m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR01177)

Target Name	RNA, U6 small nuclear 1 (RNU6-1)
Synonyms	U6; U6-1; RNU6A; RNA, U6A small nuclear Click to Show/Hide
Gene Name	RNU6-1
Chromosomal Location	15q23
Gene ID	26827
HGNC ID	HGNC:10227

Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator

Non-coding RNA

m6A Regulator: Methyltransferase-like 16 (METTL16)

Regulator Info

In total 3 item(s) under this m6A regulator
Crosstalk ID: M6ACROT05782		Crosstalk Info
Epigenetic Regulator	RNA, U6 small nuclear 1 (RNU6-1)
Crosstalk relationship	m6A → ncRNA
Crosstalk ID: M6ACROT05783		Crosstalk Info
Epigenetic Regulator	RNA, U6 small nuclear 1 (RNU6-1)
Crosstalk relationship	m6A → ncRNA
Crosstalk ID: M6ACROT05790		Crosstalk Info
Epigenetic Regulator	RNA, U6 small nuclear 1 (RNU6-1)
Crosstalk relationship	m6A → ncRNA

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR01177)

RNA, U6 small nuclear 1 (RNU6-1)

2'-O-Methylation (2'-O-Me)

In total 9 m6A sequence/site(s) in this target gene
mod ID: 2OMSITE000116		Click to Show/Hide the Full List
mod site	chr15:67839975-67839976:-		[4]
Sequence	ATTAGCATGGCCCCTGCGCAAGGATGACACGCAAATTCGTG
Seq Type List	RiboMeth-seq
Transcript ID List	rmsk_4369517; ENST00000383898.1
External Link	RMBase: Nm_site_1949
mod ID: 2OMSITE000122		Click to Show/Hide the Full List
mod site	chr15:67839992-67839993:-		[4]
Sequence	GGAACGATACAGAGAAGATTAGCATGGCCCCTGCGCAAGGA
Cell/Tissue List	N.A.; HEK293
Seq Type List	RiboMeth-seq
Transcript ID List	ENST00000383898.1; rmsk_4369517
External Link	RMBase: Nm_site_1955
mod ID: 2OMSITE000123		Click to Show/Hide the Full List
mod site	chr15:67839998-67839999:-		[4]
Sequence	AAAATTGGAACGATACAGAGAAGATTAGCATGGCCCCTGCG
Cell/Tissue List	N.A.; HEK293
Seq Type List	RiboMeth-seq
Transcript ID List	rmsk_4369517; ENST00000383898.1
External Link	RMBase: Nm_site_1956
mod ID: 2OMSITE000115		Click to Show/Hide the Full List
mod site	chr15:67839968-67839969:-		[4]
Sequence	TGGCCCCTGCGCAAGGATGACACGCAAATTCGTGAAGCGTT
Seq Type List	RiboMeth-seq
Transcript ID List	rmsk_4369517; ENST00000383898.1
External Link	RMBase: Nm_site_1948
mod ID: 2OMSITE000118		Click to Show/Hide the Full List
mod site	chr15:67839982-67839983:-		[4]
Sequence	AGAGAAGATTAGCATGGCCCCTGCGCAAGGATGACACGCAA
Seq Type List	RiboMeth-seq
Transcript ID List	rmsk_4369517; ENST00000383898.1
External Link	RMBase: Nm_site_1951
mod ID: 2OMSITE000119		Click to Show/Hide the Full List
mod site	chr15:67839983-67839984:-		[4]
Sequence	CAGAGAAGATTAGCATGGCCCCTGCGCAAGGATGACACGCA
Cell/Tissue List	N.A.; HEK293
Seq Type List	RiboMeth-seq
Transcript ID List	rmsk_4369517; ENST00000383898.1
External Link	RMBase: Nm_site_1952
mod ID: 2OMSITE000120		Click to Show/Hide the Full List
mod site	chr15:67839985-67839986:-		[4]
Sequence	TACAGAGAAGATTAGCATGGCCCCTGCGCAAGGATGACACG
Cell/Tissue List	N.A.; HEK293
Seq Type List	RiboMeth-seq
Transcript ID List	rmsk_4369517; ENST00000383898.1
External Link	RMBase: Nm_site_1953
mod ID: 2OMSITE000121		Click to Show/Hide the Full List
mod site	chr15:67839991-67839992:-		[4]
Sequence	GAACGATACAGAGAAGATTAGCATGGCCCCTGCGCAAGGAT
Seq Type List	RiboMeth-seq
Transcript ID List	ENST00000383898.1; rmsk_4369517
External Link	RMBase: Nm_site_1954
mod ID: 2OMSITE000117		Click to Show/Hide the Full List
mod site	chr15:67839981-67839982:-		[5]
Sequence	GAGAAGATTAGCATGGCCCCTGCGCAAGGATGACACGCAAA
Cell/Tissue List	HEK293
Seq Type List	RiboMeth-seq
Transcript ID List	ENST00000383898.1; rmsk_4369517
External Link	RMBase: Nm_site_1950

Pseudouridine (Pseudo)

In total 3 m6A sequence/site(s) in this target gene
mod ID: PSESITE000061		Click to Show/Hide the Full List
mod site	chr15:67839959-67839960:-		[6]
Sequence	CGCAAGGATGACACGCAAATTCGTGAAGCGTTCCATATTTT
Transcript ID List	rmsk_4369517; ENST00000383898.1
External Link	RMBase: Pseudo_site_1658
mod ID: PSESITE000062		Click to Show/Hide the Full List
mod site	chr15:67840005-67840006:-		[7]
Sequence	ATATACTAAAATTGGAACGATACAGAGAAGATTAGCATGGC
Transcript ID List	rmsk_4369517; ENST00000383898.1
External Link	RMBase: Pseudo_site_1659
mod ID: PSESITE000063		Click to Show/Hide the Full List
mod site	chr15:67840014-67840015:-		[7]
Sequence	CGGCAGCACATATACTAAAATTGGAACGATACAGAGAAGAT
Transcript ID List	rmsk_4369517; ENST00000383898.1
External Link	RMBase: Pseudo_site_1660

Ref 1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2109).
Ref 2	A novel c-Met inhibitor, MK8033, synergizes with carboplatin plus paclitaxel to inhibit ovarian cancer cell growth. Oncol Rep. 2013 May;29(5):2011-8. doi: 10.3892/or.2013.2329. Epub 2013 Mar 5.
Ref 3	UCN-01: a potent abrogator of G2 checkpoint function in cancer cells with disrupted p53. J Natl Cancer Inst. 1996 Jul 17;88(14):956-65. doi: 10.1093/jnci/88.14.956.
Ref 4	Substoichiometric ribose methylations in spliceosomal snRNAs. Org Biomol Chem. 2017 Oct 31;15(42):8872-8876. doi: 10.1039/c7ob02317k.
Ref 5	High-throughput identification of C/D box snoRNA targets with CLIP and RiboMeth-seq. Nucleic Acids Res. 2017 Mar 17;45(5):2341-2353. doi: 10.1093/nar/gkw1321.
Ref 6	Pseudouridine profiling reveals regulated mRNA pseudouridylation in yeast and human cells. Nature. 2014 Nov 6;515(7525):143-6. doi: 10.1038/nature13802. Epub 2014 Sep 5.
Ref 7	snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs. Nucleic Acids Res. 2006 Jan 1;34(Database issue):D158-62. doi: 10.1093/nar/gkj002.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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