type I interferon production. The obvious advantage is that m6A deficiency in HBV and HCV induces a higher IFN synthesis and in turn enhance adaptive immunity. | |||
Responsed Disease | Acute hepatitis C [ICD-11: 1E50.2] | |||
Target Regulator | Methyltransferase-like 3 (METTL3) | WRITER | ||
Target Regulation | Down regulation | |||
Pathway Response | RIG-I-like receptor signaling pathway | hsa04622 | ||
In-vitro Model | Huh-7 | Adult hepatocellular carcinoma | Homo sapiens | CVCL_0336 |
Hep-G2 | Hepatoblastoma | Homo sapiens | CVCL_0027 | |
Experiment 4 Reporting the m6A-centered Disease Response by This Target Gene | [1] | |||
Response Summary | METTL3 and METTL14 leads to an increase in viral RNA recognition by RIG-I-like receptor 1 (RIG-I), thereby stimulating type I interferon production. The obvious advantage is that m6A deficiency in HBV and HCV induces a higher IFN synthesis and in turn enhance adaptive immunity. | |||
Responsed Disease | Acute hepatitis C [ICD-11: 1E50.2] | |||
Target Regulator | Methyltransferase-like 14 (METTL14) | WRITER | ||
Target Regulation | Down regulation | |||
Pathway Response | RIG-I-like receptor signaling pathway | hsa04622 | ||
In-vitro Model | Huh-7 | Adult hepatocellular carcinoma | Homo sapiens | CVCL_0336 |
Hep-G2 | Hepatoblastoma | Homo sapiens | CVCL_0027 | |