m6A-centered Disease Response Information
General Information of the Disease (ID: M6ADIS0072)
| Name |
Melanoma of uvea
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|---|---|---|---|---|---|
| ICD |
ICD-11: 2D0Y
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Full List of Target Gene(s) of This m6A-centered Disease Response
Forkhead box protein M1 (FOXM1)
| In total 1 item(s) under this target gene | ||||
| Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene | [1] | |||
| Response Summary | AKLBH5-induced m6A demethylation of Forkhead box protein M1 (FOXM1) mRNA promotes uveal melanoma progression. | |||
| Responsed Disease | Melanoma of uvea [ICD-11: 2D0Y] | |||
| Target Regulator | RNA demethylase ALKBH5 (ALKBH5) | ERASER | ||
| Target Regulation | Up regulation | |||
| Cell Process | Cell proliferation | |||
| Cell migration | ||||
| Cell invasion | ||||
| Cell apoptosis | ||||
| In-vitro Model | ARPE-19 | Normal | Homo sapiens | CVCL_0145 |
| C918 | Uveal melanoma | Homo sapiens | CVCL_8471 | |
| MuM-2B | Uveal melanoma | Homo sapiens | CVCL_3447 | |
| In-vivo Model | The in vivo experiment method for transplantation of tumors was subcutaneous injection of 1 × 107 ALKBH5-stable knockdown C918 cells into BALB/c nude mice. | |||
Hepatocyte growth factor receptor (c-Met/MET)
| In total 1 item(s) under this target gene | ||||
| Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene | [2] | |||
| Response Summary | METTL3-mediated m6A RNA methylation modulates uveal melanoma cell proliferation, migration, and invasion by targeting Hepatocyte growth factor receptor (c-Met/MET). Cycloleucine (Cyc) was used to block m6 A methylation in UM cells. | |||
| Responsed Disease | Melanoma of uvea [ICD-11: 2D0Y] | |||
| Target Regulator | Methyltransferase-like 3 (METTL3) | WRITER | ||
| Target Regulation | Up regulation | |||
| Pathway Response | Cell cycle | hsa04110 | ||
| Cell Process | Cell proliferation | |||
| Cell migration | ||||
| Cell invasion | ||||
| Arrest cell cycle at G1 phase | ||||
| In-vitro Model | M17 (Neuroblastoma cells) | |||
| M21 | Melanoma | Homo sapiens | CVCL_D031 | |
| M23 | Cutaneous melanoma | Homo sapiens | CVCL_RT32 | |
| SP-6.5 | Uveal melanoma | Homo sapiens | CVCL_7997 | |
Mammalian target of rapamycin complex 1 (mTORC1)
| In total 1 item(s) under this target gene | ||||
| Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene | [3] | |||
| Response Summary | m6A RNA methylation regulators take a crucial role in the potential malignant progression and prognostic value of uveal melanoma and were regarded as a new promising biomarker for UM prognosis and treatment strategy development. The malignant hallmarks of Mammalian target of rapamycin complex 1 (mTORC1) signaling, oxidative phosphorylation, interferon-a response and apoptosis signaling are also significantly enriched in the C1 subtype. | |||
| Responsed Disease | Melanoma of uvea [ICD-11: 2D0Y] | |||
| Pathway Response | mTOR signaling pathway | hsa04150 | ||
| Cell Process | Oxidative phosphorylation | |||
| Cell apoptosis | ||||
References