m6A-centered Disease Response Information

General Information of the Disease (ID: M6ADIS0126)
Name
Effects of heat
ICD
ICD-11: NF01
Full List of Target Gene(s) of This m6A-centered Disease Response
Heat shock 70 kDa protein 1A (HSPA1A)
 Target Info 
In total 1 item(s) under this target gene
Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene [1]
Response Summary Heat directly binds to Heat shock 70 kDa protein 1A (HSPA1A), thereby targeting stress genes in a trans-acting manner. Intriguingly, Heat is heavily methylated in the form of m6A. Heat mediates these effects via the nuclear m6A reader YTHDC1, forming a transcriptional silencing complex for stress genes. Reveals a crucial role of nuclear epitranscriptome in the transcriptional regulation of heat shock response.
Responsed Disease Effects of heat [ICD-11: NF01]
Target Regulator YTH domain-containing protein 1 (YTHDC1) READER
 Regulator Info 
Target Regulation Down regulation
Pathway Response RNA degradation hsa03018
In-vitro Model HeLa Endocervical adenocarcinoma Homo sapiens CVCL_0030
MEF (Mouse embryonic fibroblasts)
References
Ref 1 A heat shock-responsive lncRNA Heat acts as a HSF1-directed transcriptional brake via m(6)A modification. Proc Natl Acad Sci U S A. 2021 Jun 22;118(25):e2102175118. doi: 10.1073/pnas.2102175118.