General Information of the Disease (ID: M6ADIS0033)
Name
Diabetic skin lesions
ICD
ICD-11: EB90
Full List of Target Gene(s) of This m6A-centered Disease Response
Sequestosome-1 (SQSTM1)
In total 1 item(s) under this target gene
Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene [1]
Response Summary In diabetes/diabetic skin, YTHDC1 interacted and cooperated with ELAVL1/HuR (ELAV like RNA binding protein 1) in modulating the expression of Sequestosome-1 (SQSTM1).
Responsed Disease Diabetic skin lesions [ICD-11: EB90.0]
Target Regulator YTH domain-containing protein 1 (YTHDC1) READER
Target Regulation Up regulation
Pathway Response Autophagy hsa04140
Cell Process Cellular Processes
Cellular Transport
Cellular catabolism
Cell apoptosis
Cell autophagy
In-vitro Model HaCaT Normal Homo sapiens CVCL_0038
NHEK (Normal human epithelial keratinocytes)
In-vivo Model The WT-si-NC, WT-si-Ythdc1 and WT-si-Sqstm1 groups were intracutaneously injected with corresponding siRNAs (si-NC, si-Ythdc1, or si-Sqstm1, 2.5 nmol) on the circle.
References
Ref 1 m(6)A reader YTHDC1 modulates autophagy by targeting SQSTM1 in diabetic skin. Autophagy. 2022 Jun;18(6):1318-1337. doi: 10.1080/15548627.2021.1974175. Epub 2021 Oct 17.