m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR01443)

Target Name	Toll-like receptor 2 (TLR2)
Synonyms	Toll/interleukin-1 receptor-like protein 4; CD antigen CD282 Click to Show/Hide
Gene Name	TLR2
Chromosomal Location	4q31.3
Family	Toll-like receptor family
Function	Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides (PubMed:21078852, PubMed:17889651). Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also activate immune cells and promote apoptosis in response to the lipid moiety of lipoproteins (PubMed:10426995, PubMed:10426996). Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6 (PubMed:11441107). Stimulation of monocytes in vitro with M.tuberculosis PstS1 induces p38 MAPK and ERK1/2 activation primarily via this receptor, but also partially via TLR4 (PubMed:16622205). MAPK activation in response to bacterial peptidoglycan also occurs via this receptor (PubMed:16622205). Acts as a receptor for M.tuberculosis lipoproteins LprA, LprG, LpqH and PstS1, some lipoproteins are dependent on other coreceptors (TLR1, CD14 and/or CD36); the lipoproteins act as agonists to modulate antigen presenting cell functions in response to the pathogen (PubMed:19362712). M.tuberculosis HSP70 (dnaK) but not HSP65 (groEL-2) acts via this protein to stimulate NF-kappa-B expression (PubMed:15809303). Recognizes M.tuberculosis major T-antigen EsxA (ESAT-6) which inhibits downstream MYD88-dependent signaling (shown in mouse) (By similarity). Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Forms the cluster TLR2:TLR6:CD14:CD36 in response to diacylated lipopeptides and TLR2:TLR1:CD14 in response to triacylated lipopeptides (PubMed:16880211). Required for normal uptake of M.tuberculosis, a process that is inhibited by M.tuberculosis LppM (By similarity). Click to Show/Hide
Gene ID	7097
Uniprot ID	TLR2_HUMAN
HGNC ID	HGNC:11848
KEGG ID	hsa:7097

Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator

Histone modification

m6A Regulator: Methyltransferase-like 3 (METTL3)

Regulator Info

In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT03503		Crosstalk Info
Epigenetic Regulator	Histone-lysine N-methyltransferase 2A (KMT2A)
Regulated Target	Histone H3 lysine 4 trimethylation (H3K4me3)
Crosstalk relationship	Histone modification → m6A
Disease	Intervertebral disc degeneration	Disease Info

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR01443)

Toll-like receptor 2 (TLR2)

Adenosine-to-Inosine editing (A-to-I)

In total 2 m6A sequence/site(s) in this target gene
mod ID: A2ISITE000626		Click to Show/Hide the Full List
mod site	chr4:153701466-153701467:+		[3]
Sequence	TAAATACATTTCTGTTCTTTATAAATTACTTGGTCTCTGGT
Transcript ID List	ENST00000643501.1; ENST00000642580.1; ENST00000646900.1; ENST00000644308.1; ENST00000642700.1; ENST00000646219.1; rmsk_1478210
External Link	RMBase: RNA-editing_site_107105
mod ID: A2ISITE000627		Click to Show/Hide the Full List
mod site	chr4:153702626-153702627:+		[3]
Sequence	GTTATTGAGTCTTGCTCTGTAATTCCGGATGGTTGTGCTTT
Transcript ID List	ENST00000646900.1; ENST00000642700.1; ENST00000643501.1; ENST00000646219.1; ENST00000260010.6; ENST00000642580.1; ENST00000644308.1
External Link	RMBase: RNA-editing_site_107106

5-methylcytidine (m5C)

In total 1 m6A sequence/site(s) in this target gene
mod ID: M5CSITE003350		Click to Show/Hide the Full List
mod site	chr4:153704664-153704665:+
Sequence	CTCTCGGTGTCGGAATGTCACAGGACAGCACTGGTGTCTGG
Cell/Tissue List	lung
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000642580.1; ENST00000644308.1; ENST00000643087.1; ENST00000642700.1; ENST00000260010.6
External Link	RMBase: m5C_site_34415

N6-methyladenosine (m6A)

In total 45 m6A sequence/site(s) in this target gene
mod ID: M6ASITE068436		Click to Show/Hide the Full List
mod site	chr4:153703037-153703038:+		[4]
Sequence	GGGCAGCTCAGGATCTTTAAACTCCATTCCCTCAGGGCTCA
Motif Score	2.627720238
Cell/Tissue List	CD34
Seq Type List	m6A-seq
Transcript ID List	ENST00000642700.1; ENST00000644308.1; ENST00000642580.1; ENST00000260010.6; ENST00000643087.1; ENST00000646900.1
External Link	RMBase: m6A_site_654801
mod ID: M6ASITE068437		Click to Show/Hide the Full List
mod site	chr4:153703136-153703137:+		[4]
Sequence	TGACCTACAGAGGTGTGTGAACCTCCAGGCTCTGGTGCTGA
Motif Score	2.930744048
Cell/Tissue List	CD34; MSC
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000643087.1; ENST00000260010.6; ENST00000642580.1; ENST00000646900.1; ENST00000642700.1; ENST00000644308.1
External Link	RMBase: m6A_site_654802
mod ID: M6ASITE068438		Click to Show/Hide the Full List
mod site	chr4:153703215-153703216:+		[5]
Sequence	TCTTCCCTGGGCAGTCTTGAACATTTAGACTTATCCTATAA
Motif Score	2.951386905
Cell/Tissue List	MSC
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000260010.6; ENST00000643087.1; ENST00000642580.1; ENST00000642700.1; ENST00000646900.1; ENST00000644308.1
External Link	RMBase: m6A_site_654803
mod ID: M6ASITE068439		Click to Show/Hide the Full List
mod site	chr4:153703223-153703224:+		[5]
Sequence	GGGCAGTCTTGAACATTTAGACTTATCCTATAATTACTTAT
Motif Score	3.319380952
Cell/Tissue List	MSC
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000260010.6; ENST00000642700.1; ENST00000643087.1; ENST00000642580.1; ENST00000646900.1; ENST00000644308.1
External Link	RMBase: m6A_site_654804
mod ID: M6ASITE068440		Click to Show/Hide the Full List
mod site	chr4:153703295-153703296:+		[5]
Sequence	TTCTTCTTTAACATTCTTAAACTTACTGGGAAATCCTTACA
Motif Score	2.627720238
Cell/Tissue List	MSC
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000644308.1; ENST00000642700.1; ENST00000642580.1; ENST00000643087.1; ENST00000646900.1; ENST00000260010.6
External Link	RMBase: m6A_site_654805
mod ID: M6ASITE068441		Click to Show/Hide the Full List
mod site	chr4:153703318-153703319:+		[4]
Sequence	TACTGGGAAATCCTTACAAAACCCTAGGGGAAACATCTCTT
Motif Score	2.185083333
Cell/Tissue List	CD34; MSC
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000260010.6; ENST00000642580.1; ENST00000642700.1; ENST00000643087.1; ENST00000644308.1; ENST00000646900.1
External Link	RMBase: m6A_site_654806
mod ID: M6ASITE068442		Click to Show/Hide the Full List
mod site	chr4:153703330-153703331:+		[4]
Sequence	CTTACAAAACCCTAGGGGAAACATCTCTTTTTTCTCATCTC
Motif Score	2.20572619
Cell/Tissue List	CD34; MSC
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000644308.1; ENST00000642580.1; ENST00000260010.6; ENST00000643087.1; ENST00000642700.1; ENST00000646900.1
External Link	RMBase: m6A_site_654807
mod ID: M6ASITE068443		Click to Show/Hide the Full List
mod site	chr4:153703385-153703386:+		[4]
Sequence	CCTGAGAGTGGGAAATATGGACACCTTCACTAAGATTCAAA
Motif Score	3.643047619
Cell/Tissue List	CD34; hESC-HEK293T; CD8T; MM6; MSC; NB4
Seq Type List	m6A-seq; MAZTER-seq; m6A-CLIP/IP; MeRIP-seq
Transcript ID List	ENST00000642580.1; ENST00000260010.6; ENST00000644308.1; ENST00000642700.1; ENST00000646900.1; ENST00000643087.1
External Link	RMBase: m6A_site_654808
mod ID: M6ASITE068444		Click to Show/Hide the Full List
mod site	chr4:153703422-153703423:+		[6]
Sequence	CAAAGAAAAGATTTTGCTGGACTTACCTTCCTTGAGGAACT
Motif Score	4.065041667
Cell/Tissue List	MM6; peripheral-blood; MSC; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000642700.1; ENST00000642580.1; ENST00000260010.6; ENST00000644308.1; ENST00000643087.1; ENST00000646900.1
External Link	RMBase: m6A_site_654809
mod ID: M6ASITE068445		Click to Show/Hide the Full List
mod site	chr4:153703440-153703441:+		[6]
Sequence	GGACTTACCTTCCTTGAGGAACTTGAGATTGATGCTTCAGA
Motif Score	3.373380952
Cell/Tissue List	MM6; peripheral-blood; MSC; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000260010.6; ENST00000642580.1; ENST00000642700.1; ENST00000646900.1; ENST00000643087.1; ENST00000644308.1
External Link	RMBase: m6A_site_654810
mod ID: M6ASITE068446		Click to Show/Hide the Full List
mod site	chr4:153703590-153703591:+		[6]
Sequence	AGTTCCGTGGAATGTTTGGAACTGCGAGATACTGATTTGGA
Motif Score	3.373380952
Cell/Tissue List	MM6; peripheral-blood; MSC; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000642580.1; ENST00000644308.1; ENST00000642700.1; ENST00000646900.1; ENST00000643087.1; ENST00000260010.6
External Link	RMBase: m6A_site_654811
mod ID: M6ASITE068447		Click to Show/Hide the Full List
mod site	chr4:153703610-153703611:+		[6]
Sequence	ACTGCGAGATACTGATTTGGACACTTTCCATTTTTCAGAAC
Motif Score	3.643047619
Cell/Tissue List	MM6; peripheral-blood; MSC
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000644308.1; ENST00000646900.1; ENST00000643087.1; ENST00000642580.1; ENST00000642700.1; ENST00000260010.6
External Link	RMBase: m6A_site_654812
mod ID: M6ASITE068448		Click to Show/Hide the Full List
mod site	chr4:153703629-153703630:+		[7]
Sequence	GACACTTTCCATTTTTCAGAACTATCCACTGGTGAAACAAA
Motif Score	3.373380952
Cell/Tissue List	CD8T; MM6; peripheral-blood; MSC
Seq Type List	m6A-CLIP/IP; m6A-seq; MeRIP-seq
Transcript ID List	ENST00000644308.1; ENST00000260010.6; ENST00000642580.1; ENST00000642700.1; ENST00000643087.1; ENST00000646900.1
External Link	RMBase: m6A_site_654813
mod ID: M6ASITE068449		Click to Show/Hide the Full List
mod site	chr4:153703645-153703646:+		[6]
Sequence	CAGAACTATCCACTGGTGAAACAAATTCATTGATTAAAAAG
Motif Score	2.20572619
Cell/Tissue List	MM6; peripheral-blood; MSC
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000643087.1; ENST00000642700.1; ENST00000260010.6; ENST00000646900.1; ENST00000644308.1; ENST00000642580.1
External Link	RMBase: m6A_site_654814
mod ID: M6ASITE068450		Click to Show/Hide the Full List
mod site	chr4:153703719-153703720:+		[6]
Sequence	AGTTTGTTTCAGGTTATGAAACTTTTGAATCAGATTTCTGG
Motif Score	2.627720238
Cell/Tissue List	MM6; peripheral-blood; MSC
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000642580.1; ENST00000644308.1; ENST00000642700.1; ENST00000643087.1; ENST00000260010.6
External Link	RMBase: m6A_site_654815
mod ID: M6ASITE068451		Click to Show/Hide the Full List
mod site	chr4:153703763-153703764:+		[7]
Sequence	GTTAGAATTAGAGTTTGATGACTGTACCCTTAATGGAGTTG
Motif Score	3.28175
Cell/Tissue List	CD8T
Seq Type List	m6A-CLIP/IP
Transcript ID List	ENST00000642700.1; ENST00000643087.1; ENST00000260010.6; ENST00000644308.1; ENST00000642580.1
External Link	RMBase: m6A_site_654816
mod ID: M6ASITE068452		Click to Show/Hide the Full List
mod site	chr4:153704077-153704078:+		[4]
Sequence	ATGCCTGGCCCTCTCTACAAACTTTAATTTTAAGGCAAAAT
Motif Score	2.627720238
Cell/Tissue List	CD34; CD8T; MSC
Seq Type List	m6A-seq; m6A-CLIP/IP; MeRIP-seq
Transcript ID List	ENST00000642700.1; ENST00000260010.6; ENST00000643087.1; ENST00000642580.1; ENST00000644308.1
External Link	RMBase: m6A_site_654817
mod ID: M6ASITE068453		Click to Show/Hide the Full List
mod site	chr4:153704119-153704120:+		[4]
Sequence	ATTTGGCATCATTGGAAAAAACCGGAGAGACTTTGCTCACT
Motif Score	2.185083333
Cell/Tissue List	CD34; MM6; MSC
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000260010.6; ENST00000642580.1; ENST00000643087.1; ENST00000644308.1; ENST00000642700.1
External Link	RMBase: m6A_site_654818
mod ID: M6ASITE068454		Click to Show/Hide the Full List
mod site	chr4:153704128-153704129:+		[4]
Sequence	CATTGGAAAAAACCGGAGAGACTTTGCTCACTCTGAAAAAC
Motif Score	3.319380952
Cell/Tissue List	CD34; CD8T; MM6; MSC
Seq Type List	m6A-seq; m6A-CLIP/IP; MeRIP-seq
Transcript ID List	ENST00000642700.1; ENST00000643087.1; ENST00000644308.1; ENST00000260010.6; ENST00000642580.1
External Link	RMBase: m6A_site_654819
mod ID: M6ASITE068455		Click to Show/Hide the Full List
mod site	chr4:153704147-153704148:+		[4]
Sequence	GACTTTGCTCACTCTGAAAAACTTGACTAACATTGATATCA
Motif Score	2.627720238
Cell/Tissue List	CD34; MM6; MSC
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000644308.1; ENST00000642700.1; ENST00000643087.1; ENST00000260010.6; ENST00000642580.1
External Link	RMBase: m6A_site_654820
mod ID: M6ASITE068456		Click to Show/Hide the Full List
mod site	chr4:153704197-153704198:+		[4]
Sequence	GTTTTCATTCTATGCCTGAAACTTGTCAGTGGCCAGAAAAG
Motif Score	2.627720238
Cell/Tissue List	CD34; MM6; MSC
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000260010.6; ENST00000644308.1; ENST00000642580.1; ENST00000642700.1; ENST00000643087.1
External Link	RMBase: m6A_site_654821
mod ID: M6ASITE068457		Click to Show/Hide the Full List
mod site	chr4:153704231-153704232:+		[7]
Sequence	AGAAAAGATGAAATATTTGAACTTATCCAGCACACGAATAC
Motif Score	3.373380952
Cell/Tissue List	CD8T; MM6; MSC
Seq Type List	m6A-CLIP/IP; m6A-seq; MeRIP-seq
Transcript ID List	ENST00000643087.1; ENST00000260010.6; ENST00000642700.1; ENST00000644308.1; ENST00000642580.1
External Link	RMBase: m6A_site_654822
mod ID: M6ASITE068458		Click to Show/Hide the Full List
mod site	chr4:153704278-153704279:+		[6]
Sequence	TAACAGGCTGCATTCCCAAGACACTGGAAATTTTAGATGTT
Motif Score	2.897386905
Cell/Tissue List	MM6; MSC
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000644308.1; ENST00000642700.1; ENST00000643087.1; ENST00000260010.6; ENST00000642580.1
External Link	RMBase: m6A_site_654823
mod ID: M6ASITE068459		Click to Show/Hide the Full List
mod site	chr4:153704349-153704350:+		[6]
Sequence	AATTTGCCGCAACTCAAAGAACTTTATATTTCCAGAAATAA
Motif Score	3.373380952
Cell/Tissue List	MM6; MSC
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000644308.1; ENST00000642580.1; ENST00000260010.6; ENST00000642700.1; ENST00000643087.1
External Link	RMBase: m6A_site_654824
mod ID: M6ASITE068460		Click to Show/Hide the Full List
mod site	chr4:153704377-153704378:+		[8]
Sequence	TTTCCAGAAATAAGTTGATGACTCTACCAGATGCCTCCCTC
Motif Score	3.28175
Cell/Tissue List	AML
Seq Type List	miCLIP
Transcript ID List	ENST00000643087.1; ENST00000642580.1; ENST00000644308.1; ENST00000260010.6; ENST00000642700.1
External Link	RMBase: m6A_site_654825
mod ID: M6ASITE068461		Click to Show/Hide the Full List
mod site	chr4:153704485-153704486:+		[7]
Sequence	ACTCATTTCACACACTGAAGACTTTGGAAGCTGGTGGCAAT
Motif Score	3.319380952
Cell/Tissue List	CD8T; MM6; Huh7; MSC
Seq Type List	m6A-CLIP/IP; m6A-seq; MeRIP-seq
Transcript ID List	ENST00000260010.6; ENST00000642580.1; ENST00000643087.1; ENST00000642700.1; ENST00000644308.1
External Link	RMBase: m6A_site_654826
mod ID: M6ASITE068462		Click to Show/Hide the Full List
mod site	chr4:153704600-153704601:+		[8]
Sequence	GCCAGCAAATTACCTGTGTGACTCTCCATCCCATGTGCGTG
Motif Score	3.28175
Cell/Tissue List	AML
Seq Type List	miCLIP
Transcript ID List	ENST00000644308.1; ENST00000642700.1; ENST00000260010.6; ENST00000643087.1; ENST00000642580.1
External Link	RMBase: m6A_site_654827
mod ID: M6ASITE068463		Click to Show/Hide the Full List
mod site	chr4:153704668-153704669:+		[6]
Sequence	CGGTGTCGGAATGTCACAGGACAGCACTGGTGTCTGGCATG
Motif Score	3.643047619
Cell/Tissue List	MM6; peripheral-blood; MSC; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000260010.6; ENST00000644308.1; ENST00000643087.1; ENST00000642700.1; ENST00000642580.1
External Link	RMBase: m6A_site_654828
mod ID: M6ASITE068464		Click to Show/Hide the Full List
mod site	chr4:153704819-153704820:+		[9]
Sequence	CAGGAAAGCTCCCAGCAGGAACATCTGCTATGATGCATTTG
Motif Score	2.951386905
Cell/Tissue List	peripheral-blood; MM6
Seq Type List	m6A-seq
Transcript ID List	ENST00000644308.1; ENST00000260010.6; ENST00000642580.1; ENST00000642700.1; ENST00000643087.1
External Link	RMBase: m6A_site_654829
mod ID: M6ASITE068465		Click to Show/Hide the Full List
mod site	chr4:153704876-153704877:+		[4]
Sequence	GGATGCCTACTGGGTGGAGAACCTTATGGTCCAGGAGCTGG
Motif Score	2.930744048
Cell/Tissue List	CD34; MM6; peripheral-blood
Seq Type List	m6A-seq
Transcript ID List	ENST00000642700.1; ENST00000643087.1; ENST00000642580.1; ENST00000260010.6; ENST00000644308.1
External Link	RMBase: m6A_site_654830
mod ID: M6ASITE068466		Click to Show/Hide the Full List
mod site	chr4:153704900-153704901:+		[4]
Sequence	TATGGTCCAGGAGCTGGAGAACTTCAATCCCCCCTTCAAGT
Motif Score	3.373380952
Cell/Tissue List	CD34; MM6; peripheral-blood; MSC
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000643087.1; ENST00000642580.1; ENST00000644308.1; ENST00000642700.1; ENST00000260010.6
External Link	RMBase: m6A_site_654831
mod ID: M6ASITE068467		Click to Show/Hide the Full List
mod site	chr4:153704939-153704940:+		[4]
Sequence	GTTGTGTCTTCATAAGCGGGACTTCATTCCTGGCAAGTGGA
Motif Score	4.065041667
Cell/Tissue List	CD34; MM6; peripheral-blood; MSC
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000644308.1; ENST00000260010.6; ENST00000643087.1; ENST00000642580.1; ENST00000642700.1
External Link	RMBase: m6A_site_654832
mod ID: M6ASITE068468		Click to Show/Hide the Full List
mod site	chr4:153705001-153705002:+		[4]
Sequence	CCATTGAAAAGAGCCACAAAACTGTCTTTGTGCTTTCTGAA
Motif Score	2.627720238
Cell/Tissue List	CD34; MM6; peripheral-blood; MSC; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000642580.1; ENST00000644308.1; ENST00000260010.6; ENST00000642700.1; ENST00000643087.1
External Link	RMBase: m6A_site_654833
mod ID: M6ASITE068469		Click to Show/Hide the Full List
mod site	chr4:153705023-153705024:+		[4]
Sequence	TGTCTTTGTGCTTTCTGAAAACTTTGTGAAGAGTGAGTGGT
Motif Score	2.627720238
Cell/Tissue List	CD34; MM6; Huh7; peripheral-blood; MSC; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000642580.1; ENST00000260010.6; ENST00000643087.1; ENST00000642700.1; ENST00000644308.1
External Link	RMBase: m6A_site_654834
mod ID: M6ASITE068470		Click to Show/Hide the Full List
mod site	chr4:153705054-153705055:+		[4]
Sequence	AGTGAGTGGTGCAAGTATGAACTGGACTTCTCCCATTTCCG
Motif Score	3.373380952
Cell/Tissue List	CD34; MM6; Huh7; CD4T; peripheral-blood; MSC; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000642580.1; ENST00000643087.1; ENST00000260010.6; ENST00000644308.1; ENST00000642700.1
External Link	RMBase: m6A_site_654835
mod ID: M6ASITE068471		Click to Show/Hide the Full List
mod site	chr4:153705059-153705060:+		[4]
Sequence	GTGGTGCAAGTATGAACTGGACTTCTCCCATTTCCGTCTTT
Motif Score	4.065041667
Cell/Tissue List	CD34; MM6; Huh7; CD4T; peripheral-blood; MSC; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000642580.1; ENST00000260010.6; ENST00000644308.1; ENST00000642700.1; ENST00000643087.1
External Link	RMBase: m6A_site_654836
mod ID: M6ASITE068472		Click to Show/Hide the Full List
mod site	chr4:153705089-153705090:+		[4]
Sequence	TTTCCGTCTTTTTGATGAGAACAATGATGCTGCCATTCTCA
Motif Score	2.951386905
Cell/Tissue List	CD34; MM6; Huh7; CD4T; peripheral-blood; MSC; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000644308.1; ENST00000642700.1; ENST00000643087.1; ENST00000260010.6; ENST00000642580.1
External Link	RMBase: m6A_site_654837
mod ID: M6ASITE068473		Click to Show/Hide the Full List
mod site	chr4:153705176-153705177:+		[10]
Sequence	CAAGCTGCGGAAGATAATGAACACCAAGACCTACCTGGAGT
Motif Score	2.951386905
Cell/Tissue List	A549; MM6; Huh7; peripheral-blood; MSC; NB4
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000643087.1; ENST00000644308.1; ENST00000642700.1; ENST00000260010.6; ENST00000642580.1
External Link	RMBase: m6A_site_654838
mod ID: M6ASITE068474		Click to Show/Hide the Full List
mod site	chr4:153705184-153705185:+		[10]
Sequence	GGAAGATAATGAACACCAAGACCTACCTGGAGTGGCCCATG
Motif Score	2.876744048
Cell/Tissue List	A549; MM6; Huh7; peripheral-blood; MSC; NB4
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000644308.1; ENST00000643087.1; ENST00000642700.1; ENST00000260010.6; ENST00000642580.1
External Link	RMBase: m6A_site_654839
mod ID: M6ASITE068475		Click to Show/Hide the Full List
mod site	chr4:153705277-153705278:+		[6]
Sequence	CCTAGGTTCCCATATTTAAGACCAGTCTTTGTCTAGTTGGG
Motif Score	2.876744048
Cell/Tissue List	MM6; peripheral-blood; MSC
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000642700.1; ENST00000260010.6; ENST00000642580.1; ENST00000644308.1
External Link	RMBase: m6A_site_654840
mod ID: M6ASITE068476		Click to Show/Hide the Full List
mod site	chr4:153705334-153705335:+		[6]
Sequence	TTATAGTTAAGTTCATTCAGACATAATTATATAAAAACTAC
Motif Score	2.897386905
Cell/Tissue List	MM6; MSC
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000642700.1; ENST00000260010.6; ENST00000644308.1; ENST00000642580.1
External Link	RMBase: m6A_site_654841
mod ID: M6ASITE068477		Click to Show/Hide the Full List
mod site	chr4:153705350-153705351:+		[5]
Sequence	TCAGACATAATTATATAAAAACTACGTGGATGTACCGTCAT
Motif Score	2.627720238
Cell/Tissue List	MSC
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000642580.1; ENST00000644308.1; ENST00000642700.1; ENST00000260010.6
External Link	RMBase: m6A_site_654842
mod ID: M6ASITE068478		Click to Show/Hide the Full List
mod site	chr4:153705377-153705378:+		[7]
Sequence	GGATGTACCGTCATTTGAGGACTTGCTTACTAAAACTACAA
Motif Score	4.065041667
Cell/Tissue List	CD8T; MSC
Seq Type List	m6A-CLIP/IP; MeRIP-seq
Transcript ID List	ENST00000642700.1; ENST00000260010.6; ENST00000644308.1; ENST00000642580.1
External Link	RMBase: m6A_site_654843
mod ID: M6ASITE068479		Click to Show/Hide the Full List
mod site	chr4:153705391-153705392:+		[5]
Sequence	TTGAGGACTTGCTTACTAAAACTACAAAACTTCAAATTTTG
Motif Score	2.627720238
Cell/Tissue List	MSC
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000642580.1; ENST00000642700.1; ENST00000260010.6
External Link	RMBase: m6A_site_654844
mod ID: M6ASITE068480		Click to Show/Hide the Full List
mod site	chr4:153705399-153705400:+		[5]
Sequence	TTGCTTACTAAAACTACAAAACTTCAAATTTTGTCTGGGGT
Motif Score	2.627720238
Cell/Tissue List	MSC
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000642700.1; ENST00000260010.6; ENST00000642580.1
External Link	RMBase: m6A_site_654845

Ref 1	Interaction of nilotinib, dasatinib and bosutinib with ABCB1 and ABCG2: implications for altered anti-cancer effects and pharmacological properties. Br J Pharmacol. 2009 Oct;158(4):1153-64. doi: 10.1111/j.1476-5381.2009.00383.x. Epub 2009 Sep 28.
Ref 2	F-12509A, a new sphingosine kinase inhibitor, produced by a discomycete. J Antibiot (Tokyo). 2000 May;53(5):459-66. doi: 10.7164/antibiotics.53.459.
Ref 3	RADAR: a rigorously annotated database of A-to-I RNA editing. Nucleic Acids Res. 2014 Jan;42(Database issue):D109-13. doi: 10.1093/nar/gkt996. Epub 2013 Oct 25.
Ref 4	Suppression of m(6)A reader Ythdf2 promotes hematopoietic stem cell expansion. Cell Res. 2018 Sep;28(9):904-917. doi: 10.1038/s41422-018-0072-0. Epub 2018 Jul 31.
Ref 5	Viral and cellular N(6)-methyladenosine and N(6),2'-O-dimethyladenosine epitranscriptomes in the KSHV life cycle. Nat Microbiol. 2018 Jan;3(1):108-120. doi: 10.1038/s41564-017-0056-8. Epub 2017 Nov 6.
Ref 6	FTO Plays an Oncogenic Role in Acute Myeloid Leukemia as a N(6)-Methyladenosine RNA Demethylase. Cancer Cell. 2017 Jan 9;31(1):127-141. doi: 10.1016/j.ccell.2016.11.017. Epub 2016 Dec 22.
Ref 7	A majority of m6A residues are in the last exons, allowing the potential for 3' UTR regulation. Genes Dev. 2015 Oct 1;29(19):2037-53. doi: 10.1101/gad.269415.115. Epub 2015 Sep 24.
Ref 8	The N(6)-methyladenosine (m(6)A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells. Nat Med. 2017 Nov;23(11):1369-1376. doi: 10.1038/nm.4416. Epub 2017 Sep 18.
Ref 9	R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m(6)A/MYC/CEBPA Signaling. Cell. 2018 Jan 11;172(1-2):90-105.e23. doi: 10.1016/j.cell.2017.11.031. Epub 2017 Dec 14.
Ref 10	Viral N(6)-methyladenosine upregulates replication and pathogenesis of human respiratory syncytial virus. Nat Commun. 2019 Oct 9;10(1):4595. doi: 10.1038/s41467-019-12504-y.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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