m6A-centered Disease Response Information

General Information of the Disease (ID: M6ADIS0162)
Name
Pre-eclampsia
ICD
ICD-11: JA24
Full List of Target Gene(s) of This m6A-centered Disease Response
Forkhead box protein O3 (FOXO3)
 Target Info 
In total 1 item(s) under this target gene
Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene [1]
Response Summary Global RNA m6A methylation and METTL14 expression were significantly increased in placental tissues obtained from patients with preeclampsia. Forkhead box protein O3 (FOXO3) inhibition effectively prevented the impairment of trophoblast proliferation and invasion, and diminished the induction of trophoblast autophagy and apoptosis in METTL14-overexpressing HTR-8/SVneo cells.
Responsed Disease Pre-eclampsia [ICD-11: JA24]
Target Regulator Methyltransferase-like 14 (METTL14) WRITER
 Regulator Info 
Target Regulation Up regulation
Cell Process Cell autophagy
In-vitro Model HTR-8/SVneo Normal Homo sapiens CVCL_7162
HTR-8 Normal Homo sapiens CVCL_D728
Heat shock 70 kDa protein 1A (HSPA1A)
 Target Info 
In total 2 item(s) under this target gene
Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene [2]
Response Summary Findings show that METTL3 and METTL14 were up-regulated in preeclampsia(PE). Heat shock 70 kDa protein 1A (HSPA1A) is involved in the pathophysiology of PE as its mRNA and protein expression is regulated by m6A modification.
Responsed Disease Pre-eclampsia [ICD-11: JA24]
Target Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
Target Regulation Up regulation
Pathway Response Wnt signaling pathway hsa04310
mTOR signaling pathway hsa04150
Experiment 2 Reporting the m6A-centered Disease Response by This Target Gene [2]
Response Summary Findings show that METTL3 and METTL14 were up-regulated in preeclampsia(PE). Heat shock 70 kDa protein 1A (HSPA1A) is involved in the pathophysiology of PE as its mRNA and protein expression is regulated by m6A modification.
Responsed Disease Pre-eclampsia [ICD-11: JA24]
Target Regulator Methyltransferase-like 14 (METTL14) WRITER
 Regulator Info 
Target Regulation Up regulation
Pathway Response Wnt signaling pathway hsa04310
mTOR signaling pathway hsa04150
References
Ref 1 Upregulation of METTL14 contributes to trophoblast dysfunction by elevating FOXO3a expression in an m(6)A-dependent manner. Placenta. 2022 Jun 24;124:18-27. doi: 10.1016/j.placenta.2022.05.008. Epub 2022 May 14.
Ref 2 Integrated analysis of the transcriptome-wide m6A methylome in preeclampsia and healthy control placentas. PeerJ. 2020 Sep 15;8:e9880. doi: 10.7717/peerj.9880. eCollection 2020.