m6A-centered Disease Response Information
General Information of the Disease (ID: M6ADIS0159)
Name |
Injury of heart
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ICD |
ICD-11: NB31
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Full List of Target Gene(s) of This m6A-centered Disease Response
miR-503
In total 1 item(s) under this target gene | ||||
Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene | [1] | |||
Response Summary | Hypoxia induced rapid H3K4 methylation of the promoter of the methyltransferase-like 3 gene (METTL3) and resulted in its overexpression. METTL3 overexpression evokes N6-methyladenosine (m6A)-dependent miR-503 biogenesis in endothelial cells. In summary, this study highlights a novel endogenous mechanism wherein EVs aggravate myocardial injury during the onset of AMI via endothelial cell-secreted miR-503 shuttling. | |||
Responsed Disease | Myocardial injury [ICD-11: NB31.Z] | |||
Target Regulator | Methyltransferase-like 3 (METTL3) | WRITER | ||
Target Regulation | Up regulation | |||
Cell Process | Mitochondrial metabolic dysfunction | |||
In-vivo Model | To generate an AMI mouse model, mice were anesthetised by intraperitoneal injection of sterile pentobarbital sodium at 50 mg/kg body weight. | |||