m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR01840)

Target Name	Ribose-5-phosphate isomerase (RPIA)
Synonyms	RPI; Phosphoriboisomerase Click to Show/Hide
Gene Name	RPIA
Chromosomal Location	2p11.2
Family	Ribose 5-phosphate isomerase family
Function	Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate and participates in the first step of the non-oxidative branch of the pentose phosphate pathway. Click to Show/Hide
Gene ID	22934
Uniprot ID	RPIA_HUMAN
HGNC ID	HGNC:10297
KEGG ID	hsa:22934

Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator

DNA modification

m6A Regulator: Methyltransferase-like 3 (METTL3)

Regulator Info

In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT06003		Crosstalk Info
Epigenetic Regulator	Methylcytosine dioxygenase TET1 (TET1)
Regulated Target	Ribose-5-phosphate isomerase (RPIA)
Crosstalk relationship	m6A → DNA modification
Disease	Esophageal Squamous Cell Carcinoma	Disease Info

m6A Regulator: RNA-binding protein FXR1 (FXR1)

Regulator Info

In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT06004		Crosstalk Info
Epigenetic Regulator	Methylcytosine dioxygenase TET1 (TET1)
Regulated Target	Ribose-5-phosphate isomerase (RPIA)
Crosstalk relationship	m6A → DNA modification
Disease	Esophageal Squamous Cell Carcinoma	Disease Info

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR01840)

Ribose-5-phosphate isomerase (RPIA)

Adenosine-to-Inosine editing (A-to-I)

In total 3 m6A sequence/site(s) in this target gene
mod ID: A2ISITE009827		Click to Show/Hide the Full List
mod site	chr2:88716215-88716216:+		[2]
Sequence	AAGAATGCAGTCTTTTGTCTATTATCTACTTATGACCCGGA
Transcript ID List	rmsk_606929; ENST00000283646.5
External Link	RMBase: RNA-editing_site_78487
mod ID: A2ISITE009828		Click to Show/Hide the Full List
mod site	chr2:88716218-88716219:+		[2]
Sequence	AATGCAGTCTTTTGTCTATTATCTACTTATGACCCGGAAGA
Transcript ID List	ENST00000283646.5; rmsk_606929
External Link	RMBase: RNA-editing_site_78488
mod ID: A2ISITE009829		Click to Show/Hide the Full List
mod site	chr2:88716335-88716336:+		[2]
Sequence	ATGTCTCCCTAAAACGTGTAAAAGCAAGCTGTACCCCAACC
Transcript ID List	rmsk_606929; ENST00000283646.5
External Link	RMBase: RNA-editing_site_78489

N6-methyladenosine (m6A)

In total 27 m6A sequence/site(s) in this target gene
mod ID: M6ASITE046131		Click to Show/Hide the Full List
mod site	chr2:88691792-88691793:+		[3]
Sequence	GGCCTCCGGCGGAGGAGGGAACAGCTGGGACCTCCCGGGTT
Motif Score	2.951386905
Cell/Tissue List	HeLa; HepG2; Jurkat; CD4T; GSC-11; HEK293T; HEK293A-TOA; MSC; iSLK; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000283646.5
External Link	RMBase: m6A_site_483077
mod ID: M6ASITE046132		Click to Show/Hide the Full List
mod site	chr2:88691801-88691802:+		[3]
Sequence	CGGAGGAGGGAACAGCTGGGACCTCCCGGGTTCCCACGTGC
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; Jurkat; CD4T; GSC-11; HEK293T; HEK293A-TOA; MSC; TREX; iSLK; TIME; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000283646.5
External Link	RMBase: m6A_site_483078
mod ID: M6ASITE046133		Click to Show/Hide the Full List
mod site	chr2:88691848-88691849:+		[3]
Sequence	CGGGGCGTGCACAGTCTGGGACCCGTGGCGGTGCTGGCAAC
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293T; iSLK; MSC; TREX; TIME; endometrial; HEC-1-A; GSCs; NB4; MM6
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000283646.5
External Link	RMBase: m6A_site_483079
mod ID: M6ASITE046135		Click to Show/Hide the Full List
mod site	chr2:88691888-88691889:+		[3]
Sequence	CACAAGCACCAGCTGCGGGGACTCCAACAGCATCTGCCCGG
Motif Score	4.065041667
Cell/Tissue List	HeLa; HepG2; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293T; iSLK; MSC; endometrial; HEC-1-A; GSCs; NB4; MM6
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000283646.5
External Link	RMBase: m6A_site_483080
mod ID: M6ASITE046136		Click to Show/Hide the Full List
mod site	chr2:88691972-88691973:+		[3]
Sequence	GGGCCGCGCGGCTGTGGAGAACCACGTGAGGGTGAGCACTT
Motif Score	2.930744048
Cell/Tissue List	HeLa; HepG2; CD4T; peripheral-blood; HEK293T; HEC-1-A; NB4; MM6
Seq Type List	m6A-seq
Transcript ID List	ENST00000283646.5
External Link	RMBase: m6A_site_483081
mod ID: M6ASITE046137		Click to Show/Hide the Full List
mod site	chr2:88698516-88698517:+		[4]
Sequence	TGGGAATTGGAAGTGGTTCTACAATTGTCCATGCTGTGCAG
Motif Score	2.078666667
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000283646.5
External Link	RMBase: m6A_site_483082
mod ID: M6ASITE046138		Click to Show/Hide the Full List
mod site	chr2:88729327-88729328:+		[4]
Sequence	ACCCTCAGTGATCTGGATCGACACCCAGAGGTAAGATTGCC
Motif Score	2.865571429
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000283646.5
External Link	RMBase: m6A_site_483083
mod ID: M6ASITE046139		Click to Show/Hide the Full List
mod site	chr2:88736566-88736567:+		[4]
Sequence	GAATCTCGGGGATCAGTGGCACAAGGGAATCCCCATCGAGG
Motif Score	2.830589286
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000283646.5
External Link	RMBase: m6A_site_483084
mod ID: M6ASITE046140		Click to Show/Hide the Full List
mod site	chr2:88736668-88736669:+		[4]
Sequence	TGAACTTCGAATGGCTGTCAACAAGGCTGTGAGTGGCCTGG
Motif Score	2.173910714
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000283646.5
External Link	RMBase: m6A_site_483085
mod ID: M6ASITE046141		Click to Show/Hide the Full List
mod site	chr2:88738013-88738014:+		[5]
Sequence	TAATGGGAATTTTATCTTGGACTGGAAGTTTGACCGGGTAC
Motif Score	4.065041667
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000283646.5
External Link	RMBase: m6A_site_483086
mod ID: M6ASITE046142		Click to Show/Hide the Full List
mod site	chr2:88738032-88738033:+		[5]
Sequence	GACTGGAAGTTTGACCGGGTACACAAATGGAGTGAAGTGAA
Motif Score	2.856142857
Cell/Tissue List	HEK293T; hESC-HEK293T
Seq Type List	DART-seq; MAZTER-seq
Transcript ID List	ENST00000283646.5
External Link	RMBase: m6A_site_483087
mod ID: M6ASITE046143		Click to Show/Hide the Full List
mod site	chr2:88750007-88750008:+		[4]
Sequence	GGACACAGGCCTATTCATCAACATGGCTGAGAGAGTCTACT
Motif Score	2.173910714
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000283646.5
External Link	RMBase: m6A_site_483088
mod ID: M6ASITE046144		Click to Show/Hide the Full List
mod site	chr2:88750052-88750053:+		[5]
Sequence	GATGCAGGATGGCTCAGTGAACATGAGGGAGAAGCCTTTCT
Motif Score	2.951386905
Cell/Tissue List	HEK293T; hESC-HEK293T
Seq Type List	DART-seq; MAZTER-seq
Transcript ID List	ENST00000283646.5
External Link	RMBase: m6A_site_483089
mod ID: M6ASITE046146		Click to Show/Hide the Full List
mod site	chr2:88750177-88750178:+		[3]
Sequence	CTTAATGTATCTCTGCCTGGACAACTTGTGGTGGGGGGTGG
Motif Score	3.643047619
Cell/Tissue List	HeLa; HEK293T; hESC-HEK293T; MT4
Seq Type List	m6A-seq; DART-seq; MAZTER-seq; MeRIP-seq
Transcript ID List	ENST00000283646.5
External Link	RMBase: m6A_site_483090
mod ID: M6ASITE046147		Click to Show/Hide the Full List
mod site	chr2:88750277-88750278:+		[4]
Sequence	TTTTAAAAAGAGAAATATAAACATATATTTTTACTATTAAA
Motif Score	2.20572619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000283646.5
External Link	RMBase: m6A_site_483091
mod ID: M6ASITE046148		Click to Show/Hide the Full List
mod site	chr2:88750377-88750378:+		[5]
Sequence	AAAAAAAAAAAATGAGGTAAACTGTATTTAAAACCTTTGAC
Motif Score	2.627720238
Cell/Tissue List	HEK293T; Huh7
Seq Type List	DART-seq; MeRIP-seq
Transcript ID List	ENST00000283646.5
External Link	RMBase: m6A_site_483092
mod ID: M6ASITE046149		Click to Show/Hide the Full List
mod site	chr2:88750389-88750390:+		[6]
Sequence	TGAGGTAAACTGTATTTAAAACCTTTGACTTGAGTCTGCTG
Motif Score	2.185083333
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000283646.5
External Link	RMBase: m6A_site_483093
mod ID: M6ASITE046150		Click to Show/Hide the Full List
mod site	chr2:88750454-88750455:+		[6]
Sequence	GCTGAGAAATAAAAATCAAAACTTCTTTAAGCTGGTAAAGT
Motif Score	2.627720238
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000283646.5
External Link	RMBase: m6A_site_483094
mod ID: M6ASITE046151		Click to Show/Hide the Full List
mod site	chr2:88750516-88750517:+		[5]
Sequence	CTCCTGATGCCTTACTGGAAACTTTGTTTACTTGTCTGCTA
Motif Score	2.627720238
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000283646.5
External Link	RMBase: m6A_site_483095
mod ID: M6ASITE046152		Click to Show/Hide the Full List
mod site	chr2:88750525-88750526:+		[5]
Sequence	CCTTACTGGAAACTTTGTTTACTTGTCTGCTACCCTCTGAT
Motif Score	2.494845238
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000283646.5
External Link	RMBase: m6A_site_483096
mod ID: M6ASITE046153		Click to Show/Hide the Full List
mod site	chr2:88750574-88750575:+		[4]
Sequence	AGTTAGTTTTTATTGTGAGCACACATAGTACCTAGTTACAT
Motif Score	2.830589286
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000283646.5
External Link	RMBase: m6A_site_483097
mod ID: M6ASITE046154		Click to Show/Hide the Full List
mod site	chr2:88750576-88750577:+		[5]
Sequence	TTAGTTTTTATTGTGAGCACACATAGTACCTAGTTACATCT
Motif Score	2.084928571
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000283646.5
External Link	RMBase: m6A_site_483098
mod ID: M6ASITE046155		Click to Show/Hide the Full List
mod site	chr2:88750591-88750592:+		[4]
Sequence	AGCACACATAGTACCTAGTTACATCTTAAGATCAGGTTTAT
Motif Score	2.07285119
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000283646.5
External Link	RMBase: m6A_site_483099
mod ID: M6ASITE046157		Click to Show/Hide the Full List
mod site	chr2:88750646-88750647:+		[5]
Sequence	GAGCGGTATGGTATGGAATGACTTGGAATGTAAGCTGTCAG
Motif Score	3.28175
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000283646.5
External Link	RMBase: m6A_site_483100
mod ID: M6ASITE046158		Click to Show/Hide the Full List
mod site	chr2:88750682-88750683:+		[4]
Sequence	GTCAGGGAGAAAATGTTGTTACACTTTTGCTAAGATCTGGG
Motif Score	2.07285119
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000283646.5
External Link	RMBase: m6A_site_483101
mod ID: M6ASITE046159		Click to Show/Hide the Full List
mod site	chr2:88750787-88750788:+		[5]
Sequence	ACTGCTGTGAAATGTGAAGTACTTTGTTTTTTTATTTTTAA
Motif Score	3.278136905
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000283646.5
External Link	RMBase: m6A_site_483102
mod ID: M6ASITE046160		Click to Show/Hide the Full List
mod site	chr2:88750915-88750916:+		[5]
Sequence	TGTTTGCAGGTTTAAATAAAACAGTGTGGTGCCATTTTGAC
Motif Score	2.20572619
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000283646.5
External Link	RMBase: m6A_site_483103

Ref 1	RNA m(6)A regulates transcription via DNA demethylation and chromatin accessibility. Nat Genet. 2022 Sep;54(9):1427-1437. doi: 10.1038/s41588-022-01173-1. Epub 2022 Sep 7.
Ref 2	RADAR: a rigorously annotated database of A-to-I RNA editing. Nucleic Acids Res. 2014 Jan;42(Database issue):D109-13. doi: 10.1093/nar/gkt996. Epub 2013 Oct 25.
Ref 3	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 4	Deciphering the "m(6)A Code" via Antibody-Independent Quantitative Profiling. Cell. 2019 Jul 25;178(3):731-747.e16. doi: 10.1016/j.cell.2019.06.013. Epub 2019 Jun 27.
Ref 5	DART-seq: an antibody-free method for global m(6)A detection. Nat Methods. 2019 Dec;16(12):1275-1280. doi: 10.1038/s41592-019-0570-0. Epub 2019 Sep 23.
Ref 6	N6-Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection. Cell Host Microbe. 2016 Nov 9;20(5):654-665. doi: 10.1016/j.chom.2016.09.015. Epub 2016 Oct 20.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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