m6A-centered Disease Response Information

General Information of the Disease (ID: M6ADIS0005)
Name
Hypopharyngeal cancer
ICD
ICD-11: 2B6D
Full List of Target Gene(s) of This m6A-centered Disease Response
Transferrin receptor protein 1 (TFRC)
 Target Info 
In total 1 item(s) under this target gene
Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene [1]
Response Summary YTHDF1 enhanced Transferrin receptor protein 1 (TFRC) expression in HPSCC through an m6A-dependent mechanism.
Responsed Disease Hypopharyngeal squamous cell carcinoma [ICD-11: 2B6D.0]
Target Regulator YTH domain-containing family protein 1 (YTHDF1) READER
 Regulator Info 
Target Regulation Up regulation
Pathway Response Ferroptosis hsa04216
Cell Process Ferroptosis
In-vitro Model YCU-MS861 Maxillary sinus squamous cell carcinoma Homo sapiens CVCL_8021
YCU-MS861 Maxillary sinus squamous cell carcinoma Homo sapiens CVCL_8021
FaDu Hypopharyngeal squamous cell carcinoma Homo sapiens CVCL_1218
Detroit 562 Pharyngeal squamous cell carcinoma Homo sapiens CVCL_1171
hsa_circ_0081609 (circCUX1)
 Target Info 
In total 1 item(s) under this target gene
Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene [2]
Response Summary METTL3-mediated m6A modification plays a key role in stabilizing the expression of hsa_circ_0081609 (circCUX1), thereby inhibiting the expression of caspase 1 and conferring the radiotherapy resistance of hypopharyngeal squamous cell carcinoma.
Responsed Disease Hypopharyngeal squamous cell carcinoma [ICD-11: 2B6D.0]
Target Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
Target Regulation Up regulation
In-vitro Model CLA-27 cell line (The head and neck tumor cell lines)
HOK Normal Hexagrammos otakii CVCL_YE19
SAS Tongue squamous cell carcinoma Homo sapiens CVCL_1675
SCC-15 Tongue squamous cell carcinoma Homo sapiens CVCL_1681
SCC-4 Tongue squamous cell carcinoma Homo sapiens CVCL_1684
SCC-9 Tongue squamous cell carcinoma Homo sapiens CVCL_1685
Tca8113 Endocervical adenocarcinoma Homo sapiens CVCL_6851
References
Ref 1 YTHDF1-enhanced iron metabolism depends on TFRC m(6)A methylation. Theranostics. 2020 Oct 26;10(26):12072-12089. doi: 10.7150/thno.51231. eCollection 2020.
Ref 2 N6-methyladenosine modification of circCUX1 confers radioresistance of hypopharyngeal squamous cell carcinoma through caspase1 pathway. Cell Death Dis. 2021 Mar 19;12(4):298. doi: 10.1038/s41419-021-03558-2.