m6A-centered Disease Response Information
General Information of the Disease (ID: M6ADIS0154)
| Name |
Infantile hemangioma
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|---|---|---|---|---|---|
| ICD |
ICD-11: 2E81
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Full List of Target Gene(s) of This m6A-centered Disease Response
Nuclear paraspeckle assembly transcript 1 (NEAT1)
| In total 1 item(s) under this target gene | ||||
| Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene | [1] | |||
| Response Summary | ALKBH5 knockdown suppressed cell proliferation, migration and invasion of infantile hemangioma cells, while promoting cell apoptosis. ALKBH5 promoted lncRNA Nuclear paraspeckle assembly transcript 1 (NEAT1) expression by reducing the m6A modification of lncRNA NEAT1. | |||
| Responsed Disease | Infantile hemangioma [ICD-11: 2E+81] | |||
| Target Regulator | RNA demethylase ALKBH5 (ALKBH5) | ERASER | ||
| Target Regulation | Up regulation | |||
| Cell Process | Cell proliferation | |||
| Cell migration | ||||
| Cell invasion | ||||
| Cell apoptosis | ||||
| In-vitro Model | XPTS-1 | Infantile hemangioma | Homo sapiens | CVCL_9U60 |
| HEK293T | Normal | Homo sapiens | CVCL_0063 | |