m6A-centered Crosstalk Information
Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
| Crosstalk ID |
M6ACROT05084
|
[1] | |||
Non-coding RNA
FAS-AS1
FMR1
lncRNA miRNA circRNA
Direct
Enhancement
m6A modification
ADAM8
ADAM8
FMR1
 : m6A sites
|
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| m6A Modification: | |||||
|---|---|---|---|---|---|
| m6A Regulator | Synaptic functional regulator FMR1 (FMR1) | READER | |||
| m6A Target | Disintegrin and metalloproteinase domain-containing protein 8 (ADAM8) | ||||
| Epigenetic Regulation that have Cross-talk with This m6A Modification: | |||||
| Epigenetic Regulation Type | Non-coding RNA (ncRNA) | ||||
| Epigenetic Regulator | FAS antisense RNA 1 (FAS-AS1) | LncRNA | View Details | ||
| Regulated Target | Fragile X messenger ribonucleoprotein 1 (FMR1) | View Details | |||
| Crosstalk Relationship | ncRNA → m6A | Enhancement | |||
| Crosstalk Mechanism | ncRNAs directly impacts m6A modification through recruiting m6A regulator | ||||
| Crosstalk Summary | FAS-AS1 maintained the stability of Disintegrin and metalloproteinase domain-containing protein 8 (ADAM8) mRNA by recruiting FMR1. METTL14 knockdown repressed FAS-AS1 expression in an m6A-dependent manner. METTL14-mediated lncRNA-FAS-AS1 promotes osteoarthritis progression by up-regulating ADAM8 | ||||
| Responsed Disease | Osteoarthritis | ICD-11: FA05 | |||