m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR01681)

Target Name	Ubiquitin-like-conjugating enzyme ATG10 (ATG10)
Synonyms	EC 2.3.2.-; Autophagy-related protein 10; APG10-like Click to Show/Hide
Gene Name	ATG10
Chromosomal Location	5q14.1-q14.2
Family	ATG10 family
Function	E2-like enzyme involved in autophagy. Acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5. ATG12 conjugation to ATG5 is required for autophagy. Likely serves as an ATG5-recognition molecule. Not involved in ATG12 conjugation to ATG3 (By similarity). Plays a role in adenovirus-mediated cell lysis. Click to Show/Hide
Gene ID	83734
Uniprot ID	ATG10_HUMAN
HGNC ID	HGNC:20315
KEGG ID	hsa:83734

Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator

Non-coding RNA

m6A Regulator: YTH domain-containing protein 1 (YTHDC1)

Regulator Info

In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT05025		Crosstalk Info
Epigenetic Regulator	Colorectal neoplasia differentially expressed (CRNDE)
Regulated Target	YTH N6-methyladenosine RNA binding protein C1 (YTHDC1)
Crosstalk relationship	ncRNA → m6A
Disease	Acute ischemic stroke	Disease Info

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR01681)

Ubiquitin-like-conjugating enzyme ATG10 (ATG10)

Adenosine-to-Inosine editing (A-to-I)

In total 7 m6A sequence/site(s) in this target gene
mod ID: A2ISITE000754		Click to Show/Hide the Full List
mod site	chr5:81990499-81990500:+		[2]
Sequence	TGCTGAGAAGGATCTTTAGTAGGGAAATTCTGTCTGTCAGA
Transcript ID List	ENST00000513443.5; ENST00000282185.8; ENST00000458350.7; ENST00000504770.5; ENST00000355178.8; ENST00000513634.1
External Link	RMBase: RNA-editing_site_110161
mod ID: A2ISITE000755		Click to Show/Hide the Full List
mod site	chr5:82022457-82022458:+		[2]
Sequence	CCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGTACCCA
Transcript ID List	ENST00000355178.8; ENST00000504770.5; ENST00000458350.7; ENST00000513443.5; ENST00000513634.1; ENST00000282185.8
External Link	RMBase: RNA-editing_site_110162
mod ID: A2ISITE000756		Click to Show/Hide the Full List
mod site	chr5:82022957-82022958:+		[2]
Sequence	ATCTATTCCATACCACCATTATGTAGCCAACACAATGGATC
Transcript ID List	ENST00000282185.8; ENST00000504770.5; ENST00000513443.5; ENST00000513634.1; ENST00000458350.7; ENST00000355178.8
External Link	RMBase: RNA-editing_site_110163
mod ID: A2ISITE000757		Click to Show/Hide the Full List
mod site	chr5:82063136-82063137:+		[2]
Sequence	GAGATCAGCCTGGACAGTATAGTGAGACTCCATCACTACAA
Transcript ID List	ENST00000355178.8; ENST00000282185.8; ENST00000513634.1; ENST00000458350.7; rmsk_1669843; ENST00000513443.5; ENST00000504770.5
External Link	RMBase: RNA-editing_site_110164
mod ID: A2ISITE000758		Click to Show/Hide the Full List
mod site	chr5:82123245-82123246:+		[2]
Sequence	GGATGGAGGCTATTATCCTTAGCAAACTAATGCAGGAACAG
Transcript ID List	ENST00000513443.5; ENST00000355178.8; ENST00000508814.5; rmsk_1669924; ENST00000504770.5; ENST00000282185.8; ENST00000513634.1; ENST00000458350.7
External Link	RMBase: RNA-editing_site_110165
mod ID: A2ISITE000759		Click to Show/Hide the Full List
mod site	chr5:82187213-82187214:+		[2]
Sequence	AAATCTCACCTTTAAAAAAAAGGCATATGGGCCAGGCATGG
Transcript ID List	ENST00000508814.5; ENST00000514253.2; ENST00000282185.8; ENST00000458350.7; ENST00000504770.5; ENST00000513634.1
External Link	RMBase: RNA-editing_site_110166
mod ID: A2ISITE000760		Click to Show/Hide the Full List
mod site	chr5:82246344-82246345:+		[2]
Sequence	CCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCATGCT
Transcript ID List	ENST00000282185.8; ENST00000513634.1; ENST00000514253.2; ENST00000458350.7; ENST00000508814.5; ENST00000504770.5
External Link	RMBase: RNA-editing_site_110167

5-methylcytidine (m5C)

In total 8 m6A sequence/site(s) in this target gene
mod ID: M5CSITE003529		Click to Show/Hide the Full List
mod site	chr5:81976265-81976266:+
Sequence	TGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAG
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000504770.5; ENST00000513443.5; ENST00000355178.8; ENST00000282185.8; ENST00000510085.1; ENST00000458350.7
External Link	RMBase: m5C_site_35379
mod ID: M5CSITE003530		Click to Show/Hide the Full List
mod site	chr5:81976266-81976267:+
Sequence	GATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGG
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000510085.1; ENST00000458350.7; ENST00000355178.8; ENST00000513443.5; ENST00000504770.5; ENST00000282185.8
External Link	RMBase: m5C_site_35380
mod ID: M5CSITE003531		Click to Show/Hide the Full List
mod site	chr5:81976267-81976268:+
Sequence	ATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGC
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000282185.8; ENST00000504770.5; ENST00000355178.8; ENST00000510085.1; ENST00000458350.7; ENST00000513443.5
External Link	RMBase: m5C_site_35381
mod ID: M5CSITE003532		Click to Show/Hide the Full List
mod site	chr5:81976274-81976275:+
Sequence	CGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCC
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000504770.5; ENST00000282185.8; ENST00000510085.1; ENST00000355178.8; ENST00000458350.7; ENST00000513443.5
External Link	RMBase: m5C_site_35382
mod ID: M5CSITE003533		Click to Show/Hide the Full List
mod site	chr5:81976283-81976284:+
Sequence	CTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGCGCCC
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000458350.7; ENST00000504770.5; ENST00000510085.1; ENST00000355178.8; ENST00000513443.5; ENST00000282185.8
External Link	RMBase: m5C_site_35383
mod ID: M5CSITE003534		Click to Show/Hide the Full List
mod site	chr5:81976287-81976288:+
Sequence	CAAAGTGCTGGGATTACAGGCGTGAGCCACTGCGCCCGGCC
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000355178.8; ENST00000504770.5; ENST00000513443.5; ENST00000458350.7; ENST00000510085.1; ENST00000282185.8
External Link	RMBase: m5C_site_35384
mod ID: M5CSITE003535		Click to Show/Hide the Full List
mod site	chr5:81976293-81976294:+
Sequence	GCTGGGATTACAGGCGTGAGCCACTGCGCCCGGCCTGTTGT
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000513443.5; ENST00000355178.8; ENST00000510085.1; ENST00000458350.7; ENST00000504770.5; ENST00000282185.8
External Link	RMBase: m5C_site_35385
mod ID: M5CSITE003536		Click to Show/Hide the Full List
mod site	chr5:81976294-81976295:+
Sequence	CTGGGATTACAGGCGTGAGCCACTGCGCCCGGCCTGTTGTA
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000282185.8; ENST00000510085.1; ENST00000513443.5; ENST00000504770.5; ENST00000458350.7; ENST00000355178.8
External Link	RMBase: m5C_site_35386

N6-methyladenosine (m6A)

In total 15 m6A sequence/site(s) in this target gene
mod ID: M6ASITE069620		Click to Show/Hide the Full List
mod site	chr5:81972054-81972055:+		[3]
Sequence	CTCCGACTCGGCCGTGGCGGACCTGACTGAAGGAGGCCGCG
Motif Score	3.622404762
Cell/Tissue List	HeLa; HEK293T
Seq Type List	m6A-seq
Transcript ID List	ENST00000458350.7; ENST00000510085.1; ENST00000355178.8; ENST00000282185.8
External Link	RMBase: m6A_site_675426
mod ID: M6ASITE069621		Click to Show/Hide the Full List
mod site	chr5:81972076-81972077:+		[3]
Sequence	CTGACTGAAGGAGGCCGCGGACCTGACTGAAGGAGGCCACG
Motif Score	3.622404762
Cell/Tissue List	HeLa; HEK293T
Seq Type List	m6A-seq
Transcript ID List	ENST00000458350.7; ENST00000282185.8; ENST00000355178.8; ENST00000510085.1
External Link	RMBase: m6A_site_675427
mod ID: M6ASITE069622		Click to Show/Hide the Full List
mod site	chr5:82178513-82178514:+		[4]
Sequence	GAGACCTTTAACTCTGAAGGACATATGGGAAGGAGTTCATG
Motif Score	3.643047619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000513634.1; ENST00000282185.8; ENST00000514253.2; ENST00000508814.5; ENST00000504770.5; ENST00000458350.7
External Link	RMBase: m6A_site_675428
mod ID: M6ASITE069623		Click to Show/Hide the Full List
mod site	chr5:82254142-82254143:+		[3]
Sequence	CCAGCCCTGGCTTTAATAGGACTGATACCATGGAATATTTC
Motif Score	4.065041667
Cell/Tissue List	HeLa; HEK293T; U2OS; A549; Huh7; HEK293A-TOA; iSLK; AML
Seq Type List	m6A-seq; MeRIP-seq; m6A-CLIP/IP; miCLIP
Transcript ID List	ENST00000514253.2; ENST00000508814.5; ENST00000282185.8; ENST00000458350.7
External Link	RMBase: m6A_site_675429
mod ID: M6ASITE069624		Click to Show/Hide the Full List
mod site	chr5:82254201-82254202:+		[3]
Sequence	ATGGATTATTTTTCCCTTGGACACAAATGTCTACAGCAACT
Motif Score	3.643047619
Cell/Tissue List	HeLa; HEK293T; hESC-HEK293T; hESCs; A549; Huh7; HEK293A-TOA; iSLK; MSC; TREX
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq
Transcript ID List	ENST00000514253.2; ENST00000458350.7; ENST00000508814.5; ENST00000282185.8
External Link	RMBase: m6A_site_675430
mod ID: M6ASITE069625		Click to Show/Hide the Full List
mod site	chr5:82254252-82254253:+		[3]
Sequence	AGGCTGAATGTTTAGAAGAAACACTTCAAAGGGATACATCA
Motif Score	2.20572619
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; H1A; H1B; hESCs; fibroblasts; GM12878; MM6; Huh7; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000282185.8; ENST00000508814.5; ENST00000514253.2; ENST00000458350.7
External Link	RMBase: m6A_site_675431
mod ID: M6ASITE069626		Click to Show/Hide the Full List
mod site	chr5:82254357-82254358:+		[3]
Sequence	CTTGATCCTGGGAGTTCGAGACCAGCCTGGGCAACATGGTG
Motif Score	2.876744048
Cell/Tissue List	HeLa; A549; HEK293T; H1A; H1B; hESCs; fibroblasts; Huh7; peripheral-blood; HEK293A-TOA; iSLK; MSC; TIME; TREX
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	rmsk_1670143; ENST00000458350.7; ENST00000514253.2; ENST00000508814.5; ENST00000282185.8
External Link	RMBase: m6A_site_675432
mod ID: M6ASITE069627		Click to Show/Hide the Full List
mod site	chr5:82254380-82254381:+		[3]
Sequence	AGCCTGGGCAACATGGTGAAACCCTGTCGGTACAAAAAAAT
Motif Score	2.185083333
Cell/Tissue List	HeLa; A549; HEK293T; H1A; H1B; hESCs; Huh7; peripheral-blood; HEK293A-TOA; iSLK; MSC; TIME; TREX
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000514253.2; rmsk_1670143; ENST00000282185.8; ENST00000458350.7; ENST00000508814.5
External Link	RMBase: m6A_site_675433
mod ID: M6ASITE069628		Click to Show/Hide the Full List
mod site	chr5:82254510-82254511:+		[3]
Sequence	AGAGGTTGCAGTGAGCTGAGACTGTGCCACTGCAGTCCAGC
Motif Score	3.319380952
Cell/Tissue List	HeLa; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000508814.5; ENST00000458350.7; rmsk_1670143; ENST00000514253.2; ENST00000282185.8
External Link	RMBase: m6A_site_675434
mod ID: M6ASITE069629		Click to Show/Hide the Full List
mod site	chr5:82254548-82254549:+		[3]
Sequence	AGCCTGGGTGACAGAGCCAGACACTGTCTCGGGGAAAAAAA
Motif Score	2.897386905
Cell/Tissue List	HeLa; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	rmsk_1670143; ENST00000458350.7; ENST00000514253.2; ENST00000282185.8; ENST00000508814.5
External Link	RMBase: m6A_site_675435
mod ID: M6ASITE069630		Click to Show/Hide the Full List
mod site	chr5:82254582-82254583:+		[5]
Sequence	AAAAAAAAAAAAAAAAAAAGACACATCACTATAAATAGCAA
Motif Score	2.897386905
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000508814.5; ENST00000514253.2; ENST00000458350.7; ENST00000282185.8
External Link	RMBase: m6A_site_675436
mod ID: M6ASITE069631		Click to Show/Hide the Full List
mod site	chr5:82254607-82254608:+		[5]
Sequence	TCACTATAAATAGCAAAAAAACAAATCTAACTTATTAATAC
Motif Score	2.20572619
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000508814.5; ENST00000282185.8; ENST00000458350.7; ENST00000514253.2
External Link	RMBase: m6A_site_675437
mod ID: M6ASITE069632		Click to Show/Hide the Full List
mod site	chr5:82276157-82276158:+		[3]
Sequence	TGTATAGGGCCAAAAGAGAAACATTGGCTACTTTGACAACC
Motif Score	2.20572619
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000508814.5; ENST00000514253.2
External Link	RMBase: m6A_site_675508
mod ID: M6ASITE069633		Click to Show/Hide the Full List
mod site	chr5:82276187-82276188:+		[3]
Sequence	CTTTGACAACCTTAAAGCGGACTCCAGGAATATCACCAACA
Motif Score	4.065041667
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000514253.2; ENST00000508814.5
External Link	RMBase: m6A_site_675509
mod ID: M6ASITE069634		Click to Show/Hide the Full List
mod site	chr5:82276241-82276242:+		[3]
Sequence	GACCAAATCCAGCAACCAGAACTTCATCATTTTCCTGGAAT
Motif Score	3.373380952
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000508814.5; ENST00000514253.2
External Link	RMBase: m6A_site_675510

Ref 1	Phase I study of barasertib (AZD1152), a selective inhibitor of Aurora B kinase, in patients with advanced solid tumors. Invest New Drugs. 2013 Apr;31(2):370-80. doi: 10.1007/s10637-012-9825-7. Epub 2012 Jun 2.
Ref 2	RADAR: a rigorously annotated database of A-to-I RNA editing. Nucleic Acids Res. 2014 Jan;42(Database issue):D109-13. doi: 10.1093/nar/gkt996. Epub 2013 Oct 25.
Ref 3	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 4	Deciphering the "m(6)A Code" via Antibody-Independent Quantitative Profiling. Cell. 2019 Jul 25;178(3):731-747.e16. doi: 10.1016/j.cell.2019.06.013. Epub 2019 Jun 27.
Ref 5	N6-Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection. Cell Host Microbe. 2016 Nov 9;20(5):654-665. doi: 10.1016/j.chom.2016.09.015. Epub 2016 Oct 20.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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