Name	Ovarian dysfunction
ICD	ICD-11: 5A80

In total 1 item(s) under this target gene
Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene				[1]
Response Summary	FTO induced the dysfunctions of GCs by upregulating Flotillin-2 (FLOT2), suggesting that FTO/FLOT2 plays a role in the pathophysiology of polycystic ovarian syndrome.
Responsed Disease	Polycystic ovary syndrome [ICD-11: 5A80.1]
Target Regulator	Fat mass and obesity-associated protein (FTO)		ERASER	Regulator Info
Target Regulation	Up regulation
Cell Process	Cell apoptosis
In-vitro Model	KGN	Ovarian granulosa cell tumor	Homo sapiens	CVCL_0375

In total 1 item(s) under this target gene
Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene				[2]
Response Summary	Altered m6 A modification was involved in up-regulated expression of Forkhead box protein O3 (FOXO3) mRNA in the luteinized granulosa cells from non-obese polycystic ovary syndrome patients following controlled ovarian hyperstimulation.
Responsed Disease	Ovarian dysfunction [ICD-11: 5A80]
Pathway Response	FoxO signaling pathway			hsa04068
In-vitro Model	Granulosa cell (A group of somatic cells in the follicle that interact with the oocyte and promote oogenesis)

In total 1 item(s) under this target gene
Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene				[3]
Response Summary	METTL3 targets Intersectin-2 (ITSN2) for m6A modification and then enhances its stability to influence the oocytes meiosis. mRNA m6A modification in follicle development and coordination of RNA stabilization during oocyte growth.
Responsed Disease	Ovarian dysfunction [ICD-11: 5A80]
Target Regulator	Methyltransferase-like 3 (METTL3)		WRITER	Regulator Info
Target Regulation	Up regulation
In-vivo Model	All mice described above were maintained on the C57BL/6 J background. Mice lacking Mettl3 in oocytes (referred to as Mettl3Gdf9 cKO) were generated by crossing Mettl3flox/flox mice with Gdf9-Cre mice. The Mettl3flox/flox female mice were used as the control group (referred to as WT). For the fertility test, six pairs of 6 weeks Mettl3flox/flox and Mettl3Gdf9 cKO female mice were randomly selected and continually mated to Mettl3flox/flox male mice which have been confirmed fertility for 5 months. The number of pups and litter size from each female was recorded.

In total 1 item(s) under this target gene
Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene				[4]
Response Summary	Correlation analysis indicated that Mimecan (OGN) function is closely related to m6A and ferroptosis. The hub gene OGN represent a significant gene involved in OC and PCOS progression by regulating the hormonal response.
Responsed Disease	Polycystic ovary syndrome [ICD-11: 5A80.1]
Cell Process	Hormonal response
In-vitro Model	SK-OV-3	Ovarian serous cystadenocarcinoma	Homo sapiens	CVCL_0532
	KGN	Ovarian granulosa cell tumor	Homo sapiens	CVCL_0375

Ref 1	N6-methyladenosine Demethylase FTO Induces the Dysfunctions of Ovarian Granulosa Cells by Upregulating Flotillin 2. Reprod Sci. 2022 Apr;29(4):1305-1315. doi: 10.1007/s43032-021-00664-6. Epub 2021 Jul 12.
Ref 2	Altered m(6) A modification is involved in up-regulated expression of FOXO3 in luteinized granulosa cells of non-obese polycystic ovary syndrome patients. J Cell Mol Med. 2020 Oct;24(20):11874-11882. doi: 10.1111/jcmm.15807. Epub 2020 Sep 1.
Ref 3	METTL3-mediated mRNA N(6)-methyladenosine is required for oocyte and follicle development in mice. Cell Death Dis. 2021 Oct 23;12(11):989. doi: 10.1038/s41419-021-04272-9.
Ref 4	Identification of key genes associated with polycystic ovary syndrome (PCOS) and ovarian cancer using an integrated bioinformatics analysis. J Ovarian Res. 2022 Feb 28;15(1):30. doi: 10.1186/s13048-022-00962-w.