m6A-centered Disease Response Information

General Information of the Disease (ID: M6ADIS0145)
Name
Herpes infection
ICD
ICD-11: 1F00
Full List of Target Gene(s) of This m6A-centered Disease Response
Forkhead box protein O1 (FOXO1)
 Target Info 
In total 1 item(s) under this target gene
Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene [1]
Response Summary METTL14 promotes Forkhead box protein O1 (FOXO1) expression by enhancing its m6A modification and inducing endothelial cell inflammatory response as well as atherosclerotic plaque formation.
Responsed Disease Herpes infection [ICD-11: 1F00]
Target Regulator Methyltransferase-like 14 (METTL14) WRITER
 Regulator Info 
Target Regulation Up regulation
Pathway Response FoxO signaling pathway hsa04068
In-vitro Model HUVEC-C Normal Homo sapiens CVCL_2959
In-vivo Model METTL14+/- mice are generated by mating wild-type mice (C57/BL6 background) with METTL14+/- mice. METTL14+/-/APOE-/- healthy offspring mice are produced by heterozygous METTL14+/- mice and heterozygous APOE-/- mice by Mendelian ratios. APOE-/- mice and C57/BL6 mice were purchased from Model Animal Research Center of Nanjing (Nanjing, Jiangsu, China). All mice were housed in the Laboratory Animals Center of the Henan Provincial People's Hospital, with controlled temperature and humidity and a 12:12-hour dark-light cycle, and were provided water and mouse chow ad libitum.
Mammalian target of rapamycin complex 2 (mTORC2)
 Target Info 
In total 1 item(s) under this target gene
Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene [2]
Response Summary METTL3 knockdown suppressed the HSV-1 intermediate early and early genes (ICP0, ICP8 and UL23) and late genes (VP16, UL44, UL49 and ICP47). The components of m6A modification machinery, particularly m6A initiator METTL3 and reader YTHDF3, would be potential important targets for combating herpes virus type 1 (HSV-1) infections.
Responsed Disease Herpes infection [ICD-11: 1F00]
Target Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
In-vitro Model HeLa Endocervical adenocarcinoma Homo sapiens CVCL_0030
RD Embryonal rhabdomyosarcoma Homo sapiens CVCL_1649
References
Ref 1 METTL14 aggravates endothelial inflammation and atherosclerosis by increasing FOXO1 N6-methyladeosine modifications. Theranostics. 2020 Jul 11;10(20):8939-8956. doi: 10.7150/thno.45178. eCollection 2020.
Ref 2 Targeting m6A modification inhibits herpes virus 1 infection. Genes Dis. 2021 Feb 22;9(4):1114-1128. doi: 10.1016/j.gendis.2021.02.004. eCollection 2022 Jul.