m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00254)
Target Name Flotillin-2 (FLOT2)
Synonyms
Epidermal surface antigen; ESA; Membrane component chromosome 17 surface marker 1; ESA1; M17S1
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Gene Name FLOT2
Chromosomal Location 17q11.2
Family band 7/mec-2 family; Flotillin subfamily
Function
May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. May be involved in epidermal cell adhesion and epidermal structure and function.
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Gene ID 2319
Uniprot ID
FLOT2_HUMAN
HGNC ID
HGNC:3758
Ensembl Gene ID
ENSG00000132589
KEGG ID
hsa:2319
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
FLOT2 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Fat mass and obesity-associated protein (FTO) [ERASER]
 Regulator Info 
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary FTO induced the dysfunctions of GCs by upregulating Flotillin-2 (FLOT2), suggesting that FTO/FLOT2 plays a role in the pathophysiology of polycystic ovarian syndrome.
Target Regulation Up regulation
Responsed Disease Polycystic ovary syndrome ICD-11: 5A80.1
 Disease Info 
Cell Process Cell apoptosis
In-vitro Model KGN Ovarian granulosa cell tumor Homo sapiens CVCL_0375
Ovarian dysfunction [ICD-11: 5A80]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary FTO induced the dysfunctions of GCs by upregulating Flotillin-2 (FLOT2), suggesting that FTO/FLOT2 plays a role in the pathophysiology of polycystic ovarian syndrome.
Responsed Disease Polycystic ovary syndrome [ICD-11: 5A80.1]
Target Regulator Fat mass and obesity-associated protein (FTO) ERASER
 Regulator Info 
Target Regulation Up regulation
Cell Process Cell apoptosis
In-vitro Model KGN Ovarian granulosa cell tumor Homo sapiens CVCL_0375
References
Ref 1 N6-methyladenosine Demethylase FTO Induces the Dysfunctions of Ovarian Granulosa Cells by Upregulating Flotillin 2. Reprod Sci. 2022 Apr;29(4):1305-1315. doi: 10.1007/s43032-021-00664-6. Epub 2021 Jul 12.