m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR01702)

Target Name	Disintegrin and metalloproteinase domain-containing protein 8 (ADAM8)
Synonyms	ADAM 8; EC 3.4.24.-; Cell surface antigen MS2; CD antigen CD156a Click to Show/Hide
Gene Name	ADAM8
Chromosomal Location	10q26.3
Function	Possible involvement in extravasation of leukocytes. Click to Show/Hide
Gene ID	101
Uniprot ID	ADAM8_HUMAN
HGNC ID	HGNC:215
KEGG ID	hsa:101

Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator

Non-coding RNA

m6A Regulator: Synaptic functional regulator FMR1 (FMR1)

Regulator Info

In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT05084		Crosstalk Info
Epigenetic Regulator	FAS antisense RNA 1 (FAS-AS1)
Regulated Target	Fragile X messenger ribonucleoprotein 1 (FMR1)
Crosstalk relationship	ncRNA → m6A
Disease	Osteoarthritis	Disease Info

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR01702)

Disintegrin and metalloproteinase domain-containing protein 8 (ADAM8)

Adenosine-to-Inosine editing (A-to-I)

In total 19 m6A sequence/site(s) in this target gene
mod ID: A2ISITE004487		Click to Show/Hide the Full List
mod site	chr10:133264123-133264124:-		[2]
Sequence	AGCTGCAGTGAGCCAACATCACGCCACTGCACTCCAGTCTG
Transcript ID List	ENST00000485491.6; rmsk_3455495; ENST00000415217.7; ENST00000445355.8
External Link	RMBase: RNA-editing_site_19436
mod ID: A2ISITE004488		Click to Show/Hide the Full List
mod site	chr10:133264129-133264130:-		[2]
Sequence	AGAGGAAGCTGCAGTGAGCCAACATCACGCCACTGCACTCC
Transcript ID List	ENST00000485491.6; rmsk_3455495; ENST00000415217.7; ENST00000445355.8
External Link	RMBase: RNA-editing_site_19437
mod ID: A2ISITE004489		Click to Show/Hide the Full List
mod site	chr10:133264149-133264150:-		[2]
Sequence	AGGATCGCTTGAACCCAGGAAGAGGAAGCTGCAGTGAGCCA
Transcript ID List	rmsk_3455495; ENST00000415217.7; ENST00000485491.6; ENST00000445355.8
External Link	RMBase: RNA-editing_site_19438
mod ID: A2ISITE004490		Click to Show/Hide the Full List
mod site	chr10:133264153-133264154:-		[2]
Sequence	CGGGAGGATCGCTTGAACCCAGGAAGAGGAAGCTGCAGTGA
Transcript ID List	ENST00000415217.7; ENST00000485491.6; rmsk_3455495; ENST00000445355.8
External Link	RMBase: RNA-editing_site_19439
mod ID: A2ISITE004491		Click to Show/Hide the Full List
mod site	chr10:133264157-133264158:-		[2]
Sequence	GAGGCGGGAGGATCGCTTGAACCCAGGAAGAGGAAGCTGCA
Transcript ID List	rmsk_3455495; ENST00000445355.8; ENST00000485491.6; ENST00000415217.7
External Link	RMBase: RNA-editing_site_19440
mod ID: A2ISITE004492		Click to Show/Hide the Full List
mod site	chr10:133264231-133264232:-		[2]
Sequence	CCCGTCTCTACAAAAAATAAAAAATTAGCTGGGTATGGTGG
Transcript ID List	rmsk_3455495; ENST00000485491.6; ENST00000415217.7; ENST00000445355.8
External Link	RMBase: RNA-editing_site_19441
mod ID: A2ISITE004493		Click to Show/Hide the Full List
mod site	chr10:133264263-133264264:-		[2]
Sequence	GTTCAAGACCAGCCTGGGCAACATAGGGAGACCCCGTCTCT
Transcript ID List	ENST00000485491.6; ENST00000445355.8; rmsk_3455495; ENST00000415217.7
External Link	RMBase: RNA-editing_site_19442
mod ID: A2ISITE004494		Click to Show/Hide the Full List
mod site	chr10:133264551-133264552:-		[2]
Sequence	GGTCCTTTGGAAGCTGCTGAAAACTGCAAATGCTTAGCCCA
Transcript ID List	ENST00000485491.6; ENST00000415217.7; ENST00000445355.8
External Link	RMBase: RNA-editing_site_19443
mod ID: A2ISITE004495		Click to Show/Hide the Full List
mod site	chr10:133265546-133265547:-		[2]
Sequence	TGCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGACGTG
Transcript ID List	ENST00000485491.6; ENST00000445355.8; ENST00000415217.7
External Link	RMBase: RNA-editing_site_19444
mod ID: A2ISITE004496		Click to Show/Hide the Full List
mod site	chr10:133265570-133265571:-		[2]
Sequence	TCTTGATCTCTTGACCTCGTAATCTGCCTGCCTTGGCCTCC
Transcript ID List	ENST00000415217.7; ENST00000485491.6; ENST00000445355.8
External Link	RMBase: RNA-editing_site_19445
mod ID: A2ISITE004497		Click to Show/Hide the Full List
mod site	chr10:133265596-133265597:-		[2]
Sequence	GGGTTTCACTGTGTTAGCCAAGATGGTCTTGATCTCTTGAC
Transcript ID List	ENST00000445355.8; ENST00000415217.7; ENST00000485491.6
External Link	RMBase: RNA-editing_site_19446
mod ID: A2ISITE004498		Click to Show/Hide the Full List
mod site	chr10:133265601-133265602:-		[2]
Sequence	AGACGGGGTTTCACTGTGTTAGCCAAGATGGTCTTGATCTC
Transcript ID List	ENST00000485491.6; ENST00000415217.7; ENST00000445355.8
External Link	RMBase: RNA-editing_site_19447
mod ID: A2ISITE004499		Click to Show/Hide the Full List
mod site	chr10:133265661-133265662:-		[3]
Sequence	TGAGACTACAGGTGCCCGCGACCATGCCTGGCTAAATTTTT
Transcript ID List	ENST00000445355.8; ENST00000415217.7; ENST00000485491.6
External Link	RMBase: RNA-editing_site_19448
mod ID: A2ISITE004500		Click to Show/Hide the Full List
mod site	chr10:133265672-133265673:-		[2]
Sequence	CCCAATGTATCTGAGACTACAGGTGCCCGCGACCATGCCTG
Transcript ID List	ENST00000445355.8; ENST00000485491.6; ENST00000415217.7
External Link	RMBase: RNA-editing_site_19449
mod ID: A2ISITE004501		Click to Show/Hide the Full List
mod site	chr10:133265677-133265678:-		[2]
Sequence	AGCCTCCCAATGTATCTGAGACTACAGGTGCCCGCGACCAT
Transcript ID List	ENST00000445355.8; ENST00000485491.6; ENST00000415217.7
External Link	RMBase: RNA-editing_site_19450
mod ID: A2ISITE004502		Click to Show/Hide the Full List
mod site	chr10:133265679-133265680:-		[2]
Sequence	TCAGCCTCCCAATGTATCTGAGACTACAGGTGCCCGCGACC
Transcript ID List	ENST00000485491.6; ENST00000415217.7; ENST00000445355.8
External Link	RMBase: RNA-editing_site_19451
mod ID: A2ISITE004503		Click to Show/Hide the Full List
mod site	chr10:133265721-133265722:-		[2]
Sequence	CACTGCAATCTCCGCCTCTCAGGTTCATGCCATTCTCCTGC
Transcript ID List	ENST00000415217.7; ENST00000485491.6; ENST00000445355.8
External Link	RMBase: RNA-editing_site_19452
mod ID: A2ISITE004504		Click to Show/Hide the Full List
mod site	chr10:133265734-133265735:-		[2]
Sequence	CGCGATCTCAGCTCACTGCAATCTCCGCCTCTCAGGTTCAT
Transcript ID List	ENST00000485491.6; ENST00000445355.8; ENST00000415217.7
External Link	RMBase: RNA-editing_site_19453
mod ID: A2ISITE004505		Click to Show/Hide the Full List
mod site	chr10:133265745-133265746:-		[2]
Sequence	GAGTGCAGTGGCGCGATCTCAGCTCACTGCAATCTCCGCCT
Transcript ID List	ENST00000485491.6; ENST00000445355.8; ENST00000415217.7
External Link	RMBase: RNA-editing_site_19454

5-methylcytidine (m5C)

In total 3 m6A sequence/site(s) in this target gene
mod ID: M5CSITE004810		Click to Show/Hide the Full List
mod site	chr10:133262923-133262924:-
Sequence	CCCCAGCTGTCTGCAGGCACCAGGCTGGGATGAGCTGTGTG
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000445355.8; ENST00000415217.7
External Link	RMBase: m5C_site_6158
mod ID: M5CSITE004811		Click to Show/Hide the Full List
mod site	chr10:133262952-133262953:-
Sequence	TTCCTTCTCCCCGCCTTGGCCACGTGTAGCCCCAGCTGTCT
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000415217.7; ENST00000445355.8
External Link	RMBase: m5C_site_6159
mod ID: M5CSITE004812		Click to Show/Hide the Full List
mod site	chr10:133272492-133272493:-
Sequence	GTCAGCCCCGACCCCAGTGTCACACTGGAGAACCTCCTGAC
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000445355.8; ENST00000561175.1; ENST00000485491.6; ENST00000537099.5; ENST00000415217.7; ENST00000560135.5
External Link	RMBase: m5C_site_6160

N6-methyladenosine (m6A)

In total 16 m6A sequence/site(s) in this target gene
mod ID: M6ASITE002822		Click to Show/Hide the Full List
mod site	chr10:133262600-133262601:-		[4]
Sequence	TCCCATGGGATTCAAGAGGGACAGCCCCAGCTTTGTGTGTG
Motif Score	3.643047619
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000445355.8; ENST00000415217.7
External Link	RMBase: m6A_site_124462
mod ID: M6ASITE002823		Click to Show/Hide the Full List
mod site	chr10:133262669-133262670:-		[5]
Sequence	GAGAGGGTGTCAGTGAGCAGACTGCACCCCAAGCTCCCGAC
Motif Score	3.319380952
Cell/Tissue List	H1B; H1A; LCLs; peripheral-blood; HEK293T; endometrial; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000445355.8; ENST00000415217.7
External Link	RMBase: m6A_site_124463
mod ID: M6ASITE002824		Click to Show/Hide the Full List
mod site	chr10:133262713-133262714:-		[6]
Sequence	CAGAAAGACTCCATCCCAGGACCAGGTTCCCCTGCGTGCTC
Motif Score	3.622404762
Cell/Tissue List	HeLa; H1B; H1A; LCLs; peripheral-blood; HEK293T; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000445355.8; ENST00000415217.7
External Link	RMBase: m6A_site_124464
mod ID: M6ASITE002825		Click to Show/Hide the Full List
mod site	chr10:133262726-133262727:-		[6]
Sequence	CGTGGGGCATCCCCAGAAAGACTCCATCCCAGGACCAGGTT
Motif Score	3.319380952
Cell/Tissue List	HeLa; H1B; H1A; LCLs; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000445355.8; ENST00000415217.7
External Link	RMBase: m6A_site_124465
mod ID: M6ASITE002826		Click to Show/Hide the Full List
mod site	chr10:133272966-133272967:-		[7]
Sequence	GGAGCTGTATGTGGTCGTGGACAATGCAGAGGTGTGTTGGG
Motif Score	3.643047619
Cell/Tissue List	CD4T
Seq Type List	m6A-seq
Transcript ID List	ENST00000537099.5; ENST00000560135.5; ENST00000415217.7; ENST00000485491.6; ENST00000463298.5; ENST00000445355.8
External Link	RMBase: m6A_site_124466
mod ID: M6ASITE002827		Click to Show/Hide the Full List
mod site	chr10:133272997-133272998:-		[7]
Sequence	ACTCTCTGCCATCCCGAGAGACCCGCTACGTGGAGCTGTAT
Motif Score	2.876744048
Cell/Tissue List	CD4T
Seq Type List	m6A-seq
Transcript ID List	ENST00000463298.5; ENST00000415217.7; ENST00000560135.5; ENST00000485491.6; ENST00000537099.5; ENST00000445355.8
External Link	RMBase: m6A_site_124467
mod ID: M6ASITE002828		Click to Show/Hide the Full List
mod site	chr10:133273289-133273290:-		[7]
Sequence	AGCCTGGGCAGCCTCCTGGGACCCCGGACGGCAGCCGTCTT
Motif Score	3.622404762
Cell/Tissue List	CD4T; NB4
Seq Type List	m6A-seq
Transcript ID List	ENST00000463298.5; ENST00000560135.5; ENST00000415217.7; ENST00000445355.8; ENST00000486609.1; ENST00000485491.6; ENST00000537099.5
External Link	RMBase: m6A_site_124468
mod ID: M6ASITE002829		Click to Show/Hide the Full List
mod site	chr10:133273330-133273331:-		[7]
Sequence	ACCTGCTGCAGACGGCCGGGACCTGCGGGGTCAGCGACGAC
Motif Score	3.622404762
Cell/Tissue List	CD4T; NB4
Seq Type List	m6A-seq
Transcript ID List	ENST00000463298.5; ENST00000445355.8; ENST00000415217.7; ENST00000485491.6; ENST00000537099.5; ENST00000486609.1; ENST00000559180.1; ENST00000560135.5
External Link	RMBase: m6A_site_124469
mod ID: M6ASITE002830		Click to Show/Hide the Full List
mod site	chr10:133273419-133273420:-		[7]
Sequence	TTTCTTCCAGGTGGGGTCAGACCTGCACCTGATCGAGCCCC
Motif Score	2.876744048
Cell/Tissue List	CD4T; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000537099.5; ENST00000486609.1; ENST00000415217.7; ENST00000560135.5; ENST00000445355.8; ENST00000559180.1; ENST00000463298.5; ENST00000485491.6
External Link	RMBase: m6A_site_124470
mod ID: M6ASITE002831		Click to Show/Hide the Full List
mod site	chr10:133273491-133273492:-		[7]
Sequence	CTCTGGTCCTTCGGGGCAGGACCAGGCCACTCTGAAGCCCA
Motif Score	3.622404762
Cell/Tissue List	CD4T
Seq Type List	m6A-seq
Transcript ID List	ENST00000415217.7; ENST00000445355.8; ENST00000560135.5; ENST00000559180.1; ENST00000486609.1; ENST00000463298.5; ENST00000485491.6; ENST00000537099.5
External Link	RMBase: m6A_site_124471
mod ID: M6ASITE002832		Click to Show/Hide the Full List
mod site	chr10:133273797-133273798:-		[7]
Sequence	CCACGTAGAGGGGTACCCGGACTCAGCCGCCAGCCTCAGCA
Motif Score	4.065041667
Cell/Tissue List	CD4T
Seq Type List	m6A-seq
Transcript ID List	ENST00000485491.6; ENST00000415217.7; ENST00000486609.1; ENST00000537099.5; ENST00000559180.1; ENST00000560135.5; ENST00000445355.8; ENST00000463298.5
External Link	RMBase: m6A_site_124472
mod ID: M6ASITE002833		Click to Show/Hide the Full List
mod site	chr10:133274000-133274001:-		[7]
Sequence	TGGGCTCCGGCTACACAGAGACCTATACGGCTGCCAATGGC
Motif Score	2.876744048
Cell/Tissue List	CD4T
Seq Type List	m6A-seq
Transcript ID List	ENST00000486609.1; ENST00000463298.5; ENST00000537099.5; ENST00000559180.1; ENST00000445355.8; ENST00000560135.5; ENST00000485491.6; ENST00000415217.7
External Link	RMBase: m6A_site_124473
mod ID: M6ASITE002834		Click to Show/Hide the Full List
mod site	chr10:133274026-133274027:-		[7]
Sequence	ACAGCACTTCTTTTCCAGGGACCTGCTGGGCTCCGGCTACA
Motif Score	3.622404762
Cell/Tissue List	CD4T
Seq Type List	m6A-seq
Transcript ID List	ENST00000537099.5; ENST00000559180.1; ENST00000415217.7; ENST00000445355.8; ENST00000463298.5; ENST00000485491.6; ENST00000486609.1; ENST00000560135.5
External Link	RMBase: m6A_site_124474
mod ID: M6ASITE002835		Click to Show/Hide the Full List
mod site	chr10:133274161-133274162:-		[7]
Sequence	CACCCTCCACCTGCGGAAGAACAGGTGAGTGGGTCTCGGGT
Motif Score	2.951386905
Cell/Tissue List	CD4T
Seq Type List	m6A-seq
Transcript ID List	ENST00000486609.1; ENST00000560135.5; ENST00000485491.6; ENST00000559180.1; ENST00000537099.5; ENST00000415217.7; ENST00000445355.8; ENST00000463298.5
External Link	RMBase: m6A_site_124475
mod ID: M6ASITE002836		Click to Show/Hide the Full List
mod site	chr10:133275738-133275739:-		[7]
Sequence	TGGGGTCTTTTAGGCACAGAACCCTCACTTGAGTCTTTGTC
Motif Score	2.930744048
Cell/Tissue List	CD4T
Seq Type List	m6A-seq
Transcript ID List	ENST00000463298.5; ENST00000537099.5; ENST00000559180.1; ENST00000486609.1; ENST00000445355.8; ENST00000560135.5; ENST00000485491.6; ENST00000415217.7
External Link	RMBase: m6A_site_124476
mod ID: M6ASITE002837		Click to Show/Hide the Full List
mod site	chr10:133275792-133275793:-		[7]
Sequence	CTGTGTGTGGGTGCTGCAGGACACAGGCCCACCGGCCATGC
Motif Score	3.643047619
Cell/Tissue List	CD4T
Seq Type List	m6A-seq
Transcript ID List	ENST00000463298.5; ENST00000445355.8; ENST00000485491.6; ENST00000415217.7; ENST00000559180.1; ENST00000537099.5; ENST00000486609.1; ENST00000560135.5
External Link	RMBase: m6A_site_124477

Ref 1	Structure-based optimization of potent and selective inhibitors of the tyrosine kinase erythropoietin producing human hepatocellular carcinoma receptor B4 (EphB4). J Med Chem. 2009 Oct 22;52(20):6433-46. doi: 10.1021/jm9009444.
Ref 2	Widespread RNA editing of embedded alu elements in the human transcriptome. Genome Res. 2004 Sep;14(9):1719-25. doi: 10.1101/gr.2855504.
Ref 3	Comprehensive analysis of RNA-Seq data reveals extensive RNA editing in a human transcriptome. Nat Biotechnol. 2012 Feb 12;30(3):253-60. doi: 10.1038/nbt.2122.
Ref 4	m(6)A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer. Nat Cell Biol. 2018 Sep;20(9):1074-1083. doi: 10.1038/s41556-018-0174-4. Epub 2018 Aug 27.
Ref 5	m(6)A RNA modification controls cell fate transition in mammalian embryonic stem cells. Cell Stem Cell. 2014 Dec 4;15(6):707-19. doi: 10.1016/j.stem.2014.09.019. Epub 2014 Oct 16.
Ref 6	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 7	N(6)-methyladenosine of HIV-1 RNA regulates viral infection and HIV-1 Gag protein expression. Elife. 2016 Jul 2;5:e15528. doi: 10.7554/eLife.15528.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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