m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00458)
Target Name Intersectin-2 (ITSN2)
Synonyms
SH3 domain-containing protein 1B; SH3P18; SH3P18-like WASP-associated protein; KIAA1256; SH3D1B; SWAP
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Gene Name ITSN2
Function
Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR). Plays a role in dendrite formation by melanocytes.
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Gene ID 26574
Uniprot ID
ITSN2_HUMAN
HGNC ID
HGNC:6184
Ensembl Gene ID
ENSG00000198399
KEGG ID
hsa:50618
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
ITSN2 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Methyltransferase-like 3 (METTL3) [WRITER]
 Regulator Info 
Representative RNA-seq result indicating the expression of this target gene regulated by METTL3
Cell Line Pancreatic islets Mus musculus
Treatment: Mettl3 knockout mice
Control: Mettl3 flox/flox mice
 GSE155612
Regulation
logFC: 8.48E-01
p-value: 1.42E-04
More Results Click to View More RNA-seq Results
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary METTL3 targets Intersectin-2 (ITSN2) for m6A modification and then enhances its stability to influence the oocytes meiosis. mRNA m6A modification in follicle development and coordination of RNA stabilization during oocyte growth.
Target Regulation Up regulation
Responsed Disease Ovarian dysfunction ICD-11: 5A80
 Disease Info 
In-vivo Model All mice described above were maintained on the C57BL/6 J background. Mice lacking Mettl3 in oocytes (referred to as Mettl3Gdf9 cKO) were generated by crossing Mettl3flox/flox mice with Gdf9-Cre mice. The Mettl3flox/flox female mice were used as the control group (referred to as WT). For the fertility test, six pairs of 6 weeks Mettl3flox/flox and Mettl3Gdf9 cKO female mice were randomly selected and continually mated to Mettl3flox/flox male mice which have been confirmed fertility for 5 months. The number of pups and litter size from each female was recorded.
Ovarian dysfunction [ICD-11: 5A80]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary METTL3 targets Intersectin-2 (ITSN2) for m6A modification and then enhances its stability to influence the oocytes meiosis. mRNA m6A modification in follicle development and coordination of RNA stabilization during oocyte growth.
Responsed Disease Ovarian dysfunction [ICD-11: 5A80]
Target Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
Target Regulation Up regulation
In-vivo Model All mice described above were maintained on the C57BL/6 J background. Mice lacking Mettl3 in oocytes (referred to as Mettl3Gdf9 cKO) were generated by crossing Mettl3flox/flox mice with Gdf9-Cre mice. The Mettl3flox/flox female mice were used as the control group (referred to as WT). For the fertility test, six pairs of 6 weeks Mettl3flox/flox and Mettl3Gdf9 cKO female mice were randomly selected and continually mated to Mettl3flox/flox male mice which have been confirmed fertility for 5 months. The number of pups and litter size from each female was recorded.
Female infertility [ICD-11: GA31]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary METTL3 targets Intersectin-2 (ITSN2) for m6A modification and then enhances its stability to influence the oocytes meiosis. mRNA m6A modification in follicle development and coordination of RNA stabilization during oocyte growth.
Responsed Disease Female infertility [ICD-11: GA31]
Target Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
Target Regulation Up regulation
In-vivo Model All mice described above were maintained on the C57BL/6 J background. Mice lacking Mettl3 in oocytes (referred to as Mettl3Gdf9 cKO) were generated by crossing Mettl3flox/flox mice with Gdf9-Cre mice. The Mettl3flox/flox female mice were used as the control group (referred to as WT). For the fertility test, six pairs of 6 weeks Mettl3flox/flox and Mettl3Gdf9 cKO female mice were randomly selected and continually mated to Mettl3flox/flox male mice which have been confirmed fertility for 5 months. The number of pups and litter size from each female was recorded.
References
Ref 1 METTL3-mediated mRNA N(6)-methyladenosine is required for oocyte and follicle development in mice. Cell Death Dis. 2021 Oct 23;12(11):989. doi: 10.1038/s41419-021-04272-9.